LOCUS       NM_130457               4863 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus contactin associated protein-like 4 (Cntnap4), mRNA.
ACCESSION   NM_130457
VERSION     NM_130457.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4863)
  AUTHORS   Hu,W., Wang,M., Sun,G., Zhang,L. and Lu,H.
  TITLE     Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through
            directly regulating contactin-associated protein-like 4 (CNTNAP4)
            transcription: An experimental study
  JOURNAL   Cell Signal 118, 111139 (2024)
   PUBMED   38479556
  REMARK    GeneRIF: Early B Cell Factor 3 (EBF3) attenuates Parkinson's
            disease through directly regulating contactin-associated
            protein-like 4 (CNTNAP4) transcription: An experimental study.
REFERENCE   2  (bases 1 to 4863)
  AUTHORS   Zhang,W., Ding,L., Chen,H., Zhang,M., Ma,R., Zheng,S., Gong,J.,
            Zhang,Z., Xu,H., Xu,P. and Zhang,Y.
  TITLE     Cntnap4 partial deficiency exacerbates alpha-synuclein pathology
            through astrocyte-microglia C3-C3aR pathway
  JOURNAL   Cell Death Dis 14 (4), 285 (2023)
   PUBMED   37087484
  REMARK    GeneRIF: Cntnap4 partial deficiency exacerbates alpha-synuclein
            pathology through astrocyte-microglia C3-C3aR pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4863)
  AUTHORS   Zhang,W., Huang,J., Gao,F., You,Q., Ding,L., Gong,J., Zhang,M.,
            Ma,R., Zheng,S., Sun,X. and Zhang,Y.
  TITLE     Lactobacillus reuteri normalizes altered fear memory in male
            Cntnap4 knockout mice
  JOURNAL   EBioMedicine 86, 104323 (2022)
   PUBMED   36395738
  REMARK    GeneRIF: Lactobacillus reuteri normalizes altered fear memory in
            male Cntnap4 knockout mice.
REFERENCE   4  (bases 1 to 4863)
  AUTHORS   Zhang,W., Zhou,M., Lu,W., Gong,J., Gao,F., Li,Y., Xu,X., Lin,Y.,
            Zhang,X., Ding,L., Zhang,Z., Li,G., Chen,X., Sun,X., Zhu,X., Xu,P.
            and Zhang,Y.
  TITLE     CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian
            phenotypes
  JOURNAL   Theranostics 10 (7), 3000-3021 (2020)
   PUBMED   32194851
  REMARK    GeneRIF: CNTNAP4 deficiency in dopaminergic neurons initiates
            parkinsonian phenotypes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4863)
  AUTHORS   Li,C., Zheng,Z., Ha,P., Chen,X., Jiang,W., Sun,S., Chen,F.,
            Asatrian,G., Berthiaume,E.A., Kim,J.K., Chen,E.C., Pang,S.,
            Zhang,X., Ting,K. and Soo,C.
  TITLE     Neurexin Superfamily Cell Membrane Receptor Contactin-Associated
            Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1
            (Nell-1)-Responsive Osteogenesis
  JOURNAL   J Bone Miner Res 33 (10), 1813-1825 (2018)
   PUBMED   29905970
  REMARK    GeneRIF: a novel biological functional axis for Nell-1 and Cntnap4
            in osteogenesis and, potentially, in neural development and
            function, is reported.
REFERENCE   6  (bases 1 to 4863)
  AUTHORS   Ashrafi,S., Betley,J.N., Comer,J.D., Brenner-Morton,S., Bar,V.,
            Shimoda,Y., Watanabe,K., Peles,E., Jessell,T.M. and
            Kaltschmidt,J.A.
  TITLE     Neuronal Ig/Caspr recognition promotes the formation of axoaxonic
            synapses in mouse spinal cord
  JOURNAL   Neuron 81 (1), 120-129 (2014)
   PUBMED   24411736
REFERENCE   7  (bases 1 to 4863)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 4863)
  AUTHORS   Tripathi,P., Wang,Y., Casey,A.M. and Chen,F.
  TITLE     Absence of canonical Smad signaling in ureteral and bladder
            mesenchyme causes ureteropelvic junction obstruction
  JOURNAL   J Am Soc Nephrol 23 (4), 618-628 (2012)
   PUBMED   22282597
REFERENCE   9  (bases 1 to 4863)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4863)
  AUTHORS   Spiegel,I., Salomon,D., Erne,B., Schaeren-Wiemers,N. and Peles,E.
  TITLE     Caspr3 and caspr4, two novel members of the caspr family are
            expressed in the nervous system and interact with PDZ domains
  JOURNAL   Mol Cell Neurosci 20 (2), 283-297 (2002)
   PUBMED   12093160
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC034628.1.
