LOCUS       NM_001109749            6176 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus contactin 4 (Cntn4), transcript variant 1, mRNA.
ACCESSION   NM_001109749
VERSION     NM_001109749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6176)
  AUTHORS   Bamford,R.A., Zuko,A., Eve,M., Sprengers,J.J., Post,H.,
            Taggenbrock,R.L.R.E., Fabetaler,D., Mehr,A., Jones,O.J.R.,
            Kudzinskas,A., Gandawijaya,J., Muller,U.C., Kas,M.J.H.,
            Burbach,J.P.H. and Oguro-Ando,A.
  TITLE     CNTN4 modulates neural elongation through interplay with APP
  JOURNAL   Open Biol 14 (5), 240018 (2024)
   PUBMED   38745463
  REMARK    GeneRIF: CNTN4 modulates neural elongation through interplay with
            APP.
REFERENCE   2  (bases 1 to 6176)
  AUTHORS   Chen,P., Liu,Z., Zhang,Q., Lin,D., Song,L., Liu,J., Jiao,H.F.,
            Lai,X., Zou,S., Wang,S., Zhou,T., Li,B.M., Zhu,L., Pan,B.X. and
            Fei,E.
  TITLE     DSCAM Deficiency Leads to Premature Spine Maturation and
            Autism-like Behaviors
  JOURNAL   J Neurosci 42 (4), 532-551 (2022)
   PUBMED   34848499
REFERENCE   3  (bases 1 to 6176)
  AUTHORS   Zhao,R., Zhu,T., Liu,Q., Tian,Q., Wang,M., Chen,J., Tong,D., Yu,B.,
            Guo,H., Xia,K., Qiu,Z. and Hu,Z.
  TITLE     The autism risk gene CNTN4 modulates dendritic spine formation
  JOURNAL   Hum Mol Genet 31 (2), 207-218 (2021)
   PUBMED   34415325
REFERENCE   4  (bases 1 to 6176)
  AUTHORS   Oguro-Ando,A., Bamford,R.A., Sital,W., Sprengers,J.J., Zuko,A.,
            Matser,J.M., Oppelaar,H., Sarabdjitsingh,A., Joels,M.,
            Burbach,J.P.H. and Kas,M.J.
  TITLE     Cntn4, a risk gene for neuropsychiatric disorders, modulates
            hippocampal synaptic plasticity and behavior
  JOURNAL   Transl Psychiatry 11 (1), 106 (2021)
   PUBMED   33542194
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6176)
  AUTHORS   Filova,I., Dvorakova,M., Bohuslavova,R., Pavlinek,A., Elliott,K.L.,
            Vochyanova,S., Fritzsch,B. and Pavlinkova,G.
  TITLE     Combined Atoh1 and Neurod1 Deletion Reveals Autonomous Growth of
            Auditory Nerve Fibers
  JOURNAL   Mol Neurobiol 57 (12), 5307-5323 (2020)
   PUBMED   32880858
REFERENCE   6  (bases 1 to 6176)
  AUTHORS   Williams,S.E., Grumet,M., Colman,D.R., Henkemeyer,M., Mason,C.A.
            and Sakurai,T.
  TITLE     A role for Nr-CAM in the patterning of binocular visual pathways
  JOURNAL   Neuron 50 (4), 535-547 (2006)
   PUBMED   16701205
REFERENCE   7  (bases 1 to 6176)
  AUTHORS   Hansford,L.M., Smith,S.A., Haber,M., Norris,M.D., Cheung,B. and
            Marshall,G.M.
  TITLE     Cloning and characterization of the human neural cell adhesion
            molecule, CNTN4 (alias BIG-2)
  JOURNAL   Cytogenet Genome Res 101 (1), 17-23 (2003)
   PUBMED   14571131
REFERENCE   8  (bases 1 to 6176)
  AUTHORS   Saito,H., Mimmack,M., Kishimoto,J., Keverne,E.B. and Emson,P.C.
  TITLE     Expression of olfactory receptors, G-proteins and AxCAMs during the
            development and maturation of olfactory sensory neurons in the
            mouse
  JOURNAL   Brain Res Dev Brain Res 110 (1), 69-81 (1998)
   PUBMED   9733924
REFERENCE   9  (bases 1 to 6176)
  AUTHORS   Cangiano,G., Ambrosini,M., Patruno,A., Tino,A., Buttiglione,M. and
            Gennarini,G.
