LOCUS       NM_001379213            1968 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ciliary neurotrophic factor receptor (Cntfr),
            transcript variant 5, mRNA.
ACCESSION   NM_001379213 XM_006537599
VERSION     NM_001379213.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Dobrowolski,M., Cave,C., Levy-Myers,R., Lee,C., Park,S., Choi,B.R.,
            Xiao,B., Yang,W. and Sockanathan,S.
  TITLE     GDE3 regulates oligodendrocyte precursor proliferation via release
            of soluble CNTFRalpha
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31932351
  REMARK    GeneRIF: These studies uncover new physiological roles for GDE3 in
            gliogenesis and identify GDE3 as a key regulator of CNTF-dependent
            regulation of oligodendrocyte precursor proliferation through
            release of CNTFRalpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Lee,N., Wanek,H.A. and MacLennan,A.J.
  TITLE     Muscle ciliary neurotrophic factor receptor alpha helps maintain
            choline acetyltransferase levels in denervated motor neurons
            following peripheral nerve lesion
  JOURNAL   Exp Neurol 317, 202-205 (2019)
   PUBMED   30902524
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Lee,N., Spearry,R.P., Rydyznski,C.E. and MacLennan,A.J.
  TITLE     Muscle ciliary neurotrophic factor receptor alpha contributes to
            motor neuron STAT3 activation following peripheral nerve lesion
  JOURNAL   Eur J Neurosci 49 (9), 1084-1090 (2019)
   PUBMED   30554447
  REMARK    GeneRIF: The present data add to the evidence suggesting that
            enhancing muscle CNTFRalpha expression may promote motor neuron
            regeneration in trauma and disease.
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   DeChiara,T.M., Vejsada,R., Poueymirou,W.T., Acheson,A., Suri,C.,
            Conover,J.C., Friedman,B., McClain,J., Pan,L., Stahl,N., Ip,N.Y.
            and Yancopoulos,G.D.
  TITLE     Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit
            profound motor neuron deficits at birth
  JOURNAL   Cell 83 (2), 313-322 (1995)
   PUBMED   7585948
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Valenzuela,D.M., Stitt,T.N., DiStefano,P.S., Rojas,E., Mattsson,K.,
            Compton,D.L., Nunez,L., Park,J.S., Stark,J.L., Gies,D.R. et al.
  TITLE     Receptor tyrosine kinase specific for the skeletal muscle lineage:
            expression in embryonic muscle, at the neuromuscular junction, and
            after injury
  JOURNAL   Neuron 15 (3), 573-584 (1995)
   PUBMED   7546737
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Valenzuela,D.M., Rojas,E., Le Beau,M.M., Espinosa,R. 3rd,
            Brannan,C.I., McClain,J., Masiakowski,P., Ip,N.Y., Copeland,N.G.,
            Jenkins,N.A. et al.
  TITLE     Genomic organization and chromosomal localization of the human and
            mouse genes encoding the alpha receptor component for ciliary
            neurotrophic factor
  JOURNAL   Genomics 25 (1), 157-163 (1995)
   PUBMED   7774913
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL831723.9.
            
            On Mar 27, 2020 this sequence version replaced XM_006537599.4.
            
            Summary: This gene encodes the alpha subunit of the ciliary
            neurotrophic factor (CNTF) receptor that triggers the assembly of a
            trimolecular complex upon binding to CNTF, and initiate a
            downstream signaling process. The encoded preproprotein undergoes
            proteolytic processing to generate a
            glycosylphosphatidylinositol-linked cell surface protein. Mice
            lacking the encoded protein die shortly after birth and exhibit a
            reduction of motoneuron number at birth. The transgenic disruption
            of this gene specifically in the skeletal muscle followed by a
            peripheral nerve lesion impairs motor neuron axonal regeneration
            across the lesion site. Alternative splicing of this gene results
            in multiple transcript variants. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.2449764.1,
                                           SRR7345562.3379813.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AL831723.9         221623-221729       c
            108-197             AL831723.9         212806-212895       c
            198-282             AL831723.9         201029-201113       c
            283-516             AL831723.9         196852-197085       c
            517-634             AL831723.9         189549-189666       c
            635-801             AL831723.9         189211-189377       c
            802-965             AL831723.9         187982-188145       c
            966-1146            AL831723.9         184790-184970       c
