LOCUS       NM_001004357            7002 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus contactin associated protein-like 2 (Cntnap2),
            transcript variant 1, mRNA.
ACCESSION   NM_001004357
VERSION     NM_001004357.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7002)
  AUTHORS   Meng,J., Pan,P., Guo,G., Chen,A., Meng,X. and Liu,H.
  TITLE     Transient CSF1R inhibition ameliorates behavioral deficits in
            Cntnap2 knockout and valproic acid-exposed mouse models of autism
  JOURNAL   J Neuroinflammation 21 (1), 262 (2024)
   PUBMED   39425203
  REMARK    GeneRIF: Transient CSF1R inhibition ameliorates behavioral deficits
            in Cntnap2 knockout and valproic acid-exposed mouse models of
            autism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7002)
  AUTHORS   Wang,H.C. and Feldman,D.E.
  TITLE     Degraded tactile coding in the Cntnap2 mouse model of autism
  JOURNAL   Cell Rep 43 (8), 114612 (2024)
   PUBMED   39110592
  REMARK    GeneRIF: Degraded tactile coding in the Cntnap2 mouse model of
            autism.
REFERENCE   3  (bases 1 to 7002)
  AUTHORS   Al Abed,A.S., Allen,T.V., Ahmed,N.Y., Sellami,A., Sontani,Y.,
            Rawlinson,E.C., Marighetto,A., Desmedt,A. and Dehorter,N.
  TITLE     Parvalbumin interneuron activity in autism underlies susceptibility
            to PTSD-like memory formation
  JOURNAL   iScience 27 (5), 109747 (2024)
   PUBMED   38741709
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7002)
  AUTHORS   Zhang,Q., Xing,M., Bao,Z., Xu,L., Bai,Y., Chen,W., Pan,W., Cai,F.,
            Wang,Q., Guo,S., Zhang,J., Wang,Z., Wu,Y., Zhang,Y., Li,J.D. and
            Song,W.
  TITLE     Contactin-associated protein-like 2 (CNTNAP2) mutations impair the
            essential alpha-secretase cleavages, leading to autism-like
            phenotypes
  JOURNAL   Signal Transduct Target Ther 9 (1), 51 (2024)
   PUBMED   38424048
  REMARK    GeneRIF: Contactin-associated protein-like 2 (CNTNAP2) mutations
            impair the essential alpha-secretase cleavages, leading to
            autism-like phenotypes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 7002)
  AUTHORS   Lacas-Gervais,S., Guo,J., Strenzke,N., Scarfone,E., Kolpe,M.,
            Jahkel,M., De Camilli,P., Moser,T., Rasband,M.N. and Solimena,M.
  TITLE     BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon
            initial segments
  JOURNAL   J Cell Biol 166 (7), 983-990 (2004)
   PUBMED   15381686
REFERENCE   7  (bases 1 to 7002)
  AUTHORS   Traka,M., Goutebroze,L., Denisenko,N., Bessa,M., Nifli,A.,
            Havaki,S., Iwakura,Y., Fukamauchi,F., Watanabe,K., Soliven,B.,
            Girault,J.A. and Karagogeos,D.
  TITLE     Association of TAG-1 with Caspr2 is essential for the molecular
            organization of juxtaparanodal regions of myelinated fibers
  JOURNAL   J Cell Biol 162 (6), 1161-1172 (2003)
   PUBMED   12975355
REFERENCE   8  (bases 1 to 7002)
  AUTHORS   Poliak,S., Salomon,D., Elhanany,H., Sabanay,H., Kiernan,B.,
            Pevny,L., Stewart,C.L., Xu,X., Chiu,S.Y., Shrager,P., Furley,A.J.
            and Peles,E.
  TITLE     Juxtaparanodal clustering of Shaker-like K+ channels in myelinated
            axons depends on Caspr2 and TAG-1
  JOURNAL   J Cell Biol 162 (6), 1149-1160 (2003)
   PUBMED   12963709
REFERENCE   9  (bases 1 to 7002)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 7002)
  AUTHORS   Poliak,S., Gollan,L., Salomon,D., Berglund,E.O., Ohara,R.,
            Ranscht,B. and Peles,E.
