LOCUS       NM_001310511            3760 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus canopy FGF signaling regulator 1 (Cnpy1), transcript
            variant 1, mRNA.
ACCESSION   NM_001310511
VERSION     NM_001310511.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3760)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   3  (bases 1 to 3760)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   4  (bases 1 to 3760)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   5  (bases 1 to 3760)
  AUTHORS   Williamson,I., Kane,L., Devenney,P.S., Flyamer,I.M., Anderson,E.,
            Kilanowski,F., Hill,R.E., Bickmore,W.A. and Lettice,L.A.
  TITLE     Developmentally regulated Shh expression is robust to TAD
            perturbations
  JOURNAL   Development 146 (19) (2019)
   PUBMED   31511252
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3760)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3760)
  AUTHORS   Anderson,E., Devenney,P.S., Hill,R.E. and Lettice,L.A.
  TITLE     Mapping the Shh long-range regulatory domain
  JOURNAL   Development 141 (20), 3934-3943 (2014)
   PUBMED   25252942
REFERENCE   8  (bases 1 to 3760)
  AUTHORS   Paek,H., Antoine,M.W., Diaz,F. and Hebert,J.M.
  TITLE     Increased beta-catenin activity in the anterior neural plate
            induces ectopic mid-hindbrain characteristics
  JOURNAL   Dev Dyn 241 (2), 242-246 (2012)
   PUBMED   22102609
REFERENCE   9  (bases 1 to 3760)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   10 (bases 1 to 3760)
  AUTHORS   Jukkola,T., Lahti,L., Naserke,T., Wurst,W. and Partanen,J.
  TITLE     FGF regulated gene-expression and neuronal differentiation in the
            developing midbrain-hindbrain region
  JOURNAL   Dev Biol 297 (1), 141-157 (2006)
   PUBMED   16782087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139155.1, AK162570.1, AC129184.3 and BX630527.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162570.1, AK035938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AK139155.1         2-198
            198-2130            AK162570.1         2-1934
            2131-3355           AC129184.3         87141-88365
            3356-3760           BX630527.1         4-408               c
FEATURES             Location/Qualifiers
     source          1..3760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 13.99 cM"
     gene            1..3760
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /note="canopy FGF signaling regulator 1"
                     /db_xref="GeneID:269637"
                     /db_xref="MGI:MGI:2442451"
     exon            1..1045
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             896..1180
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /note="canopy 1 homolog"
                     /codon_start=1
                     /product="protein canopy homolog 1"
                     /protein_id="NP_001297440.1"
                     /db_xref="CCDS:CCDS80237.1"
                     /db_xref="GeneID:269637"
                     /db_xref="MGI:MGI:2442451"
                     /translation="MRMNDYQLEDDPVTKQKYFRRYAPRKGDKIYKEYKKFFFYSDAF
                     RPLKFACEAIIEKYEDEIFELIAQEANHLADMLCNEKSDLCGTPTNSPEP"
     exon            1046..1142
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..3760
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3729..3734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /note="hexamer: ATTAAA"
     regulatory      3742..3747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      3751
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
                     /note="major polyA site"
     polyA_site      3760
                     /gene="Cnpy1"
                     /gene_synonym="1500012D20Rik; 9630008K15Rik"
ORIGIN      
        1 gtcgcgcagt cgttggcacc ggaagggttc acactgcgtg tgaaagggga caaagggagc
       61 tggatatatc aacactgcag aaaccgagtt catttgtcat gcagcccctt tcagcgcagt
      121 tgtcatgcaa acttccttct ttgatcagca gagggtggag agagagaaag cccgcaaagc
      181 cgcgggcccg gacgaacgcc cttggcggct ccacgcccct tccggaagga gccgcaggga
      241 cccggcctcc tgcaccttga cccgtctaga cgccgcacaa ggttttgtct cggtttccaa
      301 gggcgcgggg tgctctttga cccgcgcccg gggcggaggt ggtggcacgg atcccagcgc
      361 gccccggcag gtcctggagg gagaggggct cccgggacgc gcgccagctg ttcccagagc
