LOCUS       NM_009925               3139 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus collagen, type X, alpha 1 (Col10a1), mRNA.
ACCESSION   NM_009925
VERSION     NM_009925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3139)
  AUTHORS   Hata,K., Wakamori,K., Hirakawa-Yamamura,A., Ichiyama-Kobayashi,S.,
            Yamaguchi,M., Okuzaki,D., Takahata,Y., Murakami,T., Uzawa,N.,
            Yamashiro,T. and Nishimura,R.
  TITLE     Serinc5 Regulates Sequential Chondrocyte Differentiation by
            Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes
  JOURNAL   J Cell Physiol 240 (1), e31490 (2025)
   PUBMED   39568258
REFERENCE   2  (bases 1 to 3139)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   3  (bases 1 to 3139)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3139)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   5  (bases 1 to 3139)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
REFERENCE   6  (bases 1 to 3139)
  AUTHORS   Gack,S., Vallon,R., Schmidt,J., Grigoriadis,A., Tuckermann,J.,
            Schenkel,J., Weiher,H., Wagner,E.F. and Angel,P.
  TITLE     Expression of interstitial collagenase during skeletal development
            of the mouse is restricted to osteoblast-like cells and
            hypertrophic chondrocytes
  JOURNAL   Cell Growth Differ 6 (6), 759-767 (1995)
   PUBMED   7669731
REFERENCE   7  (bases 1 to 3139)
  AUTHORS   Luo,G., D'Souza,R., Hogue,D. and Karsenty,G.
  TITLE     The matrix Gla protein gene is a marker of the chondrogenesis cell
            lineage during mouse development
  JOURNAL   J Bone Miner Res 10 (2), 325-334 (1995)
   PUBMED   7754814
REFERENCE   8  (bases 1 to 3139)
  AUTHORS   Giros,B., Pohl,M., Rochelle,J.M. and Seldin,M.F.
  TITLE     Chromosomal localization of opioid peptide and receptor genes in
            the mouse
  JOURNAL   Life Sci 56 (18), PL369-PL375 (1995)
   PUBMED   7752808
REFERENCE   9  (bases 1 to 3139)
  AUTHORS   Apte,S.S., Seldin,M.F., Hayashi,M. and Olsen,B.R.
  TITLE     Cloning of the human and mouse type X collagen genes and mapping of
            the mouse type X collagen gene to chromosome 10
  JOURNAL   Eur J Biochem 206 (1), 217-224 (1992)
   PUBMED   1587271
REFERENCE   10 (bases 1 to 3139)
  AUTHORS   Elima,K., Metsaranta,M., Kallio,J., Perala,M., Eerola,I.,
            Garofalo,S., De Crombrugghe,B. and Vuorio,E.
  TITLE     Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X)
            collagen mRNAs
  JOURNAL   Biochim Biophys Acta 1130 (1), 78-80 (1992)
   PUBMED   1543751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY141606.1, CN664467.1, AC153960.3 and CJ326431.1.
