LOCUS       NM_133973               2754 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus component of oligomeric golgi complex 4 (Cog4),
            transcript variant 1, mRNA.
ACCESSION   NM_133973
VERSION     NM_133973.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN843612.1, AY223866.1 and BM226598.2.
            
            On Nov 30, 2006 this sequence version replaced NM_133973.1.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172465.1, BC023120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               CN843612.1         20-205
            187-2415            AY223866.1         214-2442
            2416-2754           BM226598.2         3-341               c
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.76 cM"
     gene            1..2754
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /note="component of oligomeric golgi complex 4"
                     /db_xref="GeneID:102339"
                     /db_xref="MGI:MGI:2142808"
     exon            1..186
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2385
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     conserved oligomeric Golgi complex subunit 4; COG complex
                     subunit 4"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 4
                     isoform 1"
                     /protein_id="NP_598734.1"
                     /db_xref="CCDS:CCDS40477.1"
                     /db_xref="GeneID:102339"
                     /db_xref="MGI:MGI:2142808"
                     /translation="MAEVESPLKLSGAPPPPEGVGGGHCSEISTELIRSLTELQELEA
                     VYERLCGEEKAVEKELDALLEQQNTIESKMVTLHRMGPSLQLIEGDAKQLAGMITFTC
                     SLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHR
                     YLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERF
                     FKIFPLLGLHEDGLSKFSEYLCKQVASKAEENLLLVLGSDMSDRRAAVIFADTLTLLF
                     EGIARIVETHQPIVETYYGPGRLFTLIKYLQVECDTQVEKVVNKFIKQRDYHQQFRLV
                     QSNLMRNSATEKIEPRELDPVLTEVTLMNARSELYLRFLRKRISADFEVGDSMASEEV
                     KQEHQKCLDKLLNNCLLSCTMQELIGFYITMEEYFMRETVNKAVALDTYEKGQLTSSM
                     VDDVFYIVKKCIGRALSSSNIDCLCAMINLATRELEADFRDVLCNKLRMGFPATTLQD
                     IQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLE
                     SDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLAELNSSAVKPQVQPWI
                     NTFLSVSHSIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSL
                     VAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLE
                     RVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRNEDIKRLRL"
     exon            187..269
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            270..384
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            385..559
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            560..753
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            754..859
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1017
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1076
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1210
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1329
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1496
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1662
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1725
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1842
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1935
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2019
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2121
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2250
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2754
