LOCUS       NM_144910               8564 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 6-like
            (Cnot6l), transcript variant 1, mRNA.
ACCESSION   NM_144910
VERSION     NM_144910.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8564)
  AUTHORS   Zhang,Y., Liu,G., Ding,H. and Fan,B.
  TITLE     High expression of CNOT6L contributes to the negative development
            of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 24723 (2024)
   PUBMED   39433858
  REMARK    GeneRIF: High expression of CNOT6L contributes to the negative
            development of type 2 diabetes.
            Erratum:[Sci Rep. 2024 Dec 23;14(1):30627. doi:
            10.1038/s41598-024-83685-w.. PMID: 39715822]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8564)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8564)
  AUTHORS   Qian,B., Li,Y., Yan,R., Han,S., Bu,Z., Gong,J., Zheng,B., Yuan,Z.,
            Ren,S., He,Q., Zhang,J., Xu,C., Wang,R., Sun,Z., Lin,M., Zhou,J.
            and Ye,L.
  TITLE     RNA binding protein RBM46 regulates mitotic-to-meiotic transition
            in spermatogenesis
  JOURNAL   Sci Adv 8 (34), eabq2945 (2022)
   PUBMED   36001654
REFERENCE   4  (bases 1 to 8564)
  AUTHORS   Quan,Y., Wang,M., Xu,C., Wang,X., Wu,Y., Qin,D., Lin,Y., Lu,X.,
            Lu,F. and Li,L.
  TITLE     Cnot8 eliminates naive regulation networks and is essential for
            naive-to-formative pluripotency transition
  JOURNAL   Nucleic Acids Res 50 (8), 4414-4435 (2022)
   PUBMED   35390160
REFERENCE   5  (bases 1 to 8564)
  AUTHORS   Katsumura,S., Siddiqui,N., Goldsmith,M.R., Cheah,J.H., Fujikawa,T.,
            Minegishi,G., Yamagata,A., Yabuki,Y., Kobayashi,K., Shirouzu,M.,
            Inagaki,T., Huang,T.H., Musi,N., Topisirovic,I., Larsson,O. and
            Morita,M.
  TITLE     Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates
            food intake and energy expenditure
  JOURNAL   Cell Metab 34 (4), 564-580 (2022)
   PUBMED   35385705
  REMARK    GeneRIF: Deadenylase-dependent mRNA decay of GDF15 and FGF21
            orchestrates food intake and energy expenditure.
REFERENCE   6  (bases 1 to 8564)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   7  (bases 1 to 8564)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 8564)
  AUTHORS   Morita,M., Suzuki,T., Nakamura,T., Yokoyama,K., Miyasaka,T. and
            Yamamoto,T.
  TITLE     Depletion of mammalian CCR4b deadenylase triggers elevation of the
            p27Kip1 mRNA level and impairs cell growth
  JOURNAL   Mol Cell Biol 27 (13), 4980-4990 (2007)
   PUBMED   17452450
  REMARK    GeneRIF: CCR4b may be involved in various cellular events that
            include cell proliferation.
REFERENCE   9  (bases 1 to 8564)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 8564)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018506.1, CF173938.1, AK151728.1, AK030112.1 and AC129600.4.
