LOCUS       NM_001411160            3758 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus contactin 6 (Cntn6), transcript variant 8, mRNA.
ACCESSION   NM_001411160
VERSION     NM_001411160.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Ide,H., Miike,K., Ohmori,T., Maruyama,K., Izumi,Y., Tanigawa,S. and
            Nishinakamura,R.
  TITLE     Mouse embryonic kidney transplantation identifies maturation
            defects in the medulla
  JOURNAL   Sci Rep 14 (1), 30293 (2024)
   PUBMED   39639083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Zhang,H.Y., Wu,F.Y., Zhang,C.X., Wu,C.Y., Cui,R.J., Liu,X.Y.,
            Yang,L., Zhang,Y., Sun,F., Cheng,F., Yang,R.M., Song,H.D. and
            Zhao,S.X.
  TITLE     Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism,
            Mediates Thyroid Hormone Biosynthesis Through Notch Signaling
  JOURNAL   Thyroid 34 (3), 324-335 (2024)
   PUBMED   38183624
  REMARK    GeneRIF: Contactin 6, A Novel Causative Gene for Congenital
            Hypothyroidism, Mediates Thyroid Hormone Biosynthesis Through Notch
            Signaling.
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Zhang,W., Huang,H., Gui,A., Mu,D., Zhao,T., Li,H., Watanabe,K.,
            Xiao,Z., Ye,H. and Xu,Y.
  TITLE     Contactin-6-deficient male mice exhibit the abnormal function of
            the accessory olfactory system and impaired reproductive behavior
  JOURNAL   Brain Behav 13 (4), e2893 (2023)
   PUBMED   36860170
  REMARK    GeneRIF: Contactin-6-deficient male mice exhibit the abnormal
            function of the accessory olfactory system and impaired
            reproductive behavior.
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Williams,S.E., Grumet,M., Colman,D.R., Henkemeyer,M., Mason,C.A.
            and Sakurai,T.
  TITLE     A role for Nr-CAM in the patterning of binocular visual pathways
  JOURNAL   Neuron 50 (4), 535-547 (2006)
   PUBMED   16701205
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Cui,X.Y., Hu,Q.D., Tekaya,M., Shimoda,Y., Ang,B.T., Nie,D.Y.,
            Sun,L., Hu,W.P., Karsak,M., Duka,T., Takeda,Y., Ou,L.Y., Dawe,G.S.,
            Yu,F.G., Ahmed,S., Jin,L.H., Schachner,M., Watanabe,K.,
            Arsenijevic,Y. and Xiao,Z.C.
  TITLE     NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell
            differentiation into oligodendrocytes
  JOURNAL   J Biol Chem 279 (24), 25858-25865 (2004)
   PUBMED   15082708
  REMARK    GeneRIF: NB-3/Notch1 pathway promotes neural progenitor cell
            differentiation into oligodendrocytes via Deltex1.
REFERENCE   9  (bases 1 to 3758)
  AUTHORS   Takeda,Y., Akasaka,K., Lee,S., Kobayashi,S., Kawano,H.,
            Murayama,S., Takahashi,N., Hashimoto,K., Kano,M., Asano,M.,
            Sudo,K., Iwakura,Y. and Watanabe,K.
  TITLE     Impaired motor coordination in mice lacking neural recognition
            molecule NB-3 of the contactin/F3 subgroup
  JOURNAL   J Neurobiol 56 (3), 252-265 (2003)
   PUBMED   12884264
  REMARK    GeneRIF: Mice deficient for NB-3 are slow to learn to stay on the
            rotating rod in the rotorod test during repeated trials and display
            dysfunction of equilibrium and vestibular senses in the wire hang
            and horizontal rod-walking tests.
REFERENCE   10 (bases 1 to 3758)
  AUTHORS   Lee,S., Takeda,Y., Kawano,H., Hosoya,H., Nomoto,M., Fujimoto,D.,
            Takahashi,N. and Watanabe,K.
