LOCUS       NM_001410683            4570 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 4 (Cnot4),
            transcript variant 7, mRNA.
ACCESSION   NM_001410683 XM_036166282
VERSION     NM_001410683.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4570)
  AUTHORS   Dai,X.X., Jiang,Y., Gu,J.H., Jiang,Z.Y., Wu,Y.W., Yu,C., Yin,H.,
            Zhang,J., Shi,Q.H., Shen,L., Sha,Q.Q. and Fan,H.Y.
  TITLE     The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA
            Degradation, Efficient DNA Damage Repair, and XY Chromosome
            Crossover during Male Germ Cell Meiosis
  JOURNAL   Adv Sci (Weinh) 8 (10), 2003636 (2021)
   PUBMED   34026442
  REMARK    GeneRIF: The CNOT4 Subunit of the CCR4-NOT Complex is Involved in
            mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome
            Crossover during Male Germ Cell Meiosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4570)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4570)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 4570)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 4570)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140110.2.
            
            On Aug 13, 2022 this sequence version replaced XM_036166282.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.114095.1,
                                           SRR1660825.108390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC140110.2         111439-111883       c
            446-711             AC140110.2         105710-105975       c
            712-909             AC140110.2         103730-103927       c
            910-996             AC140110.2         95966-96052         c
            997-1098            AC140110.2         95119-95220         c
            1099-1224           AC140110.2         94337-94462         c
            1225-1349           AC140110.2         90647-90771         c
            1350-1407           AC140110.2         81960-82017         c
            1408-1657           AC140110.2         78591-78840         c
            1658-2155           AC140110.2         76811-77308         c
            2156-4570           AC140110.2         69693-72107         c
FEATURES             Location/Qualifiers
     source          1..4570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.2 cM"
     gene            1..4570
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="CCR4-NOT transcription complex, subunit 4"
                     /db_xref="GeneID:53621"
                     /db_xref="MGI:MGI:1859026"
     exon            1..445
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            446..711
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..2256
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 7;
                     negative regulator of transcription 4; E3
                     ubiquitin-protein ligase CNOT4; CCR4-associated factor 4;
                     transcriptional repressor NOT4Hp; potential
                     transcriptional repressor NOT4Hp; RING-type E3 ubiquitin
                     transferase CNOT4"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 4 isoform
                     3"
                     /protein_id="NP_001397612.1"
                     /db_xref="GeneID:53621"
                     /db_xref="MGI:MGI:1859026"
                     /translation="MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHR
                     IRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLAS
                     VRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAY
                     VTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGD
                     EAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQSPIDKP
                     SDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLF
                     SDNFRHPNPIPSGLPPFPSSPQTPSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGS
