LOCUS       NM_001363084            2190 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 8 (Cnot8),
            transcript variant 4, mRNA.
ACCESSION   NM_001363084 XM_006534104
VERSION     NM_001363084.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Soeda,S., Oyama,M., Kozuka-Hata,H. and Yamamoto,T.
  TITLE     The CCR4-NOT complex suppresses untimely translational activation
            of maternal mRNAs
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37767629
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Stoney,P.N., Yanagiya,A., Nishijima,S. and Yamamoto,T.
  TITLE     CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The
            CCR4-NOT Complex
  JOURNAL   J Mol Biol 434 (9), 167523 (2022)
   PUBMED   35248544
  REMARK    GeneRIF: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into
            The CCR4-NOT Complex.
REFERENCE   3  (bases 1 to 2190)
  AUTHORS   Quan,Y., Wang,M., Xu,C., Wang,X., Wu,Y., Qin,D., Lin,Y., Lu,X.,
            Lu,F. and Li,L.
  TITLE     Cnot8 eliminates naive regulation networks and is essential for
            naive-to-formative pluripotency transition
  JOURNAL   Nucleic Acids Res 50 (8), 4414-4435 (2022)
   PUBMED   35390160
  REMARK    GeneRIF: Cnot8 eliminates naive regulation networks and is
            essential for naive-to-formative pluripotency transition.
REFERENCE   4  (bases 1 to 2190)
  AUTHORS   Mostafa,D., Takahashi,A., Yanagiya,A., Yamaguchi,T., Abe,T.,
            Kureha,T., Kuba,K., Kanegae,Y., Furuta,Y., Yamamoto,T. and
            Suzuki,T.
  TITLE     Essential functions of the CNOT7/8 catalytic subunits of the
            CCR4-NOT complex in mRNA regulation and cell viability
  JOURNAL   RNA Biol 17 (3), 403-416 (2020)
   PUBMED   31924127
  REMARK    GeneRIF: Essential functions of the CNOT7/8 catalytic subunits of
            the CCR4-NOT complex in mRNA regulation and cell viability.
REFERENCE   5  (bases 1 to 2190)
  AUTHORS   Vincentz,J.W., Firulli,B.A., Toolan,K.P., Arking,D.E.,
            Sotoodehnia,N., Wan,J., Chen,P.S., de Gier-de Vries,C.,
            Christoffels,V.M., Rubart-von der Lohe,M. and Firulli,A.B.
  TITLE     Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA
            Transcription Factor Binding and Disrupts Conduction System
            Development and Function
  JOURNAL   Circ Res 125 (6), 575-589 (2019)
   PUBMED   31366290
REFERENCE   6  (bases 1 to 2190)
  AUTHORS   Chen,C., Ito,K., Takahashi,A., Wang,G., Suzuki,T., Nakazawa,T.,
            Yamamoto,T. and Yokoyama,K.
  TITLE     Distinct expression patterns of the subunits of the CCR4-NOT
            deadenylase complex during neural development
  JOURNAL   Biochem Biophys Res Commun 411 (2), 360-364 (2011)
   PUBMED   21741365
REFERENCE   7  (bases 1 to 2190)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   8  (bases 1 to 2190)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2190)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2190)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB843287.1 and AL672182.18.
