LOCUS       NM_001305982            2153 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus Coenzyme A synthase (Coasy), transcript variant 1,
            mRNA.
ACCESSION   NM_001305982
VERSION     NM_001305982.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Cavestro,C., D'Amato,M., Colombo,M.N., Cascone,F., Moro,A.S.,
            Levi,S., Tiranti,V. and Di Meo,I.
  TITLE     CoA synthase plays a critical role in neurodevelopment and
            neurodegeneration
  JOURNAL   Front Cell Neurosci 18, 1458475 (2024)
   PUBMED   39301217
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   Di Meo,I., Cavestro,C., Pedretti,S., Fu,T., Ligorio,S.,
            Manocchio,A., Lavermicocca,L., Santambrogio,P., Ripamonti,M.,
            Levi,S., Ayciriex,S., Mitro,N. and Tiranti,V.
  TITLE     Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron
            Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse
            Model
  JOURNAL   Int J Mol Sci 21 (24), 9707 (2020)
   PUBMED   33352696
  REMARK    GeneRIF: Neuronal Ablation of CoA Synthase Causes Motor Deficits,
            Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN
            Mouse Model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Zhyvoloup,A., Nemazanyy,I., Panasyuk,G., Valovka,T., Fenton,T.,
            Rebholz,H., Wang,M.L., Foxon,R., Lyzogubov,V., Usenko,V.,
            Kyyamova,R., Gorbenko,O., Matsuka,G., Filonenko,V. and Gout,I.T.
  TITLE     Subcellular localization and regulation of coenzyme A synthase
  JOURNAL   J Biol Chem 278 (50), 50316-50321 (2003)
   PUBMED   14514684
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Aghajanian,S. and Worrall,D.M.
  TITLE     Identification and characterization of the gene encoding the human
            phosphopantetheine adenylyltransferase and dephospho-CoA kinase
            bifunctional enzyme (CoA synthase)
  JOURNAL   Biochem J 365 (Pt 1), 13-18 (2002)
   PUBMED   11994049
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Zhyvoloup,A., Nemazanyy,I., Babich,A., Panasyuk,G., Pobigailo,N.,
            Vudmaska,M., Naidenov,V., Kukharenko,O., Palchevskii,S.,
            Savinska,L., Ovcharenko,G., Verdier,F., Valovka,T., Fenton,T.,
            Rebholz,H., Wang,M.L., Shepherd,P., Matsuka,G., Filonenko,V. and
            Gout,I.T.
  TITLE     Molecular cloning of CoA Synthase. The missing link in CoA
            biosynthesis
  JOURNAL   J Biol Chem 277 (25), 22107-22110 (2002)
   PUBMED   11980892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB872569.1, AK004878.1,
            AK159405.1 and BC064753.1.
            
            Summary: This gene encodes the bifunctional protein coenzyme A
            (CoA) synthase which carries out the last two steps in the
            biosynthesis of CoA from pantothenic acid (vitamin B5). The
            phosphopantetheine adenylyltransferase domain of this protein
            catalyzes the conversion of phosphopantetheine into dephospho-CoA
            while its dephospho-CoA kinase domain completes the final step by
            phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr
            2015].
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BB872569.1         2-42
            42-751              AK004878.1         2-711
            752-2137            AK159405.1         701-2086
            2138-2153           BC064753.1         2026-2041
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.17 cM"
     gene            1..2153
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /note="Coenzyme A synthase"
                     /db_xref="GeneID:71743"
                     /db_xref="MGI:MGI:1918993"
     exon            1..126
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..834
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1829
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /EC_number="2.7.7.3"
                     /EC_number="2.7.1.24"
                     /note="bifunctional coenzyme A synthase;
                     4'-phosphopantetheine adenylyltransferase and
                     dephospho-CoA kinase; CoA synthase"
                     /codon_start=1
                     /product="bifunctional coenzyme A synthase precursor"
                     /protein_id="NP_001292911.1"
                     /db_xref="CCDS:CCDS25446.1"
