LOCUS       NM_001401301            6270 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus collagen, type XI, alpha 2 (Col11a2), transcript
            variant 3, mRNA.
ACCESSION   NM_001401301 XM_006523564
VERSION     NM_001401301.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6270)
  AUTHORS   Ushiki,A., Sheng,R.R., Zhang,Y., Zhao,J., Nobuhara,M., Murray,E.,
            Ruan,X., Rios,J.J., Wise,C.A. and Ahituv,N.
  TITLE     Deletion of Pax1 scoliosis-associated regulatory elements leads to
            a female-biased tail abnormality
  JOURNAL   Cell Rep 43 (3), 113907 (2024)
   PUBMED   38461417
REFERENCE   2  (bases 1 to 6270)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6270)
  AUTHORS   Liu,J., Chanumolu,S.K., White,K.M., Albahrani,M., Otu,H.H. and
            Nawshad,A.
  TITLE     Transcriptional analysis of cleft palate in TGFbeta3 mutant mice
  JOURNAL   Sci Rep 10 (1), 14940 (2020)
   PUBMED   32913205
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6270)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   5  (bases 1 to 6270)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6270)
  AUTHORS   Tsumaki,N., Kimura,T., Matsui,Y., Nakata,K. and Ochi,T.
  TITLE     Separable cis-regulatory elements that contribute to tissue- and
            site-specific alpha 2(XI) collagen gene expression in the embryonic
            mouse cartilage
  JOURNAL   J Cell Biol 134 (6), 1573-1582 (1996)
   PUBMED   8830784
REFERENCE   7  (bases 1 to 6270)
  AUTHORS   Vuristo,M.M., Pihlajamaa,T., Vandenberg,P., Prockop,D.J. and
            Ala-Kokko,L.
  TITLE     The human COL11A2 gene structure indicates that the gene has not
            evolved with the genes for the major fibrillar collagens
  JOURNAL   J Biol Chem 270 (39), 22873-22881 (1995)
   PUBMED   7559422
REFERENCE   8  (bases 1 to 6270)
  AUTHORS   Vikkula,M., Mariman,E.C., Lui,V.C., Zhidkova,N.I., Tiller,G.E.,
            Goldring,M.B., van Beersum,S.E., de Waal Malefijt,M.C., van den
            Hoogen,F.H., Ropers,H.H. et al.
  TITLE     Autosomal dominant and recessive osteochondrodysplasias associated
            with the COL11A2 locus
  JOURNAL   Cell 80 (3), 431-437 (1995)
   PUBMED   7859284
REFERENCE   9  (bases 1 to 6270)
  AUTHORS   Tsumaki,N. and Kimura,T.
  TITLE     Differential expression of an acidic domain in the amino-terminal
            propeptide of mouse pro-alpha 2(XI) collagen by complex alternative
            splicing
  JOURNAL   J Biol Chem 270 (5), 2372-2378 (1995)
   PUBMED   7836472
REFERENCE   10 (bases 1 to 6270)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5.
            
            On Feb 8, 2022 this sequence version replaced XM_006523564.5.
            
            Summary: This gene encodes the alpha-2 subunit of type XI collagen,
            one of the low abundance fibrillar collagens found in cartilage.
