LOCUS       NM_212484               5726 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 6 (Cnot6),
            transcript variant 2, mRNA.
ACCESSION   NM_212484 XM_203423
VERSION     NM_212484.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5726)
  AUTHORS   Quan,Y., Wang,M., Xu,C., Wang,X., Wu,Y., Qin,D., Lin,Y., Lu,X.,
            Lu,F. and Li,L.
  TITLE     Cnot8 eliminates naive regulation networks and is essential for
            naive-to-formative pluripotency transition
  JOURNAL   Nucleic Acids Res 50 (8), 4414-4435 (2022)
   PUBMED   35390160
REFERENCE   3  (bases 1 to 5726)
  AUTHORS   Katsumura,S., Siddiqui,N., Goldsmith,M.R., Cheah,J.H., Fujikawa,T.,
            Minegishi,G., Yamagata,A., Yabuki,Y., Kobayashi,K., Shirouzu,M.,
            Inagaki,T., Huang,T.H., Musi,N., Topisirovic,I., Larsson,O. and
            Morita,M.
  TITLE     Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates
            food intake and energy expenditure
  JOURNAL   Cell Metab 34 (4), 564-580 (2022)
   PUBMED   35385705
REFERENCE   4  (bases 1 to 5726)
  AUTHORS   Dai,X.X., Jiang,Z.Y., Wu,Y.W., Sha,Q.Q., Liu,Y., Ding,J.Y.,
            Xi,W.D., Li,J. and Fan,H.Y.
  TITLE     CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a
            key mechanism of gonadotropin-triggered follicle development
  JOURNAL   Cell Rep 37 (7), 110007 (2021)
   PUBMED   34788619
REFERENCE   5  (bases 1 to 5726)
  AUTHORS   Dai,X.X., Jiang,Y., Gu,J.H., Jiang,Z.Y., Wu,Y.W., Yu,C., Yin,H.,
            Zhang,J., Shi,Q.H., Shen,L., Sha,Q.Q. and Fan,H.Y.
  TITLE     The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA
            Degradation, Efficient DNA Damage Repair, and XY Chromosome
            Crossover during Male Germ Cell Meiosis
  JOURNAL   Adv Sci (Weinh) 8 (10), 2003636 (2021)
   PUBMED   34026442
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5726)
  AUTHORS   Chang,T.C., Yamashita,A., Chen,C.Y., Yamashita,Y., Zhu,W.,
            Durdan,S., Kahvejian,A., Sonenberg,N. and Shyu,A.B.
  TITLE     UNR, a new partner of poly(A)-binding protein, plays a key role in
            translationally coupled mRNA turnover mediated by the c-fos major
            coding-region determinant
  JOURNAL   Genes Dev 18 (16), 2010-2023 (2004)
   PUBMED   15314026
REFERENCE   7  (bases 1 to 5726)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 5726)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5726)
  AUTHORS   Dupressoir,A., Morel,A.P., Barbot,W., Loireau,M.P., Corbo,L. and
            Heidmann,T.
  TITLE     Identification of four families of yCCR4- and Mg2+-dependent
            endonuclease-related proteins in higher eukaryotes, and
            characterization of orthologs of yCCR4 with a conserved
            leucine-rich repeat essential for hCAF1/hPOP2 binding
  JOURNAL   BMC Genomics 2, 9 (2001)
   PUBMED   11747467
REFERENCE   10 (bases 1 to 5726)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY741392.1, BC062950.1, AK039164.1 and BB402523.1.
