LOCUS       NM_026949               2221 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 8 (Cnot8),
            transcript variant 1, mRNA.
ACCESSION   NM_026949
VERSION     NM_026949.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2221)
  AUTHORS   Soeda,S., Oyama,M., Kozuka-Hata,H. and Yamamoto,T.
  TITLE     The CCR4-NOT complex suppresses untimely translational activation
            of maternal mRNAs
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37767629
REFERENCE   2  (bases 1 to 2221)
  AUTHORS   Stoney,P.N., Yanagiya,A., Nishijima,S. and Yamamoto,T.
  TITLE     CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The
            CCR4-NOT Complex
  JOURNAL   J Mol Biol 434 (9), 167523 (2022)
   PUBMED   35248544
  REMARK    GeneRIF: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into
            The CCR4-NOT Complex.
REFERENCE   3  (bases 1 to 2221)
  AUTHORS   Quan,Y., Wang,M., Xu,C., Wang,X., Wu,Y., Qin,D., Lin,Y., Lu,X.,
            Lu,F. and Li,L.
  TITLE     Cnot8 eliminates naive regulation networks and is essential for
            naive-to-formative pluripotency transition
  JOURNAL   Nucleic Acids Res 50 (8), 4414-4435 (2022)
   PUBMED   35390160
  REMARK    GeneRIF: Cnot8 eliminates naive regulation networks and is
            essential for naive-to-formative pluripotency transition.
REFERENCE   4  (bases 1 to 2221)
  AUTHORS   Mostafa,D., Takahashi,A., Yanagiya,A., Yamaguchi,T., Abe,T.,
            Kureha,T., Kuba,K., Kanegae,Y., Furuta,Y., Yamamoto,T. and
            Suzuki,T.
  TITLE     Essential functions of the CNOT7/8 catalytic subunits of the
            CCR4-NOT complex in mRNA regulation and cell viability
  JOURNAL   RNA Biol 17 (3), 403-416 (2020)
   PUBMED   31924127
  REMARK    GeneRIF: Essential functions of the CNOT7/8 catalytic subunits of
            the CCR4-NOT complex in mRNA regulation and cell viability.
REFERENCE   5  (bases 1 to 2221)
  AUTHORS   Vincentz,J.W., Firulli,B.A., Toolan,K.P., Arking,D.E.,
            Sotoodehnia,N., Wan,J., Chen,P.S., de Gier-de Vries,C.,
            Christoffels,V.M., Rubart-von der Lohe,M. and Firulli,A.B.
  TITLE     Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA
            Transcription Factor Binding and Disrupts Conduction System
            Development and Function
  JOURNAL   Circ Res 125 (6), 575-589 (2019)
   PUBMED   31366290
REFERENCE   6  (bases 1 to 2221)
  AUTHORS   Chen,C., Ito,K., Takahashi,A., Wang,G., Suzuki,T., Nakazawa,T.,
            Yamamoto,T. and Yokoyama,K.
  TITLE     Distinct expression patterns of the subunits of the CCR4-NOT
            deadenylase complex during neural development
  JOURNAL   Biochem Biophys Res Commun 411 (2), 360-364 (2011)
   PUBMED   21741365
REFERENCE   7  (bases 1 to 2221)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   8  (bases 1 to 2221)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2221)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2221)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD553562.1, AK150757.1, AK075727.1 and BY419531.1.
