LOCUS       NM_007726               5795 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus cannabinoid receptor 1 (Cnr1), transcript variant 1,
            mRNA.
ACCESSION   NM_007726
VERSION     NM_007726.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5795)
  AUTHORS   Min,R., Qin,Y., Kerst,S., Saiepour,M.H., van Lier,M. and
            Levelt,C.N.
  TITLE     Inhibitory maturation and ocular dominance plasticity in mouse
            visual cortex require astrocyte CB1 receptors
  JOURNAL   iScience 27 (12), 111410 (2024)
   PUBMED   39687028
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5795)
  AUTHORS   Cosentino,L., Urbinati,C., Lanzillotta,C., De Rasmo,D., Valenti,D.,
            Pellas,M., Quattrini,M.C., Piscitelli,F., Kostrzewa,M., Di
            Domenico,F., Pietraforte,D., Bisogno,T., Signorile,A., Vacca,R.A.
            and De Filippis,B.
  TITLE     Pharmacological inhibition of the CB1 cannabinoid receptor restores
            abnormal brain mitochondrial CB1 receptor expression and rescues
            bioenergetic and cognitive defects in a female mouse model of Rett
            syndrome
  JOURNAL   Mol Autism 15 (1), 39 (2024)
   PUBMED   39300547
  REMARK    GeneRIF: Pharmacological inhibition of the CB1 cannabinoid receptor
            restores abnormal brain mitochondrial CB1 receptor expression and
            rescues bioenergetic and cognitive defects in a female mouse model
            of Rett syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5795)
  AUTHORS   Vass,Z., Shenker-Horvath,K., Banyai,B., Veto,K.N., Torok,V.,
            Gem,J.B., Nadasy,G.L., Kovacs,K.B., Horvath,E.M., Jakus,Z.,
            Hunyady,L., Szekeres,M. and Dornyei,G.
  TITLE     Investigating the Role of Cannabinoid Type 1 Receptors in Vascular
            Function and Remodeling in a Hypercholesterolemic Mouse Model with
            Low-Density Lipoprotein-Cannabinoid Type 1 Receptor Double Knockout
            Animals
  JOURNAL   Int J Mol Sci 25 (17), 9537 (2024)
   PUBMED   39273484
  REMARK    GeneRIF: Investigating the Role of Cannabinoid Type 1 Receptors in
            Vascular Function and Remodeling in a Hypercholesterolemic Mouse
            Model with Low-Density Lipoprotein-Cannabinoid Type 1 Receptor
            Double Knockout Animals.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5795)
  AUTHORS   Schott,M., Leon-Perinan,D., Splendiani,E., Strenger,L., Licha,J.R.,
            Pentimalli,T.M., Schallenberg,S., Alles,J., Samut Tagliaferro,S.,
            Boltengagen,A., Ehrig,S., Abbiati,S., Dommerich,S., Pagani,M.,
            Ferretti,E., Macino,G., Karaiskos,N. and Rajewsky,N.
  TITLE     Open-ST: High-resolution spatial transcriptomics in 3D
  JOURNAL   Cell 187 (15), 3953-3972 (2024)
   PUBMED   38917789
REFERENCE   5  (bases 1 to 5795)
  AUTHORS   Sotzen,M., Ahmed,A., Olson,L.K. and Alshaarawy,O.
  TITLE     Characterization of the effects of cannabinoid receptor deletion on
            energy metabolism in female C57BL mice
  JOURNAL   Front Endocrinol (Lausanne) 15, 1386230 (2024)
   PUBMED   38962676
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5795)
  AUTHORS   Ho,B.Y. and Zhao,J.
  TITLE     Determination of the cannabinoid receptors in mouse x rat hybridoma
            NG108-15 cells and rat GH4C1 cells
  JOURNAL   Neurosci Lett 212 (2), 123-126 (1996)
   PUBMED   8832654
REFERENCE   7  (bases 1 to 5795)
  AUTHORS   Onaivi,E.S., Chakrabarti,A., Gwebu,E.T. and Chaudhuri,G.
  TITLE     Neurobehavioral effects of delta 9-THC and cannabinoid (CB1)
            receptor gene expression in mice
  JOURNAL   Behav Brain Res 72 (1-2), 115-125 (1995)
   PUBMED   8788864
REFERENCE   8  (bases 1 to 5795)
  AUTHORS   Moore,K.J.
  TITLE     Insight into the microphthalmia gene
  JOURNAL   Trends Genet 11 (11), 442-448 (1995)
   PUBMED   8578601
  REMARK    Review article
REFERENCE   9  (bases 1 to 5795)
  AUTHORS   Paria,B.C., Das,S.K. and Dey,S.K.
