LOCUS       NM_001405430            5444 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus centlein, centrosomal protein (Cntln), transcript
            variant 3, mRNA.
ACCESSION   NM_001405430 XM_006538026
VERSION     NM_001405430.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5444)
  AUTHORS   Li,L., Li,J. and Yuan,L.
  TITLE     A direct interaction between CENTLEIN and RABIN8 is required for
            primary cilium formation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (9), 1434-1444 (2023)
   PUBMED   37475549
  REMARK    GeneRIF: A direct interaction between CENTLEIN and RABIN8 is
            required for primary cilium formation.
REFERENCE   2  (bases 1 to 5444)
  AUTHORS   Zhang,Y., Liu,C., Wu,B., Li,L., Li,W. and Yuan,L.
  TITLE     The missing linker between SUN5 and PMFBP1 in sperm head-tail
            coupling apparatus
  JOURNAL   Nat Commun 12 (1), 4926 (2021)
   PUBMED   34389728
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5444)
  AUTHORS   Jing,Z., Yin,H., Wang,P., Gao,J. and Yuan,L.
  TITLE     Centlein, a novel microtubule-associated protein stabilizing
            microtubules and involved in neurite formation
  JOURNAL   Biochem Biophys Res Commun 472 (2), 360-365 (2016)
   PUBMED   26915804
  REMARK    GeneRIF: Taken together, we propose that centlein is involved in MT
            stability and neuritogenesis in vivo.
REFERENCE   4  (bases 1 to 5444)
  AUTHORS   Makino,K., Umeda,K., Uezu,A., Hiragami,Y., Sakamoto,T., Ihn,H. and
            Nakanishi,H.
  TITLE     Identification and characterization of the novel centrosomal
            protein centlein
  JOURNAL   Biochem Biophys Res Commun 366 (4), 958-962 (2008)
   PUBMED   18086554
REFERENCE   5  (bases 1 to 5444)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470174.9, AL805906.7 and AL806524.10.
            
            On Apr 22, 2022 this sequence version replaced XM_006538026.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.6437.1,
                                           SRR13948564.3048640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               BX470174.9         70554-70988
            436-524             BX470174.9         74807-74895
            525-609             AL805906.7         28420-28504
            610-744             AL805906.7         37138-37272
            745-924             AL805906.7         37862-38041
            925-1058            AL805906.7         51993-52126
            1059-1221           AL805906.7         54725-54887
            1222-1419           AL805906.7         60186-60383
            1420-1572           AL805906.7         75491-75643
            1573-1698           AL805906.7         77317-77442
            1699-1820           AL805906.7         85785-85906
            1821-1940           AL805906.7         87267-87386
            1941-2041           AL805906.7         114650-114750
            2042-2133           AL805906.7         127165-127256
            2134-2666           AL805906.7         130466-130998
            2667-2844           AL805906.7         144040-144217
            2845-2938           AL805906.7         148342-148435
            2939-3162           AL805906.7         148519-148742
            3163-3354           AL805906.7         173499-173690
            3355-3452           AL806524.10        3196-3293
            3453-3579           AL806524.10        4795-4921
            3580-3717           AL806524.10        6704-6841
            3718-3903           AL806524.10        7160-7345
            3904-4089           AL806524.10        21711-21896
            4090-4167           AL806524.10        24888-24965
            4168-5444           AL806524.10        37088-38364
FEATURES             Location/Qualifiers