                     /db_xref="GeneID:71743"
                     /db_xref="MGI:MGI:1918993"
                     /translation="MAVFRSGLLVLTTPLATLAARLPPILTSASRLVNHTLYVHLQPG
                     MNLGGPAQPQASPVQATFEVLDFITHLYTGADLHRHLDVRILLTNIQTKSTFLPVLSS
                     VQNLAHPPEVVLTDFQTLDGSQYNPVKQQLERYATSCYSCSPQLASVLLYPDYGTGEL
                     PLEPPNALLPSTIRPASPVARSPRQPVRGYHRGAVGGTFDRLHNAHKVLLSVACVLAQ
                     EQLVVGVADKDLLKSKLLPELLQPYAERVEHLTEFLVDIKPSLTFELVPLLDPYGPAG
                     SDPTLEFLVVSEETYRGGMAVNRFRLENGKEELALYQIQLLKDQSHNENEEDKVSSSS
                     FRQRILGNLLQPPNERPELPSGLYVLGLTGISGSGKSSVAQRLKNLGAYIIDSDHLGH
                     RAYAPGGPAYQPVVEAFGTDILHKDGTINRKVLGSRVFGNKKQMKILTDIVWPVIAKL
                     AREEMDVAVAKGKTLCVIDAAMLLEAGWQSMVHEVWTVVIPETEAVRRIVERDGLSEA
                     AAQSRLQSQMSGQQLVEQSNVVLSTLWESHVTQSQVEKAWNLLQKRLPKAYQTRN"
     exon            835..1049
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1181
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1371
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1436
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1521
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1619
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1766
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..2138
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /note="hexamer: ATTAAA"
     polyA_site      2138
                     /gene="Coasy"
                     /gene_synonym="1300003G02Rik; Dpck; Ppat; Ukr1"
                     /note="major polyA site"
ORIGIN      
        1 gcctcgcccc gccccaggag tctctcggcg atgctttgtt tgattgctct gagttcccgt
       61 agctccacgc tttgaggctg gtgggtagtg cttccgggct gcagcctagg acgcctccac
      121 ggcggtgcct ggagagcatg gccgtgttcc gctcaggcct cctggtgctg acaacgccgc
      181 tggccaccct ggccgcacgc ctgcctccca tcctgacctc ggcgtcccgc ctggtgaatc
      241 acaccctcta tgtgcacctg cagccgggca tgaacctggg gggacccgct cagcctcagg
      301 ccagccctgt gcaggccaca tttgaggttc tggatttcat cacgcacctc tacactggtg
      361 ccgacctgca caggcacctg gacgtcagaa ttctactgac caatatccaa accaagagca
      421 cctttctccc tgtgctgtcc tcagtccaga atctggccca ccctccagaa gtggttctga
      481 cggacttcca gaccctggac gggagccagt acaaccctgt taaacaacag ctagagcgtt
      541 atgccaccag ttgttacagc tgttctccac agctggcttc tgtgttgctg tatccggatt
      601 atggaactgg agagctgcct ttggagcccc cgaatgccct cttaccctct actataaggc
      661 cggcttcccc ggttgccaga tctccaaggc agcctgtgcg tggctaccac cgtggggccg
      721 tgggtggcac ttttgaccgc ttgcacaatg cccacaaagt gttgctcagt gttgcatgtg
      781 tactggccca ggagcagctt gtggtgggag tagctgacaa agatctgttg aagagcaagt
      841 tgctccccga gctgctccag ccgtatgcag agcgcgtgga gcatctgact gagttcctgg
      901 tggacatcaa gccctccctg acctttgaac tcgtccccct gctggatccc tatgggcctg
      961 ctgggtccga ccccaccttg gagttcctgg tggtcagcga ggagacctac cgtgggggga
     1021 tggctgtcaa ccgcttccgc cttgagaatg gcaaagaaga acttgctttg taccagatac
     1081 aactgctgaa ggaccagagt cacaatgaaa atgaggagga caaggtcagc tcctccagct
     1141 ttcgccagcg aatcctggga aacctgcttc agcctccaaa tgagaggccg gagctcccgt
     1201 caggtctcta tgtgctcggg ctcacaggca tcagtggctc tgggaaaagc tcggtagctc
     1261 agcggctgaa gaacttggga gcatacatca tcgacagcga ccatctgggc catcgggcct
     1321 atgctcctgg gggtcctgcc taccagcctg tggtggaggc ctttggaaca gatattctcc
     1381 ataaagatgg caccatcaat aggaaggtcc tgggcagccg ggtgtttggg aacaagaagc
     1441 agatgaagat cctcacagat attgtgtggc cagttatcgc aaagctggcc cgggaggaga
     1501 tggatgtggc tgtggctaag ggaaaaactc tgtgtgtaat cgatgctgct atgctgcttg
     1561 aagctggctg gcagagtatg gtacacgagg tgtggaccgt cgtcatccct gagactgagg
     1621 ctgttcgacg cattgttgag agggatggac taagtgaggc agccgctcag agccggctgc
     1681 agagccagat gagcggccag cagctggtag agcagagcaa cgtggttctg agcaccttgt
     1741 gggagtcaca tgtcacacag agccaggtgg aaaaggcgtg gaatcttcta cagaagcgcc
     1801 tccctaaggc ttaccagacc aggaactgac agtggatttt ctatggcgcc aaactggccc
     1861 ttgaaactaa caaatctaat ggtgaggaga aatgggggcc ttgatgttta ccctctatct
     1921 ggcctcaggg gctttaagct aagctgtgca ggacacagag aagcttggaa gtccgcctag
     1981 catgctggaa tttgtccagc aatgaggaca cagctaatgg ggagcgatcc gctctgaggt
     2041 tctgtccgct ttttggtggt ggatgtgatg tctacctagt gttgatgggt ttggtgaagt
     2101 ctggacccag taactgaatt aaagatgttt ccaagtgcaa aaaaaaaaaa aaa
//