  TITLE     Localization of Caspr2 in myelinated nerves depends on axon-glia
            interactions and the generation of barriers along the axon
  JOURNAL   J Neurosci 21 (19), 7568-7575 (2001)
   PUBMED   11567047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB628899.1, AK129232.1, AC166176.5, AC166249.3, CB526509.1,
            BC064467.1 and BP766118.1.
            
            On Jan 16, 2008 this sequence version replaced NM_001004357.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129232.1, SRR1660811.193445.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BB628899.1         434-460
            28-646              AK129232.1         1-619
            647-779             AC166176.5         164132-164264
            780-983             AC166249.3         97549-97752         c
            984-1109            CB526509.1         36-161
            1110-1887           BC064467.1         1-778
            1888-2085           AK129232.1         1861-2058
            2086-3804           BC064467.1         977-2695
            3805-5996           AK129232.1         3778-5969
            5997-6983           AK129232.1         5971-6957
            6984-7002           BP766118.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..7002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 21.81 cM"
     gene            1..7002
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /note="contactin associated protein-like 2"
                     /db_xref="GeneID:66797"
                     /db_xref="MGI:MGI:1914047"
     exon            1..326
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..4228
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; cell recognition molecule Caspr2"
                     /codon_start=1
                     /product="contactin-associated protein-like 2 isoform a
                     precursor"
                     /protein_id="NP_001004357.2"
                     /db_xref="CCDS:CCDS39475.1"
                     /db_xref="GeneID:66797"
                     /db_xref="MGI:MGI:1914047"
                     /translation="MVMSLRAGYRAALSLWILSSFICRAWTAPSTFQKCDEPLISGLP
                     HVSFSSSSSLSSSYAPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQG
                     RYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNVNSDSVVRHDLQHAVVARYVR
                     VVPLDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRFRNKKMKTLKDVIALKFKT
                     SESEGVLLHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDDHHW
                     HSVLIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSNRKNFK
                     GCMESINYNGVNITDLARRKKLEPSNMGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQ
                     DLFSVSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHINNTQTKTSQIDISSG
                     SGLNDGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNA
                     SYSALQPSFQGCMQLIQVDDQLVNLYEVAHRKPGSFANVTIDMCAIIDRCVPNHCEHG
                     GKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGP
                     LKVYCNMTEDKVWTIVSHDLQMQTTVVGYNPEKYSVTQLIYSASMDQISAITSSAEYC
                     EQYVSYFCRMSRLLNTPDGSPYTWWVGKANEKHYYWGGSEPGIQKCACGIERNCTDPK
                     YYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYW
                     NAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLGNTDFIKLELKSATEV
                     SFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHT
                     RLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGA
                     NCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTG
                     SRAENSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVSSLTTDFLAVLVKPTGNLQI
