LOCUS       NM_009923               2333 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp),
            transcript variant 2, mRNA.
ACCESSION   NM_009923
VERSION     NM_009923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Baudouin,L., Ades,N., Kante,K., Bachelin,C., Hmidan,H., Deboux,C.,
            Panic,R., Ben Messaoud,R., Velut,Y., Hamada,S., Pionneau,C.,
            Duarte,K., Poea-Guyon,S., Barnier,J.V., Nait Oumesmar,B. and
            Bouslama-Oueghlani,L.
  TITLE     Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane
            expansion in oligodendrocytes
  JOURNAL   Glia 72 (8), 1518-1540 (2024)
   PUBMED   38794866
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Spate,E., Zhou,B., Sun,T., Kusch,K., Asadollahi,E., Siems,S.B.,
            Depp,C., Werner,H.B., Saher,G., Hirrlinger,J., Mobius,W., Nave,K.A.
            and Goebbels,S.
  TITLE     Downregulated expression of lactate dehydrogenase in adult
            oligodendrocytes and its implication for the transfer of glycolysis
            products to axons
  JOURNAL   Glia 72 (8), 1374-1391 (2024)
   PUBMED   38587131
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Nagy,N., Hadinger,N., Toth,O., Racz,G.A., Pinter,T., Gal,Z.,
            Urban,M., Gocza,E., Hiripi,L., Acsady,L. and Vertessy,B.G.
  TITLE     Characterization of dUTPase expression in mouse postnatal
            development and adult neurogenesis
  JOURNAL   Sci Rep 14 (1), 13139 (2024)
   PUBMED   38849394
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Sullivan,J.M., Bagnell,A.M., Alevy,J., Avila,E.M., Mihaljevic,L.,
            Saavedra-Rivera,P.C., Kong,L., Huh,J.S., McCray,B.A.,
            Aisenberg,W.H., Zuberi,A.R., Bogdanik,L., Lutz,C.M., Qiu,Z.,
            Quinlan,K.A., Searson,P.C. and Sumner,C.J.
  TITLE     Gain-of-function mutations of TRPV4 acting in endothelial cells
            drive blood-CNS barrier breakdown and motor neuron degeneration in
            mice
  JOURNAL   Sci Transl Med 16 (748), eadk1358 (2024)
   PUBMED   38776392
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Liu,X., Xin,D.E., Zhong,X., Zhao,C., Li,Z., Zhang,L., Dourson,A.J.,
            Lee,L., Mishra,S., Bayat,A.E., Nicholson,E., Seibel,W.L., Yan,B.,
            Mason,J., Turner,B.J., Gonsalvez,D.G., Ong,W., Chew,S.Y., Ghosh,B.,
            Yoon,S.O., Xin,M., He,Z., Tchieu,J., Wegner,M., Nave,K.A.,
            Franklin,R.J.M., Dutta,R., Trapp,B.D., Hu,M., Smith,M.A.,
            Jankowski,M.P., Barton,S.K., He,X. and Lu,Q.R.
  TITLE     Small-molecule-induced epigenetic rejuvenation promotes SREBP
            condensation and overcomes barriers to CNS myelin regeneration
  JOURNAL   Cell 187 (10), 2465-2484 (2024)
   PUBMED   38701782
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Kurihara,T., Monoh,K., Takahashi,Y., Goto,K. and Kondo,H.
  TITLE     2',3'-Cyclic-nucleotide 3'-phosphodiesterase. Complementary DNA and
            gene cloning for mouse enzyme and in situ hybridization of the
            messenger RNA in mouse brain
  JOURNAL   Adv Second Messenger Phosphoprotein Res 25, 101-110 (1992)
   PUBMED   1313252
  REMARK    Review article
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Rebbe,N.F., Tong,B.D., Finley,E.M. and Hickman,S.
  TITLE     Identification of nucleotide pyrophosphatase/alkaline
            phosphodiesterase I activity associated with the mouse plasma cell
            differentiation antigen PC-1
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5192-5196 (1991)
   PUBMED   1647027
REFERENCE   8  (bases 1 to 2333)
  AUTHORS   Kurihara,T., Monoh,K., Sakimura,K. and Takahashi,Y.
  TITLE     Alternative splicing of mouse brain 2',3'-cyclic-nucleotide
            3'-phosphodiesterase mRNA
  JOURNAL   Biochem Biophys Res Commun 170 (3), 1074-1081 (1990)
   PUBMED   2167669
REFERENCE   9  (bases 1 to 2333)
  AUTHORS   Monoh,K., Kurihara,T., Sakimura,K. and Takahashi,Y.
  TITLE     Structure of mouse 2',3'-cyclic-nucleotide 3'-phosphodiesterase
            gene
  JOURNAL   Biochem Biophys Res Commun 165 (3), 1213-1220 (1989)
   PUBMED   2558653
REFERENCE   10 (bases 1 to 2333)
  AUTHORS   Kurihara,T., Takahashi,Y., Fujita,N., Sato,S. and Miyatake,T.
  TITLE     Developmental expression of 2',3'-cyclic-nucleotide
            3'-phosphodiesterase mRNA in brains of normal and quaking mice
  JOURNAL   Brain Res Mol Brain Res 5 (3), 247-250 (1989)
   PUBMED   2542718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY333311.1, AK158318.1, AK087415.1 and BY596086.1.
