LOCUS       NM_021383               3285 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 9 (Cnot9),
            mRNA.
ACCESSION   NM_021383
VERSION     NM_021383.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3285)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3285)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3285)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3285)
  AUTHORS   Sun,M., Mondal,K., Patel,V., Horner,V.L., Long,A.B., Cutler,D.J.,
            Caspary,T. and Zwick,M.E.
  TITLE     Multiplex Chromosomal Exome Sequencing Accelerates Identification
            of ENU-Induced Mutations in the Mouse
  JOURNAL   G3 (Bethesda) 2 (1), 143-150 (2012)
   PUBMED   22384391
REFERENCE   5  (bases 1 to 3285)
  AUTHORS   Suzuki,A., Saba,R., Miyoshi,K., Morita,Y. and Saga,Y.
  TITLE     Interaction between NANOS2 and the CCR4-NOT deadenylation complex
            is essential for male germ cell development in mouse
  JOURNAL   PLoS One 7 (3), e33558 (2012)
   PUBMED   22448252
REFERENCE   6  (bases 1 to 3285)
  AUTHORS   Suzuki,A., Igarashi,K., Aisaki,K., Kanno,J. and Saga,Y.
  TITLE     NANOS2 interacts with the CCR4-NOT deadenylation complex and leads
            to suppression of specific RNAs
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3594-3599 (2010)
   PUBMED   20133598
REFERENCE   7  (bases 1 to 3285)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3285)
  AUTHORS   Morita,M., Suzuki,T., Nakamura,T., Yokoyama,K., Miyasaka,T. and
            Yamamoto,T.
  TITLE     Depletion of mammalian CCR4b deadenylase triggers elevation of the
            p27Kip1 mRNA level and impairs cell growth
  JOURNAL   Mol Cell Biol 27 (13), 4980-4990 (2007)
   PUBMED   17452450
REFERENCE   9  (bases 1 to 3285)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 3285)
  AUTHORS   Gregory,R.C., Lord,K.A., Panek,L.B., Gaines,P., Dillon,S.B. and
            Wojchowski,D.M.
  TITLE     Subtraction cloning and initial characterization of novel
            epo-immediate response genes
  JOURNAL   Cytokine 12 (7), 845-857 (2000)
   PUBMED   10880228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY705231.1, BC050898.1 and BC051948.1.
            
            On May 7, 2009 this sequence version replaced NM_021383.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051948.1, AK005025.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               BY705231.1         1-199
            200-3265            BC050898.1         1-3066
            3266-3285           BC051948.1         3106-3125
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..3285
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /note="CCR4-NOT transcription complex, subunit 9"
                     /db_xref="GeneID:58184"
                     /db_xref="MGI:MGI:1928902"
     exon            1..402
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..1278
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /note="cell differentiation protein RCD1 homolog; rcd-1;
                     EPO-induced protein FL10; RCD1 required for cell
                     differentiation 1 homolog; cell differentiation protein
                     RQCD1 homolog"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 9"
                     /protein_id="NP_067358.1"
                     /db_xref="CCDS:CCDS35615.1"
                     /db_xref="GeneID:58184"
                     /db_xref="MGI:MGI:1928902"
                     /translation="MHSLATAAPVPTALAQVDREKIYQWINELSSPETRENALLELSK
                     KRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVAS
                     HPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLT
                     TEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVL
                     QLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWL
                     AQLVKNLQEGQVTDPRGIPLPPQ"
     exon            403..582
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..698
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..808
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..918
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1017
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1109
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..3266
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /note="hexamer: AATAAA"
     polyA_site      1881
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /note="major polyA site"