            
            On Oct 22, 2013 this sequence version replaced NM_144910.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and the
            5' coding region and initiates translation at a downstream start
            codon, compared to variant 2. Variants 1 and 3 encode the same
            isoform (1), which is shorter and has a distinct N-terminus,
            compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018506.1, SRR9219382.21117.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BC018506.1         1-18
            19-182              CF173938.1         1-164
            183-760             AK151728.1         318-895
            761-1888            AK030112.1         769-1896
            1889-2096           AK151728.1         1885-2092
            2097-8564           AC129600.4         179744-186211       c
FEATURES             Location/Qualifiers
     source          1..8564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.29 cM"
     gene            1..8564
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /note="CCR4-NOT transcription complex, subunit 6-like"
                     /db_xref="GeneID:231464"
                     /db_xref="MGI:MGI:2443154"
     exon            1..54
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            55..176
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1717
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /EC_number="3.1.13.4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 6-like
                     isoform 1"
                     /protein_id="NP_659159.1"
                     /db_xref="CCDS:CCDS19448.1"
                     /db_xref="GeneID:231464"
                     /db_xref="MGI:MGI:2443154"
                     /translation="MPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLS
                     TSLWSLTHLTALHLNDNNLARIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL
                     LLNDNYLRVLPYELGRLFQLQTLGLTGNPLSQDIMSLYQDPDGTRKLLNFMLDNLAVH
                     PEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKG
                     IMEEIVNWDADIISLQEVETEQYFTLFLPALKDRGYDGFFSPKSRAKIMSEQERKHVD
                     GCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELF
                     GTGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPT
                     ADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCSGKNGS
                     SEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLV
                     ENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR"
     exon            177..363
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..449
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..539
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            540..608
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..766
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            767..921
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1073
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1301
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1504
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..8564
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5580..5585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5619
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /note="major polyA site"
     regulatory      6070..6075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /note="hexamer: CATAAA"
     polyA_site      6108
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
     regulatory      8540..8545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8564
                     /gene="Cnot6l"
