LOCUS       NM_001379216            3579 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ciliary neurotrophic factor receptor (Cntfr),
            transcript variant 8, mRNA.
ACCESSION   NM_001379216 XM_017319941
VERSION     NM_001379216.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Dobrowolski,M., Cave,C., Levy-Myers,R., Lee,C., Park,S., Choi,B.R.,
            Xiao,B., Yang,W. and Sockanathan,S.
  TITLE     GDE3 regulates oligodendrocyte precursor proliferation via release
            of soluble CNTFRalpha
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31932351
  REMARK    GeneRIF: These studies uncover new physiological roles for GDE3 in
            gliogenesis and identify GDE3 as a key regulator of CNTF-dependent
            regulation of oligodendrocyte precursor proliferation through
            release of CNTFRalpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Lee,N., Wanek,H.A. and MacLennan,A.J.
  TITLE     Muscle ciliary neurotrophic factor receptor alpha helps maintain
            choline acetyltransferase levels in denervated motor neurons
            following peripheral nerve lesion
  JOURNAL   Exp Neurol 317, 202-205 (2019)
   PUBMED   30902524
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Lee,N., Spearry,R.P., Rydyznski,C.E. and MacLennan,A.J.
  TITLE     Muscle ciliary neurotrophic factor receptor alpha contributes to
            motor neuron STAT3 activation following peripheral nerve lesion
  JOURNAL   Eur J Neurosci 49 (9), 1084-1090 (2019)
   PUBMED   30554447
  REMARK    GeneRIF: The present data add to the evidence suggesting that
            enhancing muscle CNTFRalpha expression may promote motor neuron
            regeneration in trauma and disease.
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   DeChiara,T.M., Vejsada,R., Poueymirou,W.T., Acheson,A., Suri,C.,
            Conover,J.C., Friedman,B., McClain,J., Pan,L., Stahl,N., Ip,N.Y.
            and Yancopoulos,G.D.
  TITLE     Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit
            profound motor neuron deficits at birth
  JOURNAL   Cell 83 (2), 313-322 (1995)
   PUBMED   7585948
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Valenzuela,D.M., Stitt,T.N., DiStefano,P.S., Rojas,E., Mattsson,K.,
            Compton,D.L., Nunez,L., Park,J.S., Stark,J.L., Gies,D.R. et al.
  TITLE     Receptor tyrosine kinase specific for the skeletal muscle lineage:
            expression in embryonic muscle, at the neuromuscular junction, and
            after injury
  JOURNAL   Neuron 15 (3), 573-584 (1995)
   PUBMED   7546737
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Valenzuela,D.M., Rojas,E., Le Beau,M.M., Espinosa,R. 3rd,
            Brannan,C.I., McClain,J., Masiakowski,P., Ip,N.Y., Copeland,N.G.,
            Jenkins,N.A. et al.
  TITLE     Genomic organization and chromosomal localization of the human and
            mouse genes encoding the alpha receptor component for ciliary
            neurotrophic factor
  JOURNAL   Genomics 25 (1), 157-163 (1995)
   PUBMED   7774913
REFERENCE   9  (bases 1 to 3579)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   10 (bases 1 to 3579)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL831723.9.
            
            On Mar 25, 2020 this sequence version replaced XM_017319941.1.