  TITLE     Expression and regulation of a gene encoding neural recognition
            molecule NB-3 of the contactin/F3 subgroup in mouse brain
  JOURNAL   Gene 245 (2), 253-266 (2000)
   PUBMED   10717476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117728.10, AC116110.7, AC153990.2 and AC153023.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.147840.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AC117728.10        151515-151825
            312-407             AC116110.7         40026-40121
            408-547             AC116110.7         61352-61491
            548-674             AC116110.7         135295-135421
            675-850             AC116110.7         142788-142963
            851-946             AC153990.2         111804-111899       c
            947-1150            AC153990.2         86785-86988         c
            1151-1253           AC153990.2         84693-84795         c
            1254-1438           AC153990.2         45168-45352         c
            1439-1575           AC153990.2         40373-40509         c
            1576-1705           AC153990.2         38464-38593         c
            1706-1856           AC153990.2         36609-36759         c
            1857-1984           AC153990.2         8615-8742           c
            1985-2160           AC153023.2         78178-78353
            2161-2278           AC153023.2         78707-78824
            2279-2437           AC153023.2         79463-79621
            2438-2587           AC153023.2         81384-81533
            2588-2658           AC153023.2         84435-84505
            2659-2893           AC153023.2         91336-91570
            2894-3009           AC153023.2         91705-91820
            3010-3196           AC153023.2         93698-93884
            3197-3309           AC153023.2         105059-105171
            3310-3478           AC153023.2         107484-107652
            3479-3758           AC153023.2         108807-109086
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 48.93 cM"
     gene            1..3758
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /note="contactin 6"
                     /db_xref="GeneID:53870"
                     /db_xref="MGI:MGI:1858223"
     exon            1..311
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..407
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..547
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..3579
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /note="isoform a precursor is encoded by transcript
                     variant 8; mNB-3; neural recognition molecule NB-3"
                     /codon_start=1
                     /product="contactin-6 isoform a precursor"
                     /protein_id="NP_001398089.1"
                     /db_xref="GeneID:53870"
                     /db_xref="MGI:MGI:1858223"
                     /translation="MRLLWKLVILLPLINSCAGEGRFSRPIFIQEPQDVIFPLDLSRS
                     EIILTCTANGYPSPHYRWKQNGTDIDFGMTYHYRLDGGSLAISSPRTDQDIGIYQCLA
                     TNPVGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGELSYAWTFN
                     DSPLYVQEDKRRFVSQDTGNLYFAKVEPSDVGNYTCFVTNKEAHRSVQGPPTPLVLRT
                     DGVMGEYEPKIEVRFPETIQAAKDSSIKLECFALGNPVPDISWKRLDGSPMPGKIKYS
                     KSQAILEIPKFQQEDEGFYECIAGNLRGRNLAKGQLIFYAPPEWEQKIQNTYLSIYDS
                     LFWECKASGNPNPSYTWLKNGQRLNTEERIQIENGTLIITMLNISDSGIYQCAAENKY
                     QTIYANAELRVLASAPDFSKNPIKKISVVQVGGDISIECKPNAFPKASISWKRGTENL
