LOCUS       NM_029746               2839 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus component of oligomeric golgi complex 2 (Cog2), mRNA.
ACCESSION   NM_029746
VERSION     NM_029746.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2839)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2839)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2839)
  AUTHORS   Kim,S., Zhang,S., Choi,K.H., Reister,R., Do,C., Baykiz,A.F. and
            Gershenfeld,H.K.
  TITLE     An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger
            41, is a candidate gene for anxiety-like behavior and
            beta-carboline-induced seizures
  JOURNAL   Biol Psychiatry 65 (5), 425-431 (2009)
   PUBMED   18986647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093818.1, AK012236.1, CO423795.1, CX205121.1, W74920.1,
            AK004441.1, AC126930.4 and AI837595.1.
            
            On Sep 1, 2009 this sequence version replaced NM_029746.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011435.1, AK169298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CJ093818.1         1-67
            68-485              AK012236.1         2-419
            486-948             CO423795.1         43-505
            949-1459            CX205121.1         158-668
            1460-1631           W74920.1           345-516
            1632-1873           AK004441.1         110-351
            1874-1874           AC126930.4         36989-36989         c
            1875-2822           AK004441.1         352-1299
            2823-2839           AI837595.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.78 cM"
     gene            1..2839
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /note="component of oligomeric golgi complex 2"
                     /db_xref="GeneID:76332"
                     /db_xref="MGI:MGI:1923582"
     exon            1..185
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2309
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /note="low density lipoprotein receptor defect C
                     complementing; COG complex subunit 2; low density
                     lipoprotein receptor defect C-complementing protein"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 2"
                     /protein_id="NP_084022.2"
                     /db_xref="CCDS:CCDS22771.1"
                     /db_xref="GeneID:76332"
                     /db_xref="MGI:MGI:1923582"
                     /translation="MEKRRMNLPTGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEE
                     LRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDRALNQLSVPLGQLREEVLSL
                     RSSVSEGILAVDERMSKQEDIRKKKMSVLRLIQVIRSVEKIEKILNSQSSKDVSSQEA
                     SSPLLTGQVLERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEG
                     LQTSDVDIVRHCLRTYATIDKTQDAEALVGQVLVKPYVNEVIVEQFVESHPSSLQLMY
                     NKLLEFVPHHCRLLREVTGGAVSSEKGTIVPGYDFLVNSVWPEIVRGLEEKLPSLFNP
                     GDPDAFHQKYTVSMDFVQRFERQCGSQASVKRLRAHPAYHNFSNKWNLPVYFQIRFRE
                     VAGSLEAALTDGLEDAPAGSPYCLLASHRTWISLGKCWSDEMFLPLLAHRLWRLTLQI
                     LARFSVFVSELSVRPVSNESAKETKKPLTGSKDPSEDQGSHASEASAASISSTQLVYV
                     VSDLGRLQEWLPDLLETVKQKLEMIGFKNFSSISAALEDSQSALSAHVPALSSRIVQD
                     LSESCFSYLKSALEVPRLYRRTNKEVPSTASSYVDSALKPLYQLQSGHGDKVQPAVMQ
                     SWLQEALSDSTHRYFETVSDVLNSVKKMEESLKRLKQARRSPATNPVSSSGGGMSDDD
                     KIRLQLALDVEHLGEQIQRMGLQTSDIKSFPALMELVLAARDQAAAEQP"
     exon            186..347
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            348..413
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            414..494
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            495..598
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            599..707
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            708..887
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1012
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1139
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1279
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1341
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1493