  TITLE     Functional organization of the promoter region of the mouse F3
            axonal glycoprotein gene
  JOURNAL   Brain Res Mol Brain Res 48 (2), 279-290 (1997)
   PUBMED   9332725
REFERENCE   10 (bases 1 to 6176)
  AUTHORS   Mimmack,M.L., Saito,H., Evans,G., Bresler,M., Keverne,E.B. and
            Emson,P.C.
  TITLE     A novel splice variant of the cell adhesion molecule BIG-2 is
            expressed in the olfactory and vomeronasal neuroepithelia
  JOURNAL   Brain Res Mol Brain Res 47 (1-2), 345-350 (1997)
   PUBMED   9221934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153596.5, AC162466.6, AC153898.4, AC156281.4, AC153991.3,
            AC159546.4, AC153988.5 and AC164169.8.
            
            On Aug 31, 2022 this sequence version replaced NM_001109749.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 4, and 6-9 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.337981.1,
                                           SRR9219379.6085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC153596.5         116584-116807       c
            225-368             AC162466.6         125456-125599
            369-424             AC153898.4         77754-77809
            425-482             AC156281.4         66093-66150         c
            483-630             AC156281.4         8572-8719           c
            631-757             AC153991.3         155698-155824
            758-933             AC153991.3         164564-164739
            934-1029            AC159546.4         62629-62724
            1030-1227           AC159546.4         114354-114551
            1228-1330           AC159546.4         130899-131001
            1331-1515           AC159546.4         134129-134313
            1516-1652           AC159546.4         148265-148401
            1653-1782           AC159546.4         150122-150251
            1783-1933           AC159546.4         175127-175277
            1934-2061           AC153988.5         29109-29236         c
            2062-2237           AC164169.8         109702-109877
            2238-2358           AC164169.8         116772-116892
            2359-2517           AC164169.8         121575-121733
            2518-2667           AC164169.8         126986-127135
            2668-2738           AC164169.8         128783-128853
            2739-2973           AC164169.8         129934-130168
            2974-3086           AC164169.8         132540-132652
            3087-3273           AC164169.8         133450-133636
            3274-3386           AC164169.8         134071-134183
            3387-3555           AC164169.8         148468-148636
            3556-6176           AC164169.8         151720-154340
FEATURES             Location/Qualifiers
     source          1..6176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 48.93 cM"
     gene            1..6176
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /note="contactin 4"
                     /db_xref="GeneID:269784"
                     /db_xref="MGI:MGI:1095737"
     exon            1..224
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            225..368
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..424
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..482
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..630
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..3656
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; brain-derived immunoglobulin superfamily
                     molecule; brain-derived immunoglobulin superfamily protein
                     2; axonal-associated cell adhesion molecule"
                     /codon_start=1
                     /product="contactin-4 isoform 1 precursor"
