LOCUS       NM_009924               4084 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus cannabinoid receptor 2 (Cnr2), transcript variant 1,
            mRNA.
ACCESSION   NM_009924
VERSION     NM_009924.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4084)
  AUTHORS   Kwon,E.K., Choi,Y., Sim,S., Ye,Y.M., Shin,Y.S., Park,H.S. and
            Ban,G.Y.
  TITLE     Cannabinoid receptor 2 as a regulator of inflammation induced
            oleoylethanolamide in eosinophilic asthma
  JOURNAL   J Allergy Clin Immunol 153 (4), 998-1009 (2024)
   PUBMED   38061443
  REMARK    GeneRIF: Cannabinoid receptor 2 as a regulator of inflammation
            induced oleoylethanolamide in eosinophilic asthma.
REFERENCE   2  (bases 1 to 4084)
  AUTHORS   Fan,D.Y., Zhai,H.Y., Zhao,Y., Qiao,X., Zhu,D.C., Liu,H.J. and
            Liu,C.
  TITLE     The role of cannabinoid receptor 2 in bone remodeling during
            orthodontic tooth movement
  JOURNAL   BMC Oral Health 24 (1), 23 (2024)
   PUBMED   38178129
  REMARK    GeneRIF: The role of cannabinoid receptor 2 in bone remodeling
            during orthodontic tooth movement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4084)
  AUTHORS   Rodriguez-Serrano,L.M. and Chavez-Hernandez,M.E.
  TITLE     Role of the CB2 Cannabinoid Receptor in the Regulation of Food
            Intake: A Systematic Review
  JOURNAL   Int J Mol Sci 24 (24), 17516 (2023)
   PUBMED   38139344
  REMARK    GeneRIF: Role of the CB2 Cannabinoid Receptor in the Regulation of
            Food Intake: A Systematic Review.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4084)
  AUTHORS   Hasegawa,Y., Kim,J., Ursini,G., Jouroukhin,Y., Zhu,X., Miyahara,Y.,
            Xiong,F., Madireddy,S., Obayashi,M., Lutz,B., Sawa,A., Brown,S.P.,
            Pletnikov,M.V. and Kamiya,A.
  TITLE     Microglial cannabinoid receptor type 1 mediates social memory
            deficits in mice produced by adolescent THC exposure and 16p11.2
            duplication
  JOURNAL   Nat Commun 14 (1), 6559 (2023)
   PUBMED   37880248
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4084)
  AUTHORS   Zhao,F.Z., Gu,W.J., Li,L.Z., Qu,Z.K., Xu,M.Y., Liu,K., Zhang,F.,
            Liu,H., Xu,J. and Yin,H.Y.
  TITLE     Cannabinoid receptor 2 alleviates sepsis-associated acute lung
            injury by modulating maturation of dendritic cells
  JOURNAL   Int Immunopharmacol 123, 110771 (2023)
   PUBMED   37582314
  REMARK    GeneRIF: Cannabinoid receptor 2 alleviates sepsis-associated acute
            lung injury by modulating maturation of dendritic cells.
REFERENCE   6  (bases 1 to 4084)
  AUTHORS   Sherwood,T.A., Nong,L., Agudelo,M., Newton,C., Widen,R. and
            Klein,T.W.
  TITLE     Identification of transcription start sites and preferential
            expression of select CB2 transcripts in mouse and human B
            lymphocytes
  JOURNAL   J Neuroimmune Pharmacol 4 (4), 476-488 (2009)
   PUBMED   19757078
  REMARK    GeneRIF: Resting splenic B cells in mice use multiple transcript
            start sites and express at least three CB2 transcript variants.
REFERENCE   7  (bases 1 to 4084)
  AUTHORS   Shire,D., Calandra,B., Rinaldi-Carmona,M., Oustric,D., Pessegue,B.,
            Bonnin-Cabanne,O., Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     Molecular cloning, expression and function of the murine CB2
            peripheral cannabinoid receptor
  JOURNAL   Biochim Biophys Acta 1307 (2), 132-136 (1996)
   PUBMED   8679694
REFERENCE   8  (bases 1 to 4084)
  AUTHORS   Paria,B.C., Das,S.K. and Dey,S.K.
  TITLE     The preimplantation mouse embryo is a target for cannabinoid
            ligand-receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9460-9464 (1995)
   PUBMED   7568154
REFERENCE   9  (bases 1 to 4084)
  AUTHORS   Das,S.K., Paria,B.C., Chakraborty,I. and Dey,S.K.
  TITLE     Cannabinoid ligand-receptor signaling in the mouse uterus
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4332-4336 (1995)
   PUBMED   7753807
REFERENCE   10 (bases 1 to 4084)
  AUTHORS   Munro,S., Thomas,K.L. and Abu-Shaar,M.
