LOCUS       NP_001074598            1287 aa            linear   ROD 31-DEC-2024
DEFINITION  contactin-associated protein-like 3 precursor [Mus musculus].
ACCESSION   NP_001074598 XP_138666
VERSION     NP_001074598.1
DBSOURCE    REFSEQ: accession NM_001081129.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1287)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1287)
  AUTHORS   Chen,S., Liu,G., Li,A., Liu,Z., Long,B., Yang,X., Gong,H. and Li,X.
  TITLE     Three-dimensional mapping in multi-samples with large-scale imaging
            and multiplexed post staining
  JOURNAL   Commun Biol 6 (1), 148 (2023)
   PUBMED   36737476
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1287)
  AUTHORS   Cui,W., Gao,N., Dong,Z., Shen,C., Zhang,H., Luo,B., Chen,P.,
            Comoletti,D., Jing,H., Wang,H., Robinson,H., Xiong,W.C. and Mei,L.
  TITLE     In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon
            cluster development
  JOURNAL   Curr Biol 31 (15), 3330-3342 (2021)
   PUBMED   34143959
  REMARK    GeneRIF: In trans neuregulin3-Caspr3 interaction controls DA axonal
            bassoon cluster development.
REFERENCE   4  (residues 1 to 1287)
  AUTHORS   Zhang,Z., Wei,S., Du,H., Su,Z., Wen,Y., Shang,Z., Song,X., Xu,Z.,
            You,Y. and Yang,Z.
  TITLE     Zfhx3 is required for the differentiation of late born D1-type
            medium spiny neurons
  JOURNAL   Exp Neurol 322, 113055 (2019)
   PUBMED   31491374
REFERENCE   5  (residues 1 to 1287)
  AUTHORS   Tong,D.L., Chen,R.G., Lu,Y.L., Li,W.K., Zhang,Y.F., Lin,J.K.,
            He,L.J., Dang,T., Shan,S.F., Xu,X.H., Zhang,Y., Zhang,C., Du,Y.S.,
            Zhou,W.H., Wang,X. and Qiu,Z.
  TITLE     The critical role of ASD-related gene CNTNAP3 in regulating
            synaptic development and social behavior in mice
  JOURNAL   Neurobiol Dis 130, 104486 (2019)
   PUBMED   31150793
  REMARK    GeneRIF: These evidences elucidate the pivotal role of CNTNAP3 in
            synapse development and social behaviors, providing mechanistic
            insights into autism spectrum disorders
REFERENCE   6  (residues 1 to 1287)
  AUTHORS   Hirata,H., Takahashi,A., Shimoda,Y. and Koide,T.
  TITLE     Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early
            Phase of the Accelerated Rotarod Task
  JOURNAL   PLoS One 11 (1), e0147887 (2016)
   PUBMED   26807827
  REMARK    GeneRIF: Our findings suggest that reduced activation of neural
            cells in the dorsal striatum in Caspr3-KO mice leads to a decline
            in motor learning in the accelerated rotarod task.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1287)
  AUTHORS   Hirata,H., Umemori,J., Yoshioka,H., Koide,T., Watanabe,K. and
            Shimoda,Y.
  TITLE     Cell adhesion molecule contactin-associated protein 3 is expressed
            in the mouse basal ganglia during early postnatal stages
  JOURNAL   J Neurosci Res 94 (1), 74-89 (2016)
   PUBMED   26389685
  REMARK    GeneRIF: The findings of this study suggest that Caspr3 may play an
            important role in basal ganglia development during early postnatal
            stages.
REFERENCE   8  (residues 1 to 1287)
  AUTHORS   Araujo,D.J., Anderson,A.G., Berto,S., Runnels,W., Harper,M.,
            Ammanuel,S., Rieger,M.A., Huang,H.C., Rajkovich,K., Loerwald,K.W.,
            Dekker,J.D., Tucker,H.O., Dougherty,J.D., Gibson,J.R. and
            Konopka,G.