            The encoded protein, in association with other collagen subunits,
            forms a heterotrimeric type XI procollagen that may undergo
            proteolytic processing similar to the alpha-1 subunit. Mice lacking
            the encoded protein exhibit a mild phenotype similar to nonocular
            Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED) as
            well as a nonsyndromic form of deafness called DFNA13. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.16621.1,
                                           SRR10223970.19182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               CR974462.5         132644-132908
            266-415             CR974462.5         135332-135481
            416-626             CR974462.5         135573-135783
            627-789             CR974462.5         136406-136568
            790-981             CR974462.5         137991-138182
            982-1059            CR974462.5         138943-139020
            1060-1122           CR974462.5         139612-139674
            1123-1302           CR974462.5         140270-140449
            1303-1362           CR974462.5         142791-142850
            1363-1404           CR974462.5         142966-143007
            1405-1467           CR974462.5         143218-143280
            1468-1542           CR974462.5         143594-143668
            1543-1629           CR974462.5         144129-144215
            1630-1686           CR974462.5         144434-144490
            1687-1740           CR974462.5         144652-144705
            1741-1794           CR974462.5         144786-144839
            1795-1848           CR974462.5         144925-144978
            1849-1902           CR974462.5         145123-145176
            1903-1956           CR974462.5         145337-145390
            1957-2001           CR974462.5         145484-145528
            2002-2055           CR974462.5         145636-145689
            2056-2100           CR974462.5         146113-146157
            2101-2154           CR974462.5         146366-146419
            2155-2199           CR974462.5         146585-146629
            2200-2253           CR974462.5         146748-146801
            2254-2298           CR974462.5         147045-147089
            2299-2352           CR974462.5         147322-147375
            2353-2397           CR974462.5         147477-147521
            2398-2451           CR974462.5         148009-148062
            2452-2559           CR974462.5         148390-148497
            2560-2613           CR974462.5         149224-149277
            2614-2667           CR974462.5         149565-149618
            2668-2712           CR974462.5         149717-149761
            2713-2766           CR974462.5         150090-150143
            2767-2811           CR974462.5         150277-150321
            2812-2865           CR974462.5         150423-150476
            2866-2919           CR974462.5         150572-150625
            2920-2973           CR974462.5         150792-150845
            2974-3081           CR974462.5         151222-151329
            3082-3171           CR974462.5         151450-151539
            3172-3225           CR974462.5         151728-151781
            3226-3333           CR974462.5         151997-152104
            3334-3441           CR974462.5         152237-152344
            3442-3495           CR974462.5         152465-152518
            3496-3549           CR974462.5         152642-152695
            3550-3657           CR974462.5         152851-152958
            3658-3711           CR974462.5         153103-153156
            3712-3765           CR974462.5         153374-153427
            3766-3819           CR974462.5         153571-153624
            3820-3873           CR974462.5         153751-153804
            3874-3981           CR974462.5         154012-154119
            3982-4035           CR974462.5         154391-154444
            4036-4089           CR974462.5         154636-154689
            4090-4143           CR974462.5         154781-154834
            4144-4197           CR974462.5         155387-155440
            4198-4305           CR974462.5         155630-155737
            4306-4359           CR974462.5         155841-155894
            4360-4413           CR974462.5         156011-156064
            4414-4521           CR974462.5         156282-156389
            4522-4575           CR974462.5         156578-156631
            4576-4611           CR974462.5         156805-156840
            4612-4665           CR974462.5         157036-157089
            4666-4933           CR974462.5         157196-157463
            4934-5046           CR974462.5         157903-158015
            5047-5253           CR974462.5         158178-158384
            5254-6270           CR974462.5         158840-159856
FEATURES             Location/Qualifiers
     source          1..6270
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..6270
                     /gene="Col11a2"
