LOCUS       NM_028065               1902 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus canopy FGF signaling regulator 3 (Cnpy3), transcript
            variant 1, mRNA.
ACCESSION   NM_028065
VERSION     NM_028065.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Zhou,Y.Q., Bao,T.S., Xie,J.X., Yao,L.L., Yu,S.T., Li,Q.,
            Huang,P.Q., Zhou,W.Z., Wang,Y.Y., Chen,S.Y., Wang,X.Q., Zhang,X.L.,
            Jiang,S.H., Yi,S.Q., Zhang,Z.G., Ma,M.Z., Hu,L.P., Xu,J. and Li,J.
  TITLE     The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer
            by enhancing the endocytosis and recycling of TrkB in tumour cells
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1049-1067 (2023)
   PUBMED   37012514
  REMARK    GeneRIF: The SLITRK4-CNPY3 axis promotes liver metastasis of
            gastric cancer by enhancing the endocytosis and recycling of TrkB
            in tumour cells.
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Mo,Y., Wang,S., Chang,Y., Sun,X., Liu,Z., Sun,P., Xu,Y., Zhong,X.
            and Peng,L.
  TITLE     A novel rare variant of CNPY3 from familial NMOSD impairs the
            TLR-mediated immune response
  JOURNAL   J Neuroimmunol 377, 578065 (2023)
   PUBMED   36931208
  REMARK    GeneRIF: A novel rare variant of CNPY3 from familial NMOSD impairs
            the TLR-mediated immune response.
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Xiao,L., Li,X.X., Chung,H.K., Kalakonda,S., Cai,J.Z., Cao,S.,
            Chen,N., Liu,Y., Rao,J.N., Wang,H.Y., Gorospe,M. and Wang,J.Y.
  TITLE     RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering
            Membrane Localization of TLR2 via Post-transcriptional Control of
            CNPY3
  JOURNAL   Gastroenterology 157 (3), 731-743 (2019)
   PUBMED   31103627
  REMARK    GeneRIF: HuR regulates Paneth cell function by modulating TLR2
            localization via posttranscriptional control of CNPY3 expression.
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Mutoh,H., Kato,M., Akita,T., Shibata,T., Wakamoto,H., Ikeda,H.,
            Kitaura,H., Aoto,K., Nakashima,M., Wang,T., Ohba,C., Miyatake,S.,
            Miyake,N., Kakita,A., Miyake,K., Fukuda,A., Matsumoto,N. and
            Saitsu,H.
  TITLE     Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum
            Chaperone, Cause Early-Onset Epileptic Encephalopathy
  JOURNAL   Am J Hum Genet 102 (2), 321-329 (2018)
   PUBMED   29394991
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Motoi,Y., Shibata,T., Takahashi,K., Kanno,A., Murakami,Y., Li,X.,
            Kasahara,T. and Miyake,K.
  TITLE     Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in
            endolysosomes
  JOURNAL   Int Immunol 26 (10), 563-573 (2014)
   PUBMED   24860120
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Saitoh,S. and Miyake,K.
  TITLE     Regulatory molecules required for nucleotide-sensing Toll-like
            receptors
  JOURNAL   Immunol Rev 227 (1), 32-43 (2009)
   PUBMED   19120473
  REMARK    GeneRIF: association with PRAT4A is required for ligand-induced
            trafficking of TLR9 to endolysosomes
            Review article
REFERENCE   7  (bases 1 to 1902)
  AUTHORS   Kiyokawa,T., Akashi-Takamura,S., Shibata,T., Matsumoto,F.,
            Nishitani,C., Kuroki,Y., Seto,Y. and Miyake,K.