                     KQSKRVLFLEDGSLKICNVTRADAGSYTCVATNQFGNGKSSGGLVVKERTIITVPPSK
                     MDVTVGESIVLPCQVSHDPTMEVLFVWYFNGDIIDLKKGVAHFERIGGESVGDLMIRN
                     IQLGHSGKYLCTVQTTLERLSAVADIIVRGPPGPPEDVKVEHISSTTSQLSWRPGPDN
                     NSPIQIFTIQTRTPFSVGWQAVATVPEILNGQTYNATVVGLSPWVEYEFRVVAGNNIG
                     IGEPSKPSELLRTKASVPNVAPGNINGGGGSRSELVITWEAIPEELQNGEGFGYIVMF
                     RPVGTTAWMKERVALVESSKFIYRNESIMPLSPFEVKVGVYNNEGEGSLSTVTIVYSG
                     EDEPQLAPRGTSVQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDNSKESMIGKIR
                     VSGNVTTKNITGLRANTIYFASVRAYNTAGTGPSSLPVNVTTKKSPPSQPPANIAWKL
                     SNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLI
                     EIRTVSDGGDGSSSEEIRIPKMSSLSSTGVQISKPSTQSLSMVGVFYCFAIHPLSR"
     exon            548..674
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..850
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..946
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1150
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1253
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1438
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1575
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1705
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1856
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1984
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2160
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2278
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2437
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2587
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2658
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2893
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3009
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3196
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3309
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3478
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3758
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3732..3737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /note="hexamer: AATAAA"
     polyA_site      3758
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /note="major polyA site"
ORIGIN      
        1 gtatttcatg cttaagacca gagaggagcc acgcaatact cagtggataa aaggcttgca
       61 gtcccagctg ggaaaaagag tcccattatc tcccagctgc atagacattc catacggctt
      121 ggttctgcct ggatgcacag catgcctgac tgaggactcc agacagagtt ctgcagaaaa
      181 attgtaaaga tcccgagaca tttccctggt aagatccgta agtacagaat tgcgctgtct
      241 gctgcaatga gaattttgct gggcaagctg cagcttttct tgctttcaat ctctttgtat
      301 tagtaaaaca gcaataagga agtttacata caacaaagca cttgaaaagg agaaagtctc
      361 ctgtgtctga cttgatgttg ttttctccgg atccgcaggc agagacgata gattgctaac
      421 aaactgacta gaagatacaa tcttctttcc tgctgattgc atgggagaaa tttttgacct
      481 tcgaacgtgg agatgaggtt gctatggaaa ctggtaattc tgctgccact cataaactct
      541 tgtgcaggtg agggtcgttt cagccgtcct atttttatcc aggagccaca agatgtcatt
      601 tttcctttgg atttatctag atctgaaatt attctgactt gtactgcaaa tggataccct
      661 tctccccatt acaggtggaa acagaatggt acagatattg acttcggcat gacttatcac
      721 tataggttgg atggaggcag tttggccatc agcagcccca gaacagatca agatattggc
      781 atataccagt gtctggccac caatcctgtg ggcaccattc tgagtagaaa agccaagcta
      841 cagtttgcat atattgaaga ctttgaaacc aaaaccagaa gcacagtatc tgtccgagaa
      901 ggtcaaggag tggtactact ctgtggccca ccaccacatt ttggagaatt atcatatgcc