            
            On Mar 19, 2014 this sequence version replaced NM_212484.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.18681.1, BC062950.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY741392.1         3-14
            13-2525             BC062950.1         1-2513
            2526-5717           AK039164.1         296-3487
            5718-5726           BB402523.1         260-268
FEATURES             Location/Qualifiers
     source          1..5726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.76 cM"
     gene            1..5726
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /note="CCR4-NOT transcription complex, subunit 6"
                     /db_xref="GeneID:104625"
                     /db_xref="MGI:MGI:2144529"
     exon            1..369
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            370..483
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2030
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /EC_number="3.1.13.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytoplasmic deadenylase; carbon catabolite repressor
                     protein 4 homolog"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 6 isoform
                     2"
                     /protein_id="NP_997649.1"
                     /db_xref="CCDS:CCDS24621.1"
                     /db_xref="GeneID:104625"
                     /db_xref="MGI:MGI:2144529"
                     /translation="MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLS
                     SSLWSLTHLTALHLSDNSLSCIPSDIAKLHNLVYLDLSHNQIQSLPAELGNMVSLREL
                     HLNYNQLRVLPFELGKLFQLQTLSLKGNPLTQDILNLCLEPDGTRRLLNYLLDNLSVS
                     TEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKA
                     IIQEILSCNADIISLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVD
                     GCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKELI
                     EMSSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSS
                     VLGECGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCNGKN
                     GMTNGRITHGFKLKSAYENGLMPYTNYTFDFKGIIDYIFYSKPQLNTLAILGPLDHHW
                     LVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR"
     exon            484..670
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            671..756
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            757..846
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            847..915
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1073
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1228
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1383
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1614
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1817
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..5726
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3707..3712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /note="hexamer: ATTACA"
     polyA_site      3723
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /note="major polyA site"
     regulatory      5697..5702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /note="hexamer: AATAAA"
     polyA_site      5722
                     /gene="Cnot6"
                     /gene_synonym="CCR4"
                     /note="major polyA site"
ORIGIN      
        1 ggagggggac ggcggccgcc gccatgatgc ttgtttgctt tcaatgaaaa cgaggggggc
       61 gcggaagagg aggcgtcggc gtcggtggcg gcggcgtcga cggcgcggag gcgaaggcgg