            
            On Jun 19, 2003 this sequence version replaced NM_130457.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034628.1, AK142816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 58.7 cM"
     gene            1..4863
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /note="contactin associated protein-like 4"
                     /db_xref="GeneID:170571"
                     /db_xref="MGI:MGI:2183572"
     exon            1..183
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            184..294
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..488
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..636
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            637..840
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1025
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1169
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1431
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1581
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1753
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1860
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1980
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2178
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2335
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2463
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2634
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2853
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3093
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3318
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3452
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3540
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3759
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3831
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4850
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4551..4556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /note="hexamer: AATACA"
     polyA_site      4572
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /note="major polyA site"
     regulatory      4690..4695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /note="hexamer: TATAAA"
     polyA_site      4710
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
     regulatory      4828..4833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4850
                     /gene="Cntnap4"
                     /gene_synonym="Caspr4; E130114F09Rik"
ORIGIN      
        1 gaagacccag tcagtgctgg gtgaaggact gaggagaacc tgtctccagc gctctgagag
       61 ccactcgaga tattttgggg agctcaaaaa ttatgaatat gggatctgtc gctggagctg
      121 ttctcaagat gttacttctg ttgtctactc aaaattggaa cagagtggaa gctgggaatt
      181 catatgactg tgatgagccc ctggtgtctg ccttgcctca ggcatccttc agcagttctt
      241 ctgagctatc cagcagtcac ggtcctggat tcgcaaggct gaatcgaaga gacggagctg
      301 gtggctggtc cccacttgtg tccaacaaat accagtggct gcagattgac cttggagaga
      361 ggatggaagt cacgtccgtg gccacccaag gtggatatgg gagctccaac tgggtgacca
      421 gctatctcct gatgttcagt gatagtggaa ggaactggaa gcagtataga caagaagaca
      481 gcatctgggg attttctggg aacgcgaacg cagacagcgt tgtgtactat agactccagc
      541 cttcaatcaa agccaggttc ctacgcttca ttcctctaga atggaacccc aagggcagaa
      601 tcgggatgcg cattgaggtg ttcgggtgtg cataccggtc ggttgtaatt gatcttgatg
      661 gaaaaagttc cctcctctac agatttgatc aaaactcctt gagtccaata agagatatca
      721 tatctttgaa atttaaaacc atggagagcg atgggatcct actgcacagg gcagggcctg
      781 ctggagatca tatcacattg gagttaagaa gaggaaagct cttcttactt attaattcag
      841 gtgatgctag actgacctcc agttcgaccc tgatcaacct cacactgggc agcctgctgg
      901 atgatcagca ctggcattct gtgctcatcc agagactggg gaaacaggtc aactttacag
      961 tggacgagca caggcgtcac ttccatgccc aaggagaatt caattacctg gatcttgatt
     1021 atgagatcag ctttggaggg atctcagcac ctgcaaaatc agtgtccttg ccatacaaac
     1081 atttccatgg atgtttagag aacctctttt ataatggcgt agatgtcatt ggcttggtca
     1141 aggaacacag ccctcagatc atcaccatgg gaaatgcctc cttttcttgt tcacaaccac
     1201 agtctatgcc tctgactttt ctgagcccca ggagttattt ggtcctccca gcgtctacta
     1261 aagaggaagc catttcagcc agctttcaat tccgaacctg gaataaggcg ggacttctgc
     1321 tcttcagtga actccagctg gtgtcaggca gtctcctcct cttgctcagc gatggaaaac
     1381 ttaaactgac tctttaccag ccaggaaagt cacccagtga catcacagca ggtgcaggct
