LOCUS       NM_177381               4229 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus component of oligomeric golgi complex 3 (Cog3),
            transcript variant 1, mRNA.
ACCESSION   NM_177381
VERSION     NM_177381.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4229)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4229)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4229)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4229)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122285.4.
            
            On Apr 13, 2022 this sequence version replaced NM_177381.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038030.1, SRR1660815.7574.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC122285.4         85196-85431         c
            237-383             AC122285.4         77984-78130         c
            384-445             AC122285.4         74497-74558         c
            446-611             AC122285.4         73272-73437         c
            612-686             AC122285.4         72612-72686         c
            687-779             AC122285.4         71467-71559         c
            780-905             AC122285.4         70435-70560         c
            906-986             AC122285.4         68894-68974         c
            987-1030            AC122285.4         64829-64872         c
            1031-1157           AC122285.4         63842-63968         c
            1158-1249           AC122285.4         62907-62998         c
            1250-1389           AC122285.4         61526-61665         c
            1390-1550           AC122285.4         60202-60362         c
            1551-1656           AC122285.4         58639-58744         c
            1657-1781           AC122285.4         55642-55766         c
            1782-1871           AC122285.4         53033-53122         c
            1872-1992           AC122285.4         50623-50743         c
            1993-2081           AC122285.4         48040-48128         c
            2082-2216           AC122285.4         47799-47933         c
            2217-2292           AC122285.4         44132-44207         c
            2293-2420           AC122285.4         38853-38980         c
            2421-2519           AC122285.4         38021-38119         c
            2520-4229           AC122285.4         33282-34991         c
FEATURES             Location/Qualifiers
     source          1..4229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 40.29 cM"
     gene            1..4229
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /note="component of oligomeric golgi complex 3"
                     /db_xref="GeneID:338337"
                     /db_xref="MGI:MGI:2450151"
     exon            1..236
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2549
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     conserved oligomeric Golgi complex subunit 3; COG complex
                     subunit 3; component of oligomeric golgi complex 2"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 3
                     isoform 1"
                     /protein_id="NP_796355.2"
                     /db_xref="CCDS:CCDS36979.1"
                     /db_xref="GeneID:338337"
                     /db_xref="MGI:MGI:2450151"
                     /translation="MAEAALLLPPEAAAERDAREKLSLWDGRPDSMAPLTDRQTDSVL
                     ELKAAVENLPVPAELPIEDVCSLASQSLPIELTAVVPDSTEDILLKGFTSLGMEEERI
                     ETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGFQEQCDAILNDVNSALQHQESLQK
                     QYLFVSNKTGTLHEACEQLLKEQSELADLAEHIQQKLSYFNELETINTKLNSPTLSVN
                     SEGFIPMLAKLDDCITYISSHPNFKDYPVYLLKFKQCLSKALHLMKTYTVNTLQTLTN
                     QLLKRDPSSVPNADNAFTLFYVKFRAAAPKVRTLIEQIEQRSEKIPEYQHLLNDIHQC
                     YLDQRELLLGPSIAYTVTELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTKPT
