LOCUS       NM_019953               1017 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Mus musculus canopy FGF signaling regulator 2 (Cnpy2), mRNA.
ACCESSION   NM_019953
VERSION     NM_019953.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Huang,H., Tang,N., Li,Y., Huo,Q., Chen,Q. and Meng,Q.
  TITLE     The role of CNPY2 in endothelial injury and inflammation during the
            progress of atherosclerosis
  JOURNAL   J Mol Histol 54 (3), 195-205 (2023)
   PUBMED   37103758
  REMARK    GeneRIF: The role of CNPY2 in endothelial injury and inflammation
            during the progress of atherosclerosis.
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Hong,F., Lin,C.Y., Yan,J., Dong,Y., Ouyang,Y., Kim,D., Zhang,X.,
            Liu,B., Sun,S., Gu,W. and Li,Z.
  TITLE     Canopy Homolog 2 contributes to liver oncogenesis by promoting
            unfolded protein response-dependent destabilization of tumor
            protein P53
  JOURNAL   Hepatology 76 (6), 1587-1601 (2022)
   PUBMED   34986508
  REMARK    GeneRIF: Canopy Homolog 2 contributes to liver oncogenesis by
            promoting unfolded protein response-dependent destabilization of
            tumor protein P53.
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Urra,H. and Hetz,C.
  TITLE     Fine-tuning PERK signaling to control cell fate under stress
  JOURNAL   Nat Struct Mol Biol 24 (10), 789-790 (2017)
   PUBMED   28981072
  REMARK    GeneRIF: Sustained PERK activation can amplify PERK signaling by
            further enhancing CNPY2 expression via direct transactivation
            through CHOP.
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Hong,F., Liu,B., Wu,B.X., Morreall,J., Roth,B., Davies,C., Sun,S.,
            Diehl,J.A. and Li,Z.
  TITLE     CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded
            protein response
  JOURNAL   Nat Struct Mol Biol 24 (10), 834-839 (2017)
   PUBMED   28869608
  REMARK    GeneRIF: Free CNPY2 then engages protein kinase R-like endoplasmic
            reticulum kinase (PERK) to induce expression of the transcription
            factor C/EBP homologous protein (CHOP), thereby initiating the
            unfolded protein response.
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Yan,P., Gong,H., Zhai,X., Feng,Y., Wu,J., He,S., Guo,J., Wang,X.,
            Guo,R., Xie,J. and Li,R.K.
  TITLE     Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and
            Development through Activation of p53 Pathway
  JOURNAL   Am J Pathol 186 (4), 1015-1024 (2016)
   PUBMED   26835537
  REMARK    GeneRIF: CNPY2 may play a critical role in colorectal cancer
            development by enhancing cell proliferation, migration, and
            angiogenesis and by inhibiting apoptosis through negative
            regulation of the p53 pathway
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Hatta,K., Guo,J., Ludke,A., Dhingra,S., Singh,K., Huang,M.L.,
            Weisel,R.D. and Li,R.K.
  TITLE     Expression of CNPY2 in mouse tissues: quantification and
            localization
  JOURNAL   PLoS One 9 (11), e111370 (2014)
   PUBMED   25393402
  REMARK    GeneRIF: The data demonstrate CNPY2 is widely distributed in
            tissues and suggest the protein has biological functions that have
            yet to be identified.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   Do,H.T., Tselykh,T.V., Makela,J., Ho,T.H., Olkkonen,V.M.,
            Bornhauser,B.C., Korhonen,L., Zelcer,N. and Lindholm,D.
  TITLE     Fibroblast growth factor-21 (FGF21) regulates low-density
            lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin
            ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting
            saposin-like protein (Msap)
  JOURNAL   J Biol Chem 287 (16), 12602-12611 (2012)
   PUBMED   22378787
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   10 (bases 1 to 1017)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF186115.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_019953.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186115.1, AK150953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.52 cM"
     gene            1..1017
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /note="canopy FGF signaling regulator 2"
                     /db_xref="GeneID:56530"
                     /db_xref="MGI:MGI:1928477"
     exon            1..317
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /inference="alignment:Splign:2.1.0"
     exon            318..430
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..891
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /note="putative secreted protein ZSIG9; protein canopy
                     homolog 2; canopy 2 homolog; MIR-interacting saposin-like
                     protein; transmembrane protein 4"
                     /codon_start=1
                     /product="protein canopy homolog 2 precursor"
                     /protein_id="NP_064337.1"
                     /db_xref="CCDS:CCDS24272.1"
                     /db_xref="GeneID:56530"
                     /db_xref="MGI:MGI:1928477"
                     /translation="MKGWGWLALLLGVLLGTAWARRSQDLHCGACRALVDELEWEIAR
                     VDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEVCDRMKEYGEQIDPSTHR
                     KNYVRVVSRNGESSELDLQGIRIDSDISGTLKFACESIVEEYEDELIEFFSREADNVK
                     DKLCSKRTDLCDHALHRSHDEL"
     exon            431..546
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /inference="alignment:Splign:2.1.0"
     exon            751..847
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1017
                     /gene="Cnpy2"
                     /gene_synonym="5330432A10Rik; D10Bwg1546e; Tmem4; Zsig9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtcctcg ctgcctcgga ggcgctccta aagctgcctg ctcgcgcgag agtttggagg
       61 ggcgggctta gggtcagttt cggtgggggg ctcgcacggg accctcagat ctccgcttag
      121 gtgcctagtt aagtgcggga agctgggcca ggcggtcact ggccaccctg aacctggcgg
      181 gagccggagc gctctggaga agccgggaca gccccgtttt tcccagccag ctgctagggt
      241 tgggacccac agaaaacaaa gtgagagtcc ggctgctttc cagagcctgg gccacggcgg
      301 cggccgtggg agcagaggtg gagcgaccct gttacactaa agatgaaagg ctggggttgg
      361 ctagccctac ttttgggggt cctgctggga actgcctggg ctcgaaggag ccaagatcta
      421 cactgtggag cttgcagggc tctggtggat gaattagagt gggaaattgc ccgcgtggac
      481 cccaagaaga ccattcagat gggatccttc cgaatcaatc cagatggcag ccagtcagtt
      541 gtggaggtac cttatgcccg ctcagaggcc cacctcacag agttgcttga ggaggtgtgt
      601 gaccgaatga aggagtacgg ggaacagatt gacccttcta cccaccgcaa gaactacgta
      661 cgcgtcgtga gccggaatgg agaatccagt gaactagact tacagggcat ccgaattgac
      721 tcagatatca gcggcaccct caagtttgcg tgtgagagca ttgtggaaga atacgaggat
      781 gagcttatcg aattcttctc cagagaggct gacaacgtta aagacaaact ttgcagtaag
      841 cggacagatc tatgtgacca tgccctgcac agatctcacg atgagctatg aatcactgga
      901 gcaagcagcc tacaccaaac gtgatggaac acccccagga ggggaagatg gcagcattgc
      961 cttttatatt acgtttttat ggaaatgaac tgaaaaaaac tcttgaaacc gaaagta
//