                     /gene_synonym="4932442K20Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgccccgccg ccgccgccgt cgccgccgtc cggaccctgg cgcgctgaat gcagactaat
       61 agggatgcca aaggaaaaat atgatcctcc agatcctcgc agaatttaca ccatcatgtc
      121 cgcagaggag gtagccaatg ggaaaaaatc tcactgggca gagttagaga tctcgggtag
      181 agtgcggagc ttaagtacat cactctggtc attaacacac ttgacagcac tgcacctaaa
      241 tgacaataac cttgctcgca ttccacctga tattgccaag cttcataatc tggtttacct
      301 ggatctgtca tccaataaac tcagaagttt accagcagaa ctaggaaaca tggtgtctct
      361 cagggaattg cttttaaatg acaattattt acgggtgttg ccttatgaac ttggccggct
      421 cttccagcta caaactctag gtttaacagg caatccttta tcacaggata ttatgagctt
      481 ataccaggac ccagatggaa cccgaaagct actgaacttc atgcttgaca atcttgcagt
      541 tcatccagag cagcttcctc cgaggccatg gattacatta aaagaacgag accaaattct
      601 gccatcagca tcattcacgg ttatgtgtta caatgtgtta tgtgataaat atgctaccag
      661 gcagctatat ggctattgtc cgtcctgggc attaaactgg gaatacagga aaaagggaat
      721 tatggaagaa attgttaact gggacgcaga tatcattagt cttcaggaag tggaaacaga
      781 gcaatacttt actctctttc tgccagcatt gaaggatcgt ggatatgatg gatttttttc
      841 tccaaagtca cgtgccaaaa tcatgtctga gcaggaaaga aagcatgtgg atggttgtgc
      901 aatattcttc aaaacagaaa aatttacatt ggtgcagaag catacagtgg aattcaacca
      961 ggtagcaatg gcaaattcag atggatccga agcaatgcta aacagagtaa tgacgaaaga
     1021 taacattggc gttgctgtgg tgttagaggt ccacaaggag ctttttggaa caggtatgaa
     1081 gcctattcat gctgcagaca aacagctgct tatagtggca aatgcccaca tgcattggga
     1141 cccagagtat tctgatgtga aacttattca gaccatgatg tttgtctcag aggttaaaaa
     1201 cattctggag aaagcctcaa gtaggcctgg cagcccaact gcagatccca attccatccc
     1261 gctggtgcta tgtgcagatc ttaactcatt gccagattca ggtgttgtgg aatatttaag
     1321 caacggtgga gtagctgaca accataaaga cttcaaggaa ctaaggtaca atgagtgtct
     1381 tatgaacttc agctgtagtg gaaagaatgg aagctcagaa gggagaatca cacatggctt
     1441 ccaacttaag agcgcctatg aaaataactt gatgccttat accaattaca cctttgattt
     1501 caaaggtgtg attgactaca ttttctattc caagactcat atgaacgtgc ttggtgtcct
     1561 ggggccttta gatcctcaat ggctggttga gaacaacatc actgggtgtc cacaccctca
     1621 catcccttca gaccacttct cactgttaac acaacttgaa ctccaccctc cactcctgcc
     1681 tcttgtcaat ggtgttcact tgcctaatcg gaggtagtgg agtacagccc cgcagagacg
     1741 gggatctgtc gctatggacc tgtacagttg taaatcaaag tatgtaggag tgaagtatgg
     1801 ccatctttaa cgctgcttct tcaggttcct ttcactatgt gtttgctata agactgtata
     1861 tttttgtgca tactgatatc atttggcact agggctggaa ccaaagtatt gctgtctgtc
     1921 tctatccaaa agtttaatac actttaaaat tggatttatt ttcctattat attaggaacc
     1981 aacattcacg attgataaat cactaatttg agaccccaca ccattgttgt tctctaaaaa
     2041 caaatacatt cttttgaatg ttttcaaata agccaatcat ttttgtaaaa ggtgatttaa
     2101 aaaaaaaaaa aaaactccaa atacaagatt ttcaattgaa tgatggtatg ccttatagga
     2161 aaaactttga gtttctgttt tctttcataa caagctgatt tttggctctc aagtcatttg
     2221 cacattatca aagcacttaa atttgcttga tttgtacatt aaatttgata tagccactag
     2281 ctataacaag acaattcggg aaatgaaaga caattgcata acatgcttta aaatcaagca
     2341 tagtatgtga cagtttgttg gccaaatgct ggttgttttg tttgaggaat cttttctctt
     2401 ctcttctttt ttccttttcc ttttcccttt ctcttttctc ttttttcttt tcttgtctgc
     2461 ctgttagtcc taatctcttt agaagtatta actttaagcc catctctcaa gttcatttat
     2521 aaggaaatag cagataatac tgccatatat cttgaaagta aaatttggta tttttaggat
     2581 gcccacaaaa ttagtgtctg gtatttttca ttttcgtgcc caaactttta ttttctgtcc
     2641 ggttgtactg gaaaaatatg atctatatct ttaccactac agtttaacac ttaaggaaaa
     2701 ttgctgaatg aaaagcccct ggtcagtttc agaaagggca agccagataa tattatacgt
     2761 gttttccaaa gtaagtaaaa tggctgtttg tttgttgttt tggttttttt tgtttcattt