            
            On Apr 7, 2009 this sequence version replaced NM_009923.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the presence and absence of exons at its 5' end, compared to
            variant 1. These differences produce a unique 5' UTR and cause
            translation initiation at an upstream start codon, compared to
            variant 1. The encoded protein (isoform 2) is 20 aa longer at the
            N-terminus, compared to isoform 1. This isoform is also known as
            CNP2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154654.1, AK158318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY333311.1         2-8
            8-1717              AK158318.1         2-1711
            1718-2321           AK087415.1         1685-2288
            2322-2333           BY596086.1         484-495
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..2333
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="2',3'-cyclic nucleotide 3' phosphodiesterase"
                     /db_xref="GeneID:12799"
                     /db_xref="MGI:MGI:88437"
     exon            1..130
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     exon            131..800
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     exon            801..940
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     exon            941..2333
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="hexamer: AATAAA"
     polyA_site      2322
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="major polyA site"
ORIGIN      
        1 aggctatgaa agggaccctg cgtggggggg ccccggacac ccggagacgc ccgtgtccct
       61 cacgcaggcg ggcggccccg gagacatagt acccgcaaag gcggtgacgg cggtgcgccc
      121 actcatcatg aacacaagct ttacccgcaa aagccacaca ttcctgccca agctcttctt
      181 caggaaaatg tcatcctcag gagcaaagga gaagccagag ctgcagttcc ctttccttca
      241 agatgaggac acggtggcta ccctccacga gtgcaagacg ctattcatcc tgcgcggcct
      301 gccgggcagc ggcaagtcca cactggctcg gctcatcctg gagaagtacc acgacggcac
      361 caagatggtg tccgctgatg cttacaagat catccctggc tctcgggcag acttctccga
      421 ggcgtacaag cgtctagacg aggacctggc tggctactgc cgccgggaca tcagggttct
      481 tgtgcttgat gataccaacc acgagcggga gcggctggat cagctttttg aaatggcaga
      541 ccagtatcag taccaggtgg tgctggtgga gcccaagaca gcgtggcgac tagactgtgc
      601 ccagctcaag gagaagaacc aatggcagct gtcggccgat gacctgaaga agctgaagcc
      661 cgggctggag aaggactttc tgccactcta ctttggctgg ttcctgacca aaaagagttc
      721 tgagaccctc cgaaaagctg gccaggtctt tctggaggag ctggggaatc acaaggcctt
      781 caagaaagag cttcgacact ttatttctgg agatgaaccc aaggagaagc ttgagctggt
      841 cagctacttt ggaaagagac ctccaggtgt gctgcactgt acaaccaaat tctgtgacta
      901 cgggaaggcc gctggggcag aagaatacgc ccagcaggag gtggtgaaga gatcgtatgg
      961 caaggccttc aaactgtcca tctctgctct ctttgtgaca cccaagacag ctggggccca
     1021 ggtggtgctg accgatcagg agctgcagtt gtggcccagt gatctggaca agccatctgc
     1081 ctccgagggc ctgcccccag ggagccgagc tcacgtcacc ctaggctgtg cggccgacgt
     1141 gcagccagtg cagacgggtc ttgacctctt agatatttta caacaggtga aggggggcag
     1201 ccaaggtgag gcggtgggtg agctcccccg gggcaagctc tattccctgg gcaaagggcg
     1261 atggatgctg agcctgacta agaagatgga ggtcaaggcc atcttcacgg ggtactatgg
     1321 gaagggcaaa cctgtgccca tacatggcag ccggaagggg ggtgccatgc agatctgcac
     1381 catcatctga gggttcacac cgctgtacca ctgtaccact gctgtgggtg gacacagcaa
     1441 catgccttcc acctgatttt taagattttt ttttttttta ctcaaagcta acgtacctgt
     1501 aactttttag gagtctataa aataactacc agttccttgt gcccaccctt tcttttcctc
     1561 ttaatactca gctctcaaca caggcgggtg ggcagaggaa gataccattc aggaacctgg
     1621 accagaggtg gtaataaaag ggctgggtca ttgggcctgc agcagcatct gcccagatgc
     1681 atccaagaac ttgttaaccc tcccttagcc cctgcccatc caaagctggg cacacgcctc
     1741 agagctgcca catgctaggg acaaacgcta ctgccacagg aaaacagtgg tagcttagag
     1801 agggctcaga tccctgggtg ccagtttttt aatcactata gcccttggga aggcttgggc
     1861 tatttactgg gcggtaaaag gggtttacct ctcacctttg gtcattccta agttcctatc
     1921 tccttcacac tgtacctagg gtgatggttt cggtcaggcc atctccagca gcatgtctct
     1981 gctgtgtgga tggaggccaa ggtcagaaag atgccccgag aagctccagc tttgctttct
     2041 gcccagccca tcttgcctgc atggtgcctc tgggtcttta aaggagggtg gtaggtacca
     2101 agaaccagtg gaggggaccc tgagctggca agagtaagcc ccatctcctg ctctggcaaa
     2161 gcctggctcc tggagtacct cactctgcct tctgctcagt aacaggacct tgctaattgg
     2221 gttgtcaccc gagaatctgg gatgtatgct cctaccctca ccctgtgttg cccacctcag
     2281 ccaccactaa gactgatact gaaataaatc atgttaatcc cagctgtgtg cta
//
