LOCUS       NM_172496               5597 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus cordon-bleu WH2 repeat (Cobl), transcript variant 1,
            mRNA.
ACCESSION   NM_172496
VERSION     NM_172496.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5597)
  AUTHORS   Juan,A.M., Foong,Y.H., Thorvaldsen,J.L., Lan,Y., Leu,N.A.,
            Rurik,J.G., Li,L., Krapp,C., Rosier,C.L., Epstein,J.A. and
            Bartolomei,M.S.
  TITLE     Tissue-specific Grb10/Ddc insulator drives allelic architecture for
            cardiac development
  JOURNAL   Mol Cell 82 (19), 3613-3631 (2022)
   PUBMED   36108632
REFERENCE   2  (bases 1 to 5597)
  AUTHORS   Xiao,Z., Liu,S., Li,Z., Cui,J., Wang,H., Wang,Z., Ren,Q., Xia,L.,
            Wang,Z. and Li,Y.
  TITLE     The Maternal Microbiome Programs the m6A Epitranscriptome of the
            Mouse Fetal Brain and Intestine
  JOURNAL   Front Cell Dev Biol 10, 882994 (2022)
   PUBMED   35874829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5597)
  AUTHORS   Ji,Y., Koch,D., Gonzalez Delgado,J., Gunther,M., Witte,O.W.,
            Kessels,M.M., Frahm,C. and Qualmann,B.
  TITLE     Poststroke dendritic arbor regrowth requires the actin nucleator
            Cobl
  JOURNAL   PLoS Biol 19 (12), e3001399 (2021)
   PUBMED   34898601
  REMARK    GeneRIF: Poststroke dendritic arbor regrowth requires the actin
            nucleator Cobl.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5597)
  AUTHORS   Izadi,M., Seemann,E., Schlobinski,D., Schwintzer,L., Qualmann,B.
            and Kessels,M.M.
  TITLE     Functional interdependence of the actin nucleator Cobl and
            Cobl-like in dendritic arbor development
  JOURNAL   Elife 10, e67718 (2021)
   PUBMED   34264190
  REMARK    GeneRIF: Functional interdependence of the actin nucleator Cobl and
            Cobl-like in dendritic arbor development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5597)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   6  (bases 1 to 5597)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 5597)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5597)
  AUTHORS   Cole,S.E., Mao,M.S., Johnston,S.H. and Vogt,T.F.
  TITLE     Identification, expression analysis, and mapping of B3galt6, a
            putative galactosyl transferase gene with similarity to Drosophila
            brainiac
  JOURNAL   Mamm Genome 12 (2), 177-179 (2001)
   PUBMED   11210191
REFERENCE   9  (bases 1 to 5597)
  AUTHORS   Weiss,R.S., Kostrub,C.F., Enoch,T. and Leder,P.
  TITLE     Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell
            cycle checkpoint gene
  JOURNAL   Genomics 59 (1), 32-39 (1999)
   PUBMED   10395797
REFERENCE   10 (bases 1 to 5597)
  AUTHORS   Gasca,S., Hill,D.P., Klingensmith,J. and Rossant,J.
  TITLE     Characterization of a gene trap insertion into a novel gene,
            cordon-bleu, expressed in axial structures of the gastrulating
            mouse embryo
  JOURNAL   Dev Genet 17 (2), 141-154 (1995)
   PUBMED   7586755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669822.10 and AL713914.10.