  TITLE     The preimplantation mouse embryo is a target for cannabinoid
            ligand-receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9460-9464 (1995)
   PUBMED   7568154
REFERENCE   10 (bases 1 to 5795)
  AUTHORS   Chakrabarti,A., Onaivi,E.S. and Chaudhuri,G.
  TITLE     Cloning and sequencing of a cDNA encoding the mouse brain-type
            cannabinoid receptor protein
  JOURNAL   DNA Seq 5 (6), 385-388 (1995)
   PUBMED   8777318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005292.13.
            
            On Sep 14, 2018 this sequence version replaced NM_007726.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070447.1, MH013961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               BX005292.13        102474-102988
            516-5795            BX005292.13        121382-126661
FEATURES             Location/Qualifiers
     source          1..5795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.28 cM"
     gene            1..5795
                     /gene="Cnr1"
                     /gene_synonym="CB-R; CB1; CB1A; CB1B; CB1R"
                     /note="cannabinoid receptor 1"
                     /db_xref="GeneID:12801"
                     /db_xref="MGI:MGI:104615"
     exon            1..515
                     /gene="Cnr1"
                     /gene_synonym="CB-R; CB1; CB1A; CB1B; CB1R"
                     /inference="alignment:Splign:2.1.0"
     exon            516..5795
                     /gene="Cnr1"
                     /gene_synonym="CB-R; CB1; CB1A; CB1B; CB1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             578..1999
                     /gene="Cnr1"
                     /gene_synonym="CB-R; CB1; CB1A; CB1B; CB1R"
                     /note="striatal cannabinoid receptor type 1 protein;
                     brain-type cannabinoid receptor; cannabinoid receptor 1
                     (brain)"
                     /codon_start=1
                     /product="cannabinoid receptor 1"
                     /protein_id="NP_031752.1"
                     /db_xref="CCDS:CCDS18025.1"
                     /db_xref="GeneID:12801"
                     /db_xref="MGI:MGI:104615"
                     /translation="MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYF
                     PQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGEN
                     FMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSL
                     AVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYIS
                     IHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETY
                     LMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPD
                     QARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNST
                     VNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESC
                     IKSTVKIAKVTMSVSTDTSAEAL"
     regulatory      5763..5768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnr1"
                     /gene_synonym="CB-R; CB1; CB1A; CB1B; CB1R"
                     /note="hexamer: AATAAA"
     polyA_site      5792
                     /gene="Cnr1"
                     /gene_synonym="CB-R; CB1; CB1A; CB1B; CB1R"
                     /note="major polyA site"
ORIGIN      
        1 agagacagcg cgcgagctga gggagaggca gggacctcaa gcagggcgcg gcgacgggcg
       61 ctcggggtgg cccaagcggg cggccccagg ccggccagcg cggtcagtgg gacgccgggg
      121 agagccggag aacgaagcgg gcctgtccga gcccagggga gccagtccca ggggccgtgg
      181 cgcacgggtg ctagaggccg gggacgcggg cgcgcagacc gactgactta ctgaccgatc
