LOCUS       NM_001410684            3745 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 4 (Cnot4),
            transcript variant 8, mRNA.
ACCESSION   NM_001410684 XM_011241408
VERSION     NM_001410684.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3745)
  AUTHORS   Dai,X.X., Jiang,Y., Gu,J.H., Jiang,Z.Y., Wu,Y.W., Yu,C., Yin,H.,
            Zhang,J., Shi,Q.H., Shen,L., Sha,Q.Q. and Fan,H.Y.
  TITLE     The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA
            Degradation, Efficient DNA Damage Repair, and XY Chromosome
            Crossover during Male Germ Cell Meiosis
  JOURNAL   Adv Sci (Weinh) 8 (10), 2003636 (2021)
   PUBMED   34026442
  REMARK    GeneRIF: The CNOT4 Subunit of the CCR4-NOT Complex is Involved in
            mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome
            Crossover during Male Germ Cell Meiosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3745)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3745)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 3745)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 3745)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140110.2.
            
            On Aug 13, 2022 this sequence version replaced XM_011241408.3.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR17253014.713472.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC140110.2         111439-111883       c
            446-711             AC140110.2         105710-105975       c
            712-909             AC140110.2         103730-103927       c
            910-996             AC140110.2         95966-96052         c
            997-1098            AC140110.2         95119-95220         c
            1099-1224           AC140110.2         94337-94462         c
            1225-1358           AC140110.2         90638-90771         c
            1359-1416           AC140110.2         81960-82017         c
            1417-1666           AC140110.2         78591-78840         c
            1667-2164           AC140110.2         76811-77308         c
            2165-2377           AC140110.2         49877-50089         c
            2378-3745           AC140110.2         47814-49181         c
FEATURES             Location/Qualifiers
     source          1..3745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.2 cM"
     gene            1..3745
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="CCR4-NOT transcription complex, subunit 4"
                     /db_xref="GeneID:53621"
                     /db_xref="MGI:MGI:1859026"
     exon            1..445
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            446..711
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..2679
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /EC_number="2.3.2.27"
                     /note="isoform 6 is encoded by transcript variant 8;
                     negative regulator of transcription 4; E3
                     ubiquitin-protein ligase CNOT4; CCR4-associated factor 4;
                     transcriptional repressor NOT4Hp; potential
                     transcriptional repressor NOT4Hp; RING-type E3 ubiquitin
                     transferase CNOT4"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 4 isoform
                     6"
                     /protein_id="NP_001397613.1"
                     /db_xref="GeneID:53621"
                     /db_xref="MGI:MGI:1859026"
                     /translation="MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHR
                     IRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLAS
                     VRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAY
                     VTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGD
                     EAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPI
                     DKPSDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQ
                     SLFSDNFRHPNPIPSGLPPFPSSPQTPSDWPTAPEPQSLFTSETIPVSSSTDWQAAFG
                     FGSSKQPEDDLGFDPFDVTRKALADLIEKELSVQDQPSLSPTSLQNASSHTTTAKGPG
                     SGFLHSAAPTNANSLNSTFSVLPQRFPQFQQHRAVYNSFGFPGQAARYPWMAFPRNSI
                     MHLNHTANPTSNSNFLDLNLPPQHNTGLGGIPIADNNSSVESLNMKEWQDGLRALLPN
                     ININFGGLPNSSSPSNANHSAPTSNTATTDSVSWDSPGSWTDPAIITGIPASSGNTLD
                     SIQDDNPPHWLKSLQALTEMDGPSAASSQPHHSAPFSTQIPLHRASWNPYPPPSNPSS
                     FHSPPPGFQTAFRPPSKTPTDLLQSSTLDRH"
     exon            712..909
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            910..996
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1098
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1224
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1358
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1416
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1666
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..2164
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2377