            
            On Feb 2, 2022 this sequence version replaced NM_172496.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145118.1, SRR10662772.2902419.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL669822.10        79923-80180         c
            259-265             AL669822.10        2001-2007           c
            266-462             AL713914.10        188210-188406       c
            463-673             AL713914.10        179796-180006       c
            674-902             AL713914.10        177457-177685       c
            903-1000            AL713914.10        171241-171338       c
            1001-1075           AL713914.10        166752-166826       c
            1076-1249           AL713914.10        145391-145564       c
            1250-1388           AL713914.10        111261-111399       c
            1389-1559           AL713914.10        108605-108775       c
            1560-1848           AL713914.10        68503-68791         c
            1849-1946           AL713914.10        57792-57889         c
            1947-3829           AL713914.10        54736-56618         c
            3830-3949           AL713914.10        52670-52789         c
            3950-4213           AL713914.10        51297-51560         c
            4214-5597           AL713914.10        38323-39706         c
FEATURES             Location/Qualifiers
     source          1..5597
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.3 cM"
     gene            1..5597
                     /gene="Cobl"
                     /note="cordon-bleu WH2 repeat"
                     /db_xref="GeneID:12808"
                     /db_xref="MGI:MGI:105056"
     exon            1..258
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..4231
                     /gene="Cobl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein cordon-bleu"
                     /codon_start=1
                     /product="protein cordon-bleu isoform 1"
                     /protein_id="NP_766084.3"
                     /db_xref="CCDS:CCDS36113.1"
                     /db_xref="GeneID:12808"
                     /db_xref="MGI:MGI:105056"
                     /translation="MDAPRALAAKPPTGRKMKARAPPPPGKPAAQNVHSEQKLPHDAT
                     LGSQQSLVYMKEALQNSTLDITVVLPSGLEKQSVVSGSHAMMDLLVELCLQNHLNPSH
                     HVLEIWSSETQQPLSFKPNTLIGSLNVHTVLLKEKVPEERVKPGLTKAPEKSVRLVVN
                     YLRTQKAVVRVSPEVPLQNILPVICAKCEVNPEHVILLRDNVAGEELELSKSLNELGI
                     KELYAWDNRREMFRKSSLGNDETDKEKKKFLGFFKANKRSNSKAEHLGLSGADSDEDP
                     AKSASGGDLNGCVTTPNSPSLHSRSLTLGPSLSLGNISGVSMKSDMKKRRAPPPPSPK
                     LLGQDKVSEKASLSSQADLQKKKRRAPAPPPPQQPPPSPVVPNRKEDKEENRKSTVGV
                     GRQVPQKPPRGTARGPPQLVLPPPPPYPPPDTDVTEPVTFPGEGAGSETSELRPKLSL
                     PLGPGSHCSMGGVSQVPAESEETASEDTTEDSGVMSSPSDAISLDSQQDSMRSKDKWS
                     TDQEDGSDQDLAGTPELGPQKSPSWGKSGSGSSILRTEKATMPTNDDEDLFITGHLHQ
                     TLAELDEDLEGMEENYETDTSSLTNSVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSD
                     EPFDSGLFSSRCNNATTFNTGSIASQRSHLSPSQTEHSQPFVRTSRKEPDPSPPSQDN
                     RKRNQPTLANTSENENPVETDPTVTSLVSKLLIDDPKAKDKGKVHGSSHSEKTQAGHG
                     INSLRVNPRDGKDESSNSAPPPWSHHGQALGGSYGLKYGLTTYKIVPPKSEMRCYDRD
                     VSLSTGAIKIDELGNLVSPHMNGSRTISPPSAVVETDTPPIGKVKEFWRRNSMEKYLN
                     GPAECTIKRAPSTTITATPEKPQQDNGMKAAFTVTTPQQQPASQEYGAHLEEERSRPQ
                     SAVSCSVKVPASNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPHKATTEQ
                     CHEEAKLARSPPTRKDDAAPNLHSEARQHEHGTNQSSVCLPSNPGVQLPAGGHPKVEV
                     NSTYGKSSTQDYPAAVHRNSYFLPGRSSHRDRVSVGQSCGFNEKQTTSNQKANSTSNF
                     SQALDKAHPPPLLLAEARDSGRILMNGSARTPGNCEPPHSPKESTLTSYIILQTEEKP
                     SSLSTDGQDADDTLPSSIFGPKKKFKPVIQRPLPKDVSLHSALMEAIHSSGGREKLRK
                     TAEQTSEGRPKKPSYVEAESERSALLAAIRGHSGTLSLRKVSSLASEELQSFRNAALG
                     APGLDKPQQEDLGLPPPPALPPPPAPAPQAPSASVTVSRFSTGTPSNSVNARQALMDA
                     IRSGTGAARLRKVPLLV"