      421 aagccgaggc cgatgagggg caaccgggcc ctgctgcccc tgacaacctc ggtgtggacc
      481 ccgcatagcc tcctcgggaa gtccggaagg cgaggggggc agcgcgacgc gggatgggca
      541 gaagtgtggc ttccccacag aactgatgcg ctctcgacgc ccccctctcc tcccattttc
      601 tgtgcttcag cctctactca acaactttta aaaattatct ttaagtacag cttctagatt
      661 tctctgtctc ttactgtcca ctgtcaagca cgttattttc tcactagaat ttaagcctgc
      721 tttaagctgc ataaagaatg atgcggctgc gggaagccgt cccttcactt gttcactgga
      781 cccgcgtggg cgtgggcgtg ggcatgggca agtgtcctgg ctggttctgt tcttcttgta
      841 ggttcccctg gcccagtccg aggcgttcct catcgacctt ttggataaag tgtgtatgcg
      901 aatgaacgat taccagctgg aggacgaccc agtgaccaag cagaagtatt tcaggagata
      961 tgctccgagg aagggagaca aaatatacaa agaatataaa aagttcttct tttattctga
     1021 tgccttcaga cctttgaaat tcgcgtgcga agccatcatt gaaaagtatg aagatgagat
     1081 attcgaactt attgcccagg aggcaaacca tctagctgat atgctgtgca atgaaaaatc
     1141 agatctatgt ggcactccta ccaacagccc tgaaccctag gtatgagagg agtggagtca
     1201 gcccaacagg tcactgtgtg cctccacatc gtgtgactgc cgtgataagg aagttcatct
     1261 tctgtctgct gttcttgtct catgcgtgat attggtttga aaatctcttg cttggcatcg
     1321 tgacaaaccc caagtcttct cttaggtgaa gagaagttta taaaacagaa cacccctttg
     1381 catatttgga tggaagctgg gttggcaata gagcattaaa tctggccgtg ggaaaagggc
     1441 aaagctattt cttgaagtca gtaggaaatt aagggtgggt ctgagcaaat gagcctgaca
     1501 tgtccataca cagtttgcag tttcagaaga actcagtttg atttctcaaa ttcttgatca
     1561 gccacaaatt caaggtattc agttgtaaca aatgccgtgg gctggttatt ccaaaaggtt
     1621 ctgtgtggtg gttttaaagc cacccctctc agtcaggaat gggacttaca gatctggaaa
     1681 ctcttatatt ttagaactaa gattcgatag aaccgataaa agagtgaata cgtcgcacag
     1741 tcgactggcc atcatatcag agtttactgg ccctgagttc agatgattcc aaaggctatc
     1801 acatagtggg tttcaaaaaa ttcggcaccg aacacgtttt tgtcttgctt gagtctctct
     1861 tggtttgttt tcccctcact gatcatagtg tataaatttt cctactggct gatttgtcac
     1921 tcttttatgg gacttttatt tatgtattta tttttggatg tggagggata ttaaccttta
     1981 ccacacttac tgtaacaaaa tgtaataaca gtttctcctg ggtgttctca ttgtctctgc
     2041 taaatttgca ttcagtggaa ttgaacttta attattcagc atgtgtgggt acaggttaca
     2101 cctgtttaat taaagaaatt gtcaccactg tcattgaaac ttgcatgaat aacaggcaat
     2161 cgttttacca gaagagctaa aatggttgtt tataaaacca tccagaaaag acactattta
     2221 ggtcatgaac tgggctcctt ggccagaata atctttatat ttgcaaaatt ttaccaacat
     2281 aaaaggaaga gatttctatt tttttccttc cccttagtct taagtcttaa atgtcacttg
     2341 tttatctggg aatctgagaa aatctgtgct tttgcaaagt gtctgtggtt agttgtatta
     2401 taggccccct gtaaccctga gattctgtgc tccaaatgga caaggaagaa gagatacaag
     2461 gacaggtgat gctacctccc agtggggaaa gaaacatgtt atttaaagca tattctgagc
     2521 tatagtggag atgccacaaa acgggagggg ggaacctggt ccttgtatct tatttctata
     2581 acctgtaaga ttaatcagca tttgaggtag gaagtctttt tagcattgtt ttacttaggc
     2641 tttattagga catgcatcct agggtcccgt tttgtaagat ttgccttatg ggaacaaggc
     2701 tgagagggtg cggttatcag gctgctcttc tggcaccttt gtgcagatgg agcgtcaggc
     2761 tctcggcatt ggaaattgtc ctggatttct caccaagcag ggtcttagat cttaccagtt
     2821 gtttggctaa ctcatgactc attttttttt taaattcttt tccataccaa gcttgttgag
     2881 ctcatgtaaa tgcctatgga ttactgagtt gctgattaaa tcttggtttg attgagaatt
     2941 agccagagcc actgtctctc tgcctgtttc ttgtgagatg cctgctttgc tgggaagtag
     3001 ccataggaga gagaagctgt actggctgcc attctcctga ctttaaaatg acaccaaata
     3061 caaagtaaga tgaatagcca gagagaacca ctcaacacta aaagcaagca aatgaaacaa
     3121 gtgccaagca gcaagatgaa aatttctcag agttagcaaa aatcagcata gatctgggtc
     3181 aaaaaattaa taacaacaac attaatgttc cttgaaagtc agggtgagta atcgaagtca
     3241 ggaaggggga acttgtgtta gaggaagcgt gtaagccatg cttgaacctg tattctcaca
     3301 atccacatat caagctggcc aaaacaagat gcttagcttt gttctgcaag ttgctgtttg
     3361 ctaagaacaa gccaagactg ctgaacccat ttcactggcg agtagagggt cgaaccaagc
     3421 caaagtccca acaagaaaca cccacccttt tttgagacaa gtcctaagac atagccaaag
     3481 caggagctct gacctgtgtc tctgctccta ctgtgttatt ctcacacata gttccatgta
     3541 acaacaacaa caacaaaagt ttagctgtgt atcagtctca aaattcaaat tatggtagga
     3601 tattggggga agtcaatctt gtatatgttt gttggtctgc tcttaaactt gatataaact
     3661 tgtaagctaa tcttagactt agaaatgtta aaggccaatc agtagaatgt ggcactatta
     3721 gtaggtacat taaattattg caagaaaact atacttgtaa
//
