LOCUS       NM_016706               2609 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus coilin (Coil), mRNA.
ACCESSION   NM_016706 NM_181329
VERSION     NM_016706.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Krejci,J., Legartova,S. and Bartova,E.
  TITLE     Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by
            Coilin Downregulation and the Accumulation of Cajal Bodies in
            Nucleoli
  JOURNAL   Stem Cells Int 2017, 1021240 (2017)
   PUBMED   28337219
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Bogolyubova,I.O., Lyabin,D.N., Bogolyubov,D.S. and Ovchinnikov,L.P.
  TITLE     Immunocytochemical study of YB-1 nuclear distribution in different
            cell types
  JOURNAL   Tissue Cell 46 (6), 457-461 (2014)
   PUBMED   25175035
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Kappei,D., Butter,F., Benda,C., Scheibe,M., Draskovic,I.,
            Stevense,M., Novo,C.L., Basquin,C., Araki,M., Araki,K.,
            Krastev,D.B., Kittler,R., Jessberger,R., Londono-Vallejo,J.A.,
            Mann,M. and Buchholz,F.
  TITLE     HOT1 is a mammalian direct telomere repeat-binding protein
            contributing to telomerase recruitment
  JOURNAL   EMBO J 32 (12), 1681-1701 (2013)
   PUBMED   23685356
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Walker,M.P., Tian,L. and Matera,A.G.
  TITLE     Reduced viability, fertility and fecundity in mice lacking the
            cajal body marker protein, coilin
  JOURNAL   PLoS One 4 (7), e6171 (2009)
   PUBMED   19587784
  REMARK    GeneRIF: evolutionary conservation of coilin from plants to animals
            suggests that the protein plays an important role, perhaps
            coordinating the activities of various RNA-processing machineries
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Hao,L., Vassena,R., Wu,G., Han,Z., Cheng,Y., Latham,K.E. and
            Sapienza,C.
  TITLE     The unfolded protein response contributes to preimplantation mouse
            embryo death in the DDK syndrome
  JOURNAL   Biol Reprod 80 (5), 944-953 (2009)
   PUBMED   19129515
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Tucker,K.E., Berciano,M.T., Jacobs,E.Y., LePage,D.F.,
            Shpargel,K.B., Rossire,J.J., Chan,E.K., Lafarga,M., Conlon,R.A. and
            Matera,A.G.
  TITLE     Residual Cajal bodies in coilin knockout mice fail to recruit Sm
            snRNPs and SMN, the spinal muscular atrophy gene product
  JOURNAL   J Cell Biol 154 (2), 293-307 (2001)
   PUBMED   11470819
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Baran,V., Brochard,V., Renard,J.P. and Flechon,J.E.
  TITLE     Nopp 140 involvement in nucleologenesis of mouse preimplantation
            embryos
  JOURNAL   Mol Reprod Dev 59 (3), 277-284 (2001)
   PUBMED   11424213
REFERENCE   8  (bases 1 to 2609)
  AUTHORS   Tucker,K.E., Massello,L.K., Gao,L., Barber,T.J., Hebert,M.D.,
            Chan,E.K. and Matera,A.G.
  TITLE     Structure and characterization of the murine p80 coilin gene, Coil
  JOURNAL   J Struct Biol 129 (2-3), 269-277 (2000)
   PUBMED   10806077
REFERENCE   9  (bases 1 to 2609)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   10 (bases 1 to 2609)
  AUTHORS   Andrade,L.E., Chan,E.K., Raska,I., Peebles,C.L., Roos,G. and
            Tan,E.M.
  TITLE     Human autoantibody to a novel protein of the nuclear coiled body:
            immunological characterization and cDNA cloning of p80-coilin
  JOURNAL   J Exp Med 173 (6), 1407-1419 (1991)
   PUBMED   2033369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY065340.1, BY108289.1, CF948658.1, CF949734.1, CF105200.1,
            AA240407.1, BM946023.1, CK792602.1 and BX630395.1.
