LOCUS       NM_139229               2134 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus component of oligomeric golgi complex 8 (Cog8), mRNA.
ACCESSION   NM_139229
VERSION     NM_139229.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA324258.1, AK145515.1 and AI426017.1.
            
            On Aug 1, 2009 this sequence version replaced NM_139229.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049957.1, AK145515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                CA324258.1         1-48
            49-2100             AK145515.1         2-2053
            2101-2134           AI426017.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.55 cM"
     gene            1..2134
                     /gene="Cog8"
                     /note="component of oligomeric golgi complex 8"
                     /db_xref="GeneID:97484"
                     /db_xref="MGI:MGI:2142885"
     exon            1..477
                     /gene="Cog8"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2005
                     /gene="Cog8"
                     /note="COG complex subunit 8; conserved oligomeric Golgi
                     complex protein 8"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 8"
                     /protein_id="NP_631975.3"
                     /db_xref="CCDS:CCDS22643.1"
                     /db_xref="GeneID:97484"
                     /db_xref="MGI:MGI:2142885"
                     /translation="MAAALPLQPSTTASATTTATAVALGEVEDEGLLASLFRDRFPEA
                     QWREKPDVGRYLRELSGSGLDRLRREPERLAEERAQRLQQTRDLAFANYKTFIRGAEC
                     TERIHRLFGDVEASLGRLLDRLPRFQQSCRNFVKEAEEISSSRRMNTLTLNRHTEILE
                     ILEIPQLMDTCVRNSYHEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQL
                     IQQLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFH
                     ITKTIEACRVHLFDIITQYRAIFSDEDPLLPPAMGEYTVNEGAIFHGWVLQKISQFLQ
                     VLETDLYRGIGGRLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAISTFQKAVEEA
                     VEKFQDEMTSYTLISTAAILGSSNTPATVPATQPGTLQPPMVLLDFPPLACFLNNILV
                     AFNDLRLCCPVALAQDVTGTLENALTKVTKTILAFHRAEEAVFSSGEHEIFVQFCTAF
                     LEDLVPYLNRCLQVLFPPAQIAQTLGISPTQLSKHGNLGHVNISAIQEPLAFILPKRE
                     TVFCLDEQELGPDLVAPAPELPAEQRSMEPVTEKREPGEPLPQEPMEGEPLPAEPPSE
                     GGAIGSVPCPQPGEQP"
     exon            478..685
                     /gene="Cog8"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1513
                     /gene="Cog8"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1682
                     /gene="Cog8"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2104
                     /gene="Cog8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2086..2091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cog8"
                     /note="hexamer: AATAAA"
     polyA_site      2104
                     /gene="Cog8"
                     /note="major polyA site"
ORIGIN      
        1 gggaaatgtt tcccccaatc gtttccgttt cccaggagcg aaaccggctc tgaagaggaa
       61 gtgacggtac cgtgcttgag agatggcggc cgctctccct ctccagccct ccacgaccgc
      121 ttcggccacg acgacagcca cggccgtcgc gctgggggag gtggaagatg agggcctcct
      181 ggcgtcgcta ttccgggacc gcttccccga agctcagtgg cgtgagaagc ccgacgtggg
      241 ccgctacctc cgggagctga gcggctccgg gctggaccgg ctgcggcgcg aacccgagcg
      301 cttggcggaa gagcgggccc agcggctgca gcagacgcgc gacctggctt tcgccaacta
      361 caagacgttc attcgcgggg ccgagtgcac cgagcgcatc caccggctct tcggcgacgt
      421 ggaggcgtcc ctcgggcgcc tgctcgaccg tctgccccgc ttccagcaga gctgcaggaa
      481 ctttgtgaag gaagctgagg agatcagctc cagccgccgc atgaacacgc tgactctaaa
      541 ccggcacaca gaaatcctgg agattttaga gataccccag cttatggaca cgtgtgtccg
      601 aaacagctat catgaagagg cgctggagct tgccgcctat gtacggcgac tggaaaggaa
      661 gtactcctcc atccccgtta tccagggcat tgtgaatgaa gtgcgccagt ccatgcagct
      721 gatgctaagc cagctgatcc aacaactgag gactaacatc cagctcccag cctgcctccg
      781 tgtcataggc tatcttcggc gcatggatgt cttcactgag gctgagttga gggtgaaatt
      841 tcttcaggct cgggatgctt ggctccgctc catcctgact gccatcccta atgatgatcc
      901 ttacttccac atcacaaaaa ccattgaggc ttgccgggtc catctctttg atatcatcac
      961 ccagtaccgt gctattttct cagatgagga ccccctgctg ccacctgcca tgggcgagta
     1021 cactgtgaat gagggtgcca tcttccatgg atgggtgctg cagaaaatct cacagttcct
     1081 gcaggtgcta gagactgacc tttaccgggg tataggaggc cgcttggact ctctgcttgg
     1141 ccagtgcatg tactttgggc tgtcctttag ccgggtgggg gctgatttcc gcggccagtt
     1201 ggctcctgtt ttccagaggg tggcaatcag cactttccag aaagcagttg aagaagcagt
     1261 ggagaaattc caggatgaaa tgacttcata caccctcatc tcgactgcag ccatcctggg
     1321 cagcagtaac acgcctgcca cagtaccagc cacacaacca ggcacgctgc agccaccgat
     1381 ggtgctctta gacttcccgc ctcttgcctg tttcctcaac aacattttgg ttgctttcaa
     1441 tgatttacgt ctctgttgcc ctgtggctct agcacaggat gtgactggga ccttggaaaa
     1501 tgcccttacc aaggtaacca aaacaattct ggcattccat cgagccgaag aggctgtgtt
     1561 cagcagtggg gagcatgaga tctttgtcca gttctgcact gccttcctgg aagaccttgt
     1621 tccttatttg aaccgctgtc ttcaagtcct tttcccacca gctcagatag cccagacttt
     1681 aggcatttca cccacccagc tctctaagca cggaaacctt ggacacgtga acatcagcgc
     1741 catccaggaa cctctcgcct ttattttgcc taagagagaa acagttttct gtttagatga
     1801 gcaggagctg gggccggacc tcgtggcccc agctccagag ctccctgcgg agcagcggag
     1861 catggagcct gtaacagaga agagggaacc aggggagccg ctgcctcagg agcccatgga
     1921 gggggagccg ctgccagccg agccaccgag tgagggagga gccataggca gtgtcccctg
     1981 cccgcagcct ggggagcagc cctgagggta cgcgcttctg cagcgggaag gtgtgtgcag
     2041 ttgctttgcc caggatagcg cgggccctgt ggtatttgca gctttaataa aaccgacaac
     2101 tgtcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