      241 gccgcgggca cgccccgctc caccccgccc caccgcgccc cgcgccgcct cccctgctcg
      301 ctcgctgcct ctaccttctc cacttctttt ccgcctccgc ctccttctgg ctcccctggc
      361 gccagagcct ccccctggct caggcgggag cctgggctgt ctgcagagct ctcatagagt
      421 ctgggggcaa atttccttgt agcagagagc cagccccttg gctgggcgac aggtgccgag
      481 ggagcttctg gcccgtggac cgggggatgc gaaggggttc cctcctggca cctctttctc
      541 agtcacgttg agcctggcct aatcaaagac tgaggttatg aagtcgatct tagacggcct
      601 tgcagatacc accttccgta ccatcaccac agacctcctc tacgtgggct caaatgacat
      661 tcagtacgaa gatatcaaag gagacatggc atccaaatta ggatacttcc cacagaaatt
      721 ccctctaact tccttcaggg gtagtccctt ccaagaaaag atgacggcag gagacaactc
      781 cccgttggtt ccagcaggag acacaaccaa cattacagag ttctataaca agtctctctc
      841 atcgttcaag gagaacgagg acaacatcca gtgtggggag aattttatgg acatggagtg
      901 cttcatgatt ctgaatccca gccagcagct ggccatcgct gtcctgtccc tcaccctggg
      961 caccttcacg gttctggaga acctgctggt gctatgtgtc atccttcact cccgcagtct
     1021 ccgatgcagg ccttcctacc acttcattgg cagcctggcg gtggccgatc tcctgggaag
     1081 tgtcatcttt gtctacagct ttgttgactt ccacgtgttc caccgcaaag atagtcccaa
     1141 tgtgtttctg ttcaaactgg gtggggttac cgcctccttc acagcatctg tgggcagcct
     1201 gttcctcacg gccatcgaca ggtacatatc cattcacagg cctctggcct ataagaggat
     1261 cgtcaccagg cccaaggccg tagtggcctt ttgcttgatg tggactattg caatagtaat
     1321 tgctgtgttg cctctcctgg gctggaactg caagaagctg caatctgttt gctcagacat
     1381 cttcccactc attgatgaaa cctacctgat gttctggatc ggagtcacca gtgtgctgtt
     1441 gctgttcatt gtgtatgcat acatgtacat tctctggaag gctcacagcc acgcagttcg
     1501 catgatccag cgtggaaccc agaaaagcat catcattcac acctcagaag atggcaaggt
     1561 gcaggtgaca cggcctgacc aagcccgcat ggacattagg ctggccaaaa ccctggttct
     1621 gatcctggtg gtgttgatca tctgctgggg ccctctgctt gcgatcatgg tgtatgatgt
     1681 ctttgggaag atgaacaagc ttatcaagac ggtgtttgcc ttctgtagta tgctctgcct
     1741 gctgaactcc accgtgaacc ccatcatcta tgctctgagg agcaaggacc tgagacatgc
     1801 tttccgcagc atgttccctt catgtgaagg cactgcgcag cctctagata acagcatggg
     1861 ggactcagac tgcctgcaca agcacgccaa taacacagcc agcatgcaca gggccgcgga
     1921 aagctgcatc aagagcactg ttaagatcgc caaggtgacc atgtctgtgt ccacagacac
     1981 gtctgccgag gctctgtgag cctgctgctt ttgtggctgc ccagaaaaag aaaatttttt
     2041 tttttagctt aaaatttaga agtctgttgt ctcatcggtt atatattttt taagtttacc
     2101 atgtttagta aaatagtgac tgtcaccgtg cttacttagt ttgctgacat ctcagtagtt
     2161 taggtactta aactccattc cccaggggtt tacagtgaag aaagtctatc gctgcagttg
     2221 ctcggcgatc cttcaaagtc tctgaaatag aagggaaaac gttggcttcc aaatctgaag
     2281 cctaactacc catagaaaac caccatgaaa taagtaatgc ctttgtaacg acaactttaa
     2341 tgatgctgtg tctgtccata gtataaaagg tacattttta caataagtat agtgctaaag
     2401 tagagatact ttgtaacatg ttttctgtcc tgttagttgt gtgtcagtgt ttactgtgtc
     2461 tttttttttt tttttttttt ggtctagctt agcaaaaaca gaatatagcc ctcataagag
     2521 ctatggcata caggagtggt gatgtagcag ggtgacccct gtttagatag tattactgtt
     2581 catgagacaa ttttagaaac cttagtattt cttccaatat ccgtatctaa agttaatatt
     2641 gaaataagca taaaggttta tttttctgtt aaaaccacaa gaaaaatttg aagactgttc
     2701 aaagtattga gcagaattca aggacactta aaactgtgtt aggcctgcat tttcatatga
     2761 ggacattcca tatcttctgg accacagctg ttcagttgga tactggatta taatcagaat
     2821 ggaaaagaga aagcacattg acttttaaag ctgacattct gacttcctgc agttgttggc
     2881 tgtaactaga cctcttcaga cagcatgtgt caatcttagt gtacactgtg accactgtgc
     2941 agttgctgtt tccttgacgt gtattgcatt gttatgttct ggatttaagt agatttcagg