                     /protein_id="NP_001103219.1"
                     /db_xref="CCDS:CCDS51866.1"
                     /db_xref="GeneID:269784"
                     /db_xref="MGI:MGI:1095737"
                     /translation="MRLPWELLVLQSFMLCLADDYTLHGPVFVQEPSHVMFPLDSEEK
                     KVKLSCEVKGNPKPHIRWKINGTDVDIGMDFRYSVVDGSLLINNPNKTQDAGTYQCIA
                     TNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN
                     EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDG
                     VMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKS
                     NGILEIPNFQQEDAGSYECVAENSRGKNVAKGQLTFYAQPNWVQIINDIHVAMEESVF
                     WECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAENKHGV
                     IFSSAELSVIAESPDFSRTLLKRVTLVKVGGEVVIECKPKASPRPVYTWRKGREILRE
                     NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNVIVKDPTKVMVPPSSMD
                     VTVGESIVLPCQVTHDHSLDIVFTWTFNGHLIDFDKDGDHFERVGGQDSAGDLMIRNI
                     QLKHAGKYVCMVQTSVDKLSVAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNH
                     SPITMYVIQARTPFSVGWQAVNTVPDLVDGKTFTATVVGLNPWVEYEFRTVAANVIGI
                     GEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFR
                     PHGKMIWMLTVLASADASRYVFRNESVRPFSPFEVKVGVFNNKGEGPFSPTTLVYSAE
                     EEPTKPPASIFARSLSATDIEVFWASPIGKNRGRIQGYEVKYWRHDDKEENAKKIRTV
                     GNQTSTKITNLKGSALYHLSVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD
                     SKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEI
                     KPFSDGGDGSSSEQIRIPKISNSYARGSGASTSNACTLSAISTIMISLTARSSL"
     exon            631..757
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..933
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1029
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1227
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1330
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1515
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1652
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1782
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1933
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2061
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2237
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2358
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2517
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2667
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2738
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2973
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3086
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3273
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3386
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3555
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..6176
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /note="hexamer: AATAAA"
     polyA_site      5345
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /note="major polyA site"
     regulatory      6153..6158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /note="hexamer: AATAAA"
     polyA_site      6176
                     /gene="Cntn4"
                     /gene_synonym="9630050B05; Axcam; BIG-2"
                     /note="major polyA site"
ORIGIN      
        1 gagtcttccg ctagtggctg caaaggaacc gctgcagcct gaactcaggt gcgccgggtt
       61 ttgagagctg ccaccagcac agggagggag aggaacgcgc ggcagccaca gagcacaagg
      121 ttcataacca ggattggtcg caagtaggga gcttttgcca ctccgccggg accttcggac
      181 gttggcggtg gagcaagccc agttctccta ggcgctgtgc ttggattcat attgcattgt
      241 tgacaattct cacaggtgaa attcggccag agctcacttg gaaatttctg cagattggtg
