LOCUS       NM_146176               2923 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 3 (Cnot3),
            mRNA.
ACCESSION   NM_146176
VERSION     NM_146176.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Lu,P., Wang,P., Wu,B., Wang,Y., Liu,Y., Cheng,W., Feng,X., Yuan,X.,
            Atteya,M.M., Ferro,H., Sugi,Y., Rydquist,G., Esmaily,M.,
            Butcher,J.T., Chang,C.P., Lenz,J., Zheng,D. and Zhou,B.
  TITLE     A SOX17-PDGFB signaling axis regulates aortic root development
  JOURNAL   Nat Commun 13 (1), 4065 (2022)
   PUBMED   35831318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Sarkar,M., Martufi,M., Roman-Trufero,M., Wang,Y.F., Whilding,C.,
            Dormann,D., Sabbattini,P. and Dillon,N.
  TITLE     CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote
            survival of differentiating mesendodermal progenitor cells
  JOURNAL   Mol Biol Cell 32 (22), ar40 (2021)
   PUBMED   34613789
  REMARK    GeneRIF: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to
            promote survival of differentiating mesendodermal progenitor cells.
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Minegishi,K., Rothe,B., Komatsu,K.R., Ono,H., Ikawa,Y.,
            Nishimura,H., Katoh,T.A., Kajikawa,E., Sai,X., Miyashita,E.,
            Takaoka,K., Bando,K., Kiyonari,H., Yamamoto,T., Saito,H.,
            Constam,D.B. and Hamada,H.
  TITLE     Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the
            mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
  JOURNAL   Nat Commun 12 (1), 4071 (2021)
   PUBMED   34210974
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 2923)
  AUTHORS   Morita,M., Suzuki,T., Nakamura,T., Yokoyama,K., Miyasaka,T. and
            Yamamoto,T.
  TITLE     Depletion of mammalian CCR4b deadenylase triggers elevation of the
            p27Kip1 mRNA level and impairs cell growth
  JOURNAL   Mol Cell Biol 27 (13), 4980-4990 (2007)
   PUBMED   17452450
REFERENCE   8  (bases 1 to 2923)
  AUTHORS   Yin,X., Warner,D.R., Roberts,E.A., Pisano,M.M. and Greene,R.M.
  TITLE     Identification of novel CBP interacting proteins in embryonic
            orofacial tissue
  JOURNAL   Biochem Biophys Res Commun 329 (3), 1010-1017 (2005)
   PUBMED   15752756
REFERENCE   9  (bases 1 to 2923)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 2923)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV783268.1, BC053437.1 and BQ748712.1.
            
            On Apr 8, 2010 this sequence version replaced NM_146176.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053437.1, SRR7652917.757753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               CV783268.1         3-241
            240-2896            BC053437.1         1-2657
            2897-2923           BQ748712.1         528-554
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.1 cM"
     gene            1..2923
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /note="CCR4-NOT transcription complex, subunit 3"
                     /db_xref="GeneID:232791"
                     /db_xref="MGI:MGI:2385261"
     exon            1..316
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..391
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..2622
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /note="CCR4-associated factor 3"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 3"
                     /protein_id="NP_666288.1"
                     /db_xref="CCDS:CCDS20721.1"
                     /db_xref="GeneID:232791"
                     /db_xref="MGI:MGI:2385261"
                     /translation="MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKY
                     EADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRKLIETQMERFKVVERETKTKA
                     YSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDK
                     DKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPD
                     FEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPAN
                     CTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSAL
                     SSTPGNNGASTPAAPTSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPS
                     AQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSSGGSSASS
                     QALGPTSGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVPLPVNPPSSPTP
                     SFSEAKAAGTLLNGPPQFSTTPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTDR
                     DIILSSTSAPPTSSQPPLQLSEVNIPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMP
                     HPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQ
                     YLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTF
                     EYRYLEDRDLQ"