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..3745
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: AATAAA"
     polyA_site      3745
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="major polyA site"
ORIGIN      
        1 gtataagtag ccctgatttt tctatttgtt tggttagttt ttgttgtgtt ctgctttgct
       61 ttaatttgct gggttatgct ggagtaaaac ccagggtctt gggtatgtta ggcaaatcct
      121 gaacttctgg gtaatagcct taggattttg attttgagac tatcttgctg tgtatagccc
      181 agcctggcct ctgcctctca ggtgctgtct ttataggagt gtacacaact cctggctact
      241 atgtttagag aaaaggtttc ttttggtgtt gaggctttta gatactgtag cccaggtagc
      301 cgtattcttc aacgattctt ctgcctttgc ctcaggagtg ccccaagcat cgatatgtat
      361 gtctatacct cgatactgct ggaaatgtgc tgatgtgttc attctcttct gacactttga
      421 gactttgcat gtgaatataa atttggtctt cagagttcta tattttagct ctcagtgctg
      481 aattaccttc tcccttaaat tattataaac ttttgctgct gtcatataaa cgtgaagatg
      541 tctcgcagtc ctgatgcaaa ggaagaccct gtggaatgcc ctctttgcat ggagcccttg
      601 gaaatagatg atattaactt tttcccttgc acctgtggct accagatatg ccgattttgt
      661 tggcatcgaa ttcgcactga tgagaatggg ctttgtcctg catgtagaaa accatatcca
      721 gaagatccag cagtttacaa accactttcc caggaagaat tacaaaggat aaagaatgag
      781 aaaaaacaga aacaaaatga aagaaaacag aaaatctcag aaaatagaaa acatttggct
      841 agtgtacgtg ttgtacaaaa aaaccttgtg tttgttgtag gtctgtcaca gcgcctagca
      901 gacccagaag ttttaaaacg accagagtat tttgggaagt ttggtaaaat acataaagtt
      961 gtcatcaata atagcacatc ctatgcaggc tcacagggtc cgagtgccag tgcttatgta
     1021 acgtatatcc ggtcagaaga tgctctcaga gcaatacagt gtgtcaacaa tgtggtagta
     1081 gatggcagga cactaaaggc atctttaggt acaacaaagt actgcagtta tttcttaaag
     1141 aacatgcagt gcccaaagcc tgactgcatg tatcttcatg aattgggaga tgaggcagcc
     1201 agcttcacaa aagaggaaat gcaggcgggt aagcaccaag aatatgaaca gaagctcctc
     1261 caagaattat ataaattaaa tcccaatttt cttcagctat ctacgggttc agttgataag
     1321 aataagaaca aagtgacacc attacaaagg tatgataccc ccattgacaa accttcagat
     1381 tctctcagta tagggaatgg tgataattcc caacagatat ctaacagtga tacgccttca
     1441 ccaccacctg gtttatcaaa atccaaccct gtcatcccca tcagttcatc caatcacagt
     1501 gcgaggtctc cttttgaagg ggcagtaaca gagtcacagt cattattctc agacaatttt
     1561 cgccacccca accctatacc aagtgggctt cctccttttc ccagctctcc acagacaccc
     1621 agtgattggc ctacagctcc agaaccacag agcctcttca catcagaaac aatcccagtt
     1681 tcatcatcta cagactggca agcagcattc ggctttggtt cttctaaaca accagaggat
     1741 gacttggggt ttgacccctt tgatgtcact cgaaaagcct tagcagacct gattgagaag
     1801 gaactatccg tccaagatca accttccctt tcccccacat ctcttcagaa cgcctcctca
     1861 cacactacga ccgccaaagg gccaggctct ggattcctgc actctgctgc acctacaaat
     1921 gccaactctc tcaatagtac cttttcagtc ttgccacaga ggttccctca atttcagcag
     1981 caccgagcag tttataattc gttcggtttt ccaggccagg cagcccgcta tccttggatg
     2041 gcctttccac gcaatagcat catgcacttg aaccacacag caaaccccac ctcaaatagt
     2101 aatttcttgg acttgaatct cccgccacag cacaacacag gtctgggagg gatccccata
     2161 gcagacaaca acagttctgt agagagttta aatatgaagg aatggcagga cgggctaagg
     2221 gcacttctac ccaacattaa catcaacttt ggtggactgc ccaattcttc ttccccctcc
     2281 aacgccaacc acagtgcacc aacgtccaac actgccacca cggacagcgt gagttgggac
     2341 agccctggca gctggacaga cccagccatc atcacaggta ttccagcatc ttcaggaaac
     2401 actttagact ctattcaaga cgacaatcct ccacactggc taaaatccct acaggccctc
     2461 acagagatgg acggccccag cgctgcctcg tcacaacccc atcacagcgc ccccttcagc
     2521 acacagatcc ctctgcacag agccagttgg aacccctacc cacctccttc aaatccctcc
     2581 agcttccact ctccaccccc aggcttccag acagccttca gaccccccag caaaaccccc
     2641 acagatctgc tacagagttc cacactggac cgccactaag caaagaggga attgaaaagg
     2701 gcaggatttg tcccaccctg ttccccctca gcccactcac agctcccttc tcatctctta
     2761 acgttctgaa gaatccagct cctggtcggg tttttttctc cctaccccca gatacgatgc
     2821 gatcacagcg tctttaccat cttttctttc attgtaaaaa gtttcggttg atccagcatt
     2881 tgagtgagtg acactgttga atgtttctgg ggggcaggaa ttgccttttt aagcagagga
     2941 aaaagaaaat caaaaggcag tctcaatact tagaaaatta ctgtttgtct gtcgctcata
     3001 atgacataat ctgcttagca gaaaatgaca attaatctat aggaaaggtc aagtaaatgc
     3061 attgtcaact gcagaactga gagcacggcc gacttaaatg agattgctaa gttcatgggg
     3121 gaaagcagtg gtcctggctt ccatcttgta ttcaactttt cactattgca ggaaaaatgc
     3181 ttttcatttt aaattcttta ttgaattgat agggaggact caattgtgtt gttaagcaaa
     3241 gggatttatt ggaagttgat gagaagataa attgatctgt agtcgtaact ggcctactgc
     3301 taaagagttt ataaggaagg aaaagtaatt ttttaaggag aaaaaatttt ggctttagac
     3361 ttaaattcag atgttttaaa ggaaaaagat attcacagat tcaataccta tccttataag
     3421 agctgaattc tatgtgattt cctcagtctt tctcctctgt cagaatcttt tttttttctt
     3481 tgaccataag tccacctgac agggcactct gagccagcac tgctctgggg ccatcagatc
     3541 accaacagaa gcaaatctct gacctctttg cctgcagctt ttacttaacc ctgtagtttc
     3601 tggacgtttg tgcagtattg aaaagacagg agaaaagaaa acaaacctgg ttataacctg
     3661 atgctaaaac taaaaacaag gaaatgtacc tctctcttca gaattaaaac taaaatctta
     3721 aataaaacag aaaacttgat ggtga
//