      121 cggccggcgc ggcgaggagg gcgaggccgg ggtccgagag ggcggcagag cgtagcggcg
      181 gctcgtgggg tccggggcgg ccgaggcggg cggctgagga gcggcggccg aggaggggga
      241 acaaagagcg gcggcggagg cgctgcagca gcgggcggga ctggtatggt ggttccacag
      301 ggcagacccc gctgcactca tcgggaggag gcggcggcag cggcggagga aggcggcgca
      361 gctcgagagg catgcccaaa gaaaagtacg agccccctga ccctcggagg atgtacacaa
      421 ttatgtcctc tgaggaagca gcaaatggaa agaaatcaca ttgggcagag cttgaaataa
      481 gtggaaaagt aagaagctta agctcatctt tgtggtcact cactcacttg acagctttgc
      541 atctgagtga caattccctg tcctgtattc cttcagacat tgccaagctt cacaatctgg
      601 tatatctgga cctgtcccat aatcaaatcc agagtttacc ggcagaactc ggaaacatgg
      661 tatcactcag ggagctccat ttaaattaca accagttacg agttctacct tttgagctgg
      721 gaaaactgtt tcagttgcag actttaagcc tgaaaggaaa tccacttacc caggatatat
      781 tgaacctctg tctggagcca gatggaacaa gaaggctact gaactacttg ctcgataatt
      841 tgtcagtttc aacagaacaa ccacctccaa gatcttggat catgttacaa gaaccagaca
      901 gaacaaggcc aacagccttg ttttctgtca tgtgctataa tgttctttgt gataaatatg
      961 cgacccggca gttatacggc tactgtccat catgggcact taattgggac tacaggaaaa
     1021 aggccattat tcaagaaatt ttgagctgca atgctgatat tataagtctt caggaagttg
     1081 aaacagagca gtattacagt ttttttctgg tagaactgaa agaacgtggc tataatggat
     1141 tctttagtcc aaagtctcga gctcggacta tgtctgaaca agaacgaaag catgttgatg
     1201 gctgtgcaat attcttcaag acggaaaaat tcactttggt tcagaaacac acagttgaat
     1261 ttaatcagct agcaatggcg aattcagaag ggtctgaagc catgttgaac agagtcatga
     1321 caaaggataa cattggagtt gcagtactgc tagaacttcg aaaggaattg attgaaatgt
     1381 catctggaaa accacatctg ggaacagaaa aacaacttat tctcgtggct aatgctcata
     1441 tgcattggga ccctgagtac tcagacgtga agttggtaca aactatgatg ttcctctcag
     1501 aagtgaagaa tattattgat aaagcctctc ggagcctcaa atccagtgta ttgggagaat
     1561 gtggaactat tcctcttgtg ttatgtgcag atctgaattc tttgccagac tctggtgttg
     1621 tagagtattt gagcactggt ggggtagaaa caaatcataa agacttcaag gaactgaggt
     1681 acaatgaaag tctcacaaac ttcagctgca atgggaagaa tgggatgacc aatggaagga
     1741 tcactcatgg tttcaagtta aagagtgcct atgagaatgg cctgatgcct tacaccaatt
     1801 atacatttga tttcaagggt ataattgact acatcttcta ttctaaacct cagctgaata
     1861 ctttagccat cctgggacct ctggatcacc attggctagt cgagaataac atcagcggct
     1921 gcccacatcc acttattccc tctgaccact tctcactttt tgcacaattg gagctcttac
     1981 tgcctttcct gccccaagtt aatggcattc accttcctgg caggaggtag tcactttcag
     2041 aggacctcag atttacttgt aaactcgtga aaatctgaat ataggagagt aaggtatggc
     2101 cactagggat ttttctcaat gatcatttga attttcagtc tggttatttg ataaagggta
     2161 tagtatgaaa gccaggtgct agcaacagac aaattctgag cccagtgtac tttatatact
     2221 gctagacagg gactggtgtg tttacacctt ttaatttgtt acaagtaatt ttcctgtttc
     2281 ttctctccaa tgtgttttgt catgccttga aataggaaga tgtgtgagca gtgtgctgtt
     2341 tgcacagaaa tccacagcac tgttttctga ggccagtagt aacatcagag accgttcttc
     2401 cagactttac tccctctttt ttcagacttg tttgtaaaat gtagaatttg aatttagcct
     2461 ttatgattgt atatgatcca cagaagacct gatttatgaa gttttgtact aaaaaaaaaa
     2521 aaaaagcaaa attgaaaaca gttgtattgt aaactaaggc taattttttt taacctgtgt
     2581 cctgtgttct gaaggccagc tggtaacaaa gctgcatccg actttctctg cagtgatttg
     2641 cactgttggg gttgttagcc cttttgtact actttatttt taaattgaga acattactct
     2701 ttaaatgtaa gtttgcttag accttgggat attttcttgg accagaggca acttatgtat
     2761 gaattcctga atttctatgg aaactttcta ccaggacaga taagctgatc tgtaggcatt
     2821 taatggactg aagatgacag ttgacatatg tacattctgg tatttttaag tctttaagtt
     2881 ttaacttttt atgttaaaaa aattacagct gcttaggtac agcttctaag tcctttctga