     exon            392..459
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..534
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            535..624
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            625..753
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..849
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1069
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1203
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1260
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1642
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1766
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1965
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2065
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2264
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2397
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2523
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2905
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2896
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaggcctc cgccgccgcc atcttggacc gggcccgttc agcttccgtg gagccgtcgg
       61 cagccgctgc cgggcctttc cttgatccct gaatccccta ctcggtcgtc tagaacaatc
      121 ccgggcccac ttcctctatc aacaacccaa ccctacttcc ggctttcgcg ccctcttatc
      181 gcgatagcgc ccgggctcgg ggcgcgagga aagaggaaaa aaaaaaaaaa aaaaggcggc
      241 gggcgggcgc tcgcctctct ctcccccctc ctcgcctgtc gcgatacgct ccgcagcggc
      301 ggcgccagct cctgcgcggc cattttcaag agagtatgaa gagagtgcgt ctgtagggca
      361 gggaagatgg cggacaagcg caaactccaa ggtgagattg atcgctgcct caagaaggtg
      421 tccgaagggg tggagcagtt tgaagatatt tggcaaaagc tccacaatgc agccaacgcg
      481 aaccagaaag aaaagtatga ggctgaccta aagaaggaga ttaagaagct acaacggctg
      541 agggaccaga tcaagacatg ggtagcatca aatgagatca aggacaaaag gcagcttatt
      601 gaaaaccgca agctcattga gacgcaaatg gaacggttca aagttgtgga acgagagacc
      661 aaaaccaaag cgtatagcaa ggagggtctg ggtctggctc agaaggtgga tcctgcccag
      721 aaggagaagg aagaagttgg ccagtggctc acgaacacca ttgacacctt aaatatgcag
      781 gtggaccagt ttgagagtga agtggagtca ctgtcggtac agacacgcaa gaagaaaggc
      841 gacaaggata agcaggaccg gattgagggc ttgaagcggc atatcgagaa gcaccgctac
      901 catgttcgta tgctggagac catcctgcga atgctggaca atgactccat cctggttgat
      961 gccatccgca agatcaagga tgatgtggag tactacgttg actcatccca ggaccccgac
     1021 tttgaagaga acgaattcct ctatgacgac ctggacctcg aggacattcc acaggcgctg
     1081 gtcgccacct ccccccccag ccacagccac atggaggacg agatcttcaa ccagtctagc
     1141 agtacaccca cctcaacaac ctccagctct cccatcccac ccagcccagc aaactgcact
     1201 acggaaaact ctgaagatga taagaagaga ggccgatcta cagatagtga agtcagccag
     1261 tctccagcca aaaatggctc caagcctgtc cacagcaacc agcaccccca gtccccagct
     1321 gtgccgccca cctacccctc tggcccccca cctaccactt ctgccttgag ctccacccct
     1381 ggcaacaatg gggcctctac cccagcagca cctacaagtg ccctgggccc taaggccagt
     1441 ccagctccca gccacaactc gggtactcct gcaccctatg cccaggctgt ggccccacct
     1501 aatgccagcg ggcccagcaa tgcccagcca cggcccccca gtgcccagcc aagcggggga
     1561 agtggtggtg gcagcggagg gagcagcagc aatagtaaca gtggcacagg cggaggggct
     1621 ggcaagcaga acggtgccac aagctatagt tcggttgtgg cagacagccc tgcagaggtg
     1681 accctgagta gcagtggggg cagcagtgcc agcagccaag cccttgggcc cacttcgggc
     1741 cctcacaacc cagctcccag cacctcaaag gaatccagta cggcagcccc atcaggggct
     1801 gggaatgtgg cttcaggctc agggaataac tcggggggac ccagcctctt ggtgccactg
     1861 cctgtaaatc cccccagttc tccaacgccc agcttcagtg aagccaaggc agctggtacc
     1921 ctgcttaatg gtcctccaca gttcagcacc accccagaaa tcaaggcccc tgaaccactc
     1981 agctctctga aatccatggc agaacgggca gctatcagct ctggtattga ggaccctgtg
     2041 ccaacgttac acctaactga tcgagacatc atcctgagca gcacatcagc accacccacc
     2101 tcatcccagc cacccctgca gctgtcagag gtgaacatac cattgtcact gggtgtctgt
     2161 ccactggggc cagtttccct caccaaggag cagctatacc aacaggccat ggaagaggcc
     2221 gcctggcacc acatgcccca cccctctgac tccgagcgca ttcggcagta cctcccccgg
     2281 aacccttgcc cgacaccccc ctaccaccac cagatgccac ccccacactc ggacactgtg
     2341 gagttctacc agcgcctgtc aactgagacg ctcttcttca tcttctacta tctggaggga
     2401 accaaggcac agtacttggc agccaaggcc ctaaagaagc agtcctggcg attccacacc
     2461 aagtatatga tgtggttcca gaggcacgag gagcctaaga ccatcacaga tgagtttgag
     2521 cagggcacct acatctactt tgactacgag aagtggggcc agcggaagaa ggaaggcttc
     2581 acctttgagt accgctacct ggaggaccgg gacctccagt gacaccggcc cccctctacc
     2641 ctctccctcc ctcgcatgct gatccccctg cccaggtgag ggccctgccc tggaagactg
     2701 ggggaggccc aaggccatgg gacaccctcc cccccaggaa gcagggaagg gatagggagg
     2761 ttttctcttc ctctctgccc taccctgggg gcctgggggc aagggctgcc ccctcctccc
     2821 ctccccagtg agggacattt tttggtaaac ctattttcat tttggaaaat atttatgaat
     2881 aaatagtttt atatgacggc tggcaaaaaa aaaaaaaaaa aaa
//