     2821 taaggtaaca gtagagatga tttagaggaa aggacagatt tggggacata attgaaaacc
     2881 ttggatcact tttttctgac tctagctgcc aaatggccat catatgcttt taatcttcgt
     2941 tgccatactg tctagatttg aattaagcta ctgttttatt cccaaagttt gatgcctcta
     3001 tatgtattgg gaaacaccac caccaccacc atttattgtt ggccaggagg tgccacttga
     3061 gaatcttacg taagaggcag agagcataaa caccatttgt ggggagaaaa ttagttggca
     3121 aaattagaaa atgttaatta tggcacagta acattggaaa aggttgtgtc tgtgttttta
     3181 agtttttctt tattctgctt ttttgctgct ataagagttt tctgaaattt atattgtaaa
     3241 cttttcatgc actttactgt ttctagtatc aaaatgtgat atttttaata aacaagaaat
     3301 tttccattat gtgatgaaat ttaaaaagaa aataacctat atttgtgtct cactaatata
     3361 taaagtacaa gtcaaattta aattatttaa ttagctttaa atatatacaa attgtctcct
     3421 cttccaaacc tgacctctta ggctgtttta ttagtcttaa atgatacatt tcctgtggtc
     3481 attttatact aatttcttcc atagtttact gatcaggcta tataaaagaa tatttcccga
     3541 agggtaattt tagtgggatg agggtggtgg ggtgatgtaa tatcacgcag gattgcatcc
     3601 agaagagctc tgtaaagcct aaactccctt taaaaagtgc ctagtgacag aggcgttgtc
     3661 atctattgta attggaatgt cattgtagtt cagcaaagtt tgatgtaaat aaaatattct
     3721 tttaaaaatg ttaaagtacc tgaataaaca aacaaaagaa acccttgatg acagattttc
     3781 ctcagtgttc aggtatccct tcttatatac ctcaagcatc caacatctag ccatgaagat
     3841 tgattacctg acgcatagta ctggaaagta gaatagcatg aaaaacttaa ctgtgtggac
     3901 attacctttt tctgtaatca gctactgtct gtttagtttt ctcctgtttc gggtgggctt
     3961 tcttctctgg aggtatgtgc actaacagaa catccttctt tttttcatag atgcatgtta
     4021 actagcaatg tgagcaatat ttcctaccat acttcactcc caatattttt gagatgtttg
     4081 tataaaatga aatttaaagt tcacttatga ttgtatatga accacagagg agcccattta
     4141 ttaatacaaa tcttttttaa tagttaaatg tagaggggga aaataaaaaa atgggaaaca
     4201 ttgtaaacag cttaagttta ttttgtgtat gatcgaggca ctctgttgca agaaggtgtg
     4261 taattgggtc tctctgcttc caaatgcact ctttcaaacc attcattatc ctgtgtattt
     4321 taatgtggtt ttcgtaaatg ttggtagtag ctctgttgaa gtaggtgatt gtgttttgtt
     4381 ttgggtggca cacacctagg gcatggtatc ccaaatttca tgtgcacggt ttccctttag
     4441 cctcttgccc aaatttaaca cactgtttcc cctcgttccc tttgtaaaag gagtggtatc
     4501 ttgttttgag ctgccagttc agatgatcag aaatgctgct gtcctcagca ttgtcttgtt
     4561 aaatgcatgc catttggaac tttggcagtg agaagcccaa aggacaaggt gaatgacgtg
     4621 atatatattc gataaaagtg aaatatatat actcatatac tttctagttc tcagaataag
     4681 ttaataagct ttatgccttt gggctgctgc atattttatc tgataagaga aaatttgggc
     4741 atttttagat tgtgctatgt atttttttaa atgttcaata tgatttctgg taattgtctt
     4801 aagaactgga gtgttaagtt tattaaaatg gtgttgtttg aagaagggga aactgcactg
     4861 tttgccatta taaaagtaat acaagtgcat gtcccgtcac ccactgtcag gcatcagtat
     4921 cctcatagct ttacacactc tgatggggaa tattgcagca ttctcaggac tgacatctgg
     4981 aaaaggctca aatcacttac tgctccttgc ttgttgactt tgttttacaa tattgtgcct
     5041 ggtgtcaact tttaagcaac agcactgcct aaaagcaagc agagaacaga atcccagcac
     5101 cattctatag gcaacttttt agaattcaga tacagtaaat ctgttcaaga tttatgatgt
     5161 tttatgtaaa aaaaattttg tactacatag ctgaatattt ttgtttgatt tatttgatgt
     5221 aaggcgtgtg aacattcatt tgaatatcac atgttaaagt caggtatggc acaatgggct
     5281 ctgagaccag cttccccccg cacccccccc ccatttgcct tgttctaatc tctttctttt
     5341 caaattgcat ttctggtatt cataagcaga tatttaattt tactaataag catcctgtgt
     5401 gaatgtactt taaaagccac tatgttttag tgttatggtt tgtagaatta tgaaacttac
     5461 cttctccccc tccttttttt gtcttaaagt cataaatctc tgagaaggga gaaagttaaa
     5521 atccaagact catatcactt gaatctgtgg cagattatgt taaaattgag ggtgtggcaa
     5581 ttaaacctag aacatggaca atattgtgct gtttaaaaat tctgtctcct gagtatgtct
     5641 tgtcaatagg tgaaatttta agtctgtatt gtacttccaa gaattagtaa aactcgcaaa
