LOCUS       NM_172560               3950 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus centrobin, centrosomal BRCA2 interacting protein
            (Cntrob), mRNA.
ACCESSION   NM_172560
VERSION     NM_172560.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3950)
  AUTHORS   Shin,W., Yu,N.K., Kaang,B.K. and Rhee,K.
  TITLE     The microtubule nucleation activity of centrobin in both the
            centrosome and cytoplasm
  JOURNAL   Cell Cycle 14 (12), 1925-1931 (2015)
   PUBMED   26083938
  REMARK    GeneRIF: cytoplasmic centrobin has roles in noncentrosomal
            microtubule formation in specific cell types and during the cell
            cycle
REFERENCE   3  (bases 1 to 3950)
  AUTHORS   Sonn,S., Oh,G.T. and Rhee,K.
  TITLE     Nek2 and its substrate, centrobin/Nip2, are required for proper
            meiotic spindle formation of the mouse oocytes
  JOURNAL   Zygote 19 (1), 15-20 (2011)
   PUBMED   20569513
  REMARK    GeneRIF: Centrobin may be a possible substrate of Nek2 responsible
            for the meiotic spindle assembly in the mouse oocytes.
REFERENCE   4  (bases 1 to 3950)
  AUTHORS   Lee,J., Kim,S., Jeong,Y. and Rhee,K.
  TITLE     Centrobin/Nip2 expression in vivo suggests its involvement in cell
            proliferation
  JOURNAL   Mol Cells 28 (1), 31-36 (2009)
   PUBMED   19533028
  REMARK    GeneRIF: Data show that a residual amount of centrobin was detected
            at the centrosomes of the resting cells, suggesting its role for
            maintaining integrity of the centrosome, especially of the daughter
            centriole in the cells.
REFERENCE   5  (bases 1 to 3950)
  AUTHORS   Sonn,S., Jeong,Y. and Rhee,K.
  TITLE     Nip2/centrobin may be a substrate of Nek2 that is required for
            proper spindle assembly during mitosis in early mouse embryos
  JOURNAL   Mol Reprod Dev 76 (6), 587-592 (2009)
   PUBMED   19117032
  REMARK    GeneRIF: The phenotypic similarities of the Nip2/centrobin- and
            Nek2-suppressed embryos suggest that Nip2/centrobin may be a
            substrate of Nek2 that is required for mitotic spindle assembly in
            early mouse embryos.
REFERENCE   6  (bases 1 to 3950)
  AUTHORS   Jeong,Y., Lee,J., Kim,K., Yoo,J.C. and Rhee,K.
  TITLE     Characterization of NIP2/centrobin, a novel substrate of Nek2, and
            its potential role in microtubule stabilization
  JOURNAL   J Cell Sci 120 (Pt 12), 2106-2116 (2007)
   PUBMED   17535851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645527.20, AK147774.1 and AK036710.1.
            
            On Apr 27, 2007 this sequence version replaced NM_172560.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147774.1, BC058512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL645527.20        240323-240436       c
            115-280             AK147774.1         1-166
            281-348             AK036710.1         184-251
            349-534             AK147774.1         235-420
            535-544             AK036710.1         439-448
            545-909             AK147774.1         431-795
            910-1184            AK036710.1         815-1089
            1185-1716           AK147774.1         1071-1602
            1717-3950           AK036710.1         1537-3770
FEATURES             Location/Qualifiers
     source          1..3950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.51 cM"
     gene            1..3950
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /note="centrobin, centrosomal BRCA2 interacting protein"
                     /db_xref="GeneID:216846"
                     /db_xref="MGI:MGI:2443290"
     exon            1..1184
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             912..3575
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /note="LYST-interacting protein 8; centrosomal
                     BRCA2-interacting protein"
                     /codon_start=1