                     /note="collagen, type XI, alpha 2"
                     /db_xref="GeneID:12815"
                     /db_xref="MGI:MGI:88447"
     exon            1..265
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..5394
                     /gene="Col11a2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; collagen alpha-2(XI) chain; procollagen, type
                     XI, alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(XI) chain isoform 3 precursor"
                     /protein_id="NP_001388230.1"
                     /db_xref="GeneID:12815"
                     /db_xref="MGI:MGI:88447"
                     /translation="MERCSRCHRLLLFLPLVLGLSAAPGWAGAPSVDVLRALRFPSLP
                     DGVRRSKGVCPGDVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRPGLQAPLLT
                     LYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLSLADGKWHHVAVAVKGQS
                     VTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHILDDEVFEGDVQELLVVPGVQAAY
                     QSCGQKDLECEREQRDGPQTQKPHRAQRSPKKEPARLHKPQSQEPQKQPTESLYYDYE
                     PPYYDVMTTGTAPDYQYPTPGEEEGVLESSPLPFLEEEQTDLQVSPTADSFQAEEYGE
                     GGTDSPAGFYDYTYGYGDDYREETELGPALSAETAHSGAVAHGPRGLKGEKGEPAVLE
                     PGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGPPGPPGTSL
                     MLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPG
                     LKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGMKGDRGFDGLPGL
                     PGEKGQRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPP
                     GVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGAQGLPGPQGAIGPHGEKGARGKPGLPG
                     MPGSDGLPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGE
                     DGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGKLGVP
                     GLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATG
                     KSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPGHPGQRGEVGF
                     QGKTGPPGPPGVVGPQGTAGESGPMGERGHSGPPGPPGEQGLPGTSGKEGTKGDPGPP
                     GAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIG
                     PPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGE
                     VGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTR
                     GFNGPPGPIGLQGLPGPSGEKGETGDGGPMGPPGPPGPRGPAGPNGADGPQGSPGGVG
                     NLGPPGEKGEPGESGSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDNGP
                     KGNPGPVGFPGDPGPPGEAGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKR
                     GPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGPAGLAGKPGPDGLRGLPGSVGQQG
                     RPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGP
                     QGSPGQKGETGIPGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHP
                     GPPGEVIQPLPIQMPKKTRRSVDGSKLIQDEEAVPTGGAPGSPAGLEEIFGSLDSLRE
                     EIEQMRRPAGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGE
                     TCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGVSQDGPLKLRG
                     ANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFADLGAPTRRGG
                     VLLGPVCFMG"
     exon            266..415
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..626
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..789
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..981
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1059
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1122
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1302
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1362
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1404
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1467
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1542
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1629
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1686
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1740
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1794
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1848
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1902
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1956
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2001
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2055
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2100
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2154
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2199
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2253
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2298
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2352
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2397
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2451
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2559
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2613
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2667
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2712