                     SKQPEDDLGFDPFDVTRKALADLIEKELSVQDQPSLSPTSLQNASSHTTTAKGPGSGF
                     LHSAAPTNANSLNSTFSVLPQRFPQFQQHRAVYNSFGFPGQAARYPWMAFPRNSIMHL
                     NHTANPTSNSNFLDLNLPPQHNTGLGGIPIAGEEEVKVSTMPLSASSHSLQQGQQPTS
                     LHTTVA"
     exon            712..909
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            910..996
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1098
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1224
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1349
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1407
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1657
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2155
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..4570
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: TATAAA"
     polyA_site      2395
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="major polyA site"
     regulatory      2715..2720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: AATACA"
     polyA_site      2732
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: AATAAA"
     polyA_site      3345
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
     regulatory      3875..3880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: ATTAAA"
     polyA_site      3905
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
     regulatory      4332..4337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: ATTAAA"
     polyA_site      4367
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
     regulatory      4533..4538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: AATATA"
     regulatory      4539..4544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
                     /note="hexamer: ATTAAA"
     polyA_site      4554
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
     polyA_site      4570
                     /gene="Cnot4"
                     /gene_synonym="Not4; Not4h; Not4hp"
ORIGIN      
        1 gtataagtag ccctgatttt tctatttgtt tggttagttt ttgttgtgtt ctgctttgct
       61 ttaatttgct gggttatgct ggagtaaaac ccagggtctt gggtatgtta ggcaaatcct
      121 gaacttctgg gtaatagcct taggattttg attttgagac tatcttgctg tgtatagccc
      181 agcctggcct ctgcctctca ggtgctgtct ttataggagt gtacacaact cctggctact
      241 atgtttagag aaaaggtttc ttttggtgtt gaggctttta gatactgtag cccaggtagc
      301 cgtattcttc aacgattctt ctgcctttgc ctcaggagtg ccccaagcat cgatatgtat
      361 gtctatacct cgatactgct ggaaatgtgc tgatgtgttc attctcttct gacactttga
      421 gactttgcat gtgaatataa atttggtctt cagagttcta tattttagct ctcagtgctg
      481 aattaccttc tcccttaaat tattataaac ttttgctgct gtcatataaa cgtgaagatg
      541 tctcgcagtc ctgatgcaaa ggaagaccct gtggaatgcc ctctttgcat ggagcccttg
      601 gaaatagatg atattaactt tttcccttgc acctgtggct accagatatg ccgattttgt
      661 tggcatcgaa ttcgcactga tgagaatggg ctttgtcctg catgtagaaa accatatcca
      721 gaagatccag cagtttacaa accactttcc caggaagaat tacaaaggat aaagaatgag
      781 aaaaaacaga aacaaaatga aagaaaacag aaaatctcag aaaatagaaa acatttggct
      841 agtgtacgtg ttgtacaaaa aaaccttgtg tttgttgtag gtctgtcaca gcgcctagca
      901 gacccagaag ttttaaaacg accagagtat tttgggaagt ttggtaaaat acataaagtt
      961 gtcatcaata atagcacatc ctatgcaggc tcacagggtc cgagtgccag tgcttatgta
     1021 acgtatatcc ggtcagaaga tgctctcaga gcaatacagt gtgtcaacaa tgtggtagta
     1081 gatggcagga cactaaaggc atctttaggt acaacaaagt actgcagtta tttcttaaag
     1141 aacatgcagt gcccaaagcc tgactgcatg tatcttcatg aattgggaga tgaggcagcc
     1201 agcttcacaa aagaggaaat gcaggcgggt aagcaccaag aatatgaaca gaagctcctc
     1261 caagaattat ataaattaaa tcccaatttt cttcagctat ctacgggttc agttgataag
     1321 aataagaaca aagtgacacc attacaaagc cccattgaca aaccttcaga ttctctcagt
     1381 atagggaatg gtgataattc ccaacagata tctaacagtg atacgccttc accaccacct
     1441 ggtttatcaa aatccaaccc tgtcatcccc atcagttcat ccaatcacag tgcgaggtct