     source          1..5444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.2 cM"
     gene            1..5444
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /note="centlein, centrosomal protein"
                     /db_xref="GeneID:338349"
                     /db_xref="MGI:MGI:2443104"
     exon            1..435
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4269
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="centlein isoform 3"
                     /protein_id="NP_001392359.1"
                     /db_xref="GeneID:338349"
                     /db_xref="MGI:MGI:2443104"
                     /translation="MAARSPSSSPPPPPVRRSSRRSLRVGRGAEVHAVRSEASGLAGA
                     AREVVADKSDLLWRGEEGSGGRRGSGRAGAAVAPVASAPAGSWWPEGLSSEEAKATRS
                     QLLEEELSSLKEELALCQADKEFVWSLWRRLQATNPDLTQTVSLVVEREKQKSEAKDR
                     KVLEILQVKDSKIQELEQTESVLKQELHDLVKLKTLVDEENAFLRKELCDLQKKFKDK
                     SQEVKDAKECVQSKEEQNRLVIKNLEEENERLRTRCTDLLNDLEKLRNQEAHWRKEKH
                     SVDTRVKVLEENLIEAKKEIESAQTKYNVVSQQLNNKQAELLQKDMDITLIRKELQEL
                     QNVYKQNSAHTAQQADLIQQLQALNMDTQKVLRNQEDVHTAESMSYQKLYNELHMCFE
                     TTKSNEVMLRQSVVNLQGQLFQKEQENVKLKEKLEESQGTAPSLSPHDSDSSHSGKAP
                     LSTLETLMISQKSEIEYLQKKLKVANEKLMANRSCDQDFSEKGTEGKHKEPPVKRSRS
                     LSPKSSFMGSEELRKLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNY
                     RAVKEQLKQWEEDSGMAESRQMKRAEPHQLRQEDSDAVWNELAYFKRENQELMVQKMT
                     LQDELDELKMHMSIDKTTIQELNRCMAEKREEQLFRQHEDAEVKKSTPEKNEKAISEE
                     TLQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLL
                     RVSKDVEHDKSELQTKITALETEVTTLRRQVTEAKALRGKDEEVVCPEERAHRPTDKA
                     KSEMATTDVRARRCDCKTATTKVKFKAAKRKCSVGRHHTVLNHSIKVMSHVENLSKDG
                     WEDVSEGSSDSETQTFQNLGTIIVETSQNISPIEDGRNQKEIDQTEGSCAQQRAMQTY
                     SCEDIKAPQSISHNKNTKKMTFQKKSGSLQKSLHSALPARVNREKCKNLPAQKSSSST
                     ISLRERIVSLQQQNSLLQNARRAAEASAKEYKEANEKLLHQQQVSDHRFQTSRQTIKK
                     LTLDLAELRKEKEDLLKKVESSSDIMSLAEEVSRIMAPQIKVTTLGPSRSMDLEMKQL
                     QCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHERTSRMERDITMKRHLIEDLKF
                     RQKVNSESNESFNEMLETLEKKVKSLTEECSNKKVSVDSLKQRLNVAVKEKSQYEQMY
                     QKTKEELEKKDLKMSVLISKLNDTETAMAQIETAASEQLQGLALQSEQVLEGAQKKLL
                     SANEKIEEFTVFVKALVNELQSDVHGTRHQIRELKKMQKSRHACKTSTHKAQTLAASI
                     LNISRSDLEEILDTEDELEIEKTKIDIENDKEWMLYIQKLLEGQLPFASYLLEAVLEK
                     IKENKKLTEGYFTVMKDTK"
     exon            436..524
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            525..609
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..744
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..924
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1058
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1221
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1419
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1572
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1698
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1820
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1940
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2041
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2133
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2666
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2844
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2938
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3162
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3354
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3452
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3579
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3717