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2766
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2811
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2865
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2919
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..2973
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3081
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3171
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3225
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3333
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3441
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3495
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3549
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3657
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3711
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3765
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3819
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3873
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..3981
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..4035
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4089
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4143
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4197
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4305
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4359
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4413
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4521
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4575
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4611
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4612..4665
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4933
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4934..5046
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            5047..5253
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     exon            5254..6270
                     /gene="Col11a2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6270
                     /gene="Col11a2"
                     /note="major polyA site"
ORIGIN      
        1 acacagtagc ggccaccgaa gagcaagcag cactgacaag aagaggtgcc cccacaacgg
       61 caccttgctg catggagctg ggccactgaa agctgctgac atcccggggt cctggttccg
      121 aggctcagct ggcttctgtc tgctgtcagc accaggactg cctgggatct ggcattctga
      181 gccatggagc ggtgcagccg ctgccaccgc ctccttctgt tcctacctct ggtgctgggt
      241 ctgagcgctg ccccgggatg ggcaggtgct ccctctgtgg atgtgcttcg tgccctgagg
      301 ttcccctccc ttcccgatgg tgttcggaga tcaaaagggg tctgtccggg tgatgtggct
      361 taccgtgtgg cacggcctgc ccagctcagc gcacccacgc gccagctctt cccaggaggc
      421 tttcccaaag acttctctct gctgacggtt gtccggaccc gccctggcct ccaggctccc
      481 ctcttgactc tatacagcgc ccagggagtc cagcagctgg gcttggagct cggccgccct
      541 gtccgctttc tctatgagga ccagagggga cggccacaag cctccgctca gcccatcttc
      601 cgaggcctca gcctagcaga tggcaaatgg caccacgtgg ctgtggctgt gaagggtcag
      661 tctgtcactc tcattgtgga ctgtaagaag cgagttaccc ggccccttcc cagaagtgtg
      721 catccggtgt tggacaccca cggggtggtg atctttggtg cccacatcct cgacgatgaa
      781 gtctttgaag gcgatgttca ggagctcctc gttgtcccag gcgtccaagc tgcctatcag
      841 tcttgtgggc agaaggatct ggaatgtgag agagaacaga gggacggccc tcagactcag
      901 aagcctcaca gagcccagag atctccaaag aaggaaccag caagacttca taagccacag
      961 agccaggagc cccagaagca gcccactgag tctctctact atgactacga acccccctat
     1021 tacgatgtga tgactacggg gacagcccct gattatcagt accccacccc aggtgaagag
     1081 gaaggagtcc tggagtccag tcccttgcca ttccttgaag aggagcagac agatcttcag
     1141 gtctccccaa cagctgacag tttccaggca gaggaatatg gggagggagg cacagactcc
     1201 ccagcagggt tctacgatta cacctatggc tatggggatg attatcgtga ggagaccgag
     1261 cttggccctg ccctctctgc ggagacagct cactcaggag ccgttgccca cggaccccgg
     1321 gggctaaagg gagagaaggg agagcctgca gtgctggagc ctggtatgtt tgtagaggga
     1381 cccccaggcc cagaaggccc agcgggatta gctggacccc ctggcatcca ggggaaccca
     1441 ggcccggttg gagaccccgg tgagaggggc ccccctggcc gagcagggct ccccggatca
     1501 gatggacccc ctggtcctcc cggcacatct ctgatgcttc cattccggtt tggcagtagt
     1561 gggggtgaca agggccccgt ggtggcagcc caggaggccc aggcccaggc gattctgcag
     1621 caggcacggc tggcactccg tgggccccct ggccccatgg gttacacggg ccgccctgga
     1681 ccattgggtc agcctgggag ccctggcttg aagggagaat ctggagatct gggcccacag
     1741 ggccccagag gacctcaggg cctcacaggt cctcctggca aggctggacg aaggggccga
     1801 gcaggtgctg atggagcccg tgggatgccg ggagaacctg gcatgaaggg tgaccgaggt
     1861 ttcgacggac ttccagggct acctggcgag aagggacaaa ggggtgatac aggtgctcag
     1921 ggccttcctg ggcctcctgg tgaggacgga gagaggggtg atgatggaga gattgggcca
     1981 cgggggctgc ctggagagtc gggacctaga ggactccttg gccctaaagg cccgcctggt
     2041 attcctgggc cgccgggagt ccgaggcatg gacggtcccc acggccccaa agggagcttg
     2101 ggacctcaag gagagccagg acctcctgga caacagggta ctcctggggc ccagggcctc
     2161 cccggacctc agggagccat cggtcctcat ggagagaagg gtgctcgtgg gaaaccaggc
     2221 ctccctggca tgcctggatc agatggactc ccgggtcacc cagggaagga aggtccccct