            1147-1315           AL831723.9         184250-184418       c
            1316-1968           AL831723.9         183509-184161       c
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.81 cM"
     gene            1..1968
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="ciliary neurotrophic factor receptor"
                     /db_xref="GeneID:12804"
                     /db_xref="MGI:MGI:99605"
     exon            1..107
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            108..197
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1316
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="ciliary neurotrophic factor receptor subunit alpha;
                     CNTF receptor subunit alpha"
                     /codon_start=1
                     /product="ciliary neurotrophic factor receptor subunit
                     alpha preproprotein"
                     /protein_id="NP_001366142.1"
                     /db_xref="GeneID:12804"
                     /db_xref="MGI:MGI:99605"
                     /translation="MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGADVTL
                     PCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVL
                     LHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPAL
                     KNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSN
                     PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEY
                     IIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKI
                     CDPGELGSGGGPSILFLTSVPVTLVLAAAAATANNLLI"
     exon            198..282
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            283..516
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            517..634
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            635..801
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            802..965
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1146
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1315
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1968
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="hexamer: ATTAAA"
     polyA_site      1968
                     /gene="Cntfr"
                     /gene_synonym="Cntfralpha"
                     /note="major polyA site"
ORIGIN      
        1 cgtgccgcgc gtgccaggcg cgggaacgtg ccaaagcgga ggcgcgcggg ggccgtggcg
       61 gggagggggg gtcgtggtgc gcggcagcgg aggcgcgggg agacaagaac cctgccccgt
      121 cacatcatcc caggaagact ttggtctgga gaggaggata atattgatgt gtgtggagaa
      181 cagctggtgg taacgagatg gctgcttctg tcccatgggc ctgctgtgct gtgcttgccg
      241 ctgccgccgc cgctgtctac acgcagaaac acagtccaca ggaggcaccc cacgtgcagt
      301 atgagcgtct gggcgcagat gtgacgctgc cgtgtgggac agcgagctgg gacgcagctg
      361 tgacatggag ggtaaacggg acagatctgg cccctgacct gctcaacggc tctcagctga
      421 tactgcgaag cttagaactg ggccacagtg gcctatacgc ctgtttccac cgtgactcct
      481 ggcacctgcg ccaccaagtc cttctacatg tgggtttgcc gccgcgggag cctgtgctca
      541 gctgccgctc caacacttac cccaagggct tctactgcag ctggcacctg cccaccccca
      601 cctacatccc caataccttc aatgtgactg tgctgcatgg ctccaaaatt atggtctgtg
      661 agaaggaccc agccctcaag aaccgctgcc acattcggta catgcacctg ttctcaacca
      721 tcaagtacaa ggtctccata agtgtcagca acgccttggg tcacaacact acggccatca
      781 cctttgacga attcaccatt gtgaagcctg atcctccaga aaacgtggtg gcccggccag
      841 tgcccagcaa cccccgtcgg ctggaggtga catggcagac accctcaact tggcccgacc
      901 ctgaatcctt tcctctcaag ttcttcctgc gctaccggcc tctcatcctg gaccaatggc
      961 agcatgtgga gctctcggat ggcacagcac acaccatcac agatgcctac gcagggaagg
     1021 aatacatcat ccaggtggca gccaaggaca atgagattgg gacatggagt gactggagcg
     1081 tggctgctca cgccacaccc tggactgagg aacctcggca tctcacaaca gaagcccagg
     1141 cccccgagac cacgaccagc accaccagct cattggcacc cccacccacc acgaagatct
     1201 gtgaccctgg ggagcttggc agcggcggag gaccctccat actcttcttg accagtgtcc
     1261 cagtcactct ggtcctggct gccgctgctg ccacagccaa caatctcctg atctgagccc
     1321 tgcatcccac gaggacatgc cagagcgcct gcggaggagc aggaggccgg agctgagcct
     1381 gcagaccccg gtttctattt tgcacacggg caggaggacc ttttgcattc tcttcagaca
     1441 caatttgtag agaccccggc aggcccgggc ctgccttccg tccccccagc ctcatctcac
     1501 caagccggcc ctcctttcca tccagagagg aggaccatgc agctaaccca cccaccaaag
     1561 acccctctca tctttccccc ctcgggctgg accctccaac gccagcgact cccaggagcc
     1621 cttgggggac ctgaggggag cccccacccc acatccacag ttttctcctc ctgccccagc
     1681 ctcctgtctg tcccagggtc tttgttgcca ccatcagatt ataagctcct gacactgggg
     1741 gggcccagcc atccccctcc ccccggtgcc cacacttttc agtccttcca cctttgcccc
     1801 tgttttgtac gatcctccat tggccctttc ctacccccca gtatttaatg tcctgtcagt
     1861 cccttctagt ctgactcaat ggtaacttgc tgtatttgaa ttttttatag atgtatatac
     1921 atgggaggga ggggtaggga gttctcatta aacgtcacca tttcatga
//
