LOCUS       NM_001363085            2292 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 8 (Cnot8),
            transcript variant 5, mRNA.
ACCESSION   NM_001363085 XM_006534105
VERSION     NM_001363085.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Soeda,S., Oyama,M., Kozuka-Hata,H. and Yamamoto,T.
  TITLE     The CCR4-NOT complex suppresses untimely translational activation
            of maternal mRNAs
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37767629
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Stoney,P.N., Yanagiya,A., Nishijima,S. and Yamamoto,T.
  TITLE     CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The
            CCR4-NOT Complex
  JOURNAL   J Mol Biol 434 (9), 167523 (2022)
   PUBMED   35248544
  REMARK    GeneRIF: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into
            The CCR4-NOT Complex.
REFERENCE   3  (bases 1 to 2292)
  AUTHORS   Quan,Y., Wang,M., Xu,C., Wang,X., Wu,Y., Qin,D., Lin,Y., Lu,X.,
            Lu,F. and Li,L.
  TITLE     Cnot8 eliminates naive regulation networks and is essential for
            naive-to-formative pluripotency transition
  JOURNAL   Nucleic Acids Res 50 (8), 4414-4435 (2022)
   PUBMED   35390160
  REMARK    GeneRIF: Cnot8 eliminates naive regulation networks and is
            essential for naive-to-formative pluripotency transition.
REFERENCE   4  (bases 1 to 2292)
  AUTHORS   Mostafa,D., Takahashi,A., Yanagiya,A., Yamaguchi,T., Abe,T.,
            Kureha,T., Kuba,K., Kanegae,Y., Furuta,Y., Yamamoto,T. and
            Suzuki,T.
  TITLE     Essential functions of the CNOT7/8 catalytic subunits of the
            CCR4-NOT complex in mRNA regulation and cell viability
  JOURNAL   RNA Biol 17 (3), 403-416 (2020)
   PUBMED   31924127
  REMARK    GeneRIF: Essential functions of the CNOT7/8 catalytic subunits of
            the CCR4-NOT complex in mRNA regulation and cell viability.
REFERENCE   5  (bases 1 to 2292)
  AUTHORS   Vincentz,J.W., Firulli,B.A., Toolan,K.P., Arking,D.E.,
            Sotoodehnia,N., Wan,J., Chen,P.S., de Gier-de Vries,C.,
            Christoffels,V.M., Rubart-von der Lohe,M. and Firulli,A.B.
  TITLE     Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA
            Transcription Factor Binding and Disrupts Conduction System
            Development and Function
  JOURNAL   Circ Res 125 (6), 575-589 (2019)
   PUBMED   31366290
REFERENCE   6  (bases 1 to 2292)
  AUTHORS   Chen,C., Ito,K., Takahashi,A., Wang,G., Suzuki,T., Nakazawa,T.,
            Yamamoto,T. and Yokoyama,K.
  TITLE     Distinct expression patterns of the subunits of the CCR4-NOT
            deadenylase complex during neural development
  JOURNAL   Biochem Biophys Res Commun 411 (2), 360-364 (2011)
   PUBMED   21741365
REFERENCE   7  (bases 1 to 2292)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   8  (bases 1 to 2292)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2292)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2292)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672182.18.