     2281 ggaaccaaag ggaaccaggg cccgtccgga ccacagggtc ctctaggata cccaggccct
     2341 cgaggcgtca agggtgtgga tggaattcgg ggcctgaagg gccacaaggg tgaaaagggc
     2401 gaggacggct ttcctgggtt caaaggtgac ataggagtga aaggagacag gggcgaggtt
     2461 ggagtccctg gttccagggg cgaagacggc cctgaagggc caaaagggcg cactggacct
     2521 acaggagacc ctggacccac tgggctcatg ggcgagaagg gcaagctagg tgttcctggt
     2581 ctgcctggct atcctggacg ccagggcccc aagggatctc tgggtttccc tggttttcct
     2641 ggagccagtg gagagaaggg agctcggggc ctgtctggga aatcaggacc tcggggagaa
     2701 cggggcccca cgggtccaag gggtcagcgg ggacctcgag gtgccactgg gaaatctgga
     2761 gctaagggaa catcaggtgg tgacggtccc cacgggccac ccggagagag gggtcttcct
     2821 ggacctcaag gccccaatgg atttcctggc cccaaaggcc ctccgggccc tgcagggaag
     2881 gatgggctgc cgggacaccc cggccagaga ggagaagtgg gattccaagg aaagaccggc
     2941 ccaccaggcc cgcccggagt ggtgggacct cagggaacag ctggagaaag tggtcccatg
     3001 ggagagagag gtcactctgg ccccccagga cctcctggag agcaaggatt gcctggaaca
     3061 tctgggaaag aagggaccaa gggtgaccct ggtcctcctg gggccccagg gaaggatggt
     3121 cctgctggtc tgagaggctt cccaggagag cgaggccttc caggcactgc tggtggaccc
     3181 ggcttgaaag gaaatgaagg tccagctggc cctcctggcc ctgcaggctc tcctggcgag
     3241 cgaggtgcag caggatcagg gggccccatt ggtcccccgg gacgtccagg cccacaaggt
     3301 ccccctggag cagcaggaga gaaaggcgta ccgggcgaga aaggccctat tggtcccact
     3361 ggtcgtgatg gggtgcaggg ccccgtgggg cttcctggtc ctgcaggacc cccaggcgtg
     3421 gctggagagg atggagacaa gggtgaagtg ggagaccctg gacagaaggg aaccaaagga
     3481 aacaagggtg aacatggccc tcctggacct cctggtccca tcgggcctgt ggggcaacct
     3541 ggagctgcgg gagctgatgg tgagcctgga gctcggggac cccagggaca ctttggagcc
     3601 aaaggtgatg aaggaacaag agggttcaat ggacccccgg gacccatcgg cctacagggc
     3661 ctgccaggac cctctgggga gaaaggagaa acaggagacg gggggcctat gggaccccct
     3721 ggccctccag gacctcgagg ccccgctgga cccaatggtg ctgatggccc acaaggttcc
     3781 cctggaggtg ttggaaactt gggtccccct ggagaaaagg gtgaaccggg ggagtcaggg
     3841 tctccaggcg tccagggcga gccgggcgtc aagggaccac gtggagagcg tggtgagaaa
     3901 ggagagtctg ggcaggcggg agaggctgga ccaccggggc ccaaaggccc tacaggcgac
     3961 aatggcccca aggggaaccc tggtcctgtt ggctttcctg gggaccctgg cccccctgga
     4021 gaagctggcc cacggggcca ggatggtgct aagggagacc gaggcgagga tggcgagcca
     4081 ggacaacctg gatcccctgg tcccaccggg gagaatgggc cccctggacc ccttggaaag
     4141 cggggacctg ctggcactcc tggtccagaa ggacggcaag gagagaaggg agctaagggg
     4201 gaccctggtg ctgtgggggc cccgggaaag acaggccctg tgggtcctgc aggcctagca
     4261 ggaaagcccg gccccgatgg tcttcggggg ctcccgggtt cagtgggtca gcaaggccgc
     4321 cctggagcca caggccaggc tgggccccca ggtcctgtgg gacccccagg gcttcctggc
     4381 ctccggggtg atgctggagc caagggggaa aagggtcacc caggtctcat cggactgatt
     4441 gggccgactg gagagcaagg cgagaagggc gaccgtggcc tccctggacc tcagggctca
     4501 cccggacaga agggagagac gggtatccca ggagcatctg gccccatcgg tcctggaggg
     4561 cctcctggcc tgcctggacc ctctggcccc aaaggagcca aaggagccac aggcccagct
     4621 ggacccaagg gagagaaggg tgtccagggc cctccaggac acccgggccc cccgggagag
     4681 gtgatccagc cactgcccat ccagatgccc aagaagaccc gccgttccgt ggacggaagc
     4741 aaactgatac aggatgagga ggctgtgccc actggcggtg ctccgggcag tcctgcgggg
     4801 ctggaggaga tctttggctc actggactct ctgcgggagg agatcgagca gatgaggagg
     4861 ccggcgggga cccaggacag ccctgctcgc acctgccagg acttgaagct gtgccacccg
     4921 gagcttcctg atggagagta ctgggttgac cctaaccagg gctgtgctcg ggatgccttc
     4981 cgggtgttct gcaacttcac agcaggaggg gagacgtgtg tcacacccag ggatgacgtc
     5041 acacagttct cctacgtgga ctccgagggc tccccagtgg gcgtggtcca gctcaccttc
     5101 ctgcggctgc tcagcgtctc tgcccaccag gatgtctcct acccttgctc tggagtatcc
     5161 caggatggtc ccctgaaact ccgaggggcc aacgaggatg agctgagccc tgagaccagc
     5221 ccttatgtca aggagttcag agatggctgt cagacccagc aaggccggac ggtgttggag
     5281 gtgcgcacgc ctgtactgga gcagctgccc gtgctggatg cctccttcgc agacctgggg
     5341 gcccccacaa gacggggagg ggtgcttctg gggcctgtct gcttcatggg ctaggcctgt
     5401 ctctgacgct gtcaaccaaa accaggtcta gctggagtca cacagcacgg actccatgtc
     5461 acctctcgtg aggatctctc atcgtctaga gggccttggg ccaggcaggc atctcaagcc
     5521 tcaagtcagg cagcacacgg ggctggggtg aaccaggggg tgccgggata gcccaggggg
     5581 agggtggtac ctgggcctcc agctctccca cttatgaccc attagagagc tgagaccttt
     5641 atttaaaaca cttccctgtc accccaaata agtggaagag aaaggacact gtgtattttg
     5701 tatttaaaaa aataattata ttaattattt aaagagtgga agaacaaagt aacaaagaag
     5761 ataaagagag aaatgccaaa aatcccagca gatattgggg gcaggtgctg caagggtggg
     5821 cgggcagtcc atcctccatt cagggtttcc ctagtgcctg tgggtgtggc ttcctaaaat
     5881 gaacccctcc ttcctctcct tccacctggg gcactaagaa tgctggaaca tggtctcccc
     5941 tgcttcagga ctccagccct ctttccccag agtctaagct ctgtgacaca tgtgtccctg
     6001 ggaggaatga cctgttactt aagaccaggc cgctccttga agggagacca gaccagaggg
     6061 ctgtgcagga cctgcctctg gcgggttatg gagatactga agttctgcca gtggctctga
     6121 gccactgtcc tggccacacc tcctcacctt ccctgattct ggaaagaaag ctaaggtcta
     6181 gcctatggcc agaagggact cccaggaccc ctctagccct atgcccaacg tccctgctga
     6241 ctgacggtta aacaatgtga ttgtctcctc
//