                     SKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQHNAEQLGAFA
                     AGVKQMLEDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKK
                     APSEASFSDVRLEEGEASGLRKSGSTDSLNPRPQTTISPADLHGMWYPTVRRTLVCLS
                     KLYRCIDRAVFQGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIA
                     PFHTEFTIKEISLDLKKTRDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHY
                     LDSKKDVDRHLKSACEQFIQQQTRLFVEQLEEFMTKVSALKTMASQGGPKYTLSQQPW
                     AQPAKVNDLVATAYKTIKTKLPLTLRSMALYLSNKDTEFILFKPVRNNIQQVFQKFHA
                     LLKEEFSSEDIQIIACPSMEQLNLLLSVSK"
     exon            237..383
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            384..445
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            446..611
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            612..686
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            687..779
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            780..905
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            906..986
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1030
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1157
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1249
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1389
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1550
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1656
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1781
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1871
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1992
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2081
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2216
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2292
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2420
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2519
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..4229
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4209..4214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /note="hexamer: AATAAA"
     polyA_site      4229
                     /gene="Cog3"
                     /gene_synonym="E430004N23"
                     /note="major polyA site"
ORIGIN      
        1 agttcccggc tctgcctgtc gggctccggt tctgcgccgc ggaggggccc agggctgcgg
       61 agatggcgga ggcggcgctg ctgctgccgc ccgaggcggc ggccgagcgg gacgcccgcg
      121 agaagctgtc tctctgggat gggagacccg actcgatggc gccgctgaca gacaggcaga
      181 cggactcggt gctggagctc aaggcggccg tggagaacct gccggtgccc gccgagctcc
      241 caattgaaga tgtatgcagc ttagcatccc agtcgctgcc cattgagctg actgctgtag
      301 tgcctgactc tacagaagac atcctgttaa agggcttcac ttccttagga atggaagaag
      361 aaaggattga gactgcgcag cagtttttct catggtttgc aaaactgcaa actcagatgg
      421 atcaggatga aggaactaaa tatagacaga tgagggatta cttgtctggg tttcaggaac
      481 agtgtgatgc tatactgaat gacgtgaaca gtgctctgca gcatcaggag tcgttgcaga
      541 aacagtatct ttttgtgtcc aataagacag gaactcttca tgaagcctgt gaacagctcc
      601 taaaagaaca gtcggagctt gctgatcttg ctgagcacat ccaacagaag ctgtcttatt
      661 ttaatgagtt ggagacgatt aacacaaaat tgaattcccc tacgttgtct gtgaatagtg
      721 aaggatttat ccctatgttg gccaagttag atgattgtat aacatatatt tcatcgcatc
      781 ctaattttaa agattatcct gtatacttac tgaagtttaa acaatgtctt tctaaagctt
      841 tgcacctcat gaagacatat actgtgaaca cactgcagac tctcacaaat cagttactaa
      901 aaagggaccc ctcatcagtc cctaatgcag acaatgcctt cacactattt tatgtgaaat
      961 ttcgagccgc tgcccctaaa gtcagaactc taattgaaca gatagagcaa cgatctgaaa
     1021 agatacccga ataccagcac cttctcaatg acatccacca gtgttacctt gatcagcggg
     1081 agctcctttt gggcccaagt attgcctaca ctgtcacaga gttaaccagc cagaacaaca
     1141 gagaccattg tgccttggtt cgcagtggct gtgcctttat ggtccatgtc tgccaagatg