     exon            259..462
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            463..673
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            674..902
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1000
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1075
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1249
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1388
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1559
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1848
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1946
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..3829
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3949
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4213
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..5597
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5573..5578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cobl"
                     /note="hexamer: AATAAA"
     polyA_site      5597
                     /gene="Cobl"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcacctt gctcccgcgc ccggggtagc cgcgtccgtc tctctccgca cgcccccgcc
       61 cgcccggacg ccccaggtcg cttccgtcct ctcggcacgg ccgctgtcct cgctagcccc
      121 gcgtgggagg acgatgggtc agcgcggaaa aagtgaatga ggacggcggc gccgcagcca
      181 gcgccccagt cggccggcag agcaacccgc cggctccatg gacgcgccgc gtgcactggc
      241 ggccaagccc cccacaggaa ggaagatgaa ggcccgtgct ccgccacctc ctggaaagcc
      301 tgctgcccag aatgtccaca gcgaacagaa actgccccat gatgccaccc tgggatccca
      361 gcaaagcctg gtctacatga aggaggcact gcagaacagc accttggaca tcaccgtggt
      421 tctgcccagt ggactggaga agcagagtgt ggttagtggg agccacgcaa tgatggacct
      481 actggttgaa ctctgccttc agaaccacct gaatccttct caccacgtcc tagagatctg
      541 gtcttctgag acccaacagc ctttgagttt taagccaaat acgttgattg ggtccttgaa
      601 tgtgcatact gtacttctga aagaaaaagt ccctgaagaa agagttaaac ctggcctaac
      661 caaggctcct gagaaatctg tacgactggt agtgaactac ctgagaacgc agaaggctgt
      721 cgtgcgggtg agccctgagg tgccactaca gaatattctg ccagtcatct gtgcgaagtg
      781 tgaggtcaac ccagaacacg tgattctgct cagagacaat gttgccgggg aggagctgga
      841 gctgtccaag tccctgaatg aactagggat caaggagctg tatgcgtggg acaacagaag
      901 agaaatgttt agaaaatcat cacttggcaa tgatgagaca gacaaagaga agaaaaagtt
      961 tctgggattt ttcaaagcta ataaaaggag caacagtaag gctgagcatc ttgggctgtc
     1021 aggtgcagat agtgatgagg acccggcgaa gtcagcatct ggaggggact tgaacggctg
     1081 cgtaacaaca cccaactcac catccttgca ttctcggtcc ctaacactgg gtccctccct
     1141 ctccctgggc aacatctctg gagtgtctat gaagtcagac atgaagaagc gcagagcccc
     1201 tcctcctcca agtcccaagc tgctgggtca agacaaggta tcagaaaagg cctccctcag
     1261 ctcacaggct gatctccaga agaagaagag gcgggcgcca gctcctcctc caccacagca
     1321 gccaccacca agtcctgtgg tccccaaccg caaggaagat aaggaagaga acaggaagag
     1381 cacagtgggt gttggacgtc aggtgccaca aaagcctccc agaggcacag ctcggggccc
     1441 accccagtta gtgctccccc cgcccccacc ctaccctcct cctgacacag atgtgacaga
     1501 gcctgtcacc tttcctgggg aaggcgctgg ttccgagacc tcagagctga gacccaaact
     1561 gagtctgcct ctggggcctg gcagccactg cagcatgggt ggagtctctc aggtgccagc
     1621 ggagagtgag gagacagcat ctgaggacac aaccgaggac tcgggggtca tgagctctcc
     1681 ctcagatgcc atctccctgg actcacaaca agacagcatg agatccaagg acaaatggtc
     1741 cacagaccag gaagacggca gtgaccagga cctggctgga actccagaac tgggtcccca
     1801 aaagagccca tcatggggga aaagtggttc aggaagctca attctaagga ctgagaaagc
     1861 caccatgcct accaatgatg atgaagacct attcatcact ggccacttac atcagaccct
     1921 ggcagaactt gatgaagacc tggaaggaat ggaagaaaat tatgaaacag atactagctc
     1981 tctaaccaac tctgtcaatg gtgtatccaa ccacagtctg caagaagcca taatccctga
     2041 tagtggcgtg gatgacatcc cagtcacttt tatcggggaa gtttctgatg agccttttga
     2101 ctcagggctg ttctccagta gatgtaacaa tgccactact tttaacacgg ggagcattgc
     2161 tagccaaaga tctcatctgt ccccatctca gactgagcat agccagccat tcgtaaggac
     2221 aagtagaaaa gagcctgatc cctcccctcc ttcccaagat aacaggaaga gaaatcagcc
     2281 aaccttagcc aacacatctg aaaatgagaa tccagttgaa acagacccca cagttacatc
     2341 acttgtttca aagcttttaa tagatgaccc aaaagcaaag gataaaggca aagtgcatgg