      961 tggaccttca atgatagccc tttgtatgtt caagaggaca agcgaagatt tgtatctcaa
     1021 gacacaggga acttgtactt tgccaaagta gaaccatctg atgtgggcaa ttatacttgc
     1081 tttgtcacaa acaaagaggc ccatagaagt gtccaaggtc cacctacgcc tttagtgctg
     1141 cgcactgatg gtgtcatggg ggaatatgag ccaaagattg aagtgcgttt tcctgaaaca
     1201 atacaagctg caaaggattc atctataaaa ctggaatgct ttgcccttgg aaatccagtc
     1261 cctgatatta gttggaaaag gttggatgga agcccgatgc cagggaaaat caagtacagc
     1321 aaatcccaag ctatccttga aatccccaag ttccaacaag aggatgaagg cttctatgaa
     1381 tgcatcgcag gtaaccttcg aggaagaaac cttgcaaagg gtcaactaat tttctatgct
     1441 cccccagaat gggaacagaa aatccaaaac acataccttt ctatctatga cagcttgttt
     1501 tgggaatgca aagctagtgg aaatccaaat ccttcgtaca cgtggctaaa gaatggtcaa
     1561 cgtctcaaca cagaagaaag aattcagatt gaaaatggga ctcttatcat caccatgctg
     1621 aacatttcag actctgggat ctaccagtgt gctgcagaaa acaaatatca gacaatttat
     1681 gcaaatgcag aattgagagt tttagcctca gctccagatt tctccaaaaa tcccattaaa
     1741 aaaatttcag ttgttcaagt tggtggtgat atttctattg aatgcaaacc aaatgctttc
     1801 cccaaagcat cgatttcctg gaaaagagga acagagaacc tgaaacaaag taaaagagtt
     1861 cttttcttgg aggatggcag ccttaagata tgcaatgtta ccagagcaga tgctgggtct
     1921 tacacctgtg tagctacaaa tcaatttggc aatgggaaaa gcagtggagg tctcgtcgtg
     1981 aaagagagaa cgatcattac agtaccacca tctaaaatgg atgttacagt tggagagagc
     2041 atcgtcttac cctgccaagt gtctcatgac cccaccatgg aagttctatt tgtttggtac
     2101 tttaatggag atattataga tttaaagaaa ggagtagccc attttgaacg aattggggga
     2161 gaatctgttg gggatttgat gataaggaat attcaattag gccattcggg aaaatatcta
     2221 tgcacagtac aaacaacact agaacgcttg tctgctgtag ctgatatcat tgtgagaggt
     2281 cccccagggc ccccagagga tgtaaaagtg gagcacatct ctagtacgac ctcccagctc
     2341 agctggagac caggtcctga taataacagc cccattcaaa tttttactat tcaaactcgg
     2401 acaccctttt ctgtgggctg gcaagcggtt gctacagtcc ctgaaattct caatggacag
     2461 acatacaatg caacagtcgt tggtttgagt ccttgggtgg aatacgaatt tcgtgttgtt
     2521 gctgggaaca acattggaat tggagagcca agcaaaccat cagagctgct gagaaccaaa
     2581 gcatcagtcc ccaatgtggc accaggaaat atcaatggag gcggtggaag cagatcggaa
     2641 cttgtcatta cgtgggaggc cattcctgaa gaactacaga atggagaggg gtttggatat
     2701 atcgtcatgt ttcggccagt aggcacaacc gcctggatga aagaaagggt ggctcttgta
     2761 gaatcatcca agttcatcta tagaaatgaa agcatcatgc ctctgtctcc ctttgaagtc
     2821 aaagtgggag tgtacaataa tgaaggagag ggatccctga gtactgtgac cattgtctac
     2881 tctggggaag atgagcctca gctggcccca agaggaactt ctgtccagag tttttctgct
     2941 tctgaaatgg aggtttcctg gaatgctatt gcttggaata gaaacactgg aagagtgcta
     3001 ggctatgagg tcttatactg gacagacaac tccaaagaat ctatgattgg taaaattaga
     3061 gtcagtggaa atgtcacaac caagaacatc acaggactaa gagctaatac gatttacttt
     3121 gcctctgtga gagcctataa cactgcaggg actggaccct caagtctgcc agttaatgtc
     3181 accaccaaaa agtcccctcc tagccaacca ccagcaaaca ttgcctggaa gctgtcaaat
     3241 tctaaattat gcttgaactg ggagcatgta aaaaccatgg aaaatgagtc tgaagtgctg
     3301 ggctacaaga tcctctatcg gcagaaccga cagagtaaaa ctcatatttt ggaaacaaat
     3361 aatacatctg ctgaactcct ggttccattt gaagaagact atttgattga aatcagaaca
     3421 gtcagtgatg gtggagatgg aagcagcagt gaggaaatca gaattccaaa aatgtcaagt
     3481 ttgagttcca caggagttca gatctcgaag cccagcaccc agtccctgtc aatggttggg
     3541 gttttttact gttttgctat tcacccactt tcgagatgaa ccaatccatg gatctttggg
     3601 aattttctga gagcaaacca ttctgtaaat ccattctcca gcctctatca caagacatat
     3661 tcttaataca gacttgtttg gaaagaagaa aatgtatatt actaagctct tgtaaatatc
     3721 tgtggtacat taataaaaca gttttaaaca ctttgaaa
//