            
            On May 8, 2018 this sequence version replaced NM_026949.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.120740.1,
                                           SRR1660819.931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               CD553562.1         1-103
            104-1622            AK150757.1         2-1520
            1623-2211           AK075727.1         1410-1998
            2212-2221           BY419531.1         368-377
FEATURES             Location/Qualifiers
     source          1..2221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.69 cM"
     gene            1..2221
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="CCR4-NOT transcription complex, subunit 8"
                     /db_xref="GeneID:69125"
                     /db_xref="MGI:MGI:1916375"
     exon            1..239
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            240..450
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1212
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /EC_number="3.1.13.4"
                     /note="CCR4-associated factor 8"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 8"
                     /protein_id="NP_081225.1"
                     /db_xref="CCDS:CCDS24722.1"
                     /db_xref="GeneID:69125"
                     /db_xref="MGI:MGI:1916375"
                     /translation="MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFP
                     GVVVRPIGEFRSSIDYQYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFN
                     LTEDMYSQDSIDLLANSGLQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGY
                     DFGYMVKLLTDSRLPEEEHEFFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDL
                     QRIGRQHQAGSDSLLTGMAFFRMKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDC
                     AQEKMSILAMINNMQQ"
     exon            451..644
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..806
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            807..951
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1062
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..2221
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2195..2200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2218
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgaga ccggcgggac cgcgcacgcc tggagtgacg cggagagtag gcgagtcggg
       61 agggcggacg ggtagagtgg tgcaacctct tggtttggtg cccatcgtcg gccgctctgg
      121 gcgccaggac tcacgtctcc ctgtcgagct gggtttctgg agcggatccg gggcaagagg
      181 gaggagagct cggggtcaag ggccgctgcc gcccgcactc ggcggggccg ccagccagga
      241 ttggatccag tgtggacaat taaatcaaac agaaggaggc ttgtttgttt ttttacatag
      301 ttggctcacg gtggctcctc aggtgccttc aggatgcctg cggcacttgt agaaaacagt
      361 caggtcatct gtgaggtgtg ggccagcaat cttgaggaag agatgcggaa gatccgtgag
      421 attgtcctca gctacagcta tatcgctatg gacacagagt tcccaggtgt tgttgtacgg
      481 ccgatcggtg aatttcgaag ctccatagat taccagtatc agcttctgcg gtgcaatgtt
      541 gatcttctta aaatcatcca gctgggcctt acgttcacca atgagaaggg ggagtacccg
      601 tctggaatca acacatggca gttcaacttc aagttcaacc tgacagagga tatgtactcc
      661 caggattcca tagatctgct tgcaaactca gggctgcagt tccagaaaca cgaggaggaa
      721 gggatcgata cactgcactt tgcagagctg cttatgacat cgggagtggt tctctgtgac
      781 aacgtcaagt ggctttcatt tcacagtggt tatgattttg gctacatggt aaagctgcta
      841 acagactctc gcctgccgga agaagaacac gagttctttc atatcctgaa tcttttcttc
      901 ccgtccattt acgatgtgaa atacctgatg aagagctgca aaaacctgaa gggaggcctt
      961 caggaggtgg ctgatcagtt ggatctgcag aggatcggaa ggcagcatca agcaggctca
     1021 gactctctgc tgacggggat ggctttcttc aggatgaaag agctattctt tgaggacagt
     1081 attgacgatg ccaagtattg tgggcgcctc tatggcctgg gcacaggggt ggcccagaag
     1141 cagaatgagg atgtggactg tgcccaggag aagatgagca tcttggccat gatcaacaac
     1201 atgcagcagt gatggtgcgt gcaccgtgcg gtccgtgcac catgccgcct gtgacctgca
     1261 tctgctccaa gcagagactt tggctttttg tttaaagatg cctttatttt agatccagga
     1321 ggggtttgct ctgaatttgt aaacaagtct tcctcgtcct catgccccca cccctctgct
     1381 gcctcctgcc accagcatcc atggccccat ggacactttt ttaaatctcc aggatgtctg
     1441 aaacaaacca gtaaaatgtc tatgactctt acatgttgtc attcttcttc ttttggcttt
     1501 gctgctctga tgaagttgct cagatgagct gtggctgcca gagaacaagg tgtatgttct
     1561 tgggaagcag gtctatgcca gtgggctgtt ttgccttgtt tgtgcttctt caggacagag
     1621 cagtcctgat gatacagtaa ttgatggcag acagttctgt ctccttccca gttgttaggc
     1681 tgcccccctg agcctcacct tgttcacctt ggttttccga tgatgagctt ccctagacag
     1741 atcatgctcc acgtccacgg tgttctcagc accgtgatct gtcagctgtg ctctcttagc
     1801 ctccagcctg agctctcaag aggtggtaga gctaagctct ggaggtggag tcttaggaag
     1861 acccaggagt gactgagcag gacagtaaag ggattctcct cagaacccat tgagtcctcc
     1921 accccacagt tgtgcttgga agcctgttga ctgtgcttaa ggttaggcat ttaggaagca
     1981 cactgctttt taaacgacca cagaaagaaa ggacaattgt aagaagtaaa aacttatttg
     2041 gaaggcagag acagacggca gcagctcact taggcaggaa tggtcttacc ttttaaaagc
     2101 ttgtgggaaa ctgaatttga aatgacaaaa tgtcaagtat taaagctggt atttaagatg
     2161 cttgtaaata ttatttatgt ttttaatttt gtaaaataaa gattgctttt taaccattgg
     2221 c
//