            
            On or before Mar 24, 2007 this sequence version replaced
            NM_181329.2, NM_016706.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.258217.1, AK146366.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               BY065340.1         2-356
            356-642             BY108289.1         69-355
            643-1040            CF948658.1         201-598
            1041-1346           CF949734.1         315-620
            1347-1432           CF105200.1         145-230
            1433-1764           AA240407.1         33-364
            1765-2325           BM946023.1         202-762
            2326-2605           CK792602.1         245-524
            2606-2609           BX630395.1         1-4                 c
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.34 cM"
     gene            1..2609
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /note="coilin"
                     /db_xref="GeneID:12812"
                     /db_xref="MGI:MGI:104842"
     exon            1..268
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1736
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /note="nuclear phosphoprotein of Cajal body"
                     /codon_start=1
                     /product="coilin"
                     /protein_id="NP_057915.2"
                     /db_xref="CCDS:CCDS36277.1"
                     /db_xref="GeneID:12812"
                     /db_xref="MGI:MGI:104842"
                     /translation="MSKMAASETVRLRLQFDYPPPATPHCTVFWLLVDLNRCRVVTDL
                     ISLIRQRFGFSSGALLGLYLEGGLLPPAESARLVRDNDSLRVKLEDQGLPENLIVSNG
                     GDSSFPCRKAKKRAFKLMEDEETDQGYKSLKKHCKRQEDSGQNEKASDLETKLLPDET
                     GRTKSKKKSKVTGSPAEEDEEETKKKSSKRKEKCEPKKQTRASKSSKQQTPKEGASQN
                     CSFPRASPRSLGKARRRSSTGLKGSSGHLSESESCPESVSDGHCSVMMQEVTFSEKLS
                     AELLKDAPATKTAAANRQASKPGFTFSSGKGKASRTSSSSSDSSSESEDQFLVSKNML
                     EGASAGFLKPTGLFAGQGGSGPGLSLETPGIMGWKSSDSNRGRQAPGPPSTPVPTSLG
                     RGWGRGEDLLFGKGLRGRGVRGRGRGRGQAVSCVFNRSSESQKQRQLNDILTNSSVVI
                     QNPVEPPKKDYSLLPLLAAAPQVGEKIAFKLLELTSDYSPDVSDYKEGKILSHDPETQ
                     QVDIEVLSSLPALKEPGKFDLVYHNENGTEVVEYAVTQEKRITVLWRELIDPRLIIDS
                     SGSISST"
     exon            269..1367
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1454
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1502
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1572
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1661
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2607
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /note="hexamer: AATAAA"
     polyA_site      2607
                     /gene="Coil"
                     /gene_synonym="Cln80; p80; p80-coilin"
                     /note="major polyA site"
ORIGIN      
        1 ggcttccgtc gagcatgagc aagatggcag cctccgagac ggttaggcta cggcttcaat
       61 ttgactaccc gccgccggcc actccacact gcacggtctt ctggcttctg gtggacctga
      121 acagatgtcg agttgtcacg gatctcatca gtctcatccg ccagcgcttc ggcttcagtt