            
            Summary: This gene encodes the alpha subunit of the ciliary
            neurotrophic factor (CNTF) receptor that triggers the assembly of a
            trimolecular complex upon binding to CNTF, and initiate a
            downstream signaling process. The encoded preproprotein undergoes
            proteolytic processing to generate a
            glycosylphosphatidylinositol-linked cell surface protein. Mice
            lacking the encoded protein die shortly after birth and exhibit a
            reduction of motoneuron number at birth. The transgenic disruption
            of this gene specifically in the skeletal muscle followed by a
            peripheral nerve lesion impairs motor neuron axonal regeneration
            across the lesion site. Alternative splicing of this gene results
            in multiple transcript variants. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.113650.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1718              AL831723.9         213472-215189       c
            1719-1808           AL831723.9         212806-212895       c
            1809-1893           AL831723.9         201029-201113       c
            1894-2127           AL831723.9         196852-197085       c
            2128-2245           AL831723.9         189549-189666       c
            2246-2412           AL831723.9         189211-189377       c
            2413-2576           AL831723.9         187982-188145       c
            2577-2757           AL831723.9         184790-184970       c
            2758-2926           AL831723.9         184250-184418       c
            2927-3579           AL831723.9         183509-184161       c
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.81 cM"
     gene            1..3579
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="ciliary neurotrophic factor receptor"
                     /db_xref="GeneID:12804"
                     /db_xref="MGI:MGI:99605"
     exon            1..1718
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1808
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             1809..2927
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="ciliary neurotrophic factor receptor subunit alpha;
                     CNTF receptor subunit alpha"
                     /codon_start=1
                     /product="ciliary neurotrophic factor receptor subunit
                     alpha preproprotein"
                     /protein_id="NP_001366145.1"
                     /db_xref="GeneID:12804"
                     /db_xref="MGI:MGI:99605"
                     /translation="MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGADVTL
                     PCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVL
                     LHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPAL
                     KNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSN
                     PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEY
                     IIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKI
                     CDPGELGSGGGPSILFLTSVPVTLVLAAAAATANNLLI"
     exon            1809..1893
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2127
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2245
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2412
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2576
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2757
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2926
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3579
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3558..3563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="hexamer: ATTAAA"
     polyA_site      3579
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagctg taattacagg gcatttatta ttaatcagat gagattgttg gaagcagctg
       61 gtgtaatgtg cgtggagata ctgcatgctt cccccaacac acgtacacac gcacatacat
      121 gtcacacaca gcctaagtct gacttgtttt ttgttttctt gtgaaggtca gatgggtcta
      181 taattatcta ttccgctgtg tgtcagtgtg tatctgtctg tgttttcatg tagcctgtcc
      241 cctctctact gccattgtct ttatttcaag ctacctgtca ttctttggcc tgatgtctgt
