LOCUS       NM_170786               1205 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ciliary neurotrophic factor (Cntf), mRNA.
ACCESSION   NM_170786
VERSION     NM_170786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1205)
  AUTHORS   Gadomski,S., Fielding,C., Garcia-Garcia,A., Korn,C., Kapeni,C.,
            Ashraf,S., Villadiego,J., Toro,R.D., Domingues,O., Skepper,J.N.,
            Michel,T., Zimmer,J., Sendtner,R., Dillon,S., Poole,K.E.S.,
            Holdsworth,G., Sendtner,M., Toledo-Aral,J.J., De Bari,C.,
            McCaskie,A.W., Robey,P.G. and Mendez-Ferrer,S.
  TITLE     A cholinergic neuroskeletal interface promotes bone formation
            during postnatal growth and exercise
  JOURNAL   Cell Stem Cell 29 (4), 528-544 (2022)
   PUBMED   35276096
REFERENCE   3  (bases 1 to 1205)
  AUTHORS   Jia,C., Oliver,J., Gilmer,D., Lovins,C., Rodriguez-Gil,D.J. and
            Hagg,T.
  TITLE     Inhibition of focal adhesion kinase increases adult olfactory stem
            cell self-renewal and neuroregeneration through ciliary
            neurotrophic factor
  JOURNAL   Stem Cell Res 49, 102061 (2020)
   PUBMED   33130470
REFERENCE   4  (bases 1 to 1205)
  AUTHORS   Hu,Z., Deng,N., Liu,K., Zhou,N., Sun,Y. and Zeng,W.
  TITLE     CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across
            Schwann Cell-Neuron-Microglia
  JOURNAL   Cell Rep 31 (7), 107657 (2020)
   PUBMED   32433966
REFERENCE   5  (bases 1 to 1205)
  AUTHORS   Zheng,K., Zhang,Q., Sheng,Z., Li,Y. and Lu,H.H.
  TITLE     Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from
            Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of
            Akt-Nrf2 Signaling
  JOURNAL   Cell Physiol Biochem 51 (4), 1852-1862 (2018)
   PUBMED   30504707
  REMARK    GeneRIF: CNTF activates Akt-Nrf2 signaling to protect myocardial
            cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation.
REFERENCE   6  (bases 1 to 1205)
  AUTHORS   DeChiara,T.M., Vejsada,R., Poueymirou,W.T., Acheson,A., Suri,C.,
            Conover,J.C., Friedman,B., McClain,J., Pan,L., Stahl,N., Ip,N.Y.
            and Yancopoulos,G.D.
  TITLE     Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit
            profound motor neuron deficits at birth
  JOURNAL   Cell 83 (2), 313-322 (1995)
   PUBMED   7585948
REFERENCE   7  (bases 1 to 1205)
  AUTHORS   Cook,S.A., Johnson,K.R., Bronson,R.T. and Davisson,M.T.
  TITLE     Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19
            that causes motor neuron degeneration
  JOURNAL   Mamm Genome 6 (3), 187-191 (1995)
   PUBMED   7749225
REFERENCE   8  (bases 1 to 1205)
  AUTHORS   Fantuzzi,G., Benigni,F., Sironi,M., Conni,M., Carelli,M.,
            Cantoni,L., Shapiro,L., Dinarello,C.A., Sipe,J.D. and Ghezzi,P.
  TITLE     Ciliary neurotrophic factor (CNTF) induces serum amyloid A,
            hypoglycaemia and anorexia, and potentiates IL-1 induced
            corticosterone and IL-6 production in mice
  JOURNAL   Cytokine 7 (2), 150-156 (1995)
   PUBMED   7780034
REFERENCE   9  (bases 1 to 1205)
  AUTHORS   Ikeda,K., Wong,V., Holmlund,T.H., Greene,T., Cedarbaum,J.M.,
            Lindsay,R.M. and Mitsumoto,H.
  TITLE     Histometric effects of ciliary neurotrophic factor in wobbler mouse
            motor neuron disease
  JOURNAL   Ann Neurol 37 (1), 47-54 (1995)
   PUBMED   7818257
REFERENCE   10 (bases 1 to 1205)
  AUTHORS   Taylor,L.E., Bennett,G.D. and Finnell,R.H.
  TITLE     Altered gene expression in murine branchial arches following in
            utero exposure to retinoic acid
  JOURNAL   J Craniofac Genet Dev Biol 15 (1), 13-25 (1995)
   PUBMED   7601910
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC027539.1, W08735.1 and
            BQ033243.1.
