LOCUS       NM_013581               3060 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus component of oligomeric golgi complex 1 (Cog1), mRNA.
ACCESSION   NM_013581
VERSION     NM_013581.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3060)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3060)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3060)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 3060)
  AUTHORS   Febbraio,M., Abumrad,N.A., Hajjar,D.P., Sharma,K., Cheng,W.,
            Pearce,S.F. and Silverstein,R.L.
  TITLE     A null mutation in murine CD36 reveals an important role in fatty
            acid and lipoprotein metabolism
  JOURNAL   J Biol Chem 274 (27), 19055-19062 (1999)
   PUBMED   10383407
REFERENCE   5  (bases 1 to 3060)
  AUTHORS   Chatterton,J.E., Hirsch,D., Schwartz,J.J., Bickel,P.E.,
            Rosenberg,R.D., Lodish,H.F. and Krieger,M.
  TITLE     Expression cloning of LDLB, a gene essential for normal Golgi
            function and assembly of the ldlCp complex
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 915-920 (1999)
   PUBMED   9927668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY721599.1 and BC063056.1.
            
            On Nov 2, 2007 this sequence version replaced NM_013581.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063056.1, AK034636.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY721599.1         2-19
            19-3060             BC063056.1         1-3042
FEATURES             Location/Qualifiers
     source          1..3060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 79.1 cM"
     gene            1..3060
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /note="component of oligomeric golgi complex 1"
                     /db_xref="GeneID:16834"
                     /db_xref="MGI:MGI:1333873"
     exon            1..347
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2975
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /note="COG complex subunit 1; low density lipoprotein
                     receptor defect B-complementing protein; low density
                     lipoprotein B"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 1"
                     /protein_id="NP_038609.3"
                     /db_xref="CCDS:CCDS25599.1"
                     /db_xref="GeneID:16834"
                     /db_xref="MGI:MGI:1333873"
                     /translation="MAAATASSALKRLDLRDPNALFETHGAEEIRGLERQVRAEIEHK
                     KEELRQMVGERYRDLIEAADTIGQMRRCAEGLVDAVQATDQYCARLRQAGSVAPRVPR
                     APQPQPPSEKFYSMAAQIKLLLEIPEKIWSAMEASQHLQATQLYLLCCHLHSLLQLDS
                     SNSRYSPILSRFPILIRQVAAASHFRSTILHESKMLLKCQAVSDQAVAEALCSIMLLE
                     ESSPRQALTDFLLARKATIQTLLNQSHHGAGIKAQICSLVELLATTLNQAHALFYTLP
                     EGVLPDPSLPCGLLFSTLETVTRQHPTGKGIGALQGEMKLCSWFRHLPTSIIEFQPTL
                     RTLAHPISQEYLKDTLQKWIDMCNEDIKNGIGNLLMYVKSMKGLAGIRDAIWDLLSNE
                     SASHSWEVVCQRLLEKPLLFWEDLMQQLFLDRLQTLTREGFESISNSSKELLVSALQE
                     LETNNSTSNKHVHFEQNMSFFLWSESPNDLPSDAAWVSVANRAQFASSGLSMKAQAIS
                     PCVQNFCSALDSKLKVKLDDLLAYLPSSDTPLLKDTTPTHQPKNSAFDRYADAGTVQD
                     MLRTQSVACIKSVVGCIQAELCTIEEVTREQKDVLHSTKLHAVLFMARLCQSLGELCP
                     HLKQCVVGQCGGSEKPAREARALKKQGKGRAQDVLPAQAQWQGVKEVLLQQSVMAYRV
                     WSTALVKFLICGFTRSLLLRDAGSVLATATNWDELEIQEETESGSSVTSKIRLPTQPS
                     WYVQSFLFSLCQEVNRVGGHALPKVTLQEMLKTCMAQVIAAYEQLTEENQIKKEGAFP
                     MTQNRALQLLYDLRYLTMVLSSKGEEVKSGRSKADSRMEKMTERLEALIDPFDLDVFT
                     PHLNSNLNRLVQRTSVLFGLVTGTENQFASRSSTFNSQEPHNILPLASSQIRFGLLPL
                     SMTSTRKARATSRSVETQAQVGPPALSRVGDPTTHPGSLFRQLASEEDDSPAPSLFKL
                     AWLSSMTK"
     exon            348..589
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            590..771
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            772..942
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1099
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1310
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..2099
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2246
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2408
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2536