                     /product="centrobin"
                     /protein_id="NP_766148.2"
                     /db_xref="CCDS:CCDS24888.2"
                     /db_xref="GeneID:216846"
                     /db_xref="MGI:MGI:2443290"
                     /translation="MATAAPSPSSPLRPEDLLSDSSEPPGLNQVSSEVTSQLYTSLHL
                     SRQAEATARAQLYLAPTSSPPNEGLDSLAQELSRSLSVGLENNLKKKDGSKHIFEMES
                     VRGQLQTMLHTSRDTAYRTGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAPALEEL
                     FPRYTSLRPGPPTNPPDFQGLRDALDAELTRRKHCERHIQSLQTRVLELQQQLAVAVA
                     ADHKKDLMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEERQAAELTRSKQQETVTRL
                     EQSLSEAMEALSREQEGARLQQREKEALEEERQALTLRLEVEQQQCRTLQEERDEARA
                     GQLSEHRKLEALQVALQEERQAWIKQEHQLKERLQALQEEGQAQLEREKGNSQREAQA
                     AWETQQQFALLQTEVRRLEGDLDTVRRERDALQLEMSLVQARYESQRIQMESELAVQL
                     EQRVTERLAEAQENSLRQAASLRDHHRKQLQELSGQHQQELAAQLAQFKVEMADREER
                     QQQVAQDYELRLAREQARVRDLKSGNQQLEEQRAELVERLQAMLQAHWEEANQLLSTT
                     LLPPNPQAPLAEPSSPGPLEPEKGERRTWAMPPMAVALKPVLQQSREVKGDVPGAPSV
                     LCSTSPDLSLLLGPPFQNQNSFQPLEPKPDVTPPTAGPFSALEAFTDDHRAERPFPEE
                     DPGSDGDARLPPASQLEGLKNFLQQLLETAPQSNGNPSADLLLPKAGSRAVSSWEEAP
                     QVPRLPPPVHKTKVPLAMASSLFRVHGLPSTNLQGSGLSTGSPEKDGLNLVDVSELLR
                     LYQARGWGALPAEDLLLYLKRLEHSGTDGQGELVPRRNTDSRLGETTRKEIPSQAVPR
                     RLASVPKTEKPARKKSGHPGPSMRSRGGIWR"
     exon            1185..1269
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1333
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1490
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1607
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1724
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1823
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2060
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2207
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2341
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2467
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2630
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2889
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3032
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3096
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3267
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3382
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3455
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3950
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3906..3911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /note="hexamer: AATAAA"
     polyA_site      3931
                     /gene="Cntrob"
                     /gene_synonym="9830165K03Rik; Lip8; Nip2"
                     /note="major polyA site"
ORIGIN      
        1 gatgtgcggg gagcttggtc tcgcgggcgg gtgacgtaat tcggttggag gcgggattgc
       61 aagcggtggg cgggaggctg ccaacggttt tgcaagctag tgtcgcgcta gggaggttgg
      121 cctttggtct ttctctgtgg aggttatggg gcttggggga cagtcctcct catcttggga
      181 aaccagggcc gacatgctca gagtagtcgg agccaggtgg ttgcggtaga gaataccagg
      241 cggctggttg ccgggtgtat gtctgtgcgc gcgcgcgccc cttttattga gatttcttag
      301 ggtgggatag ggaggaattc tatggacctc tgctgtggct ttttttttat caggaaggat
      361 tagaggggaa atccgaggaa gtcgactctg ggtgggacag gtgaagaaag ggcgaaacgg
      421 gggtgttgtg gcattgaagt cttgcctctt tcttcactaa aaccaattgg gggacataca
      481 ttgggccagc tttggtttga ggtctgtttc agtttgcaca ttttgagtgt ggggaaaaaa
      541 aaaagctaac catggttaac ccgtgccgaa actgatttgc aatttccagg accctagtta
      601 ggaggaagga actgcagcgg ttctgtctcc ctgcatgcag gtcttctgac cattcccctg
      661 actttctgcc ttgcacatcc gcttttaacc gttcccagga gttgggagaa agaatgtgtt
      721 tgccctctcc atggtctctg gagtcagtgg acactcctct aaccagaaag ctcatttgtt
      781 gaggacccaa agtgtcttcc tcccttccaa atctttcttc tttgtgaact tatccacaag