            
            On Mar 28, 2006 this sequence version replaced NM_170786.1.
            
            Summary: The protein encoded by this gene is a polypeptide hormone
            whose actions appear to be restricted to the nervous system where
            it promotes neurotransmitter synthesis and neurite outgrowth in
            certain neuronal populations. The protein is a potent survival
            factor for neurons and oligodendrocytes, and it may be involved in
            reducing tissue destruction during inflammatory attacks. A
            read-through transcript variant composed of Zfp91 and Cntf
            sequences has been identified, but it is thought to be non-coding.
            Read-through transcription of Zfp91 and Cntf has been observed in
            both human and mouse. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027539.1, SRR1660819.15948.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BC027539.1         1-49
            50-93               W08735.1           2-45
            94-1073             BC027539.1         93-1072
            1074-1205           BQ033243.1         18-149              c
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.73 cM"
     gene            1..1205
                     /gene="Cntf"
                     /note="ciliary neurotrophic factor"
                     /db_xref="GeneID:12803"
                     /db_xref="MGI:MGI:88439"
     exon            1..352
                     /gene="Cntf"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..835
                     /gene="Cntf"
                     /codon_start=1
                     /product="ciliary neurotrophic factor"
                     /protein_id="NP_740756.1"
                     /db_xref="CCDS:CCDS29637.1"
                     /db_xref="GeneID:12803"
                     /db_xref="MGI:MGI:88439"
                     /translation="MAFAEQSPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGL
                     NKNISLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTE
                     GDFHQAIHTLTLQVSAFAYQLEELMALLEQKVPEKEADGMPVTIGDGGLFEKKLWGLK
                     VLQELSQWTVRSIHDLRVISSHHMGISAHESHYGAKQM"
     exon            353..1205
                     /gene="Cntf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1045..1050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntf"
                     /note="hexamer: AATAAA"
     polyA_site      1067
                     /gene="Cntf"
                     /note="major polyA site"
     regulatory      1184..1189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cntf"
                     /note="hexamer: AATAAA"
     polyA_site      1205
                     /gene="Cntf"
                     /note="major polyA site"
ORIGIN      
        1 cgcttcgagg gaaaaaaaaa aagactgatt aaaagggccc tttgattcca caggcacaaa
       61 atccacagcc aggaatttgc tgccacctct gagtcaggca gggggtgggg atgggggtgc
      121 acaatcccat tagagaatgc ccagtagatt tagtctgtgg gagtcacatt tcttatttgg
      181 actagtgaag acagaagcaa accagctcac ttgtttcctg ggacagttga tttaggggat
      241 ggctttcgca gagcaatcac ctctgaccct tcaccgccgg gacctctgta gccgctctat
      301 ctggctagca aggaagattc gttcagacct gactgctctt atggaatctt atgtaaaaca
      361 tcaaggcctg aataaaaata tcagccttga ctcagtggat ggtgtaccag tggcaagcac
      421 tgatcgctgg agtgagatga ctgaggcaga gcgactccaa gagaacctcc aggcttaccg
      481 taccttccaa gggatgttaa ccaagctttt agaagaccag agagtgcatt tcaccccgac
      541 tgaaggtgac ttccatcagg caatacatac tcttacgctc caagtttctg ccttcgccta
      601 ccagctagag gagttaatgg cgcttctgga acagaaggtc cctgaaaaag aggctgatgg
      661 gatgcctgtc acaattggag atggtggcct ctttgagaag aagctgtggg gcttgaaggt
      721 ccttcaagag ctttcacagt ggactgtgag gtctatccat gacctccgtg tcatttcttc
      781 tcatcacatg ggaatctcag cacatgagag ccattatggg gccaagcaaa tgtagctctt
      841 aactcttgcc tctgtctccc tctttgatct aatgggatat cagtagttcc ccaggggcct
      901 agttttctca gcatcaattt tggaaaacct tagaccacag gcatatttcg tcaagtaggg
      961 ttgacccacg tatgaacaga agataaacat ggttattctg gctgtgcata tgtgtgtaca
     1021 tgattttgtt tgtattggtg gtataataaa gtataattag ggcattatcc ttccacctta
     1081 gtgctttacc cttcctgata ctaaataacc tttccaggtg tttaacagtc ttacaggcag
     1141 aagagacatt gtgactagtt ttggttgact tctgaaaaga ctgaataaac aaattggaag
     1201 tccta
//