            
            On May 8, 2018 this sequence version replaced XM_006534104.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: CN539282.1, BU503882.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               BB843287.1         2-321
            321-419             AL672182.18        60326-60424         c
            420-613             AL672182.18        58639-58832         c
            614-775             AL672182.18        56879-57040         c
            776-920             AL672182.18        55998-56142         c
            921-1031            AL672182.18        54717-54827         c
            1032-2190           AL672182.18        51495-52653         c
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.69 cM"
     gene            1..2190
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="CCR4-NOT transcription complex, subunit 8"
                     /db_xref="GeneID:69125"
                     /db_xref="MGI:MGI:1916375"
     exon            1..97
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            98..208
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            209..419
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1181
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /EC_number="3.1.13.4"
                     /note="CCR4-associated factor 8"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 8"
                     /protein_id="NP_001350013.1"
                     /db_xref="CCDS:CCDS24722.1"
                     /db_xref="GeneID:69125"
                     /db_xref="MGI:MGI:1916375"
                     /translation="MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFP
                     GVVVRPIGEFRSSIDYQYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFN
                     LTEDMYSQDSIDLLANSGLQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGY
                     DFGYMVKLLTDSRLPEEEHEFFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDL
                     QRIGRQHQAGSDSLLTGMAFFRMKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDC
                     AQEKMSILAMINNMQQ"
     exon            420..613
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..775
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            776..920
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1031
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..2190
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="Cnot8"
                     /gene_synonym="1500015I04Rik; 1810022F04Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcattaga actgtgtcag tttggagaga agcaacatta tggaggagac agaaggtgca
       61 gacacctggc aggtggtgct ggctccctga ggaacagatc ctggagagaa acaacaaagg
      121 ctgggcttca gaaactgtcc ctgacatcgt taccccagaa gctggctgtg cgatttcaca
      181 gtttgaaagg ctagctctca tttagtcaat tggatccagt gtggacaatt aaatcaaaca
      241 gaaggaggct tgtttgtttt tttacatagt tggctcacgg tggctcctca ggtgccttca
      301 ggatgcctgc ggcacttgta gaaaacagtc aggtcatctg tgaggtgtgg gccagcaatc
      361 ttgaggaaga gatgcggaag atccgtgaga ttgtcctcag ctacagctat atcgctatgg
      421 acacagagtt cccaggtgtt gttgtacggc cgatcggtga atttcgaagc tccatagatt
      481 accagtatca gcttctgcgg tgcaatgttg atcttcttaa aatcatccag ctgggcctta
      541 cgttcaccaa tgagaagggg gagtacccgt ctggaatcaa cacatggcag ttcaacttca
      601 agttcaacct gacagaggat atgtactccc aggattccat agatctgctt gcaaactcag
      661 ggctgcagtt ccagaaacac gaggaggaag ggatcgatac actgcacttt gcagagctgc
      721 ttatgacatc gggagtggtt ctctgtgaca acgtcaagtg gctttcattt cacagtggtt
      781 atgattttgg ctacatggta aagctgctaa cagactctcg cctgccggaa gaagaacacg
      841 agttctttca tatcctgaat cttttcttcc cgtccattta cgatgtgaaa tacctgatga
      901 agagctgcaa aaacctgaag ggaggccttc aggaggtggc tgatcagttg gatctgcaga
      961 ggatcggaag gcagcatcaa gcaggctcag actctctgct gacggggatg gctttcttca
     1021 ggatgaaaga gctattcttt gaggacagta ttgacgatgc caagtattgt gggcgcctct
     1081 atggcctggg cacaggggtg gcccagaagc agaatgagga tgtggactgt gcccaggaga
     1141 agatgagcat cttggccatg atcaacaaca tgcagcagtg atggtgcgtg caccgtgcgg
     1201 tccgtgcacc atgccgcctg tgacctgcat ctgctccaag cagagacttt ggctttttgt
     1261 ttaaagatgc ctttatttta gatccaggag gggtttgctc tgaatttgta aacaagtctt
     1321 cctcgtcctc atgcccccac ccctctgctg cctcctgcca ccagcatcca tggccccatg
     1381 gacacttttt taaatctcca ggatgtctga aacaaaccag taaaatgtct atgactctta
     1441 catgttgtca ttcttcttct tttggctttg ctgctctgat gaagttgctc agatgagctg
     1501 tggctgccag agaacaaggt gtatgttctt gggaagcagg tctatgccag tgggctgttt
     1561 tgccttgttt gtgcttcttc aggacagagc agtcctgatg atacagtaat tgatggcaga
     1621 cagttctgtc tccttcccag ttgttaggct gcccccctga gcctcacctt gttcaccttg
     1681 gttttccgat gatgagcttc cctagacaga tcatgctcca cgtccacggt gttctcagca
     1741 ccgtgatctg tcagctgtgc tctcttagcc tccagcctga gctctcaaga ggtggtagag
     1801 ctaagctctg gaggtggagt cttaggaaga cccaggagtg actgagcagg acagtaaagg
     1861 gattctcctc agaacccatt gagtcctcca ccccacagtt gtgcttggaa gcctgttgac
     1921 tgtgcttaag gttaggcatt taggaagcac actgcttttt aaacgaccac agaaagaaag
     1981 gacaattgta agaagtaaaa acttatttgg aaggcagaga cagacggcag cagctcactt
     2041 aggcaggaat ggtcttacct tttaaaagct tgtgggaaac tgaatttgaa atgacaaaat
     2101 gtcaagtatt aaagctggta tttaagatgc ttgtaaatat tatttatgtt tttaattttg
     2161 taaaataaag attgcttttt aaccattggc
//