     5701 taccacctgt atactcaata gcgaatagca aagggaaggg gagcacacag gagtggtagg
     5761 tcaggtatgc gcctggaagg ggttagagag cgccatctct aacacaggct acattcccca
     5821 gtggtaaaat ttgatgttgg cttaataccg atttaaaatt tcatctttta tattcttgtg
     5881 ttttttgaaa tattttaata gttttgcaaa gtatactaac tggttcgtag cttcagtcac
     5941 agaaaacaaa ttgtatttca gtaatggtcc tgtagcaagc aagaattctt tgttacatgt
     6001 tctaagtaac aaacattttg actgaaaagt gagctgttgt gtttgtaagg ttttcttctt
     6061 ctctccaccc ataaaaccca aagtaacacc tttctaatgt gttaaaaatt tgtttaccga
     6121 cttttatttg gtttgtatcc tatttgtatg acttttgcgt attagaagta gatagattag
     6181 gtagagacat tagacttatt tttctaaatc aggaacttaa actgaagttt tgaatttgta
     6241 gacagaggac atttatgctt atgattgttc tggaagattt taatttctgt aaatgcacca
     6301 tgatccccaa atttaaaatt caaacacaag taaatgatag tacatcttta acctgcttat
     6361 ttaccaaagt ttaagaatag ggtgccaaga gcatctttca taattgtcac ctgaatgctt
     6421 aaaacgataa aagaaaaccc ttatgtgttc tgagcaagag ccacagaaag aaaactagga
     6481 agggaagcag aagggtggga gcctgctcag gaagaggata cggaagagca tgtatgcttg
     6541 ttctgaccaa aggcattcgt gtcgacgtct caggtaaaag gcctggagga agaagcagat
     6601 tccaggggaa gttttattaa cccagtaatt ttggcataag tttggttaac ttgatttatt
     6661 ctagatttga tttacttttg gatccaaagg acagactgaa agtactcttt atttagtaag
     6721 ataagctaat tttcaaagga tatgaattaa gggcgtgcct attaaatgtt gacttttatg
     6781 gtgcagccta taaaacagat agcactgaac tgaaattaga agtgtgccat cagaagccat
     6841 gacgcctgga gcggtggcat gatgcacctt tcaggatgac atgtgttcct ggttattttc
     6901 ttcagcggga tccctgcatt tgtttgtttt ccgtttatct gtcccttgga aaatcatggt
     6961 agcatccctc tggaaggtga cccttgctca cgatttcaga ggactcacat attttcttag
     7021 ctattattgt tctgtgtacc acgttgttta atttgtgtgt gtagttactt gaactcagac
     7081 tataggctca atactggtgt gccaaacaat ggctctgctt cttatggtac agacttagtg
     7141 tcctgcttac tgtttcaact ttaatgcggt aagtgttgca gtgtgtgggt tgctctttat
     7201 tcagaaacta ctgtcctttc tctgtgctta acttgctaaa agtaaattcc cttacctgtg
     7261 taattcctga gcggtgctct gctgaccttt gagagaggag gggtttggat ggctgttact
     7321 acacactgga tctggaattg ttcagtgttg tgagtggcag atttcttaaa caccagcagc
     7381 actgagaagt gcactacggg catttgtaaa gttagttgtc caaatgcaag cagtactttc
     7441 atccaaaaga agctgaggtg tgttgggttc aataggagta ctttgagtat ctcaaggagg
     7501 acaaatgatt aactctgttg tatctgaagt ggggtagccc tttctccacc ccccttgtgt
     7561 ttttgttttc taaagataaa atataccctt ttgctttctt tgaaaaggcc aggatgtttg
     7621 attatattga ccagagatta aatcgtatct agttttcaac tatataagtg ccaagtaatt
     7681 gtccatggac tttttaacca tttgattagg gaagagatta tttatttttg tttcctggca
     7741 ttaagatgat taatttattg ttttgcgtac acttgagtca ttctgtggcc tatatagtgt
     7801 ttttgtaact aactatacaa aaagcaaagc acatgaccct aagactaagc aagatgtttc
     7861 agtagttctc tccgtgaata cttgatcatt tctattaata ctgttctaag cagattctac
     7921 tgttttaggt tgtgtattta tttttccccc taagaaaaag ccaagcacta aatcaacttg
     7981 tgttctgata atcacttaca atcttaagct ttcctttctt cttttcttag gtgatttaat
     8041 gaagtgccat gtaattgtag cttactaatt aatgtttgat agactggttc tgtgatattc
     8101 taaacattta actctttctt gtcatctctg gagaagatgg ttctattctc attctctctg
     8161 ataaaatcac cagctgcttt atttttctat ttattacaca gttgataagg tctggatctt
     8221 gaccgaactg ctcagctgag atgttttcat agtggacact atagaaaatg tgtgtgcaaa
     8281 acgacacagt tgggtggtgg tattcttttt cattaatgtg aacattgact aaacaaagca
     8341 gtcctgcctt ttaaatcttg tggcagctca gaagggaggt gcttaagaac cttaactatt
     8401 atgtcagatg acaaatactt tttttccatt ttggagattg ggtactgctc acacatgatg
     8461 tatagggcta aatatatgct tgtttccttg cacctgtgta ctcttcccct tctctcccac
     8521 ttttcctttc cctgtaggca ataaatggcc attttgcaac cgca
//