     2941 gacattttct gttctgtctc cactgtgcct gcctaaattt gttctcaccg agcactgcct
     3001 gtgcatgcag agaaaatctg tgcatctttt atatttttaa aaactaacat ttgtgagaat
     3061 tttatggaaa tgcttttgta tgagctgtgg cttttccttc ctcgttgtga agcgttggat
     3121 agcacattct ggaacatgtt catgggtcct gggcttgctc accagaccca agcactgctt
     3181 cttggtgtcc ttgcacccag agtgccacta tcatgtgtat ttcttattct cttaatgttt
     3241 aaaaaaaaat cattcctttt ttttaagaag agtaattttc tgtttatgaa gcagtataaa
     3301 ttagatgcat tttcaaaaca gtttccctaa gacaattgtt tggatcattt ttaaagtgac
     3361 taaggaattt tagtatgtca accaagataa aagttatact gtaccctata ttttgcccat
     3421 agtgccatta gtagattaga gattaaagtc acctttaact ttacaaagtt aacttgtata
     3481 tgttctgttc tcagtcgtta gttctctcaa aatcaaatga attcagaggg aacttgtctg
     3541 gctgcttttg tttcaactgc aggcagtgga gcagaaggac gccgtgtggc actaaagtga
     3601 actgttgagt gttaacagtt ttatacagag actgagccat tttggatgac tcaaaatttt
     3661 atgagaagac atttaattgc ttatgctgtt tttaagagga aataaaatta catactgttt
     3721 aaataaatga attttttctt tttaagaaat tctctaaagg tcttgatatc ttggaccttg
     3781 tttttccttt aaggtttttt gttttgtttg tttaatcgta attgtaatgt tgggtttgtt
     3841 tgttgtggat ttttactttg tttaagttgt gctggcacca aacacgtcca gtttgtaatc
     3901 aacaggttgg tgtagaacca gtacataact tgcaatggct ttttgtcctg tcttccccca
     3961 cccccacccg tctctgtctc tgtcttgtaa agtgtgaata tgagatgtac tgactcgatt
     4021 ttcttaaaca ctgtgttggt agtgtgcatc atgacaattt ccagggaagg tggactgcag
     4081 tgggtggact gatgggactg aggacccact ttccctgtga cctgctaagg gcagcacagg
     4141 tctggagagt gtggtgccag gagaggggag gagcacttac tcatctctgc atttgttagt
     4201 ggatgatgta ttcctttcat ggatactgga actagagtgc acttgttaga tgctaaaggt
     4261 ttgagcttta cacaaaacat ttcatctgta tttgttactg tctacaatat atttgaattt
     4321 gggggcagcc tagtaagata taattgcctg ttatgtcttg aaagtacttg ttttgcctct
     4381 tttaggcata ctgcattctg tgggtcagtt tgaacatctc caccttgttt agatagtgat
     4441 aagttgaaca gagagtgtag atttacaagt ataatcttca aaagaaaaat attttgaatc
     4501 tatcaagaaa tgttcacacc aaaatagact gatactttgt taagcaaggt tttatgtttt
     4561 aaatgctttg tgtccaaaat aatttccaag aaactatact tcttaaaatg cataaaacta
     4621 gtctgttttc ataatgtaga ttatttttga aaaattctgt aataaatata tgtaatgttt
     4681 tgctataatg taatttcagt gttcttgctg ataagtacat cttaggagtg ttttacggag
     4741 tgtttggaat atgtttccct tttaaagatg agcagattgg aggcactcaa atctttgtaa
     4801 attttatgaa gtacagttta cagtattggt ggtaattatt tatgctttga gaatttaaat
     4861 aatgttcatt gaaattaatt tatggtatag tataaactaa aattctagaa gtaaattgtt
     4921 gattgcagct ttaataatcc cagaacatag gcatctccaa aaattgtttt tgtttgtact
     4981 tttatttgat ttggtgtcaa ccaggaaaat ttatttcata ttagcacttt gaaacctaaa
     5041 gatataatta aattcggtag aatgcacttc taaatcttta aattataatt gaaacctctt
     5101 aagattccat tttccaataa ttaacattca tggtttaaga gttccacttt ttcactattt
     5161 aaactacaga actcatttcc atcctgactc tgaagtttgg tggtcatgtc atagaaccaa
     5221 gcaggacagt acagtcttct gatgagtcaa ccataatatc cagtacagat gttgcagata
     5281 atttcgagaa cataagcagg tgtcctccaa ccacaagcag tattttaaga tgttcgcttt
     5341 attccttttg gttacataaa ttttaaaaac tggtatgttg atgtagtgtc taaaatagag
     5401 tagtctttat tcacagtaca ttatgttgtg taatgcactg gactaactct tgtttaccat
     5461 tcatgtaaca aaacccagca cacttctgca ctaagctcaa gaatgtcaca tctgcctagg
     5521 cagctcttga taggggtgat gagaaactga atttacacca tatggactgg tggtaacaag
     5581 ggcttttact gttcttttca gtggactctt cttggtcaaa ttgtaactag ctagtattat
     5641 atttatatac agggtctctt ttccttaccg atgtattttc ctactcatag ccaaccaata
     5701 aattcaatat ctgtttcaaa tatttt
//