  TITLE     A single base mutation in the PRAT4A gene reveals differential
            interaction of PRAT4A with Toll-like receptors
  JOURNAL   Int Immunol 20 (11), 1407-1415 (2008)
   PUBMED   18780723
  REMARK    GeneRIF: single base mutant associates preferentially with TLR9,
            and differentially interacts with TLR2, 4 and 9
REFERENCE   8  (bases 1 to 1902)
  AUTHORS   Takahashi,K., Shibata,T., Akashi-Takamura,S., Kiyokawa,T.,
            Wakabayashi,Y., Tanimura,N., Kobayashi,T., Matsumoto,F., Fukui,R.,
            Kouro,T., Nagai,Y., Takatsu,K., Saitoh,S. and Miyake,K.
  TITLE     A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is
            required for TLR-dependent immune responses
  JOURNAL   J Exp Med 204 (12), 2963-2976 (2007)
   PUBMED   17998391
  REMARK    GeneRIF: PRAT4A regulates the subcellular distribution and response
            of multiple toll-like recaptors and is required for both innate and
            adaptive immune responses
REFERENCE   9  (bases 1 to 1902)
  AUTHORS   Wakabayashi,Y., Kobayashi,M., Akashi-Takamura,S., Tanimura,N.,
            Konno,K., Takahashi,K., Ishii,T., Mizutani,T., Iba,H., Kouro,T.,
            Takaki,S., Takatsu,K., Oda,Y., Ishihama,Y., Saitoh,S. and Miyake,K.
  TITLE     A protein associated with toll-like receptor 4 (PRAT4A) regulates
            cell surface expression of TLR4
  JOURNAL   J Immunol 177 (3), 1772-1779 (2006)
   PUBMED   16849487
  REMARK    GeneRIF: PRAT4A is a novel protein associated with toll-like
            receptor (TLR) 4 that regulates cell surface expression of receptor
            complex TLR4/MD-2.
REFERENCE   10 (bases 1 to 1902)
  AUTHORS   Konno,K., Wakabayashi,Y., Akashi-Takamura,S., Ishii,T.,
            Kobayashi,M., Takahashi,K., Kusumoto,Y., Saitoh,S., Yoshizawa,Y.
            and Miyake,K.
  TITLE     A molecule that is associated with Toll-like receptor 4 and
            regulates its cell surface expression
  JOURNAL   Biochem Biophys Res Commun 339 (4), 1076-1082 (2006)
   PUBMED   16338228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB857917.1, BY245140.1,
            AK005532.1, AA028507.1 and AK085617.1.
            
            On Apr 10, 2015 this sequence version replaced NM_028065.3.
            
            Summary: This gene encodes a member of the canopy family of
            proteins. The encoded protein may play a role in the maturation of
            toll-like receptors. Homozygous knockout mice for this gene show
            reduced cell surface expression of toll-like receptors and an
            impaired immune response including reduced production of cytokines
            in a mouse model of sepsis. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BB857917.1         2-19
            19-20               BY245140.1         17-18
            21-1573             AK005532.1         1-1553
            1574-1859           AA028507.1         152-437
            1860-1902           AK085617.1         1854-1896
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..1902
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /note="canopy FGF signaling regulator 3"
                     /db_xref="GeneID:72029"
                     /db_xref="MGI:MGI:1919279"
     exon            1..242
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..922
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein canopy homolog 3; protein associated
                     with toll-like receptor 4; protein associated with Tlr4;
                     trinucleotide repeat-containing gene 5 protein; canopy 3
                     homolog"
                     /codon_start=1
                     /product="protein canopy homolog 3 isoform 1 precursor"
                     /protein_id="NP_082341.1"