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1667
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1740
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1883
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2023
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2207
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2825
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /note="hexamer: AATAAA"
     polyA_site      2825
                     /gene="Cog2"
                     /gene_synonym="1190002B08Rik; 2700012E02Rik; Ldlc"
                     /note="major polyA site"
ORIGIN      
        1 tgtcgctcgc tgctgccata ctggcggaag cggaagtgga gctgggacgc tgggggtggg
       61 ctgggctgcc gcgtcccctg cggtcttggc cttgaggggc ggcggccggc gtgatggaga
      121 aacgcaggat gaacctgcct acggggccgg acacgctgtg cttcgataag gacgagttca
      181 tgaaggagga tttcgatgtg gaccactttg tgtctgactg caggaagcgg gtgcagctgg
      241 aggagctgag agacgacctg gagctgtatt acaagctgct gaagacggcc atggtggagc
      301 tcatcaacaa ggactacgcc gactttgtca acctctcaac aaacctggtt ggcatggaca
      361 gagccctcaa ccaactttct gtgcctttgg gacagttacg agaagaggtt ctgagtctta
      421 ggtcctctgt cagtgaagga attctggcag tagatgaacg aatgtctaag caagaagaca
      481 ttaggaagaa aaagatgagt gtgttgagac ttatacaagt tattcgatcg gttgagaaaa
      541 ttgagaaaat cttaaactct caaagttcta aagatgtatc ttcacaagaa gcaagcagcc
      601 cactcctgac cggacaggtt ttggagagaa ttgccacaga gtttaaccag cttcagtttc
      661 atgctgtgca gagcaagggc atgccccttt tggacaaagt gagacctcgt atagctggca
      721 tcacagccat gttgcagcag tctctggaag gcctcctgct ggaaggtttg cagacctcag
      781 atgtggacat cgtccggcac tgcctgcgca cctatgccac cattgataag acacaggatg
      841 cagaagctct ggtgggccaa gtcctggtga agccatatgt caatgaggta atcgtcgagc
      901 agttcgttga gtctcacccc agtagccttc agctcatgta caacaagctt ctggaatttg
      961 tccctcacca ctgccgcctt ctccgggaag tcacaggagg agctgtgtca agtgagaaag
     1021 gcactatcgt tcctggctat gatttcttgg tgaattctgt gtggccagaa atagttcgag
     1081 gcctagagga aaagctaccc tcgctcttca accctgggga cccagacgcc tttcaccaga
     1141 aatacactgt gagcatggac tttgtgcaga ggtttgagcg gcagtgtgga tcccaggcca
     1201 gcgtaaagcg acttcgagca caccctgcct atcacaactt cagcaataag tggaacctgc
     1261 ctgtttactt tcagataagg ttccgagaag tggcaggatc cctggaagca gccctcacag
     1321 acgggctcga ggacgcccca gctggaagtc cgtattgcct tttggcttct cacagaacat
     1381 ggatcagcct gggcaaatgc tggtccgatg agatgttcct acctttgttg gcacaccgtc
     1441 tgtggaggct cacgctgcag attctggcca gattctctgt gtttgtcagt gagctttctg
     1501 tcaggcccgt ttctaatgag agtgccaagg agactaaaaa gcctttgact ggcagcaaag
     1561 acccttcgga agaccaagga agccatgctt cagaagcaag cgccgcgtcc atttctagca
     1621 ctcagctggt gtatgtggtc tcagacctgg gcaggctgca ggaatggctt ccagacctcc
     1681 tggagacggt caagcagaaa ctcgaaatga ttggctttaa gaatttttcg tctatctcag
     1741 cggccctgga agactcccag agtgccttgt ctgcccatgt gccggctctg agcagcagga
     1801 ttgtccagga cctgagtgag tcttgcttca gttatctcaa gagtgccctg gaggtcccca
     1861 ggctttaccg caggaccaat aaggaggtcc ccagcacagc ctcttcatat gtagacagtg
     1921 cactgaagcc actgtaccag cttcagagtg gacatgggga caaggtgcag ccagcagtga
     1981 tgcagagctg gctgcaggaa gctctgtcgg acagcacaca caggtacttt gagactgtgt
     2041 cagacgtgct gaactcagtg aagaagatgg aggaaagcct gaaacgcctc aaacaagcca
     2101 ggagatcccc agccaccaac cctgtcagct ccagcggcgg tggtatgagt gatgacgaca
     2161 agatccgact gcagctggcc ctggacgtgg agcacctggg agaacagata caaaggatgg
     2221 gcttgcagac cagcgacatc aagagcttcc cagccctcat ggagctcgtc cttgctgcca
     2281 gggaccaggc ggctgcagaa cagccctagg catcctggca ggacctggag tagggaagaa
     2341 agcaaccctt gtcctccggg tcacccagca acagcctgta cctccgccca cttatatggg
     2401 ccatctttca ccaagaaaga accaaaagcc tttccattgt atggaagata gtttttaaga
     2461 cattcaaagc tttttgctct agtttacaga acaaattgtt ttatttttat tgtaaatctt
     2521 agtgtagacc agctgatgtc tacaatatgg taaaagtaaa tcgacaagtg tggctggtgg
     2581 gctgtcctgg ccctgcaggg caagcactgg gcaggatgca ccaatgcaga gtagaacttt
     2641 gattgtcccc aaccctccga cctgggagat actgtcagcc ctgggcctcc ttagaggcta
     2701 caaagtggcc cgtccatctg ggcacagaag agtagcactt ccaatcttgc caatccgcac
     2761 ctctgtcaga gccagagccg gcagtaaaga ttcatttcct aaataaaaga agtacctact
     2821 gcaaaaaaaa aaaaaaaaa
//