  TITLE     Molecular characterization of a peripheral receptor for
            cannabinoids
  JOURNAL   Nature 365 (6441), 61-65 (1993)
   PUBMED   7689702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FJ357034.1, AL672076.10, AK037898.1, AK134109.1, AK036658.1 and
            X86405.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_009924.5.
            
            On Mar 7, 2015 this sequence version replaced NM_009924.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134109.1, X86405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 FJ357034.1         1-7
            8-16                AL672076.10        74307-74315
            17-215              FJ357034.1         17-215
            216-280             AK037898.1         11-75
            281-3039            AK134109.1         2-2760
            3040-3264           AK036658.1         2725-2949
            3265-4066           AK134109.1         2986-3787
            4067-4068           X86405.1           3705-3706
            4069-4084           AK134109.1         3790-3805
FEATURES             Location/Qualifiers
     source          1..4084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.01 cM"
     gene            1..4084
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:12802"
                     /db_xref="MGI:MGI:104650"
     exon            1..431
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            432..4084
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..1521
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /note="cannabinoid receptor 2 (spleen); cannabinoid
                     receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2"
                     /protein_id="NP_034054.3"
                     /db_xref="CCDS:CCDS18793.1"
                     /db_xref="GeneID:12802"
                     /db_xref="MGI:MGI:104650"
                     /translation="MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMG
                     LLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDS
                     NAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVL
                     SALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHR
                     HVATLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQ
                     VKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPR
                     SSVTETEADVKTT"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /note="hexamer: ATTAAA"
     polyA_site      3266
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /note="major polyA site"
     regulatory      4059..4064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
                     /note="hexamer: AATAAA"
     polyA_site      4080
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2-R"
ORIGIN      
        1 acatagcctg gcacatgtca cagacaaaag gatgtaaact ttacagaggt caagtgagtt
       61 gcaggacagc atacacccgg ggccagatta gaacccaagt ttctggagtc taaggtctat
      121 gcctatgccc tcccctggcc agagttccta ggaagagaga attcaaccgc agggcaagaa
      181 cactgtggca ctgaggaccc agaggggaag tggtaaccgg tacggaaggc cagatctcct
      241 ctcactcact tatctgcacc agacctcctc tcattcactc atctgcgaaa gtgtgagagc
      301 aagaaacccc aggctggagc tgcagctctt gggacctacg tgggggtccc tgctgggtct
      361 ccagatctgg atacagaata gccaggacaa ggctccacaa gaccctgggg cccagcggct
      421 gacaaatgac acccagtctt ctgggacagc tccagtagaa gaagccaaag cccatccatg
      481 gagggatgcc gggagacaga agtgaccaac ggctccaacg gtggcttgga gttcaacccc
      541 atgaaggagt acatgatcct gagcagtggc cagcagatcg ccgtggcggt gctgtgcacc
      601 ctgatggggc tgctgagcgc cctggagaac atggccgtgc tctatattat cctgtcctcc
      661 cggcggctcc gcagaaagcc ctcgtacctg ttcatcagca gcttggctgg agctgacttc
      721 ctggccagcg tgatcttcgc ctgcaacttt gtcatcttcc acgtcttcca cggggtcgac
      781 tccaacgcta tcttcctgct gaagatcggc agtgtgacca tgaccttcac agcctctgtg
      841 ggcagcctgc tgctaaccgc tgttgaccgc tacctatgtc tgtgttaccc gcctacctac
      901 aaagctctag tcacccgtgg gagggcactg gtggccctct gtgtcatgtg ggtcctctca