     1441 taggtgacgg ccagtggcat tctgtctcct tgtctgctaa aaggaatcac ctgagtgtgg
     1501 tggtggacgg ccacatcagc cctgcttctc cttggctggg gcccgagcag gttaattcag
     1561 gaggtgtctt ttattttgga ggttgtccag acaaaggctt tggatccaag tgtaagagcc
     1621 ctctaggtgg atttcaagga tgcatgaggc tcatctccat caacaacaaa atggtagatc
     1681 tgattgcagt ccagcagggg gcccttggca acttcagtga ccttcagata gactcatgtg
     1741 gcatctcaga caggtgtttg cccaactctt gtgagcatgg tggtgaatgt tctcagtctt
     1801 ggagcacctt tcattgtaac tgcacaaaca cggggtacac aggagccact tgtcacagct
     1861 ctgtctatga gcagtcatgt gaagcctata agcaccaagg aaatgcttct ggattctact
     1921 acatagactc agatgggagt ggtcctttgc agccattcct cttatactgc aatatgactg
     1981 aaacggcatg gaccgtcatg cagcacaacg gctccgactt gatgagagtc aggaacactc
     2041 actctgagaa tgcgcacact ggggtgtttg agtacacggc cagcatggaa cagctccagg
     2101 ccgccattaa ccgggcggag cactgccaac aggagctggt gtattactgc aagaagtcgc
     2161 gcctcgttaa tcagcaagat ggaagccctc ggagctggtg ggtgggaaga accaatgaga
     2221 cacagacata ttggggtggt tccttgcctg tgcatcaaaa gtgcacttgt ggcttggaag
     2281 ggaactgcat tgatgcccag tatcattgca actgtgatgc agatctgaac gaatggacca
     2341 atgacactgg attcctctcc tataaagaac atctgcctgt cactaagatt gtgattacgg
     2401 acacaggacg gccccattca gaagctgctt ataaactggg gcctctgctc tgccggggag
     2461 acaggccgtt ttggaacgca gcttccttta ataccgaggc ttcctacctc cactttccca
     2521 cattccatgg cgagctcagt gcagatgtgt ccttcttttt caagacgaca gccctctctg
     2581 gggtgttttt agaaaacctg ggaatcactg acttcatacg aatagaatta cgctcaccca
     2641 caacagtcac cttttcattt gacgtgggga atgggccttt tgaactctct gtgcattcac
     2701 ccactcactt caacgacaac cagtggcatc atgtgcgagt ggaaaggaac atgaaagagg
     2761 catcccttcg ggtggacgag ctccctccaa agatacaagc ggctcccacg gatggccatg
     2821 tcctgttaca gctcaatagt caactctttg ttggtgggac cgccaccagg cagagaggct
     2881 tcctagggtg catcaggtcc ctgcagttga atgggatggc cctggatctg gaagaaagag
     2941 ccacagtaac ccctggggtg cagccaggtt gcagaggaca ctgtgggagc tatggaaagt
     3001 tatgtcgcca tggagggaag tgcagggaaa agcccagcgg cttcttctgt gattgctctt
     3061 cctctgccta tgcaggacca ttctgctcca aagagatttc cgcatatttt ggatctgggt
     3121 cttctgtgat ttacaatttt caagaaaatt attctctaag caagaactcc agctttcacg
     3181 ctgcttcatt tcatggggat atgaagctga gcagagagat gatcaaattt agcttccgaa
     3241 ccacacgggc accaagcttg ctgcttcata tgagttcctt ttataaagaa tacctctcaa
     3301 ttatcattgc caaaaacgga agtttgcaga tacgatacaa gctaaataag tatcacgaac
     3361 ctgatgtcat cagctttgac ttgaagagca tggcagatgg gcagcttcac cacataaaga
     3421 tcaacagaga agagggaatg gtcttcgtgg agattgatga gaatacaagg agacaaacct
     3481 acttgtcgtc aggcacagaa ttcagtgcag tcaaatcttt ggtactgggc agaatgctag
     3541 agtacagtga tgtagaccag gagactgcat tggctgcagc ccatggcttc acaggctgcc
     3601 tctctgcagt gcagttcagc catattgcac ctctgaaggc tgctctgcaa cccggtcccc
     3661 cagcccctgt caccgtgaca gggcacgtga ctgagtcgag ctgtgtggcc ccttctggca
     3721 ccgatgccac atccagagaa aggacgcatt catttgcaga tcactctgga acgatggacg
     3781 acagagagcc tctcactcat gcaatcaaaa gcgactctgc agtgattgga ggtctgatag
     3841 ctgttgtgat ctttatcttg ctttgtgtct ctgccatagc tgttcgcatt tatcagcaga
     3901 aaaggttata caaaagaaat gaggcaaaaa ggtcagagaa tgtggacagc gctgaggcgg
     3961 ttttgaaaag cgagcttcat attcagaatg cagtcggtga aaatcagaaa gagtatttct
     4021 tctgattggc aatgatcctc ttaacttgca aggatgagtt ccttttacta gccaggggct
     4081 ctcagaggac gagaactgct ctaaccctga ccgtacaggc gatggatctg cagcacggcc
     4141 atcttgccat gtccaagctc aggatggttc caggcagcct cctctaggga tgggctcctt
     4201 ccagccatca ttctattaag aaaggagctc gctattggtg tccctttcca acttctgcac
     4261 atgatcaaag ccaagcttaa cttgcttcac aactatggtt tttaaatgtg gaaactttag
     4321 cccttctctt caccctgtaa aacataagtt ttgttagagg taagaactca aaattggact
     4381 ataaatggcc ttgctttact tcagaccaaa tgtcctgttt gctttcgtct tcacatggtg
     4441 ttgttcatga gcctggaaat gcttctgaga tcctgtttgg ctggtgttcg catcttcaat
     4501 ggccaaaagt ctatacataa agcccctttg cctttctctg tattacattc aatacatcaa
     4561 tagtctgaaa aattgttttc ttgtctttgg cttgtttgta ttgctctttt tctattttac
     4621 tccttttctg atacttttta atgcattttg ttttgagtgt ctgactttta aatctgaaca
     4681 caattcctat ataaaaagac taagaaagta tggtggttgt tggtatgtga tatcacgtct
     4741 ctacagagag tttcttgtca ttatttcatg atgactggtt aagaccctga gcaattgtaa
     4801 ttttccaaag gctgtacaat gttttccatt aaacttgtca caagtcctaa aaaaaaaaaa
     4861 aaa
//
