LOCUS       NM_026511               1061 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome c oxidase assembly factor 8 (Coa8),
            transcript variant 2, mRNA.
ACCESSION   NM_026511 XM_915439 XM_923726 XM_923732
VERSION     NM_026511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Signes,A., Cerutti,R., Dickson,A.S., Beninca,C., Hinchy,E.C.,
            Ghezzi,D., Carrozzo,R., Bertini,E., Murphy,M.P., Nathan,J.A.,
            Viscomi,C., Fernandez-Vizarra,E. and Zeviani,M.
  TITLE     APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS
            and ROS
  JOURNAL   EMBO Mol Med 11 (1) (2019)
   PUBMED   30552096
  REMARK    GeneRIF: The authors generated an Apopt1 knockout mouse model which
            shows impaired motor skills, e.g., decreased motor coordination and
            endurance, associated with reduced COX activity and levels in
            multiple tissues.
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Sun,X., Yasuda,O., Takemura,Y., Kawamoto,H., Higuchi,M., Baba,Y.,
            Katsuya,T., Fukuo,K., Ogihara,T. and Rakugi,H.
  TITLE     Akt activation prevents Apop-1-induced death of cells
  JOURNAL   Biochem Biophys Res Commun 377 (4), 1097-1101 (2008)
   PUBMED   18977203
  REMARK    GeneRIF: These data indicate that the inhibition of Apop-1-induced
            death by IGF-1 is mediated by the activation of the PI3K/Akt
            signaling pathway.
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Yasuda,O., Fukuo,K., Sun,X., Nishitani,M., Yotsui,T., Higuchi,M.,
            Suzuki,T., Rakugi,H., Smithies,O., Maeda,N. and Ogihara,T.
  TITLE     Apop-1, a novel protein inducing cyclophilin D-dependent but
            Bax/Bak-related channel-independent apoptosis
  JOURNAL   J Biol Chem 281 (33), 23899-23907 (2006)
   PUBMED   16782708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002873.1, AK012648.1 and BY392793.1.
            
            On Jul 21, 2009 this sequence version replaced NM_026511.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (2)
            has a distinct C-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071262.1, AK029408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK002873.1         2-3
            3-1028              AK012648.1         1-1026
            1029-1043           BY392793.1         353-367
            1044-1061           BY392793.1         372-389
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.11 cM"
     gene            1..1061
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="cytochrome c oxidase assembly factor 8"
                     /db_xref="GeneID:68020"
                     /db_xref="MGI:MGI:1915270"
     exon            1..150
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..603
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UPF0671 protein C14orf153 homolog; apoptogenic protein 1,
                     mitochondrial; apoptogenic, mitochondrial 1"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly factor 8 isoform
                     2"
                     /protein_id="NP_080787.1"
                     /db_xref="CCDS:CCDS26186.1"
                     /db_xref="GeneID:68020"
                     /db_xref="MGI:MGI:1915270"
                     /translation="MAALRPGSRALRRLLCRSFSGGGGVRLARERPTDHRDAASSRVS
                     RFCPPRQSCHDWIGPPDKCSNLRPVHFHIPENESPLEQRLRELRQETQEWNQQFWAKQ
                     NLSFNKEKEEFIYSRLQAKGAGLRTESGQRATLDAEEMADFYKDFLSKNFQKHMRYNR
                     DWYKRNFAITFFMGKVVLERMWSKLRQKKTSS"
     exon            151..348
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..412
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..503
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..1061
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="hexamer: AATAAA"
     polyA_site      840
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="major polyA site"
     regulatory      998..1003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="hexamer: ATTAAA"
     regulatory      1002..1007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="hexamer: AATAAA"
     polyA_site      1015
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
     polyA_site      1019
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
     regulatory      1030..1035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="hexamer: AATAAA"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
                     /note="hexamer: AATAAA"
     polyA_site      1048
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
     polyA_site      1061
                     /gene="Coa8"
                     /gene_synonym="1700081D05Rik; 2810002N01Rik; Apop-1;
                     Apop1; Apopt1"
ORIGIN      
        1 gcgatcctgc cgtacgcgcg ggccatggcg gctttgcggc ccggaagcag agcgcttcgc
       61 cggcttctct gccggtcctt ctccggcggc ggcggcgtta ggttggcccg tgagcgccct
      121 acggatcaca gggatgcggc gtccagccgg gtctcaagat tctgccctcc aagacagtct
      181 tgccatgatt ggataggccc cccagacaaa tgctcaaacc ttcgtcccgt tcattttcac
      241 atccctgaaa acgagtctcc cttggagcaa agacttagag aattgagaca agaaacgcaa
      301 gaatggaatc aacagttctg ggccaagcag aacttgtcct tcaataagga aaaagaagaa
      361 ttcatttact caagactaca agctaagggc gcaggcttgc ggactgagtc aggccaaaga
      421 gcaacgctgg atgcagagga gatggccgac ttctataagg actttctgag taagaatttc
      481 cagaagcaca tgcgctataa ccgagactgg tacaagcgta attttgccat cactttcttc
      541 atggggaagg tggtcctgga gaggatgtgg agcaagctaa ggcaaaagaa gacaagcagt
      601 taggaggagc ccaccagaac ttgacccaca gcaccggaac ctgacccaca gctccaggtt
      661 ctgtttatga ggccctggac actaagcgag cacagtccct tgggccgtgc ttgcctggct
      721 caggctcctc agtacgctgt atgctgaggc tgtattttgt attgtctgta ctttgaatta
      781 taccagctca gaatattgca gtgtaaaaat gtgaataaag tttcactgca agaatttaaa
      841 ccagggctgg tgagatggct cagcggttaa gagcgctgac tgctcttcca aaggtcctga
      901 gttcaaatcc cagcaaccac atggtggctc acaaccaccc gaaacgaaat ctgatgccca
      961 cttctggagt atctgaagac agctacagtg tacttacatt aaataaataa ataaataaat
     1021 aaataaataa ataaataaat aaacaaaaga atttaaacca g
//