  TITLE     FoxP1 orchestration of ASD-relevant signaling pathways in the
            striatum
  JOURNAL   Genes Dev 29 (20), 2081-2096 (2015)
   PUBMED   26494785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159190.2, AC101142.9 and AC156576.3.
            
            On Feb 6, 2007 this sequence version replaced XP_138666.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.59671.1,
                                           SRR9219379.36908.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 33.46 cM"
     Protein         1..1287
                     /product="contactin-associated protein-like 3 precursor"
                     /note="cell recognition molecule Caspr3"
                     /calculated_mol_wt=137940
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2937
     Region          57..179
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Region          215..345
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          375..522
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          554..583
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          594..636
                     /region_name="GGGWT_bact"
                     /note="fibrinogen-like bacterial YCDxxxxGGGW domain;
                     NF040941"
                     /db_xref="CDD:468872"
     Region          796..940
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1048..1176
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     CDS             1..1287
                     /gene="Cntnap3"
                     /coded_by="NM_001081129.2:137..4000"
                     /db_xref="CCDS:CCDS36703.1"
                     /db_xref="GeneID:238680"
                     /db_xref="MGI:MGI:3588199"
ORIGIN      
        1 marvngafld alllllllsv qtlplvaagd phncdaplas slpqlsfsss sqlssshgpg
       61 farlnrrdga ggwtplvsnk yqwlqidlge rmevtavatq ggygssdwvt syllmfsdgg
      121 rnwkqyhqee sisgfpgntn adsvvqyslq psfhtrflrf lpltwnpkgr igmrievygc
      181 syksevvyfd gqssllykfd ngairpvrev islkfkamqn sgiifhgkgq hgthivleln
      241 kgklvvylns gdgnlppvns imnftlgsll ddrhwhsvli elhnmhmnft ldkymhhvhv
      301 nketsyldln feisfgeilm pggrfltfph knfhgcleni yyngvniikl akkhesqili
      361 kgnvsftcpq pqtipvtfls sgsylalpss lredkmslaf qlrtwnkagh vffsqvghgs
      421 gslvlflkng klilnlsepg qplqsittga vlndglwhsv svsakgsyls llvdgdtaqt
      481 lmsveihlgd tyyfggcpnn sssfgcehsf ggfqgclrli svgdkvvdpi avqqgvlgsf
      541 sdlqidscgi idrclpsyce hgsrctqswd tfscdcegtg ytgttchssi yeqsceahrh
      601 rgspsglyyi dvdgsgplap flvycnmtad tawtvvqhgg pdvvtvrggp eghmhsatfs
      661 yaanaaqlha vvnvaehceq qvdlqcrtsg psdtgdgtsl swwvgrsnet ytywggslpn
      721 pqkctcgfeg ncidsqyhcn cdadrnewts dtivlshkeh lpvtemvvtd tgrpyseaay
      781 tlgpllcqgd ksfwnsasfn teasylhfpt frgeltadvh flfkttissg vfmenlgitd
      841 firielrapt evtfsfdvgn gpceltiqsp tpfndnrwhh vraernvkga slqvdqlpqk
      901 tqstpadghv rlqlnsqlfi ggtasrqkgf lgcirslqvn gmaldleera vmtpgvepgc
      961 sghcssyghl crnggmcqek hrgiacdcaf saydgplcsy eisayfetgs svtynfqeys
     1021 tlsantsyla sslhgdvils retitlsfrt tqtpclllyv tsfyeeylsi ilanngslqv
     1081 rykldrhrna dafnfdlrnl adghfhqlti nreeavvsve vnqstkrqvi lssgtefnav
     1141 kslvlgkvle pldadpetqq aaaqgftgcl ssvrfglevp lkaalnqnra rvtiqgsvaa
     1201 aahcaegpgs aerklspgps mdaghsgsae drqplpntdr sdpgviggit avvifillcv
     1261 saiairvhqq rrlhqknest vskteec
//