      841 tttggacccc tctcagaact gaggcaggag ttcccagtcc cctgctgagt ccagttgtct
      901 cttcactgta catggcgaca gcagccccca gtcccagttc tcctctccga cctgaggacc
      961 tcctgagcga ttcgtcagag cctcctgggt tgaaccaggt gtcctccgag gtgacctccc
     1021 aactgtatac ttctttgcat ctcagccgcc aagctgaggc cacggcccgg gcccagctgt
     1081 atctagctcc cacctcctca cctcctaacg agggcttaga cagcttggct caagaactga
     1141 gtcgcagctt gtccgttgga ttggaaaaca acttgaagaa aaaggatggg tctaagcaca
     1201 tctttgagat ggaaagtgtt cggggtcagc tccagaccat gctccatacc tcccgtgata
     1261 ctgcctatcg aactggttca gagagacggg aagaggactc ctttgacagt gatagcacag
     1321 ctaccttgct caacacccgg cctctgcaag acctgtctcc atccagctct gccccggcac
     1381 tggaagagtt gtttccccgc tacactagcc ttcggcccgg cccccccacc aaccccccag
     1441 attttcaggg gctgagggat gcactggatg cagagcttac acgcagaaag cattgcgagc
     1501 gccacatcca gagcctacag actcgcgtgc ttgagttgca acaacagcta gctgtggctg
     1561 tggctgccga ccacaagaaa gatctcatga ttgaacaact agacaagact ctggctcgag
     1621 tggtggaagg ctggaatcgc catgaggctg agcggacaga ggtgctgcgg ggacttcaag
     1681 aggagcgcca ggcagcagaa ctcaccagaa gcaagcagca ggagacagtg acccgcctgg
     1741 aacaaagcct ttctgaggcc atggaagccc tgagtcggga gcaggagggt gccagactac
     1801 agcagaggga gaaagaggcc ctggaagaag aaaggcaagc cctgactctg aggttggagg
     1861 tggagcagca gcagtgccgg accctccagg aagagcggga tgaggctagg gctgggcagc
     1921 tcagtgagca ccggaagctg gaggcccttc aagtggctct acaagaggaa aggcaggcct
     1981 ggatcaagca ggaacaccag ctgaaggaac gccttcaggc actgcaggag gaaggccagg
     2041 ctcagctgga aagagagaag gggaacagcc agagggaggc ccaggcagcc tgggagaccc
     2101 agcagcagtt tgcactgctc cagactgagg tgcggcggct ggaaggggat ctggacacag
     2161 tccggagaga gagagatgca ctgcagctgg agatgagctt ggtccaggcc agatatgaga
     2221 gccagcggat ccagatggag tcagagctgg ctgtacagct ggagcagcgg gtgactgagc
     2281 ggctggcaga ggctcaggag aacagcctgc ggcaggccgc ctccctcagg gaccatcaca
     2341 ggaagcagct acaggaactg agtggacagc accaacagga actggctgcc cagctggctc
     2401 agttcaaggt agaaatggct gaccgggagg aacgccagca gcaggtggct caggactatg
     2461 agctcagact ggcaagggag caagctcgag tgcgtgacct gaagagcggc aaccaacaac
     2521 tggaggagca gcgggcggag ctggtggagc ggctccaagc catgctgcag gcccactggg
     2581 aggaggccaa ccaactgctc agtaccacgc ttctgcctcc caatccgcag gctcctcttg
     2641 ctgagccctc cagccccggg cctctggagc cagagaaggg ggagaggagg acctgggcca
     2701 tgcctcccat ggctgtggct ctgaaacctg tgttgcagca gagccgagaa gtgaagggtg
     2761 atgtgcctgg agctccgtct gtcctctgca gcacctcccc agatctgagc ctcctgctgg
     2821 gacccccttt ccagaaccag aactcctttc agcccttgga acccaagcct gatgtgactc
     2881 cacccacagc tgggcccttc tctgcattgg aggctttcac tgatgatcac agggccgaac
     2941 gcccgtttcc tgaggaagac ccgggatctg atggcgatgc aaggctgcca cctgcttctc
     3001 agcttgaagg cctcaagaac tttttgcaac agctactgga gacagcgcct cagagcaatg
     3061 gaaacccctc agccgacctg ttgctcccta aggctggctc tcgggctgtc tcgtcttggg
     3121 aggaggcccc tcaagtgccc cgacttccac ctcctgtcca caaaaccaaa gttcccttag
     3181 ccatggcgtc aagtctcttc agggtccatg ggcttccctc aaccaatttg caaggcagtg
     3241 gtctcagcac tggctcccca gagaaagatg ggctcaacct ggtggacgtg tctgagctgt
     3301 tacgcctcta ccaggctcgg ggttggggtg ccctgcctgc tgaggacctg ctcctgtacc
     3361 tgaagaggct ggaacacagt ggaactgatg gccaagggga gcttgtcccc agaagaaaca
     3421 cagactcccg tttgggtgag accactcgga aagagatccc ctcccaggct gtccctcgac
     3481 gccttgcttc agtccctaag actgaaaagc ctgcacggaa gaaaagtggg catcccggcc
     3541 ctagcatgag gagtcggggc ggcatctgga gatgaggccc gcccttctcc tcttctgcca
     3601 ttcattttaa ttagtgccct gcattctgtc tgtctcagag gaatctggaa aatggagatt
     3661 tttgtaggaa gctactttgt gaagaaacct tccagaattg ttttattatt ttagaatata
     3721 tttgttttct atgagaaagc ctatggagcc tttgaggctg gtgtgtgact agatgtctga
     3781 gtggccctag gctcagggat gcttgcagtg gttagatgcc ccatagtaga attatgagtg
     3841 aatcttttct ttttgtataa tttatatttt gtatattttc tgaaataagt atgtattact
     3901 ttagtaataa aaaaaactcc caaactttta ataaaagagt aaattattgt
//