                     RYNLGGTREPFNIDVDHRNMANGQPHSVNITRHERTIILKLDHYPAVGYHLPSSSDTL
                     FNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASAHV
                     HIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNS
                     AIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFT
                     ETIDESKKEWLI"
     exon            327..437
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            438..631
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            632..779
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            780..983
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1168
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1312
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1577
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1727
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1899
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2006
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2126
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2327
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2484
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2612
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2783
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3002
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3239
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3479
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3613
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3707
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3947
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4028
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..7002
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4907..4912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /note="hexamer: AATAAA"
     polyA_site      4927
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /note="major polyA site"
     regulatory      5150..5155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /note="hexamer: AACAAA"
     polyA_site      5181
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
     regulatory      5279..5284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
                     /note="hexamer: AATAAA"
     polyA_site      5313
                     /gene="Cntnap2"
                     /gene_synonym="5430425M22Rik; Caspr2; mKIAA0868"
ORIGIN      
        1 agagcaagag accagaccta cagagagggg aaaaccaggc tgcgcctccc ctgctgctgc
       61 cagcccagaa ctggaacctg aagagggtga ggggagaaaa agcaaagcag gaggagcttg
      121 gcttcctctc acatctgagg acagaccggt tcccttcaag aacctcacag agaggcagac
      181 tgcatctctg cagcgagctt ttggagtacc actggcccgg cggctaagga tggtgatgtc
      241 tctgagagca ggctacaggg cagcgctctc gctctggatt ctcagcagct tcatctgcag
      301 agcctggaca gctccctcca cgttccaaaa atgtgatgag cctctcatct ctggtcttcc
      361 ccatgtgtcc ttcagcagct cttcctccct gtccagcagc tatgcacctg gttatgccaa
      421 gattaataaa cgaggaggtg ctgggggatg gtctccatca gacagtgacc actatcaatg
      481 gcttcaggtt gattttggta atcggaagca gatcagtgcc attgcaaccc aaggaaggta
      541 cagcagttct gattgggtga cacaatatcg aatgctctac agtgacacag ggagaaactg
      601 gaaaccctat catcaagatg gcaatatctg ggcttttcca ggaaacgtca attctgacag
      661 cgtggtccga cacgacctgc agcatgcagt agttgcccgt tatgtacgcg ttgtgccctt
      721 ggactggaat ggagaaggtc acatcgggct gcgtgcggaa gtctatggct gcgcctactg
      781 ggctgacgtt atcaactttg atggccacgg tgtgttacca tatcgattca gaaacaagaa
      841 gatgaaaaca ctcaaagatg ttattgcttt gaaatttaag acctctgaaa gtgaaggagt
      901 acttttgcat ggtgaaggac agcaagggga ttacattact ttggaactga aaaaagcaaa
      961 gctggtcctc agtttaaatc taggaagcaa ccagcttggc cccatctatg gccacacatc
     1021 tgtgacatct gggagcctgc tggatgatca ccactggcac tctgtactca ttgagcgcca