                     /db_xref="CCDS:CCDS28839.1"
                     /db_xref="GeneID:72029"
                     /db_xref="MGI:MGI:1919279"
                     /translation="MESMSELAPRCLLFPLLLLLPLLLLPAPKLGPSPAGAEETDWVR
                     LPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDGKGSGVKYTKSDLRLIEVTET
                     ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVA
                     DLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAERWSGKKGDI
                     ASLGGKKSKKKRSGVKGSSSGSSKQRKELGGLGEDANAEEEEGVQKASPLPHSPPDEL
                     "
     exon            243..366
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /inference="alignment:Splign:2.1.0"
     exon            367..463
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /inference="alignment:Splign:2.1.0"
     exon            464..586
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /inference="alignment:Splign:2.1.0"
     exon            587..704
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1902
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /note="hexamer: CATAAA"
     polyA_site      1859
                     /gene="Cnpy3"
                     /gene_synonym="1600025D17Rik; 2410050O22Rik; CAG4A; ERDA5;
                     PRAT4A; Tnrc5"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcccgg aagcggccgg gggaagctgc tccgcgcgcg ctgccggagg aagcgccgcc
       61 gggtccgctc tgctctgggt ccggctgggc catggagtcc atgtctgagc tcgcgccccg
      121 ctgcctctta tttcctttgc tgctgctgct tccgctgctg ctccttcctg ccccgaagct
      181 aggcccgagt cccgccgggg ctgaggagac cgactgggtg cgattgccca gcaaatgcga
      241 agtgtgcaag tatgttgctg tggagctgaa gtcggctttt gaggaaacgg gaaagaccaa
      301 ggaagtgatt gacaccggct atggcatcct ggacgggaag ggctctggag tcaagtacac
      361 caagtcggac ttacggttaa ttgaagtcac tgagaccatt tgcaagaggc ttctggacta
      421 cagcctgcac aaggagagga ctggcagcaa ccggtttgcc aagggtatgt cggagacctt
      481 tgagacgctg cacaacctag tccacaaagg ggtcaaggtg gtgatggata tcccctatga
      541 gctgtggaac gagacctcag cagaggtggc tgacctcaag aagcagtgtg acgtgctggt
      601 ggaagagttt gaagaggtga ttgaggactg gtacaggaac caccaggagg aagacctgac
      661 tgaattcctc tgtgccaacc acgtgctgaa gggaaaggac acgagttgcc tagcagagcg
      721 gtggtctggc aagaaggggg acatagcctc cctgggaggg aagaaatcca agaagaagcg
      781 cagcggagtc aagggctcct ccagtggcag cagcaagcag aggaaggaac tggggggcct
      841 gggggaggat gccaacgccg aggaggagga gggtgtgcag aaggcatcgc ccctcccaca
      901 cagcccccct gatgagctgt gagcccagct tagtgtcctt gaatcaagac ccctgacttc
      961 agagcttggg acacgcacag cgcagcgcag cgcagctcca gcaaggacag ctgctgtcca
     1021 gcatcaggtc tcctcccttg gctgtgcccc tttccttccc ttgaacaaca gcaagaggtg
     1081 gaaggatctg gggtgctggg agacggcacc ccaaagggaa gaggaggagg agcagaaggc
     1141 agctctcttt ctacacagtc cccctcacga gctccggggt ccacccagca tccccaggct
     1201 gagatccagg ctcctgacat ggaagctgaa gagcatgagg cacataagat gctcaccagc
     1261 gcccccttca gccaggaagg actccgtgca gcctcagcag ccaggcctgc ctcttccttc
     1321 caccaagcat tctcttctgc tggtccttgt cggatggtaa attcgagaac ttccaggaca
     1381 aactcgggtg tggcacaaag gggctggacg ccagagccag agccacgcca gagactgcag
     1441 agagggcacc tgacctaacc cccctggaaa gccaatctgc agttcccgtg tccacccact
     1501 cctcctgagg acgcctcatg ctctgcccag cccttctccc agggctacca gagtaaacac
     1561 cttttggcct ttcggtttgg ttcctgggtc ctcatcagcc tccagagtgt cccctcatcg
     1621 atcttttttg cctttgtccc ccaatcccag gggctggaag gccatcacca tcattggagg
     1681 cttaacctgt cagttactag gaggtgctgg gagcgcccgg ggttggtttg gggtaatcac
     1741 tcactggctc tcagccttct aacactgcag ccccttaata cagttccttc tgttgtggtg
     1801 actcccacgc ccccacacac acaccataaa attatttcga tgctgtttca taactgtaat
     1861 tttgctactg ctatgaattg taatgtaaat atttttggag at
//