      181 ccggggcgct cctgggcctc tatctggaag gggggctgct gccccctgcc gagagcgcgc
      241 gcctggtgag agacaacgac agcctcaggg ttaagttaga agaccaagga ctccctgaga
      301 acctgatagt aagcaatggt ggcgactcta gtttcccatg caggaaagca aagaaacggg
      361 cttttaagtt gatggaggat gaggaaacag atcagggata caagtctttg aagaagcact
      421 gcaagaggca ggaggacagc ggccagaatg agaaggcctc ggacctggaa actaaactcc
      481 tcccagatga gacggggcgg acaaagagca agaaaaagag caaagtgaca ggcagcccag
      541 ccgaagagga tgaggaagag accaaaaaga agtcttcaaa aagaaaggag aagtgtgaac
      601 cgaagaagca gaccagggcc tccaagtctt ccaaacaaca gacgcctaaa gagggggcct
      661 cacagaactg cagcttcccc agggcctccc ccagaagcct cggtaaagcc cgaaggagaa
      721 gcagcacggg gctaaaaggt agctcaggcc acctgtcaga gtctgagtcc tgcccagagt
      781 cagtcagcga tggccactgc agtgtcatga tgcaggaggt caccttttca gagaaactgt
      841 cagctgagct gttgaaagat gcacctgcta ccaagactgc agctgccaac aggcaggcct
      901 caaagcctgg ctttaccttc agctccggca agggcaaggc ctccagaacc tcgtcatcca
      961 gttcagactc cagttcagag tcggaagacc agttcctggt gtccaagaac atgctcgagg
     1021 gcgcatctgc tggcttctta aagccaactg gcctctttgc agggcaaggg ggttctggtc
     1081 cagggctgtc attggagact ccgggtatta tgggatggaa gtcttctgac tcaaaccggg
     1141 gcagacaagc tcctggtcct cccagtacgc ctgtccccac cagtttggga agaggatggg
     1201 ggcgaggaga ggacttgttg tttgggaagg gactgagggg ccggggtgtc cggggccgag
     1261 ggcgagggcg cgggcaagcg gtctcctgtg tctttaatag aagctctgag agtcagaagc
     1321 agagacagtt aaatgatatt ctaacaaact catctgtggt gatccagaat ccagtagagc
     1381 cccccaagaa ggactatagt ctattaccac tgttggcagc tgcccctcaa gttggagaaa
     1441 agattgcatt taagcttttg gaactcacat ccgactactc tcctgatgtc tctgactaca
     1501 aggaaggaaa aatattaagt cacgatccag agacccagca agtggacata gaggtcctct
     1561 cctcgctacc ggctttgaaa gaacctggga agtttgattt ggtctatcac aatgaaaatg
     1621 gaaccgaggt ggtggaatac gctgtgactc aggagaagag gatcaccgtg ctctggagag
     1681 agttgatcga tccgaggctg atcattgact cttcaggtag catctcgagt acataaggtg
     1741 tctggatctg acctctggcc tcgccacccc gcgctccgta accgcattgt ttgggaccat
     1801 gggtatagcc tgaagatttt aaaaagaaga ctaaatgttg tgtagacttt ctgtttctct
     1861 tcactttacc atattaggaa aaaaagatct acctcatcat ttagagtaac aaagttgtta
     1921 gtttatagat ccttatttcc ttctggctaa attcagtaac ccacttgaaa acctgggtgc
     1981 tgaccaaaat ggcggtgtgc taggctcctt cacacctgtt tggctaccag tagcaatcgt
     2041 ccgtaggagt ttacagtacc acacacaaga atgtgctgtg catcttgctt tgtttctttt
     2101 aagtcacatt gtaaagtact aaggcatgtt tcttgactta atttttgaca tgtgagctgt
     2161 tctgtgaagc atagagcatc tcgcccattc cacagtttct ccctgctctc ctcaggagtt
     2221 agtggggttg gatttgtcag aggtgatgag ttaaagagtc ctttcacact ttccagatgt
     2281 gaaacacagg actcctagga gcccgcgcag cccgcagtgg ggaggcatcc ttgttgtatt
     2341 gtgtggagga gcgctggcct cccactgcca gaaggctggg cgtgagcctc agaccaggct
     2401 ggggcaaggg gccttgctgc acaatgcaag gaacttgggc tcctcataac tgaagagagg
     2461 atcttaaaca gaaatttcct tttctgttgt tttcttcagc atgaagctaa aggctgaata
     2521 taaactgcaa aattgctttc tttgaacgaa aaatcagatt cctccttcaa ccttgcaaat
     2581 ttttaaataa aatcatatca aactcaaaa
//