     2401 ttctagtcac agtgagaaga cacaggcagg tcatggaata aactcactgc gagtgaatcc
     2461 aagagatggt aaggatgaga gctccaattc agcaccccca ccatggtctc atcatggcca
     2521 ggccttaggg ggaagctatg gactcaagta tggcctcacg acatataaaa ttgttcctcc
     2581 caaatcagag atgaggtgtt atgacaggga tgtgtccctc tccactggtg ccattaagat
     2641 tgatgaacta gggaatctgg tgagtcctca catgaacgga agcaggacca tatccccacc
     2701 atcagctgtt gtcgaaacag acactccacc tattggaaaa gtcaaagagt tctggaggcg
     2761 caactcaatg gaaaagtacc ttaatgggcc ggctgagtgc actatcaaaa gggccccctc
     2821 caccactatc actgccacac cagaaaaacc acagcaagat aatgggatga aggcagcctt
     2881 cacagtgacc actccccagc agcagcctgc ctcacaggaa tatggggcac acctggagga
     2941 agagagaagc cggccacagt cagcagtctc ttgttctgtg aaagtgccag catctaatcc
     3001 cacagacatc acattcctca agcctcaaag aagaacatcc agccagtatg tggcctctgc
     3061 tattgccaag aagatggggc ctccaaaagt ccatgctgat gtggtgagac cacataaggc
     3121 aaccactgaa cagtgtcatg aagaagcaaa gctggctaga tctcctccca ccaggaaaga
     3181 tgatgcagct cccaacctac actcagaggc aaggcagcat gaacatggga caaaccagag
     3241 ctctgtctgc cttcccagca accctggtgt gcaattgcca gcaggaggcc atcccaaagt
     3301 agaggtcaac agcacatatg ggaagtcatc gactcaagac tatcctgctg ctgtccacag
     3361 aaactcctat ttcctcccag gcagatcttc ccatagggat cgtgtttctg tgggacagag
     3421 ctgtggtttc aatgaaaagc aaactacaag taaccaaaag gcaaattcaa catctaactt
     3481 ctcgcaggca ctggacaagg cgcatccacc ccctctgctc ttggcagagg cccgtgactc
     3541 tgggaggata ctgatgaatg gctctgcacg aaccccagga aattgtgagc ccccccactc
     3601 tccaaaagaa tccaccctga ctagctatat tatcttacag acagaggaaa agcccagttc
     3661 gttatctaca gatggtcaag acgcagatga tactctaccg tccagcattt ttgggccaaa
     3721 gaaaaagttc aagcctgtca ttcaaaggcc actcccaaaa gatgtatccc tgcacagtgc
     3781 cctgatggaa gctatccact catcaggagg gagagaaaag ctccggaaga ctgcagaaca
     3841 gacgtcagaa ggaaggccaa agaaaccatc ctacgtggag gcagagagtg agcgatctgc
     3901 ccttctggca gccattcggg gtcacagtgg gactctcagc ctcaggaagg tgtcatccct
     3961 tgcctctgag gagctccaga gcttccgcaa tgctgcactc ggggctccag gtttggataa
     4021 acctcagcaa gaagaccttg gccttccacc cccacctgcc ctgccaccac cacccgctcc
     4081 agccccccag gctccttcag cctccgtaac agtttctagg ttcagcaccg gcacccccag
     4141 caactcagtg aatgctagac aagccttgat ggatgccatc cgctcgggca caggagctgc
     4201 aagactaaga aaggttccct tgctcgtgtg aagtcctacc actgaagaga ccacctgtac
     4261 agctccaagt atcatcactt tagaaatcca catgacagga aatgaaacct tcaagaagtg
     4321 gcggtacttt cctgtctcca ggccaacttg cccacggtgg attttcagtg ttcctacata
     4381 atggtcaaag aggagatact gctttgctgt gtgacttgtg tgccaaggac atatgatctg
     4441 cctctgaatg ctcacagttg ccaataaact gctcttgttg gcagagtaat gggaatacac
     4501 aggctggagc ccagcactca cacttgattt tagctatggg cacaaggaat tatgccctaa
     4561 gttgattttt ggatctttga gactttgacc acatacacat ggttaaaatc acttatgatc
     4621 ctttgaattc taggtgtaca aaaacataaa tcaacagaaa tagtcagaat ctattacatg
     4681 ctccaggatg ctgcttctgg agtaagaagc accatggagg aaggctgctg agatgacttt
     4741 tgcaggataa gaaagcgtca gattcgtatt tgtattcctc acacagtgaa gcctcacacc
     4801 tcacagatga tcttggactg tgatctgacc aactagcttt taaaattcca ctgttgctgc
     4861 ccagaatagc agccctactt gaccctctga gcaagacatt cctggctcct tagaagatga
     4921 tgggaagcag agatgagaac actggaaggg ttgtccgttt tctgtataga tgtgtcccac
     4981 ttgtatagtt tcccccctcc cccatcccca gtgtcccaga aggctatgac atgcatcagg
     5041 ttactgtgaa ggagccttgc atggagcctg agatttcacc agtagccttc tgaaatcctg
     5101 cacagggcca gagagcagag tgttgaggac ctatatgtag cagagggcag tccacattgt
     5161 gctgcacatt ctgtggctta cattttatcc tgacacactt tggcatggtc cagcagctgc
     5221 cctggtatta tatgacattc ttatagtaca ttgtgggtag acaccatctt taaagaattt
     5281 aaactcagca ggaagttttg tgattttttt taatgtatct ctaaaacctt ttcttatatg
     5341 gagaaaatca agacagcaat ataagtcaaa atgagttcat gatataaaat ctctgcctta
     5401 ctgaaaaaaa aatgaaatcc ttttactatt tccccctgtt ttaaatctag gcatcgggta
     5461 gagtgggaac ttggtattgt gtgattaaca ttgctaaact ttctcagtga ggcaagagct
     5521 accagccaat tgctcttagt cacagctgtc tgctctttct cttagtgcca caaataaatg
     5581 caaatccaat gctgtaa
//