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3903
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4089
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4167
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..5444
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4813..4818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4833
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
     regulatory      5427..5432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5444
                     /gene="Cntln"
                     /gene_synonym="B430108F07Rik; D530005L17Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggccaggct ccccaggatg gggaagggaa ggtggagttt tcaagcggga acttgacccg
       61 ttaggcgccg cggccatggc ggcgcgctcg ccgtcttcct cgccgcctcc gcccccggtg
      121 cggcggtcca gccggcggtc cctgcgcgtc gggcgcggag ccgaagtgca cgctgtgcgc
      181 agcgaggcct cgggtctggc gggcgccgcg agggaggtcg tcgcggataa aagcgactta
      241 ctttggaggg gcgaagaagg gtcaggggga cggcgagggt cggggcgggc cggggccgct
      301 gtcgctcctg tcgccagcgc gcccgcgggt tcctggtggc cagagggcct ctcctcggag
      361 gaggcgaagg cgacgcgatc gcagctgctg gaggaagagc tgagcagcct aaaggaggag
      421 ctggccctgt gtcaggctga caaggaattt gtatggtctc tgtggaggcg tcttcaggca
      481 acaaacccag atctcactca aactgtcagt ttggttgtgg aaagagaaaa acagaaatct
      541 gaagccaaag acagaaaagt tctggaaatt ttacaagtca aagattctaa aatacaagaa
      601 ttggagcaga ctgaatctgt actaaaacag gaactacatg accttgtaaa actgaagact
      661 ctggttgatg aagaaaatgc tttcttgagg aaagaattat gtgatttaca gaagaaattt
      721 aaagataaaa gccaagaagt gaaggacgcc aaggagtgtg tacagagtaa agaagagcaa
      781 aacagattgg ttataaaaaa cctggaagag gaaaatgaga gattacgaac acgctgcact
      841 gacctgctaa atgacctgga gaaactgagg aaccaggaag cacactggag aaaagagaaa
      901 cacagtgtgg acacgagagt aaaggtcctt gaagaaaatt tgattgaagc aaagaaagaa
      961 attgagtcag cacagactaa atataatgtt gtgtcacaac agctgaataa caaacaggct
     1021 gaacttctcc aaaaagatat ggatattaca ttgatcagga aagagctgca ggagctgcag
     1081 aacgtgtaca agcagaacag tgcccacaca gcccagcaag cagacctgat ccagcagctc
     1141 caggctctca acatggacac gcagaaagtc ctgaggaacc aggaagacgt ccacacggcc
     1201 gagagcatgt cataccaaaa actttataat gaattacata tgtgttttga aactacaaaa
     1261 tcaaatgaag ttatgctccg acaaagtgtt gttaatcttc aaggccaact gtttcaaaaa
     1321 gaacaagaaa atgtaaaatt aaaagaaaaa cttgaggaat cacaaggaac agcaccctct
     1381 ttatcaccac acgacagtga ttcaagccac tcaggaaagg caccgttatc aaccttggaa
     1441 acattgatga tctcacagaa gtctgaaatt gaatatttac agaagaaact gaaagtggca
     1501 aacgaaaagt tgatggcgaa tagatcttgt gaccaggatt tctcagagaa ggggactgaa
     1561 ggaaaacaca aggaaccacc tgtgaaacgc tcaaggtctt tgtccccaaa gagcagtttc
     1621 atgggctccg aggagctaag gaagcttaaa aaggctgaaa gaaagattga aaacttggag
     1681 aagacgctac agctaaagag ccaagaaaat gatgagctaa gagatgccca tgaaaaacgc
     1741 aaggagagac tacagatgtt acacaccaac tacagggcag taaaagagca attaaaacag
     1801 tgggaagaag acagtggcat ggctgaatcc agacaaatga agcgagcaga gcctcaccag
     1861 ctccgacaag aagactctga tgctgtgtgg aacgaactgg catatttcaa aagagaaaac
     1921 caggagttga tggttcaaaa gatgactctt caagatgaat tggatgagct taaaatgcat
     1981 atgtccattg ataaaacaac aatacaggaa ttgaataggt gcatggcaga gaaaagagaa
     2041 gaacaactct ttagacagca tgaagacgct gaggtcaaga agagtactcc agagaagaat
     2101 gagaaagcaa tatcggaaga gacattacag aaggtcattg agttggaaaa tcggctaaaa
     2161 tcttttgaga aaaactcaag aaaattaaaa gaagagagta agagattaaa gaaagagaat
     2221 gatttcctta aatcccactt aaaacactat caagaagact cggaggcgag agagaaggag
     2281 ctagaacaac tactgagggt gagcaaagat gtagaacatg acaaaagtga gcttcaaaca
     2341 aaaatcactg ctctggagac agaagtcact accctgagga gacaagtgac agaagctaag
     2401 gctttgagag gcaaagatga agaggtggtg tgcccagagg aaagagcaca ccgcccaaca