     regulatory      3239..3244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /note="hexamer: AATAAA"
     polyA_site      3265
                     /gene="Cnot9"
                     /gene_synonym="2610007F23Rik; Fl10; Rqcd1"
                     /note="major polyA site"
ORIGIN      
        1 aattcgtgtc cttccaagcc tgctggcctt ttcccgccct tgtctggcct tcgggagaaa
       61 gtcagagttc acgtctctca aaggatttac ctgcgatgct gtggggatac gagggccagt
      121 agtttgcaga cgtcattttg atcccgaatc tgaaggttca aagaacatac tttgagatta
      181 tttgctaggc cgaggtccgg gaggcgggaa agggctgggt gggcggaggg tcagaggtga
      241 gaggtcaaag gcccgcgaag ggggcggagc gaggcggagg cggatggcgg cacttcatct
      301 tgggcatcag agccgctgaa gctgggacgc gggtccggtg cgtccggcgg gaggaggagt
      361 gcggcggccg ctccaaacat gcacagcctg gcaacggcag cgcctgtgcc tactgcacta
      421 gcccaagtgg acagagagaa gatctatcag tggatcaatg aactgtccag tcctgagaca
      481 agggaaaatg ctttgttgga gctgagcaag aagagagagt ctgtccctga ccttgcaccc
      541 atgctatggc attcatttgg tactattgca gcactgttac aggaaattgt aaatatttat
      601 ccatctatca accccccaac cttgacagca caccagtcta acagagtttg caatgcttta
      661 gcattgctgc agtgtgtggc ctcacacccg gagaccaggt cagcttttct ggcagcacac
      721 atcccactct ttttgtaccc ctttttgcac acagtcagca aaactcgtcc ctttgaatat
      781 cttcggctca ccagccttgg agttattggg gccttggtta aaacagatga gcaagaagta
      841 atcaactttt tattgaccac agagatcatc cctctgtgtc tgcgcatcat ggagtctgga
      901 agtgaactct ctaaaacggt tgccacattc atactccaga agatcctctt ggatgacact
      961 ggtttagctt atatatgtca gacatatgag cgtttttccc atgttgccat gatcttgggt
     1021 aaaatggtcc tgcagctatc caaagaaccg tcagcccgtc tgctgaagca cgtagtaaga
     1081 tgttaccttc gactctcaga taatcccagg gcacgtgaag cactcagaca gtgcctccct
     1141 gaccagctga aggacacaac ctttgcccag gtgctaaaag acgacaccac cacgaaacgc
     1201 tggcttgcac aactggtgaa gaacctgcaa gagggccagg tcaccgatcc ccgggggatt
     1261 cccctgcccc ctcagtgatc ctcgttccct ctcactgctc ccctttgctg gggagtgagg
     1321 gtggaaccta tgaggaaaac agctcaggtt ttattgctgg gaatagacaa cctcagtgct
     1381 gaactgtact ggagaaaagg ggcaaggtac ccgctgaggt gtgtgggctg actggaggtc
     1441 ctggatcccc ctactgctcc caggaattgg gctcctgaca gcagtctgct accacaaccc
     1501 caggcgggtg tcaacaccag caaatgctgt gtttgcagca tgcccaagat gaccctgctc
     1561 ctgaacctct acctagccac tggtagagag aggagagaac gtggtaatgg cagcaacact
     1621 ctaggcatga gagcaccggg gaccaagcca tgtggctttt tttttttttt tttaaacttt
     1681 gccttcctgg acaacttaag gtgtgtctct taattctctc ttacagtatt tgtttacttt
     1741 ggatttttgt ttttaatctc aaaagagaga gatgtgttta atggacacaa gctgtagttc
     1801 tcagcaaaac tttgtcagtt ggcactgttt acaagtctgt tagctgcata agctcaataa
     1861 aaagttggtc tgggcattgc atcccctctg acagaccgat agctgcatca ggctgttggg
     1921 tggaatggga ggcaagggaa taggaaagcc aaaggccaag caggaactct gtgcctgctc
     1981 tctgctcctg ttctttccct cccatacctg gctgctgtga ggacactcac cttgttctgg
     2041 cttcagctgc tagcctaccc acatctcagc gctttcccct tttttaccac ttagacttaa
     2101 agcaggtgtc ttaatttact caaccttccc taaaagagaa ttgtattggg gcaggaggga
     2161 tcgcagttct tcaaattcag gtcttcgaag ataatttcca ggtgtcttct caaacggagt
     2221 aagcgcctgg atccaaatgg tagactactt gaccccgttc tctagcgtga gttttcatag
     2281 tgccatctcc tcatgattgt agaagcagct gaatgagttt cttcagattt aaaatgaata
     2341 gctggactct gctggctcag tctcctctcc tttttaacac actttcttag gtctatggaa
     2401 actacagggt tgccactgaa atgttttttt acttgttgat agtgtcaggg ccccccttcc
     2461 atccccatgg gcttgactct caacctgtta ctgtaaactg cgatccttcc caccgtcagc
     2521 ctttgtttct catcctcacc tccaaagatg ggattattaa tccaactcta gaaagagtcc
     2581 aaatcttcag cccgtgtctc atacacttga agatgtctat attgagtttg aagaggttat
     2641 aaagggacag atggtcatag aaacctttgc agaggcagtt gtgccaaccc aagggctctt
     2701 tcattgttcg ttggcttctg tctttaaagc caagaaagta gtaattaagt agcctagatt
     2761 taaggagggt agaataagca tttattcccc tgccttccaa attgaagagg aggacttggc
     2821 ctcaagcctg aagaacaaaa gtctcagaaa gcaaagaaca gcatcacctt gataaatgtc
     2881 ttgactcagt ctgcggcttg tgatctgaaa agttctctag ggtaccctgg tttttgaaat
     2941 atgccttcct gctgagctga agtctttcat tccacttcac tgggggagca gctgaggctt
     3001 ggggccttgc tccctgggac attctctcca tcttttggtg cattggccat attactgtgc
     3061 caatagtgtc ttaactcatg tcccatctat cctcagctgg ccttggacct acataggagt
     3121 tgaatgggga ggggctacaa tgggtcttcc tgtggttggt cctgatgttg tatgtactat
     3181 ataaagagac ccctcccctt atattgtgtt ttccatccct caccctcaac aggattaaaa
     3241 taaaacatgc tgggtttttt tgttttaaaa aaaaaaaaaa aaaaa
//