     3001 cctcgatggc caaaaaccag ttgtcttctt cttgagaaga aatattgtct gactcagtaa
     3061 aattgtgtgt gtgattgtaa gtgtatatgt gtgtgtatgt gtgtgtgtgt gtgtttgtgt
     3121 tactctatct tgtaactgtt acagaaatgt cccccatgag gaaactgacc aagggtaaac
     3181 agtaccactt gctgcgctct tgcacatgaa cttagcttct acagttgagc tcttcatgaa
     3241 atcctgttta taaaaattct gactaaatct tttcagaaga atcttcccac ctaggagacc
     3301 ggattaagca ttctaatgcc atttaggtgt tctgtaaggc cagcgttcag caagaagtca
     3361 tcagtaagag gtgccagaaa atagaggatt ctcccaggaa gaggggagtg tggaggatgg
     3421 tgggcgccta ctaataatca agtccatgga aatggaaatc agtaaagggg ttggttctaa
     3481 gacctatacc cacaccccta cagtagtaag tttcagtggt gcatgtcagc ggtgcaatct
     3541 caggttaagt aacaacatgc cagctggtcc aggccatttc attacagagg gtgacagccc
     3601 agtacctggc tctgtttgga atgattgggc taaggaaaag gtagtacctc ctctacttgc
     3661 tggtatcaag atgtgccaaa acataaagat gagggtggct agcttctgat gacatctctg
     3721 ccgtggtact cagaattggg cccttttcca ataaagagaa gtattgcttt taggaagcca
     3781 ctctatcccg ataagttcta catagagtct ctccttgttc aggttttcac cagccctaag
     3841 aactgcatgg catgaagtgg ggagctagca tctgttggtg atttctacca tttggggttc
     3901 ccagcctgac agggcagtac cccttcttgc aatcagtgtg acctgagggc caaactagga
     3961 tatgtctaga tttggcctgc tgcagtctct tgcttttctt ctctgtgcac agaggagggc
     4021 tccggatgct ggagtattag taactcctta gagaagggta ttgagagaat accaccaggg
     4081 gctaggaatt gtcagcttcg tcctacatga acctgaatat caaccgacat gtctctagct
     4141 accaggcagt accatctctt ctcacagcta caaagacctg gtaggaaatt ctaggtattt
     4201 aaaaaaaaat ccaagattca cttttagaac tgtatttgtg taaatgccat tttagtgata
     4261 agattttata gtgtattgaa ctttcaagac ctaactcata tttaataagc taagggacaa
     4321 tggggctgat agcactaaac ttggtgctta ttgatactct aagaaatatc tgtgaaatat
     4381 catcatgtgt gcgttaagct accttcattt aaaaggactt aaaataagtt ggatccactt
     4441 tggctttgac catatcattt cctaacccta ctgaccaaaa cattctccct agtgagtatt
     4501 agtcattaga attgcattca ttagtatcat taattaacta ggcccttaat tagattcatt
     4561 aatttaaatg attttaattt gatcacttat gtactctggc atcagggtta tctgtttccc
     4621 tctgacatgt gtcctgaaca tgcattcttc agccattact catcttaaaa aggggccaat
     4681 tcccaaactg cttgacttca tccaaacaaa gactgggtcc tagactagca gtatcagtta
     4741 aacaaagaga gctgtcccta agagccccta gtttttcaac tatgtattaa gtgcatgtaa
     4801 aaatcagtgt gcgtctgggc agcgtagaca tatgtctgtg ccagatgact ccaaagctgt
     4861 cggatactgt caggtttagc tggtatcaaa tgccaaggaa tttttgctac ctaaaaccat
     4921 ctgcataaaa taggcccaat taccagatga gaactaggtc tctagttacc attcagttca
     4981 ttaatttctg ccattccata cccataaaca ggaccactaa catcatgcac aaaattagat
     5041 tcctcatact cttgactgta tatttgtatg atattttaaa atctcctaaa tggccattca
     5101 cagttgcttt gcactggcct tccagtaaaa tgttaacaca gctattgtaa tatacacaaa
     5161 gcattctatc tactgatttg gactgaatgt atgtacatag gttttacaaa aaaaaagtca
     5221 gatgttaaag cagtggttta cagatcagtg attttcagat agagtttctt tcagttgctg
     5281 tggaatcttt aaaaagcact cttagtgtga acttactgaa ctctaggggt cctgcgatca
     5341 gagtccccta gagaggaaac cttttcttgt aataatatga accaagatac cagattatct
     5401 tgagtctcac ttccagtgtt tcaagtggaa aacgtatctc cttattgtct ctgtaaatgg
     5461 aacatcctta cttttttctc ttaaagaata ttgtactgtt agatgtttgt tgaactggta
     5521 gcatcattga gactgctgtg atgtctttgt cagtaatctg tataatattt tgtatacaag
     5581 tactggtaat attgttatta aatgtagctc ggtcattaaa ttactatagc aaagtagtac
     5641 ttctgtaata tttacaatgt attaagccta cagtatattt tatttcattg atgtaattta
     5701 attgttattt attcaagaga aagcagttca tcatgtctat tgtctaaaat tacctggaat
     5761 caaataaaaa ttctagatta tcatgaaaaa cataa
//