      301 taagagaatc agattcttca tgctcagcta aaggaaacaa tcctcgtggt tcttattgaa
      361 aagaagaggg attattgaca catactaatt caccagcatg tggctctcag aactgcccta
      421 agaggttatc aagaaatcca catctttctg catctgactg tggacgctct gctgttttga
      481 agattaaagg ttgcacaaag cttaaaagga acagaagcag cagttctatt cacttgttat
      541 tggacttgaa actcctttga cctgggaaac tgaagatgag gttgccatgg gaactgctag
      601 tgctgcaatc attcatgttg tgccttgcag atgactacac actgcatggc ccagtttttg
      661 ttcaagaacc aagtcatgtc atgtttcctt tggattctga ggagaaaaaa gtgaaactca
      721 gttgtgaagt taaagggaat ccaaaacctc acatcaggtg gaagataaat ggaacagatg
      781 ttgacattgg tatggatttc cgctacagtg ttgttgacgg cagcttgttg atcaataacc
      841 ccaataaaac ccaagatgct ggaacgtacc agtgcatagc aacaaactca tttggaacaa
      901 ttgtaagcag agaagcaaag cttcagtttg cttatcttga aaactttaag acaagaacaa
      961 gaagcactgt gtcagtccgt cgaggtcagg gaatggtcct tctgtgcggc ccgccacccc
     1021 attctggaga gctgagctat gcctggatct tcaatgaata cccttcctat caggataacc
     1081 gccgcttcgt ttctcaagag actgggaatc tgtatattgc caaagtggaa aaatctgatg
     1141 ttggtaatta cacctgtgta gttaccaaca ctgtgaccaa ccacaaggtc ctgggaccgc
     1201 ccacaccact aatcctgaga aatgatgggg tgatgggtga atatgagccc aaaatagaag
     1261 tacagtttcc agaaaccgtc ccggctgaga aaggaacaac agtcaaactg gaatgctttg
     1321 ccttaggaaa tccagtccca actattctat ggcgaagagc tgatggcaag ccaatagcaa
     1381 ggaaagccag aagacataag tcgaatggaa ttctggaaat tcccaatttt cagcaggaag
     1441 atgccggttc atatgaatgt gtggctgaaa actccagagg caaaaacgta gccaagggac
     1501 agttgacttt ttatgctcaa cctaactggg ttcaaataat aaatgatatc cacgtggcca
     1561 tggaagagag tgtcttctgg gaatgtaaag caaatgggag gcctaaacct acctacagat
     1621 ggctaaaaaa tggtgaccca ctgttaacac gggatagaat acaaatcgag caaggaacac
     1681 tcaacataac aatagtgaat ctctcagatg ctggcatgta ccagtgtgtg gcagaaaata
     1741 aacatggagt tatcttttcc agcgctgagc ttagtgtaat agctgaaagt ccagattttt
     1801 cccgaacact cttaaaaaga gtaacacttg tcaaagtggg aggtgaagtt gtcattgagt
     1861 gcaagccaaa agcatcccca agacctgtct acacctggag aaagggaaga gaaatattaa
     1921 gagaaaatga aagaattacc atttctgaag atgggaacct cagaatcatc aatgtgacta
     1981 aatctgatgc tggaagttac acctgcatag ccacgaacca ttttggaact gccagcagta
     2041 ctgggaatgt gattgtgaaa gacccaacaa aggtgatggt tcctccttcc agcatggatg
     2101 tcactgtagg agaaagcatt gttcttccat gccaggtaac acatgatcac tccctggaca
     2161 ttgtgtttac gtggacattt aatggacact tgatagactt tgacaaggat ggagaccact
     2221 ttgaaagagt tggagggcag gattcagctg gtgatttgat gatccgaaac atccaactga
     2281 agcatgctgg gaagtatgtc tgcatggtcc aaacaagtgt agacaaactc tctgttgctg
     2341 cggacctgat tgtaagaggt cctccaggtc ctcctgaggc tgtgaccata gatgaaatca
     2401 cagacaccac tgctcagctt tcttggagac caggacctga caaccacagc cccatcacca
     2461 tgtatgttat ccaagctagg actccattct ccgtgggctg gcaagcagtc aatacagttc
     2521 cagatctcgt cgacgggaag acattcacag caactgtggt gggtttgaat ccttgggttg
     2581 aatatgaatt ccgcactgtt gcagctaatg tgattggcat tggggaaccc agccggccct
     2641 cagagaaacg gaggacagaa gaggctctcc ctgaagtcac cccggctaac gtcagtggtg
     2701 gtggaggcag caaatctgaa ctggttataa cctgggagac agtccctgag gaattacaga
     2761 atggcagagg ctttggttac gtggttgcct tccggccaca tggcaaaatg atctggatgc
     2821 tgaccgtgct ggcttcagct gatgcctcca gatacgtgtt caggaatgag agtgtgcgtc
     2881 cattctctcc ctttgaggtt aaagtgggtg tcttcaataa caaaggggaa ggccctttca
     2941 gtcccaccac gctggtgtat tctgctgaag aagaacccac caagccacca gccagtatct
     3001 ttgccaggag tctttctgcc acggatatcg aagttttctg ggcctcccct attggaaaga
     3061 acagaggacg gattcaaggt tatgaggtaa aatattggag acatgatgac aaggaagaaa
     3121 atgctaaaaa gatacgaaca gttggaaatc agacatccac aaaaatcacc aacttgaaag
     3181 gaagtgctct gtatcactta tctgtcaagg cgtataactc agctgggaca ggaccctcca