     1501 ccttttgaag gggcagtaac agagtcacag tcattattct cagacaattt tcgccacccc
     1561 aaccctatac caagtgggct tcctcctttt cccagctctc cacagacacc cagtgattgg
     1621 cctacagctc cagaaccaca gagcctcttc acatcagaaa caatcccagt ttcatcatct
     1681 acagactggc aagcagcatt cggctttggt tcttctaaac aaccagagga tgacttgggg
     1741 tttgacccct ttgatgtcac tcgaaaagcc ttagcagacc tgattgagaa ggaactatcc
     1801 gtccaagatc aaccttccct ttcccccaca tctcttcaga acgcctcctc acacactacg
     1861 accgccaaag ggccaggctc tggattcctg cactctgctg cacctacaaa tgccaactct
     1921 ctcaatagta ccttttcagt cttgccacag aggttccctc aatttcagca gcaccgagca
     1981 gtttataatt cgttcggttt tccaggccag gcagcccgct atccttggat ggcctttcca
     2041 cgcaatagca tcatgcactt gaaccacaca gcaaacccca cctcaaatag taatttcttg
     2101 gacttgaatc tcccgccaca gcacaacaca ggtctgggag ggatccccat agcaggggaa
     2161 gaagaggtga aggtttcgac catgccactg tccgcctctt cccattcatt acaacaagga
     2221 cagcagccta caagtctcca cactactgtg gcctgacacc agaactgaga ggaaaggaga
     2281 ggattagact cggggtgctt gcatgggcaa ctggattttt gcatggttcc tttctgactt
     2341 tgcatttaat gtatacaccc aaaagagcca atataaacgt tcctcatgcc gacaactagc
     2401 gtggacctcg tagttgctaa agtatttctt cattaggcct ttaacataat ttattagcat
     2461 aataattttg ccattgtttc tcatgagtga tactattttt aactcttaca aataaactta
     2521 gagtactaat taagatccca gaggagatta gctagacctg ttcctatttt gactattatt
     2581 ggaaatatac aaaagtaatg gtagttcttt gttttttcgg tttgtgaaaa aaatggtaat
     2641 attttaatct actcctgaaa ttttgaaaca ttaagataat gtctattgca ttctttgaat
     2701 tcttgaaaag aaagaataca tataaaacaa aactggtggt gtcattcaat gctcagaaag
     2761 atgttgtcag ctgttgtttt cagttgccta gatttatatc atatattatg cattacatgt
     2821 atacaaactg ttttgttctt tctcatttgc acatttgcac ttttcttttt gaatggttgt
     2881 taattataca tagatggtta aaaggtaata ttatggccta actgcaatat catctgattt
     2941 ctaatgcact gcctagtata ccaggaaatg cctcaaaaca gaatttcaac ttgtagttga
     3001 gttattagaa acttgaacat ggggtaaaca gcgtatgtaa gtagtagcca tagtagtgta
     3061 acatttttat tgaacaaaca gtagttcagt agaatctatt tggaaatttc attgttaaat
     3121 aattgacatg tgataaaagt aactggccag aataagactt acagtagaag aaggaagctg
     3181 ggtgtcttgt aaaaatgaga ccatataggt tgtaatagat agccttagat gatcagagat
     3241 cagtgagtgg ggtacttcat aaggcagaat gtaaagtgat gctttgataa tgcaaaactt
     3301 cttgaaatag ttttaaaatg ataataaaaa aataaactga acttagttct gagcagtgga
     3361 caaaatctga tttaaaaaaa attaccataa tttgcctaaa agcatttggg gagatggaga
     3421 aagccagact ttttgagatt ttaaaaaaag tttaaaaagt atgccttaat ttgtttaaaa
     3481 aaaaaaaaaa gaaccatgaa aaatgtactg tgaataccaa aaagaaatct taacaatact
     3541 actaataaaa catctgattt gaagatgatg ctaatgttat atagcattgg catttttggg
     3601 ttgtttttta atataaaata tgggaacttc ctgttacata taacaaaaca aatggcttca
     3661 ccctgaggta gagtggagta aagtggaaat ttatttttac atatatgtat tttttaattt
     3721 ggttgaggtc acagaattga ccaattctct actcatctaa gttatgtttt tagagttcag
     3781 cataaatacc aatttctagc ctgcatttaa aagtgaattt acagcaacat tataagaaaa
     3841 ctgctgtctt tgaaagtact agatctgtat acttattaaa cttcagcctt ttaatcagac
     3901 cttaattcaa ttatgggttt catttgacta taacaggtca atgtttgctg tgtgaagttc
     3961 tgtggttaag gcttctgggc tctgtgtgtt ctgggttaag gctggaaatg ctgctcttgt
     4021 aatgatgctc actagctctt agctctctcc agcgttgatt ggcttccttc tcttgcaagc
     4081 actcggatga ttggctccca tctactaact gcttgtgctg ggagggagct actgagcaaa
     4141 gctgctttcc ttccctcgct ctgctccttt tcatttctaa tttgtacaga aaatttgtcc
     4201 aaagattttt cagacttgct cgtagtcccc aataagagtt gcaaagctgt gtgtctcctt
     4261 tctgtctatt ctccctctac ttctgatgta ccatgaattt gggaaatgct tttaggcaat
     4321 tagaactcag cattaaaact tctgtatatg gagtgcttaa aaacttactt ttaagtcatt
     4381 tttttgttgt tttttttttt ttttatttct agacccagag gcctcacttt tttatttaat
     4441 gtggtatttt agaagtcttt aaaataataa tttactcaaa tgcatggaag aaattatata
     4501 gtacataaaa gaaccatttt atgtgatgga caaatataat taaaatcatg gaaagaatga
     4561 gaaattctaa
//