            
            On Oct 12, 2007 this sequence version replaced NM_009925.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI663040.1, BY771794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               BY141606.1         2-321
            321-754             CN664467.1         23-456
            755-2648            AC153960.3         120689-122582       c
            2649-3139           CJ326431.1         16-506
FEATURES             Location/Qualifiers
     source          1..3139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     gene            1..3139
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /note="collagen, type X, alpha 1"
                     /db_xref="GeneID:12813"
                     /db_xref="MGI:MGI:88445"
     exon            1..63
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..232
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2121
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /note="collagen alpha-1(X) chain; procollagen, type X,
                     alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(X) chain precursor"
                     /protein_id="NP_034055.1"
                     /db_xref="CCDS:CCDS23780.1"
                     /db_xref="GeneID:12813"
                     /db_xref="MGI:MGI:88445"
                     /translation="MLPQIPFLLLMFLTLVHGMFYAERYQTPTGIKGPLASPKTQYFI
                     PYAIKSKGIPVRGEQGIPGPPGPTGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPGI
                     SATGKPGLPGPPGKPGERGPYGHKGDIGPAGLPGPRGPPGPPGIPGPAGISVPGKPGQ
                     QGLTGAPGPRGFPGEKGAQGAPGVNGRKGETGYGSPGRPGERGLPGPQGPIGPPGPSG
                     VGRRGENGFPGQPGIKGDRGFPGEMGPSGPPGPQGPPGKQGREGIGKPGAIGSPGQPG
                     IPGEKGHPGAPGIAGPPGAPGFGKQGLPGLRGQRGPAGLPGAPGAKGERGPAGHPGEP
                     GLPGSPGNMGPQGPKGIPGNHGIPGAKGEIGLVGPAGPPGARGARGPPGLDGKTGYPG
                     EPGLNGPKGNPGLPGQKGDPGVGGTPGLRGPVGPVGAKGVPGHNGEAGPRGEPGIPGT
                     RGPTGPPGVPGFPGSKGDPGNPGAPGPAGIATKGLNGPTGPPGPPGPRGHSGEPGLPG
                     PPGPPGPPGQAVMPDGFIKAGQRPRLSGMPLVSANHGVTGMPVSAFTVILSKAYPAVG
                     APIPFDEILYNRQQHYDPRSGIFTCKIPGIYYFSYHVHVKGTHVWVGLYKNGTPTMYT
                     YDEYSKGYLDQASGSAIMELTENDQVWLQLPNAESNGLYSSEYVHSSFSGFLVAPM"
     exon            233..3130
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /note="hexamer: AATAAA"
     polyA_site      3124
                     /gene="Col10a1"
                     /gene_synonym="Col10; Col10a-1"
                     /note="major polyA site"
ORIGIN      
        1 attatccact gctcctgggc agaggaagcc aggaaagctg ccccacgcat ctcccagcac
       61 cagaatctat ctgaaaatat gctgcctcaa ataccctttc tgctgctaat gttcttgacc
      121 ctggttcatg ggatgtttta tgctgaacgg taccaaacgc ccacaggcat aaagggccca
      181 cttgctagcc ccaagacaca atacttcatc ccatacgcca taaagagtaa agggattcca
      241 gtaagaggag aacaaggcat tcctggtcca ccaggcccaa ccggacctcg aggacaccca
      301 ggtccctcag gaccgccagg caagccaggc tatggaagtc ctggactcca aggagagcca
      361 gggttgccag gaccaccagg aatatcagcc acggggaagc caggcctgcc aggcccgcca
      421 ggcaaaccag gggagagagg accatatgga cacaaaggag atattggccc agctggctta
      481 cccggacctc ggggccctcc agggccccct ggaattcctg gcccagctgg aatttctgtg