     3241 gtgcaacagt caatgtcacg accagaaagc caccaccaag ccaaccccct ggaaacatca
     3301 tatggaattc atcggactcc aaaattatcc tgaactggga tcaagtgaag gccctggata
     3361 atgagtcaga agtaaaagga tacaaagtct tgtacagatg gaacaggcaa agcagcacat
     3421 ctgtcattga aaccaacaag acatcagtgg agctttcatt acctttcgat gaagattaca
     3481 tcatagagat caagccattc agtgatggag gagatggcag cagcagtgag caaatccgaa
     3541 tcccaaagat atcaaattcc tatgcaagag gatcgggggc ttctacctcc aatgcgtgta
     3601 cgctgtcagc catcagtaca ataatgattt ctctcacagc caggtctagt ttatgacaaa
     3661 agttatctga aggacttgct atttataata taagcaacat ttagctagtt gttttgaaga
     3721 cacccagtac taagtaatat tgttgttcaa gtacatctta ttactggaaa aaaatgtttt
     3781 ttgcttcgtt aggaatggca ttatacagta cttcctcaaa gcaaatctag ctttgtctga
     3841 agtttctttg gaaactctgc aatgcactga agacatctgt aatatgatgt taccaaagca
     3901 gtttacatat gtccttatat gcatattttt tattatatat ttagtgtttt atagaatttt
     3961 ttaaagttaa catataatat agatattgtt tttttctttc ttcctctgct ataaaatgct
     4021 ctgggcaaca caaaccacac aattatgatt tgagccgatt tcctttaagg gcagagtttg
     4081 aaactcatca cagcaaatga attacaaatg acttgtacag ttttacaagg atccagtgtc
     4141 aaaacagctg gagactgggt ctgtaactca aggctgctgt atataaatta tcccttgaat
     4201 ggttaatgca ttgaatcgag tccccttgac atatgtgata tgttttccca ccctgttgtg
     4261 aattttcttg ttgaacacaa tttgagatgg tttcaggaac tacacatccc aaaagctaaa
     4321 cttcccagcc caagaggtac cttgtgcaat tctcccatcc ctgaacttag catcatctgg
     4381 taagacttta tttgagcatc gtctttgtag tagcattatc ttaggcattg aatttgaagt
     4441 tacatatcct gtagtaacat agatgaaaag ttactatagt caaacaagtc tttcatggca
     4501 taaaaggtaa ttttactctt tagacatatc tgttttgaat gtaaattttt taataattct
     4561 gtcaatgcat ttataatttc aaaatttctt atagataaca tgtgtaactg taatgataga
     4621 gcccttcttt tgaatgacaa taacatatgt aatttgaaat ttttttccta ttttagcaaa
     4681 tagctgctgc aaagaatttt acatataact ctataactat ccgtagtaca gatgtattgt
     4741 atcttgatgt ctctcccgtt ttgcagtagc tagtctggtt gctttataag ctttgcattc
     4801 tacatcttaa aatgatacaa tgaaagatgg caatattgac aaaccttatt cttacgaaaa
     4861 gaactattta ttacgatggg ggatgttttg taagctgaca agggtggaac ataaaaggca
     4921 atgagatttt ctataaagcg ttgcacatga aaacacacag tcaccttttt cttctttctt
     4981 ggagagctca cgattgcctg taatttgtca tttttgctta cacataacat agcctttcaa
     5041 cttgctaatt atattcatcc aataaaggca tcattgattc catttgtgta aaaattagga
     5101 tggtaacagg gaaaatattg tcagtatttc agctgtgttc ctttcttact ttgatatggc
     5161 atacttctat gttaaaatat gatttaaaat cacatgcaaa aaaatcaaca aagtaataaa
     5221 atgaatgaaa aaaactgata ccccaggtag ttcccaaccc cagtgtaaat gatatctacc
     5281 agtgatctag catatgtaat cttttttaaa ggtattgtta ataaatattc tgtcatttgt
     5341 aaaaatatct gccttctggg agcattattc tttcctgctt gtcagggaaa tttttagctt
     5401 acccttgtgc tagttacaac ttgggatcgt agggggacaa aaaagtctcg agctctggcc
     5461 ccaaaactag gtgacccaat tccaaatgtg actttgaaat tgacaaccct gaagacacca
     5521 tttcaaatcc cctttggaag catagaggag caaactcaag taacatatgt cttgaagctg
     5581 aggctagaat tttgtttttc ttggctagcc aagattttgt atatttgatc taagtatacc
     5641 tgttgttttc cctacccatt gccaaaatca taaaatctct ataatcttaa gcacgtaagg
     5701 cccttcttag tctacaatct cttactccta tatacagcca cactgagccc tacttgttcc
     5761 ctgaacactg cttgcttttg atctcacctc tgtgcctttc gggactcatg gctgttcctt
     5821 cttgaaatgt tttcctctct ctcgcaccca aatatcaatc atcctagggt tccaccaaca
     5881 ctccagctca tctatgaggt cttcccatat gtgtgacctt gtgatgtcct ccctctgaat
     5941 ttgctgcaac cttccattta gtatttcata gggtactact tttggaaata tcttgtactg
     6001 ttatcttgca tttgaaccta gctcttgtat tgttcctgac ttttctttga atgtatgcct
     6061 tgtcttccca actagattgt aagctccttg agggcaggga tattggtctt ctcttccatg
     6121 tactctgcat agtgcctagc acagtgcctt gcaataaata ttcattgatg aattga
//