     2461 gacaaagcta aatctgagat ggccaccaca gatgtgagag cccggcgctg tgactgcaag
     2521 acagccacta ccaaggtgaa atttaaagct gccaagagaa agtgctcagt gggtcgccac
     2581 cacacagttc tcaatcactc catcaaggtt atgagccacg tggagaacct cagcaaggac
     2641 ggctgggagg atgtgagtga aggcagcagt gattctgaaa cacaaacctt tcaaaatttg
     2701 ggaacaatta ttgtggaaac atcccagaat ataagcccta tcgaagatgg tagaaaccag
     2761 aaagaaattg accaaacaga aggcagctgt gctcaacaaa gagctatgca gacgtactca
     2821 tgtgaggaca tcaaggcccc gcagagtatt tctcataata agaacaccaa gaaaatgaca
     2881 tttcaaaaga agagtggaag cctgcagaag agcttgcaca gtgcccttcc tgccagagtt
     2941 aacagagaaa agtgcaaaaa tctacctgcc cagaaatcca gtagcagcac catttcatta
     3001 cgagaacgga tcgtatcctt gcagcaacag aacagtttgc ttcagaacgc caggagagca
     3061 gcagaggcgt ctgctaagga gtataaagaa gcgaacgaga agctcctcca tcaacagcag
     3121 gtcagcgatc accgattcca gaccagcaga cagacaataa agaagctcac tcttgattta
     3181 gctgaacttc gaaaagaaaa agaagatttg ttgaagaaag tggagtcttc atctgacatc
     3241 atgagcttgg cagaggaagt ttctaggata atggctccgc agataaaggt caccacactg
     3301 ggtccttcaa gaagcatgga tttggaaatg aagcaactgc agtgtaaact aaagaatgca
     3361 actaatgagc tcactaaaca gtcatcaaat gtgaagtctc tgagaatgga actcctggca
     3421 aaggatgacc acataaagga gatgcacgaa aggacgtctc gaatggagag ggatataacc
     3481 atgaaaagac acctgatcga ggacttgaaa tttcgacaga aagtaaattc agaaagtaat
     3541 gagagtttta atgaaatgtt agaaactctt gaaaaaaagg tgaagtcatt aactgaagaa
     3601 tgttccaaca agaaggtatc agtagattca ctaaagcaaa gacttaacgt tgctgtgaaa
     3661 gagaagtcac agtacgagca gatgtatcag aaaactaaag aggagctaga aaaaaaggat
     3721 ctcaagatga gtgtcctgat atcaaaacta aatgacacag agacagccat ggctcagatt
     3781 gagacggcgg cttcagagca gctccagggc ttagcactgc agagcgagca ggtcctggaa
     3841 ggcgcgcaga agaagctgct gtccgccaat gagaagattg aagagttcac cgtctttgtg
     3901 aaggctttgg tcaatgagtt acaaagtgat gtccatggga caagacatca aatcagagag
     3961 cttaagaaga tgcaaaaaag cagacatgct tgtaaaacct caacgcataa agcccagacc
     4021 ttggcagctt ccatcctgaa catctcacgg tcagacctag aggagatact ggacaccgag
     4081 gatgaactgg aaattgagaa gacaaagata gacattgaaa atgacaagga gtggatgttg
     4141 tacattcaga aacttcttga aggacagctt ccgtttgcat catatttact cgaagcagta
     4201 ctggagaaaa taaaggaaaa caagaaacta actgaaggat atttcacagt gatgaaagac
     4261 actaaataaa attaaagtag agctattttc aaatacaaga acttcatgtg ctgtggttgt
     4321 aaacagtcca gatacagtat ctgctccagc tagcaatggg cagctccagc caaataaaaa
     4381 gctgctgaaa ctgattgctg aacaaatgaa gttgactaag tgcatagcca cataaaaggg
     4441 aaggctagca tttgaatgtt ggatgttgtc ccaatcaatg caaacttaaa aatggttttc
     4501 ctcccagtac ataagaagaa aacaaaacaa gtttgtcaca aactacacag attggtctga
     4561 gtataaaata aaaagttata aataaaggac taaatataaa ttttatataa aaactagact
     4621 tttctataaa actgttgtaa atgtgattca gtgaacaaca tctttgtgtg gtgagaaaat
     4681 atgcagtgaa ttgtgctaat atcaaagagg ggcactgagt gaagcttact gtatgcttcc
     4741 attgtaccag ttctcattga catactggat tatacgggag atactctgtt tttctagaac
     4801 tgtctggaaa aaaataaaaa catttctctc ctttgtctgc ttgtgcagtt atataaatca
     4861 gcagggccag aaccccaatg tataatgttg ggctagacca agcagagctc ataccatgct
     4921 gtctaattaa caatgccttc tcactgtggt gggaacactg tgtgtagttg ttaaccattc
     4981 ttctcctttt gtgtcctcac tgagttcttg ccacacattc ttggagcctc tgagtcactg
     5041 aacttgctcc tctatacttg cagttggttc tgtctttgta gaatactctg tgtgtaactg
     5101 tacgcatacc tgtcttctca tcatccagtt tcactttagc agttccatca tggcatagtc
     5161 tctgaaaatc ctactagcaa catgaaatca cctgttttta atatgctcac tcttttgctt
     5221 tatggttgat cctcatttac tcctttagaa tatagatccc atgagattaa ggtaggtgat
     5281 ggcaaattaa gacccatagc caaatcttgc ctgccatcta cttttatata gttcacagac
     5341 tgattttttt ctattttatt aaactgttta aaaacaatac tttgtagcat gtaaaatcat
     5401 atgaaatcca attttaatgt tttatcaata aagatttatt gtga
//