     1081 gggacgcagc attaacttga ccctggacag gagcatgcag cattttcgca ccaatggaga
     1141 gtttgactac ctggacttgg actatgagat aacatttgga ggcatacctt tctctggtaa
     1201 gccaagttcc agtaatagga agaacttcaa gggctgcatg gaaagcatca actacaatgg
     1261 tgtcaatatt accgatcttg cccgaagaaa gaaattagag ccatcaaata tggggaatct
     1321 gagtttctct tgtgtggagc cctatacagt accagtcttc ttcaatgcta caagctacct
     1381 ggaggtacct ggcagactta atcaggacct gttctcagtc agtttccagt ttaggacttg
     1441 gaaccccagc ggtctcttgc tcttcagtca ctttgcagat aacttgggca atgtggagat
     1501 tgaccttgta gagagcaaag tgggcgtcca cataaacaac acacagacca agacaagcca
     1561 aattgacatc tcctcaggct ccgggctgaa tgatgggcag tggcatgagg ttcgcttcct
     1621 ggccaaggaa aacttcgcag tcctcaccat tgatggagat gaagcatcag cagttcggac
     1681 caatagtcct cttcaagtga agactggcga gaaatacttc tttggaggat ttctgaacca
     1741 catgaacaat gccagctact ctgcccttca gccatcattc caaggatgca tgcagctcat
     1801 tcaggtagat gaccagcttg tgaatttata cgaagtagca cacaggaagc caggaagctt
     1861 cgcaaatgtc accattgaca tgtgtgccat catagacaga tgtgtgccca atcactgtga
     1921 gcatggtgga aagtgctcgc aaacatggga cagcttcaaa tgcacttgtg atgagacagg
     1981 atacagcggg gccacctgcc acaactccat ctacgagccc tcctgtgaag catacaaaca
     2041 ccttggccag acatcaaatt actactggat agatcctgat ggcagtggac cactggggcc
     2101 tctgaaggtt tattgcaaca tgacagagga caaggtgtgg accatagtgt ctcatgactt
     2161 acagatgcag acgacagtgg taggctacaa cccagaaaag tactctgtga cacagcttat
     2221 ctacagtgcc tccatggacc agattagtgc catcaccagt agcgccgagt actgcgaaca
     2281 gtacgtctcc tacttctgca ggatgtccag gttgttgaac accccagatg gaagtcctta
     2341 cacctggtgg gttggcaaag ccaatgagaa gcactactac tggggaggat cagagcctgg
     2401 aattcagaag tgtgcctgtg gcatagagcg caactgcaca gatcccaagt actactgcaa
     2461 ctgtgatgct gactacaagc agtggaggaa ggatgctggc ttcttatcct acaaagatca
     2521 cctgccagtg agccaggtgg tggttggaga tactgaccga caaggctcag aagccaagct
     2581 gagtgtgggt cccctgcgct gccaaggaga cagaaattat tggaatgctg cctccttccc
     2641 aaacccatca tcctacctgc acttctctac cttccaaggg gaaacaagtg ctgacatttc
     2701 tttctacttc aagacattaa tccccagggg agtatttttg gaaaatctgg ggaacacaga
     2761 cttcatcaag ctggagctca agtctgccac agaagtgtcc ttttcatttg atgttggaaa
     2821 cgggccagtg gagatcgtgg tgaggtcacc ttcacctctc aatgatgacc agtggcatcg
     2881 ggtcactgca gagaggaatg tcaagcaggc cagtctccag gtggatcgcc tgccccagca
     2941 aatccgaaaa gccccgactg aaggtcatac ccgcctggaa ctctacagtc agctgtttgt
     3001 tggtggtgct ggaggccagc agggcttcct aggctgcatc cgctccttga ggatgaatgg
     3061 agtaacactt gacttggaag aaagggcgaa ggtcacatct gggttcaagt ctggatgctc
     3121 aggccactgc accagctatg gggctaactg tgaaaatgga ggcaaatgca tcgaaaaata
     3181 ccatggctac tcctgcgact gctctaacac agcctatgat gggacattct gcaacaaaga
     3241 tgttggtgcc ttttttgaag aaggcatgtg gctgcgctat aacttccagg ccccagcggt
     3301 cactgccaga gacacaggca gcagggccga gaattctgca gaccagcagc agcacttggc
     3361 tccagatctg gcccaggagc agatccactt tagcttcagc actaccaagg caccctgcat
     3421 cctcctctat gtcagctccc tcaccactga cttcctagct gttctggtca agcccacagg
     3481 aaacttgcag atccggtata acctgggagg aaccagagag ccattcaata ttgacgtaga
     3541 ccacaggaac atggccaatg gacagccgca cagtgtcaac atcacccggc atgagaggac
     3601 cataattctc aagctcgacc attatcctgc tgtgggttac catctaccca gctcctctga
     3661 tacgctcttc aattctccca agtcgctctt ccttggaaaa gttatagaaa cgggaaaaat
     3721 cgaccaagaa attcacaaat acaacacccc aggcttcaca ggctgcctgt ccagagtcca
     3781 gttcaaccac atcgcccctc tcaaggcagc cttgagacag acaaacgcct cagcccacgt
     3841 gcacattcag ggtgagctgg tggaatctaa ctgcggggcc tccccactga cgctttcccc
     3901 catgtcttca gccactgacc cttggcacct agatcacttg gattcagcca gtgctgattt
     3961 cccatataac ccaggacaag gccaagctat aagaaatgga gtcaacagaa actcagctat
