LOCUS       NM_001419173            1861 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus canopy FGF signaling regulator 4 (Cnpy4), transcript
            variant 1, mRNA.
ACCESSION   NM_001419173
VERSION     NM_001419173.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1861)
  AUTHORS   Lo,M., Sharir,A., Paul,M.D., Torosyan,H., Agnew,C., Li,A.,
            Neben,C., Marangoni,P., Xu,L., Raleigh,D.R., Jura,N. and Klein,O.D.
  TITLE     CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol
            lipids
  JOURNAL   Nat Commun 13 (1), 2407 (2022)
   PUBMED   35504891
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1861)
  AUTHORS   Jang,C.W., Shibata,Y., Starmer,J., Yee,D. and Magnuson,T.
  TITLE     Histone H3.3 maintains genome integrity during mammalian
            development
  JOURNAL   Genes Dev 29 (13), 1377-1392 (2015)
   PUBMED   26159997
REFERENCE   4  (bases 1 to 1861)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 1861)
  AUTHORS   Konno,K., Wakabayashi,Y., Akashi-Takamura,S., Ishii,T.,
            Kobayashi,M., Takahashi,K., Kusumoto,Y., Saitoh,S., Yoshizawa,Y.
            and Miyake,K.
  TITLE     A molecule that is associated with Toll-like receptor 4 and
            regulates its cell surface expression
  JOURNAL   Biochem Biophys Res Commun 339 (4), 1076-1082 (2006)
   PUBMED   16338228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151719.3 and AC159257.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2233875.1,
                                           SRR1660811.336140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC151719.3         217678-217892
            216-342             AC151719.3         220442-220568
            343-439             AC151719.3         220665-220761
            440-562             AC159257.2         98424-98546
            563-589             AC159257.2         98793-98819
            590-707             AC159257.2         99147-99264
            708-1861            AC159257.2         99351-100504
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.98 cM"
     gene            1..1861
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /note="canopy FGF signaling regulator 4"
                     /db_xref="GeneID:66455"
                     /db_xref="MGI:MGI:1913705"
     exon            1..215
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..844
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein canopy homolog 4; protein associated
                     with Tlr4; canopy 4 homolog"
                     /codon_start=1
                     /product="protein canopy homolog 4 isoform 1 precursor"
                     /protein_id="NP_001406102.1"
                     /db_xref="GeneID:66455"
                     /db_xref="MGI:MGI:1913705"
                     /translation="MCGLRFIMGPVRLEILLFILAAYGAWAEATKEEEDDTERLPSKC
                     EVCKLLSMELQEALSRTGRSREVLELGQVLDTGKRKRHVPYSLSETRLEEALENLCER
                     ILDYNVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKK
                     QVRIPVPTSQCETMLEEFEDVVGDWYFHHQEQPLQHFLCERHVLPASETACLREAWTG
                     KEKISDGQEEADDEEEEEEEEITKTSGNPKHDPEDL"
     exon            216..342
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..439
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..562
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..589
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            590..707
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1861
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1586
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /note="major polyA site"
     regulatory      1835..1840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /note="hexamer: AATAAA"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
                     /note="hexamer: AACAAA"
     polyA_site      1854
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
     polyA_site      1861
                     /gene="Cnpy4"
                     /gene_synonym="2610019P18Rik"
ORIGIN      
        1 aaagcttgct gcgggcttcg cctaaattta aagggcccgc tgccttccag aagttggtct
       61 gaaggcaaag ggtggttgta tgtgtggact gcgttttatc atgggacctg tgcggctgga
      121 gatactgctt ttcatcctgg cagcgtacgg tgcttgggct gaggcgacaa aagaggagga
      181 agatgacaca gaacgtttgc ccagcaaatg cgaagtgtgt aagctgctga gcatggagct
      241 ccaggaagcg ttgagtcgaa ctggccgatc ccgagaagtg ctggagctgg gtcaggtgct
      301 agacactggc aagaggaaga gacacgtgcc ttacagcctc tctgagacgc ggctagaaga
      361 ggctttggag aatttgtgcg agcggatcct ggattacaat gttcatgctg aacgcaaggg
      421 ctcactaaga tacgccaagg gtcaaagtca gactatggca acactgaaag gcctggtcca
      481 gaagggagtg aaagtggatc tgggaatccc tttggagctg tgggacgagc ccagtgtgga
      541 ggtcacattc ctcaagaagc aggtgcgaat accggttccc acgtcccagt gtgagacgat
      601 gctggaggag tttgaagatg ttgtagggga ctggtacttc caccatcagg agcagcccct
      661 ccagcatttt ctctgtgagc ggcatgtgct tccagcctct gaaactgctt gtctacggga
      721 agcttggact ggaaaggaga agatcagtga tgggcaggag gaggcagatg acgaagagga
      781 ggaagaagaa gaagagataa ccaagacttc aggcaatccc aagcatgacc cagaagatct
      841 ttgaccctta cttttgaacc ccaaggatgg gtcgtggaga gttttctaaa ctcttgtgct
      901 ctcccgtcct tccccgcccc taggcttcta atgtcttctt ggtatgatct cggctatgat
      961 cctggggacc cagaatggca acaggaaagg agaagggtag gggggaagaa gcagaagcaa
     1021 gttttgcctt cagggttgaa ccacatgcag ccacttaatt gaacaagtat gtggtgacag
     1081 ttttgaaact tttctctacg ttttactggt cttcacctgc accgattggt caatagtggt
     1141 gtgagctgtg ggaaagtcac tttgcttttt aaagggtcta ttttaaaccc tttcaagagg
     1201 ccagagaaga gcgagcagcg caattggtag agtgcctgcc tagtatggac agtgatggga
     1261 gttgaaccct gatgtggtgg cataccgctg taatctcagc actcaaagaa gcgttggcag
     1321 gaatatcaga ataccatcca gctacttggc agttcgggac caaccagagc tgaaccctgt
     1381 cttaaagtaa gaagccaaaa agagaccctc aagaaccaat atacactgca aacatgaggc
     1441 cgtataccat caatctgtga ataagaacag gatgctggaa gagagtgaag caatactcgg
     1501 gttagatggg gtagacatgt gggctatatt tcctatttca caggtgccat attttctata
     1561 ttgctattaa accttttata tatatatcag ctgagtccca tttcaaacat gcacacatta
     1621 tcgatgaggg agcacccaga cagtggggcc attggcctgc tatctattag ttgctaatgg
     1681 tgttcttata attatccacc ccaaggatac tggttggggt tgggaaaaca actgtaccac
     1741 taggacttgg aaaagaggat caagagctca gtcttcctca gctatgtagc gagctcaaga
     1801 ccatcttggt ctccttgagc ccctgtatca ggaaaataaa aaacaaaaca agaactcaga
     1861 a
//