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2645
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2755
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2834
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3029
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3002..3007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="Cog1"
                     /gene_synonym="6030445I15; Ldlb; mKIAA1381"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggcc ggcggatccc tggcttagca ccatggcggc cgcgaccgcc tcctccgcgc
       61 tcaagcggct ggatctgcgc gatcccaacg cgctcttcga gactcatgga gcggaggaga
      121 tccgcgggct ggagcgccag gtccgagccg agatcgaaca caagaaggag gagctgcggc
      181 agatggtggg cgagcggtac cgcgacctga tcgaggcggc ggacaccatc ggccagatgc
      241 gccgctgcgc cgagggcctg gtggacgccg tgcaggccac cgatcaatac tgcgcccgcc
      301 tccgccaggc cggctccgtg gcgccccggg tcccacgggc cccgcagcca cagccgccgt
      361 ccgagaagtt ctacagcatg gccgcccaga ttaagctgct gctggagatc ccggagaaga
      421 tctggagcgc catggaagcc tcgcagcacc tccaggccac acagctctac ctgctctgct
      481 gccacctgca tagcctgctg cagctggact cctctaactc cagatacagc cccatcctct
      541 cgagatttcc aatcctcatc cgccaggtgg cagcagccag ccacttccgg tcaactattt
      601 tgcacgaaag caagatgctg ctcaaatgcc aggctgtgtc ggaccaggct gtggccgaag
      661 ccctctgctc cataatgctc ttggaggaga gctctccgcg ccaagccctc acagacttcc
      721 tgctggccag aaaggcgact attcagacgc tcctgaacca gtctcatcac ggtgctggca
      781 tcaaggccca gatttgctct ttggtggagc tgctggctac cactctgaac caggcacatg
      841 cccttttcta caccctacca gaaggcgtgc tgcccgaccc atccctgccc tgtggcttgc
      901 tcttttctac cctggagaca gtcacaaggc agcatcccac tggaaagggc atcggtgccc
      961 tccaagggga gatgaagcta tgcagctggt tcagacacct gcccacctcc attatcgagt
     1021 tccagcccac actccgaact ctcgcacatc ccatcagcca ggagtacctg aaagacacgc
     1081 tgcagaaatg gatcgacatg tgcaatgaag acattaaaaa tgggatcggc aatctgctta
     1141 tgtacgtgaa gagcatgaag ggtctggcag gcatcagaga cgccatatgg gatttgctta
     1201 gcaacgagtc tgccagccac agctgggagg tggtgtgtca gcggcttctg gagaagccgc
     1261 tcttgttctg ggaggacctg atgcagcagc tcttcctgga tcggttacag acactgacca
     1321 gagaaggctt tgaatccatc tccaacagct ccaaagagct tctagtctca gctctgcagg
     1381 agctggagac caacaactcc acatcgaaca agcatgtcca ctttgagcag aacatgtctt
     1441 tcttcctctg gtccgagagc cccaacgacc tgccttctga tgctgcctgg gtcagcgtag
     1501 caaaccgggc tcagtttgcc agtagtggcc tctccatgaa agcccaagcc attagcccgt
     1561 gtgtccagaa cttctgttct gccctggatt ctaagctgaa ggttaaactg gacgacctcc
     1621 tggcctacct tccctccagt gacacaccat tgctcaagga taccaccccc acgcaccagc
     1681 ctaagaactc tgcctttgat cgatacgcag atgctgggac cgtgcaggac atgctgcgta
     1741 cgcagtccgt ggcctgcatc aagtccgtcg tgggctgcat ccaggcagag ctgtgcacca
     1801 ttgaagaagt cacacgggaa caaaaggatg tccttcacag caccaagctg cacgcagtcc
     1861 tcttcatggc cagactctgc cagtctctgg gagagctgtg ccctcaccta aagcagtgtg
     1921 ttgtgggaca gtgcgggggt tctgagaaac ctgccaggga ggcgagggct ctgaaaaagc
     1981 aggggaaggg gagagctcag gatgtcctcc ccgcgcaggc ccagtggcag ggagtgaagg
     2041 aagtcctgct ccaacagagc gtcatggcct accgggtctg gagcacagca cttgtgaaat
     2101 ttctgatttg tggattcact cgatcactgc ttctcaggga tgccggctca gtcctggcca
     2161 ctgccaccaa ttgggatgaa ctagaaattc aagaggagac agagtctggc agcagtgtca
     2221 cgtctaagat ccgcctccct actcagccct cctggtatgt acagtccttc ctgtttagct
     2281 tatgccagga agttaatcgg gttggaggcc atgctttgcc aaaggtcacc ctacaggaga
     2341 tgctgaagac ctgcatggcc caagtcatag ctgcctatga gcaactcaca gaggaaaacc
     2401 agataaagaa agaaggggca tttccaatga cccagaaccg agccctgcag ctcctctacg
     2461 acctacgcta cctcaccatg gttctgagca gcaaggggga ggaggtgaag agtggccgga
     2521 gcaaggcaga ctccagaatg gagaagatga ccgagaggct ggaggccctc attgaccctt
     2581 ttgacctgga tgtcttcaca ccgcatctca acagcaacct caaccgcctg gtgcagcgga
     2641 cttcagttct atttggcttg gttacaggca cagagaatca gtttgcctcc cggagcagca
     2701 ctttcaactc ccaggagccc cataacatac tgccgctggc ctccagtcag atcaggtttg
     2761 gactccttcc actgagcatg acaagcacaa gaaaggcgag ggcaaccagt agaagcgttg
     2821 aaacccaagc ccaggttggc cccccggcac tctccagagt aggtgacccg acgacgcatc
     2881 ctggctcctt attcaggcag cttgcaagcg aggaagacga ctcacctgca ccttcattat
     2941 tcaagcttgc ctggctctct agtatgacca agtagcatag gaacaatgcc caggctctct
     3001 aaataaatac tagcgcattg tttttcctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