     4021 cattggaggg gtcatcgctg tggtgatttt caccatcctc tgcaccctgg tcttcctcat
     4081 ccggtacatg ttccgtcaca agggcaccta ccacaccaat gaggccaagg gagctgagtc
     4141 agccgagagt gcagatgctg ccatcatgaa caacgacccc aacttcacag agaccattga
     4201 cgagagcaaa aaggagtggc tcatttgagg ggtggctttt tagccatggg atagggaggg
     4261 aggagttaag ggaggagggg gagggacaga gcaccctgcg tcatacccct gagcacacgc
     4321 ttacactatc agcacaagct ggggaaggca agcaacccaa tactcttaag actgatggcc
     4381 acacaaaata tactttttaa tatttcttta tagctgagtt cccgccccct tctgtatcaa
     4441 aacaaaataa tacaaaaatg cttttagagt ttaagcaaca gttgaacttt gtaggtacta
     4501 tctgtcttat tttgtgtgtg tttagaggtg ttctaaaaac ccgtggtaac agggcaagtt
     4561 ttctacattt ttaagagccc ttagatcgtg gatatttttt tctcaagaaa aactgataca
     4621 tatccatgca gcctccgaca ttctctttct tttgcatcta gtcgactttt aatgggctgt
     4681 tgtagcaact agtttgtgtc caaataatat ttcttttggt gtcccataaa atggaaatga
     4741 gaaaaggggc aaagagccta tttgcccagt cttcttcaat gacacctcag tctaggccag
     4801 ttttctgaag gttcctgtct ggcttagcca gggaagggag agtgagtggc ctgtcctgca
     4861 gcaatggaac cagcacacgt ggatacaagc acccaagaat ccagctaata aatgcatatt
     4921 gggcttattg cttttgtttt ttattgactt ctacatgctg atgtcccatg tatgtagtct
     4981 tagacctgtt taatatctgt aactatcagc tataatattg tggtgaccaa ctgctatagg
     5041 attttgcctc tgttttaact acaacatatt ggattgtatg tgtctgtgcc tccatggggg
     5101 attagagcca gagggaatgt cttctttgct ctgtttcttt tatatttata acaaaaatat
     5161 ggatactttc tagtgaatgc ataagttagt gtgcttttct tattttgctt taaatttcaa
     5221 gtttttacac tgctgtgata aaatcctcac agatagcatc ctctggatgg cacagtacaa
     5281 taaagccaac ttgcagctgc tgttactctg gaatcatgtg ggagacactg ccatatttta
     5341 aaccaacttt atcacaggaa ctctatcatg atacagagac ctgtgacaga cacattagaa
     5401 tccgaagtca ccatcaacct gatcatcagt tatggcttct cttctagaga acatgattgt
     5461 ctagtgaata acacatctta gggtaatcag gaatcttggg aaatttgctc caaaaatttt
     5521 tcttgatttt atgtaacaat aataggcttt gtgtaagtaa atgggagcaa ttcttcctat
     5581 tggagcaccc aaaaagaatt taatcacttt atttttttaa ttacacaaaa gttctctctt
     5641 gaatggttgc catttataat tgtaatatgt cgggcctctt atacttaaaa aactcttttt
     5701 aaaaattttg taggctccaa cattttgagg aattaaatgt gatgattctt tctcctcttt
     5761 gaaggacagt gaggttaaaa tagtatgatg ctatttttct catggtctgt cttaataacc
     5821 tgcgtatttc tacttagttg ggattttacc agacactttc aaggttctcc aaatgcttaa
     5881 cttattggag gatctcaatt tcttgaataa cggaaaacct tatcccaagc tgctctttgc
     5941 acaagtttat aacgggctcc aaaaggatgc aaggggaggc aagtgccccc ccccccaccc
     6001 ttgaatcaag gaaacagaat aaaagggaat cctgagactc tttttaattg caagcagacc
     6061 tcaaacagtc ccatgaatac cctggattgt caagccttgc tcattttttc ataaagcaga
     6121 ttaaatggaa aggtatgtaa cagaacaaac tgtgaaaaca attgtagcat ttacttatga
     6181 gagcacattt gagaccaaag gtcatcttat ttcatcgaga tacctgacca tagtgcattc
     6241 ttctccataa tttcaaattg aaaaagcaaa tgtttaccat gatggcttga aattgtttcc
     6301 aatttaaaaa caacttattt tacaggcatt acttttgcac ctgacaaata ctgtcagata
     6361 gaaatgcatg ccttctgtac ttctcttccc caaaatgatt agcaagaaaa accatcaagg
     6421 acagccccag tgttaaagtg ttctcaccct gtccttctcc tcactctttc cttcccttat
     6481 ttctgccaca aaagacaaag actgagggcc agtccatctc tcacatatta gcaaggctag
     6541 ggtgctgaat gtcatcaatt aagacacaca ggaggtccac tgacacagct tctcctaagc
     6601 aattacagga tggctggcaa acaggacaca caaaggtggg tacagtagta actacattaa
     6661 ttgctaaatg agtcctaaag ttttaacctc ttcttggaat gacgccgccc ttaaccaagc
     6721 taatcacatc tgtgtatgac agacatgagt gctctgttat gaatgggaaa taattgctca
     6781 tttgaagaaa aagaaagcaa ttctctgttc cagctcttcc cttgacagtt ttccatgaca
     6841 ctgcttcaat actcatggtg taccagactt gcctgatcca attctgttct tctccactac
     6901 catctcagca tcttatatcc agtgtatcat ccaccaagca cagactaacg gaaagccctg
     6961 taagcaataa caatatataa accaaaaaaa aaaaaaaaaa aa
//