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /note="hexamer: AATAAA"
     polyA_site      2743
                     /gene="Cog4"
                     /gene_synonym="D8Ertd515e"
                     /note="major polyA site"
ORIGIN      
        1 gcccggaagc gcccaccggg agccaagatg gcggaggtgg agtctccgct gaaattgtca
       61 ggagctcctc cgccaccgga gggggtggga ggaggacact gctccgaaat ctccaccgag
      121 ctcattcgct ctctgacaga gctgcaggag ctggaagctg tgtacgaacg actctgtggc
      181 gaggagaaag cggtggagaa agaactggat gctcttttgg aacagcagaa caccattgaa
      241 agtaagatgg tcactctcca caggatgggt cccagcctgc agttgattga gggagacgca
      301 aagcaactgg ctggaatgat cacctttacc tgcagcctag ctgaaaacgt gtcgagcaaa
      361 gtccgtcagc ttgacctggc caagaaccgc ctctatcagg ccattcagag agccgatgac
      421 atcttggacc tgaagttctg catggatgga gttcagactg ctttgaggaa tgaggattat
      481 gagcaggctg cagcccacat tcatcgttac ttgtgcctgg acaagtcagt cattgagctc
      541 agccgacaag gcaaagaagg aagcatgatt gatgccaacc tgaaattact gcaggaagct
      601 gagcaacgtc ttaaggccat agtcgcagag aagtttgcta tcgctaccaa agaaggtgat
      661 ttgccccagg tggagcgatt cttcaagatc ttcccactgc tgggtttaca tgaggatggc
      721 ctgagcaagt tctcggaata cctgtgcaaa caggtcgcca gtaaggctga ggagaatctg
      781 ttgttggtgc tgggctcaga catgagtgat cggagagctg cggtcatctt tgcggatact
      841 ctcacactcc tgtttgaagg gatcgcccga attgtggaaa ctcaccaacc catcgtggag
      901 acttactatg gaccagggcg actctttacc ctgatcaaat atcttcaagt agaatgtgac
      961 acacaggtgg agaaggtcgt aaacaagttc atcaagcaaa gggactacca ccagcagttt
     1021 cggctcgtcc agagtaattt gatgagaaat tctgcaacag aaaaaattga accaagggag
     1081 ctggaccctg tcttgactga ggttaccctg atgaatgcgc gaagtgaact gtacttacgc
     1141 ttcctcagga agaggatcag cgcggatttt gaggtggggg actccatggc ttcagaagaa
     1201 gtaaagcaag agcaccagaa gtgcctggac aaactcctca ataactgcct attgagctgt
     1261 accatgcagg agctaattgg cttctatatt accatggagg agtacttcat gagagagacg
     1321 gtcaataagg ctgtggctct ggatacctat gagaaaggcc agttgacatc cagcatggtg
     1381 gatgatgtct tctacattgt caaaaagtgc attgggcggg ctctgtccag ctctaacatc
     1441 gactgtctct gtgccatgat caaccttgcc accagagagc tggaagctga cttcagggat
     1501 gttctatgta ataagctaag aatgggcttc ccagccacca ccttacagga catccagcgt
     1561 ggggtgacaa gtgccgtgaa catcatgcac agcagcctcc agcagggcaa gtttgacacc
     1621 aaaggcatcg agagcactga tgaagccaag ctgtccttcc tggtgactct gaacaatgtg
     1681 gaagtctgca gtgaaaacat ctcaactctg aagaagactc tggagagtga ctgcaccaag
     1741 ctcttcagtc agggcattgg aggggaacag gcccaggcca agtttgacag ctgcctttct
     1801 gacttagctg ctgtgtccaa caaatttcga gacctcttgc aggaagggtt ggcggagctc
     1861 aacagttcag cagtcaagcc gcaggtgcaa ccttggatca acacttttct ctcagtctcg
     1921 cacagcatcg aggaggaaga attcaacgac tatgaggcca atgacccctg ggtacagcaa
     1981 ttcatcctca acctggaaca gcagatggca gagttcaagg ccagcctgtc cccagtcatc
     2041 tatgacagcc taaccggcct catgaccagc cttgttgctg ttgaactgga aaaagtggtc
     2101 ctgaaatcca ccttcaacag gctgggcggt ctgcagtttg acaaggaact ccggtcactc
     2161 attgcttacc ttaccactgt gacaacctgg accatccgag acaagttcgc ccgcctctct
     2221 cagatggcta caatccttaa cctagagcgg gtgactgaga tactagatta ctggggtgct
     2281 aactctggcc ctttgacatg gcgcctcacc cctgctgaag tgcgacaggt gctggctctg
     2341 cgcatagact tccgcaatga ggatatcaag aggctgcgcc tatagctgcc atgtggcccg
     2401 ccagacttca ggacctgttt tctaagcagt tacagccaaa gagctatgca aaactgtctg
     2461 gcttgggtca gccaaaggtc caggctacac cactgcatgg aaaccaggaa gcaaggagtg
     2521 cactcactgc aaagttcttc ccaggagcag ttacggctgg aggctaaaag ggagagcttt
     2581 tccaacagag aggtggggac taagtgggca gcatatgcct ggccatctgt tactctctcg
     2641 cccgcacact acaacacaca tgcccatgac agcagggagg ttggaggtac ctggggactt
     2701 aacggcaagg ctatgatgtt cacaaataaa gacactacct ggagacatgc catt
//