      961 gcattgattt cttacctgcc gctcatgggg tggacttgtt gccctagtcc ctgctctgag
     1021 cttttcccac tgatccctaa cgactaccta ctgggctggc ttctattcat tgccatcctc
     1081 ttttccggca tcatctatac ctatgggtat gtcctctgga aagcccaccg gcatgtagcc
     1141 accttggctg agcaccagga caggcaggtg cctgggatag ctcggatgcg gctagacgtg
     1201 aggttggcca agactctggg cctggtgctg gctgtgctgc tcatatgctg gttccctgca
     1261 ctggctctca tgggccacag cctggtcacc acgctgagtg accaggtcaa ggaggccttc
     1321 gccttctgtt ccatgctgtg ccttgttaac tctatggtca atcctatcat ttacgccctg
     1381 cggagtggag agattcgctc tgctgcccag cactgcctga taggctggaa gaagtatcta
     1441 cagggcctcg gacctgaggg gaaagaagaa ggcccaaggt cctcggttac agaaacagag
     1501 gctgatgtga aaaccaccta ggagccagga tccagaactc caggctgctc caactgctga
     1561 caccacctgt ctttctactg gaaacagccc gagtcagaag tccgttcagt tcactccctc
     1621 gaagagagag gggttccaga cccggattct ttctgaagcc agttctaggg taatggaaac
     1681 agatccccct ttttgctaag gaatgctggt tggctggaag gtggcctggt catgcctacc
     1741 ttttccagtc tgtggagagg ggcctgtaag aatggcaggc tctgttcata tcaaatcagg
     1801 aaagccttct gactccaaag acctagaggc cagaggggcc tccagagatg atactaaagg
     1861 attcaggaga tctgtgaaga caagggacct gttctcctgg aatctagagt accccagccg
     1921 tggggccact gccctcaact tcatagatgt ccatgtcttc catagtgtgg attctagact
     1981 gtcctgctga agatagagag accagctgct tctggttcct gcttcatcct ctgtggctgt
     2041 agagctatgt gaggctctac cttcaggtca cccttgcctc ttgggggtca agaattatga
     2101 tgccctaagg accaaggatg ttcgcttaca tccttcagac agcgtcagga gctgtcagct
     2161 cagggtatcc tgttgttggg aaagggccct cccgacatcc tgataagcct tgaaagccat
     2221 tatgacctta ggtccttagg ggcgcagagg aagctgggtt cactggaggt acaaagtctt
     2281 cagagaactc tattccttgt gacattttgc tgtgtctcac acagcactat cccagtcttg
     2341 cctagcttca gtacaaagca agatattcac acagattctt tgggtcctag gctgttccca
     2401 gtgatgcttg actcagcccc actggcctct tccacactct ggtcctgaag gataagcaga
     2461 aggagttggg agggaagact tcctgctgca aaccaggcat cctaggtcca cagccccacg
     2521 ctgtgtctct gggtgcctgc ctttgccctt cagtaaaggt tgcagtccca acagatggag
     2581 gttcaaggcg ctgctggtgg taggaggggt aggtggcact ggggaccaca gacacagtga
     2641 aaggaaaact cttaaacatt taatactttt gcttttagaa gatccggccc gcagacagga
     2701 cttccccatt gcccaaagga actaacaggg tggtgtccag tgcaaagaaa aatcagcctc
     2761 cctaataaag caaggaggtc cactcggctc tacagcctct cctaagcttc tgcaaggtga
     2821 cagtttgttt tctctgtgaa ggtcaacggc gtctcatttt attcttccca agacaagttc
     2881 tgtgcatcaa aagctgctgc aaattctaat cgctgtttgg gaggatcagg ggaagaagtc
     2941 gattcgccca cgcttagtga tttagactgt atttcaacat caacttgggg gaggaagaga
     3001 cagaaaagac acggtgtttc cttattactc ctcaaaggag gaagtgcttg gttctgtcaa
     3061 cataagccga tctctccaag gtgcctgaca gaggaggagg gaatacagtt tccacagctg
     3121 tgaattcctg caccagcttt ggtccacact tatgtggtct tgatcaaccc ccgcccttta
     3181 ccttgctttg gtttccttct cggtaaattg ggaatggtgg ggaaaacaat gctctccagg
     3241 gccattaaaa cctctcattg ctctaacatg ctgtggttat ctctgcaacc atggagacct
     3301 ttgtgccata tggaccatgt gacttctggc tcccatactt cctgaagtta tgggcacaca
     3361 ccatatacca ttgggcgtgt gctgactgta gaggaattgg gtgactggcc atatgagttt
     3421 tagagatttt cccagggcaa gagggttctc ttggctctca atttttctgg tccctcatgc
     3481 ctcagtggtc ccctgtgtgt gggtcaggca tgcttgttta gcggtgccag actgaagctc
     3541 cggccttccg gtgtaccaag caagtgttgt actcctgagt caggttttct tcagttagat
     3601 gctaactaag ctctctgaga gaccctcaaa gtttttgagg tgtagctcag tcagtagagt
     3661 gctgcatctg caagagcaaa tctctgggtt caaaggtcag tactacctaa aaccaggaat
     3721 ggcagtgcca tcccctacct gtaatcccag cactcctgag gtacaagcag gaagatcagg
     3781 aatgcaaagt tactgtagct gtaagttcga agccagcctg agctagttga gaccccctta
     3841 cctcaaaata aatttaagtt acaattctaa attaaattaa aatgtctagg gctggagaga
     3901 tggcttagtg gttaagagca cagactgctt ttccagaggt cctgagttca attcccagca
     3961 accacatggt ggctcacaac catctgtaat ggaatctgat gccctcttct ggtatgtttg
     4021 aagagagcga tggtgtactc atatacataa aataagtaaa taaatctttt tttaaaaaaa
     4081 tgtt
//