      541 ccaggaaaac ctggacagca gggacttaca ggtgccccag gacctagggg ctttcctgga
      601 gagaagggtg cacaaggagc ccctggtgtg aatgggcgga aaggggaaac aggatatggc
      661 tctcctggcc gtccaggtga gaggggtctt ccaggccctc aaggtcccat aggaccccct
      721 ggcccctctg gagtgggaag aagaggtgaa aacggctttc caggacagcc gggcatcaaa
      781 ggtgaccggg gtttcccagg agaaatggga ccatcaggtc caccaggtcc ccaaggtcct
      841 cccgggaagc aaggacgaga aggtattggg aagccaggag ccattggatc ccctggtcag
      901 ccaggtatcc caggagaaaa aggccaccca ggggctccag gaatagctgg tcctccagga
      961 gctcctggct ttggaaaaca aggcttgcca ggtttgaggg gacaaagggg acctgctggt
     1021 cttcctgggg ctccaggtgc caaaggggaa cgagggccag caggtcatcc tggagaaccg
     1081 ggtctgcctg gatcccctgg gaatatggga ccccaaggac ctaaaggaat cccagggaac
     1141 catggcattc caggcgctaa aggtgagata ggtctagttg ggcctgcagg cccccctggg
     1201 gctagaggag caaggggtcc acctgggtta gatggaaaaa cagggtatcc tggggagcca
     1261 ggtctcaatg gtcctaaggg taacccaggg ttaccaggac aaaaaggtga tcctggagtg
     1321 ggaggaaccc ctggtcttcg aggtcctgtt ggccctgtag gagctaaagg agtgcctgga
     1381 cacaatggtg aggcaggtcc aagaggtgaa cctggaatac caggtaccag gggccccact
     1441 gggccaccag gtgtcccagg attccctgga tctaagggtg accctggaaa cccaggtgct
     1501 ccaggcccag ctggcatagc aactaagggc ctcaatgggc ccactggtcc tccaggccct
     1561 cctggtccaa gaggccacag tggagaacct ggtctcccag gtcctccggg tcccccagga
     1621 ccccccggcc aagcagtcat gcctgatggc ttcataaagg caggccagag gcccaggctt
     1681 tctgggatgc cgcttgtcag tgctaaccac ggggtaacag gtatgcccgt gtctgctttt
     1741 actgtcattc tctctaaagc ttacccagca gtaggtgccc ccatcccatt tgatgagatt
     1801 ctgtacaata ggcagcagca ttacgaccca agatctggta tctttacctg taagatccca
     1861 ggcatatact atttctccta ccacgtgcat gtgaaaggga ctcacgtttg ggtaggcctg
     1921 tataagaacg gcacgcctac gatgtacacg tatgatgagt acagcaaagg ctacctggat
     1981 caggcttcag ggagtgcaat catggagctc acagaaaatg accaggtatg gctccaattg
     2041 cccaatgcag aatcaaacgg cctctactcc tctgagtacg tccactcgtc cttctcagga
     2101 ttcctagtgg ctcccatgtg agcacttcct gtcaagctca tcctattctc cgcttagaaa
     2161 ggctttccac ccaattccat cgcgccctcc ctggagatgc atttggaggt aggctaaaag
     2221 taatgtgaac aacttacact ttctaaagtg cactctggga ccaagtttcc tcacttctaa
     2281 agtgaacagt aacagtgggt atgtgaggat cctccggagc actcagcaat cctaaagccc
     2341 tggggggtgg tgagggggtg gtgtctgtta ttccatcaat acttacattt ttttaacaga
     2401 agctttaaaa aaaagcctca caaaaacaga aataagactc taactcacca taaatctcat
     2461 ttcaaaaact caacattctc ctttcaaaaa agtccatttt taataatatg aaaacatcta
     2521 ggaaacatgc aggaattatc atgcaacttt atattcttta aatacttgaa tattcaaatt
     2581 gaaatgacac tgtataccct aggatatttc tgatggtgca tcactcaatg gctcatacaa
     2641 cccctttcat caagataaat tcaaatgcac aggtacacac atggtttttg aagtgcgcat
     2701 aagaaaccaa aatactgtat taaaattaat ttcgattata aggtgctttg tcacagctgt
     2761 ttcaagcttt tctgcaattg cagaaagtcc acatacctgg tgtaacttgg aaacaagtgt
     2821 ctgacttatg tcagtaacac agtgcacagt gtgattactc tgatttaatt ccttgcatct
     2881 ttgtaaaatg attttatggg cttatacaat attagaatag acactttgtg tgcctttcaa
     2941 tcgagtggaa gaataaacat taagggtttg aacatcagac tagaaacgaa aagacattat
     3001 ttatttatgc tctgtactgt atttttacat tattgtttaa aactggtagg ctgtacctca
     3061 cttattaaag cccggagtat ttaatctact tggtattacg aagcaataaa atgacatgaa
     3121 tagaccttta aaaaaaaaa
//