     1201 agcaccaact ttacaatgaa tttttcacaa agccaacatc aaaattagat gagctattgg
     1261 agaaattgtg cgtgtcgttg tatgatgtgt tccggccctt gatcatccat gtcattcact
     1321 tagagacttt atcggagctc tgtgggattc ttaaaaacga agtgcttgaa gaccacgtac
     1381 agcacaacgc tgaacaactg ggggcatttg cagctggagt aaagcagatg ttggaagatg
     1441 tacaagagag gcttgtgtat cgaacccata tctacattca gacggacatc acaggctaca
     1501 aaccagcgcc tggagatctg gcatatcctg ataagctagt catgatggag caaatcgcac
     1561 agagtttaaa ggatgagcag aagaaggcgc cttcagaagc ttccttttca gatgtacggt
     1621 tagaagaagg agaagccagt ggtttaagaa agtctggttc aacagactcc ctcaatccta
     1681 gaccacagac gacgatctct ccagcagatc ttcacgggat gtggtatccc acagttcgaa
     1741 ggacacttgt ctgtctctcc aaattatata gatgcataga tagggcggtg ttccaaggat
     1801 tatcacagga agccttgtct gcctgcatac agtccttgct aggagcatca gagtctatca
     1861 gcaaaaacaa gactcagatt gatggacaac ttttcttaat taaacacctt ttgattcttc
     1921 gagaacaaat tgctccattt cacactgaat tcaccattaa ggaaatttcc ctggacctca
     1981 agaaaactag agatgcagca tttaaaatcc tgaaccctat gactgttcca cgatttttta
     2041 ggctgaatag caacaatgcc ttgatagagt tcttgttgga ggggactcct gagatcagag
     2101 aacattatct tgactctaag aaggacgtag accggcacct gaagtcagcc tgtgagcagt
     2161 tcattcagca gcagaccagg ctgtttgtag agcagctgga ggagttcatg acaaaggtat
     2221 cagcattgaa aaccatggcc agccagggag gccccaagta caccctctca cagcagccgt
     2281 gggcacagcc agcaaaggtc aatgacctcg tggccactgc ctacaagaca ataaagacga
     2341 agctgccgct gacactgaga agcatggctt tgtatttgtc caataaggac acggagttca
     2401 tcttgtttaa gcctgtcagg aataacattc agcaagtctt ccagaagttc cacgctctgc
     2461 taaaggaaga gttcagttct gaagacatcc aaatcattgc ttgtccttcc atggaacagc
     2521 tgaacctcct gctgtcagtt tcaaagtagt cccagtggac cacgagtgtc agcagtctgt
     2581 cccacaggag aggcctgagg agtcctgcag cctgcaggat gcccaagacc cccatgtggg
     2641 acggctcctg tagaacatgg atgtgcagcc tgcagaagga aacctgggtg agccagagaa
     2701 gatcaaaatg ccaaagactg acagcaggga tagctgcctc attgaactgg tctccagcag
     2761 tggagagaag cgacaggggg ccacaattca cagtgaaatg ttccttcaca cagcttgtgc
     2821 aataaagtag gttacagtag tgactagtgt gatgcactca taggaactca gctgactgga
     2881 aagctgccgg gtctcagcaa ggcattcacc ccggccattc ctcggacgct gtgacttgaa
     2941 gaactcttcc ttctgtgtcc cgatgcagag cttctcatgc tgggtcgagc gaggttgagt
     3001 tggaatcgga tggttgctgc caagaaggca tctagctttt cctggactca ggctgtcatc
     3061 tttctgtggg ctgacacaag gcaggggcag ttgcaagaag ccaaggcctc ctataaggct
     3121 ccttgaactg catcctcctc actagagagg tgtatcttga tgatggggat cgccacagtg
     3181 ccggcaccag tgtgtgagtg ggagtgacca gtgaagaggt tttagcgtgg cacagcctgg
     3241 agaggaggcg gcctgtgggg agtgggctca tggatggagc ttagttgcag tcattcttta
     3301 taaagtgaat actctttggt tgcctatgtt gtcctagaca ctagccgtcc ggcatcccca
     3361 gtcctgccat agctgaacac ctaagtgtgg caaacgctgc ccgtacctta aatatgacac
     3421 cagtcaaaag tcaaaggact ataagcatct gtgaatttcc ctacaaattc ctctttgaat
     3481 ttgggattgg attggctttg accctggtgt tacaataaat gtagccagtt tcttggttca
     3541 gttactcaga ccgtcgtctg tagggtggga cagtgctgag ggctctgaaa tagggcagat
     3601 gacctcatgg tgcaggtgaa gggacaggaa cagcctcttg cacagttgca cgtgggtgac
     3661 ccatcccgat gcaacaggcc agtttctcag cccagtttaa attggtggtg gccgttgctt
     3721 ggtagagcat attactctgt attttgggaa actcagaggt aagagggtcc atattttttc
     3781 tttgctatga aatgaacgag ttaggaagat tgtacttact attttaaata catgtcttat
     3841 gtgataaacc ataatctcca gttctgtgta ttatatgtac attgggtgtt cagatagcct
     3901 ttccaaagaa gcgaggacgt gaccgttgta cagtgctgtg gctcagcagt ctgatggaca
     3961 gagcaggact tgttcgagga ctcttgtagt gctttgattt gtttgtttct gaaaacactc
     4021 acatacctta ccaactgctg ggagggtggg actgatccag ttcgtttgct gaatgaatat
     4081 ttgtttaaat ctgtacagtt tcacgtgttt acttatacag agtgtacata ctttgaaata
     4141 attaatttaa aatgctttat attatttagc tagaaattgc tgtttttaat aaataaattt
     4201 ttttaaaaaa taaagatctt tgcttccta
//