            
            On May 8, 2018 this sequence version replaced XM_006534105.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: CN539282.1, BU503882.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AL672182.18        76688-76886         c
            200-310             AL672182.18        66880-66990         c
            311-521             AL672182.18        60326-60536         c
            522-715             AL672182.18        58639-58832         c
            716-877             AL672182.18        56879-57040         c
            878-1022            AL672182.18        55998-56142         c
            1023-1133           AL672182.18        54717-54827         c
            1134-2292           AL672182.18        51495-52653         c
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.69 cM"
     gene            1..2292
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="CCR4-NOT transcription complex, subunit 8"
                     /db_xref="GeneID:69125"
                     /db_xref="MGI:MGI:1916375"
     exon            1..199
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            200..310
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            311..521
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1283
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /EC_number="3.1.13.4"
                     /note="CCR4-associated factor 8"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 8"
                     /protein_id="NP_001350014.1"
                     /db_xref="CCDS:CCDS24722.1"
                     /db_xref="GeneID:69125"
                     /db_xref="MGI:MGI:1916375"
                     /translation="MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFP
                     GVVVRPIGEFRSSIDYQYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFN
                     LTEDMYSQDSIDLLANSGLQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGY
                     DFGYMVKLLTDSRLPEEEHEFFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDL
                     QRIGRQHQAGSDSLLTGMAFFRMKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDC
                     AQEKMSILAMINNMQQ"
     exon            522..715
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            716..877
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1022
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1133
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..2292
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2289
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaaagtttag gtctgtgtgg gctggaaaca gaatgccttt cttttggaag gacacgtcct
       61 taatgagaga ggacagctca aaagctgaga aacagggcat ggcctcggat tctgctcccc
      121 tcgaactttc tttttccctt tgtcttctct gattttagaa aatgttaaca agcaggaaac
      181 ctggatgaag acgtgggcga tcctggagag aaacaacaaa ggctgggctt cagaaactgt
      241 ccctgacatc gttaccccag aagctggctg tgcgatttca cagtttgaaa ggctagctct
      301 catttagtca attggatcca gtgtggacaa ttaaatcaaa cagaaggagg cttgtttgtt
      361 tttttacata gttggctcac ggtggctcct caggtgcctt caggatgcct gcggcacttg
      421 tagaaaacag tcaggtcatc tgtgaggtgt gggccagcaa tcttgaggaa gagatgcgga
      481 agatccgtga gattgtcctc agctacagct atatcgctat ggacacagag ttcccaggtg
      541 ttgttgtacg gccgatcggt gaatttcgaa gctccataga ttaccagtat cagcttctgc
      601 ggtgcaatgt tgatcttctt aaaatcatcc agctgggcct tacgttcacc aatgagaagg
      661 gggagtaccc gtctggaatc aacacatggc agttcaactt caagttcaac ctgacagagg
      721 atatgtactc ccaggattcc atagatctgc ttgcaaactc agggctgcag ttccagaaac
      781 acgaggagga agggatcgat acactgcact ttgcagagct gcttatgaca tcgggagtgg
      841 ttctctgtga caacgtcaag tggctttcat ttcacagtgg ttatgatttt ggctacatgg
      901 taaagctgct aacagactct cgcctgccgg aagaagaaca cgagttcttt catatcctga
      961 atcttttctt cccgtccatt tacgatgtga aatacctgat gaagagctgc aaaaacctga
     1021 agggaggcct tcaggaggtg gctgatcagt tggatctgca gaggatcgga aggcagcatc
     1081 aagcaggctc agactctctg ctgacgggga tggctttctt caggatgaaa gagctattct
     1141 ttgaggacag tattgacgat gccaagtatt gtgggcgcct ctatggcctg ggcacagggg
     1201 tggcccagaa gcagaatgag gatgtggact gtgcccagga gaagatgagc atcttggcca
     1261 tgatcaacaa catgcagcag tgatggtgcg tgcaccgtgc ggtccgtgca ccatgccgcc
     1321 tgtgacctgc atctgctcca agcagagact ttggcttttt gtttaaagat gcctttattt
     1381 tagatccagg aggggtttgc tctgaatttg taaacaagtc ttcctcgtcc tcatgccccc
     1441 acccctctgc tgcctcctgc caccagcatc catggcccca tggacacttt tttaaatctc
     1501 caggatgtct gaaacaaacc agtaaaatgt ctatgactct tacatgttgt cattcttctt
     1561 cttttggctt tgctgctctg atgaagttgc tcagatgagc tgtggctgcc agagaacaag
     1621 gtgtatgttc ttgggaagca ggtctatgcc agtgggctgt tttgccttgt ttgtgcttct
     1681 tcaggacaga gcagtcctga tgatacagta attgatggca gacagttctg tctccttccc
     1741 agttgttagg ctgcccccct gagcctcacc ttgttcacct tggttttccg atgatgagct
     1801 tccctagaca gatcatgctc cacgtccacg gtgttctcag caccgtgatc tgtcagctgt
     1861 gctctcttag cctccagcct gagctctcaa gaggtggtag agctaagctc tggaggtgga
     1921 gtcttaggaa gacccaggag tgactgagca ggacagtaaa gggattctcc tcagaaccca
     1981 ttgagtcctc caccccacag ttgtgcttgg aagcctgttg actgtgctta aggttaggca
     2041 tttaggaagc acactgcttt ttaaacgacc acagaaagaa aggacaattg taagaagtaa
     2101 aaacttattt ggaaggcaga gacagacggc agcagctcac ttaggcagga atggtcttac
     2161 cttttaaaag cttgtgggaa actgaatttg aaatgacaaa atgtcaagta ttaaagctgg
     2221 tatttaagat gcttgtaaat attatttatg tttttaattt tgtaaaataa agattgcttt
     2281 ttaaccattg gc
//