      301 ctgccttccc tctatctccc tgcttttggg cctgtgtctt ggtgtgttgg tatctgtcac
      361 caccagccag cctgtctctc taacacactg ttttcgttac tggccttctc ttgttagtga
      421 tggttctggt ttctgggcag ggttccatga cagagtccct tttctttctc atgagtgtgc
      481 atgtaggccc ctaatcatac ctttggcaga tttactctgg gacctgttga ggaagcagtt
      541 agacccttaa tatctcctgg ggacttgtag aaggtgaggg gtctattgag tggtcagaat
      601 tcattgaagg ttttctgaag tcccagggcc cttgccagtg gccatttgca ccgtttggga
      661 agaacagctt ttgctgtctc agtgttctca ctactgagta gaaataaggc tacctcagaa
      721 tgttgttttg atgatttggc acaaaaatgt aagttaagga gctggagaga tgactcagcg
      781 gtgaagagca ctaacttgct cctgcaaagg acccaggttc ggatcccagg acccacatgg
      841 cttgtaactt cagctaaagg gatctgacac ccctgacact tctgcagcct cctgcacaca
      901 tgtggtgcac acacacacac acacttagga acatgcacat acacaacata cagttttgtt
      961 tttaaatgta acttaagggt tgttctggca gaggacccag gttcaattcc caggacccac
     1021 atggcggctc ctgtaactcc agttctgggc atccaaaccc ctcctccgat ctccaagggc
     1081 accgtgtgct catatgatgt acatgtgtac aagcaaaaca catacatata cccagacaga
     1141 gtactcatgc acataaggta agtaagaata aaggaagggt gtgtgtacgt taagctgggt
     1201 gtaggggcaa acactttgac ttccctgagg caggggccag aaaatctcta atctatacag
     1261 ggagagcctg tctaaggggg taaattagcc gtcagttagg acttaatgta aaaactgcag
     1321 agccaaggac ctgggcagtt gtgagctgat gctgcagata ggcttaatga gttagcatgg
     1381 gtccagcacg accgaaaaga ataaataccc ttagcactgt gtaagtgggt aagagctaca
     1441 gaggcaggct ggcatggaaa ggtggagggg ggaggggtac ggattccgtt ctgggctcca
     1501 ggagtggtca gacctacagt cttgtgtaag ttatttaata tctttgaatg ccagggtttt
     1561 tttgtttgtt tgcttgtttg tttgtttgtt tgtttgtttg ctgtcaagtg gcaattacgt
     1621 tagcacccat ctcatggagg gatcaccaag aagagaggat gctgcaaata tggctgctta
     1681 aacaattccg gcacatgctg gatgctcagg aagtcacgaa ccctgccccg tcacatcatc
     1741 ccaggaagac tttggtctgg agaggaggat aatattgatg tgtgtggaga acagctggtg
     1801 gtaacgagat ggctgcttct gtcccatggg cctgctgtgc tgtgcttgcc gctgccgccg
     1861 ccgctgtcta cacgcagaaa cacagtccac aggaggcacc ccacgtgcag tatgagcgtc
     1921 tgggcgcaga tgtgacgctg ccgtgtggga cagcgagctg ggacgcagct gtgacatgga
     1981 gggtaaacgg gacagatctg gcccctgacc tgctcaacgg ctctcagctg atactgcgaa
     2041 gcttagaact gggccacagt ggcctatacg cctgtttcca ccgtgactcc tggcacctgc
     2101 gccaccaagt ccttctacat gtgggtttgc cgccgcggga gcctgtgctc agctgccgct
     2161 ccaacactta ccccaagggc ttctactgca gctggcacct gcccaccccc acctacatcc
     2221 ccaatacctt caatgtgact gtgctgcatg gctccaaaat tatggtctgt gagaaggacc
     2281 cagccctcaa gaaccgctgc cacattcggt acatgcacct gttctcaacc atcaagtaca
     2341 aggtctccat aagtgtcagc aacgccttgg gtcacaacac tacggccatc acctttgacg
     2401 aattcaccat tgtgaagcct gatcctccag aaaacgtggt ggcccggcca gtgcccagca
     2461 acccccgtcg gctggaggtg acatggcaga caccctcaac ttggcccgac cctgaatcct
     2521 ttcctctcaa gttcttcctg cgctaccggc ctctcatcct ggaccaatgg cagcatgtgg
     2581 agctctcgga tggcacagca cacaccatca cagatgccta cgcagggaag gaatacatca
     2641 tccaggtggc agccaaggac aatgagattg ggacatggag tgactggagc gtggctgctc
     2701 acgccacacc ctggactgag gaacctcggc atctcacaac agaagcccag gcccccgaga
     2761 ccacgaccag caccaccagc tcattggcac ccccacccac cacgaagatc tgtgaccctg
     2821 gggagcttgg cagcggcgga ggaccctcca tactcttctt gaccagtgtc ccagtcactc
     2881 tggtcctggc tgccgctgct gccacagcca acaatctcct gatctgagcc ctgcatccca
     2941 cgaggacatg ccagagcgcc tgcggaggag caggaggccg gagctgagcc tgcagacccc
     3001 ggtttctatt ttgcacacgg gcaggaggac cttttgcatt ctcttcagac acaatttgta
     3061 gagaccccgg caggcccggg cctgccttcc gtccccccag cctcatctca ccaagccggc
     3121 cctcctttcc atccagagag gaggaccatg cagctaaccc acccaccaaa gacccctctc
     3181 atctttcccc cctcgggctg gaccctccaa cgccagcgac tcccaggagc ccttggggga
     3241 cctgagggga gcccccaccc cacatccaca gttttctcct cctgccccag cctcctgtct
     3301 gtcccagggt ctttgttgcc accatcagat tataagctcc tgacactggg ggggcccagc
     3361 catccccctc cccccggtgc ccacactttt cagtccttcc acctttgccc ctgttttgta
     3421 cgatcctcca ttggcccttt cctacccccc agtatttaat gtcctgtcag tcccttctag
     3481 tctgactcaa tggtaacttg ctgtatttga attttttata gatgtatata catgggaggg
     3541 aggggtaggg agttctcatt aaacgtcacc atttcatga
//
