LOCUS       NP_666288                751 aa            linear   ROD 18-MAR-2025
DEFINITION  CCR4-NOT transcription complex subunit 3 [Mus musculus].
ACCESSION   NP_666288
VERSION     NP_666288.1
DBSOURCE    REFSEQ: accession NM_146176.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 751)
  AUTHORS   Lu,P., Wang,P., Wu,B., Wang,Y., Liu,Y., Cheng,W., Feng,X., Yuan,X.,
            Atteya,M.M., Ferro,H., Sugi,Y., Rydquist,G., Esmaily,M.,
            Butcher,J.T., Chang,C.P., Lenz,J., Zheng,D. and Zhou,B.
  TITLE     A SOX17-PDGFB signaling axis regulates aortic root development
  JOURNAL   Nat Commun 13 (1), 4065 (2022)
   PUBMED   35831318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 751)
  AUTHORS   Sarkar,M., Martufi,M., Roman-Trufero,M., Wang,Y.F., Whilding,C.,
            Dormann,D., Sabbattini,P. and Dillon,N.
  TITLE     CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote
            survival of differentiating mesendodermal progenitor cells
  JOURNAL   Mol Biol Cell 32 (22), ar40 (2021)
   PUBMED   34613789
  REMARK    GeneRIF: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to
            promote survival of differentiating mesendodermal progenitor cells.
REFERENCE   5  (residues 1 to 751)
  AUTHORS   Minegishi,K., Rothe,B., Komatsu,K.R., Ono,H., Ikawa,Y.,
            Nishimura,H., Katoh,T.A., Kajikawa,E., Sai,X., Miyashita,E.,
            Takaoka,K., Bando,K., Kiyonari,H., Yamamoto,T., Saito,H.,
            Constam,D.B. and Hamada,H.
  TITLE     Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the
            mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
  JOURNAL   Nat Commun 12 (1), 4071 (2021)
   PUBMED   34210974
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 751)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (residues 1 to 751)
  AUTHORS   Morita,M., Suzuki,T., Nakamura,T., Yokoyama,K., Miyasaka,T. and
            Yamamoto,T.
  TITLE     Depletion of mammalian CCR4b deadenylase triggers elevation of the
            p27Kip1 mRNA level and impairs cell growth
  JOURNAL   Mol Cell Biol 27 (13), 4980-4990 (2007)
   PUBMED   17452450
REFERENCE   8  (residues 1 to 751)
  AUTHORS   Yin,X., Warner,D.R., Roberts,E.A., Pisano,M.M. and Greene,R.M.
  TITLE     Identification of novel CBP interacting proteins in embryonic
            orofacial tissue
  JOURNAL   Biochem Biophys Res Commun 329 (3), 1010-1017 (2005)
   PUBMED   15752756
REFERENCE   9  (residues 1 to 751)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (residues 1 to 751)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV783268.1, BC053437.1 and BQ748712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053437.1, SRR7652917.757753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.1 cM"
     Protein         1..751
                     /product="CCR4-NOT transcription complex subunit 3"
                     /note="CCR4-associated factor 3"
                     /calculated_mol_wt=81815
     Region          3..229
                     /region_name="Not3"
                     /note="Not1 N-terminal domain, CCR4-Not complex component;
                     pfam04065"
                     /db_xref="CDD:461155"
     Region          240..534
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K0V4.1)"
     Site            292
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75175; propagated from
                     UniProtKB/Swiss-Prot (Q8K0V4.1)"
     Region          <297..564
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Site            299
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K0V4.1)"
     Site            540
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75175; propagated from
                     UniProtKB/Swiss-Prot (Q8K0V4.1)"
     Region          618..743
                     /region_name="NOT2_3_5"
                     /note="NOT2 / NOT3 / NOT5 family; pfam04153"
                     /db_xref="CDD:461199"
     Region          659..751
                     /region_name="Repressor domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K0V4.1)"
     CDS             1..751
                     /gene="Cnot3"
                     /gene_synonym="A930039N10Rik"
                     /coded_by="NM_146176.3:367..2622"
                     /db_xref="CCDS:CCDS20721.1"
                     /db_xref="GeneID:232791"
                     /db_xref="MGI:MGI:2385261"
ORIGIN      
        1 madkrklqge idrclkkvse gveqfediwq klhnaananq kekyeadlkk eikklqrlrd
       61 qiktwvasne ikdkrqlien rklietqmer fkvveretkt kayskeglgl aqkvdpaqke
      121 keevgqwltn tidtlnmqvd qfesevesls vqtrkkkgdk dkqdrieglk rhiekhryhv
      181 rmletilrml dndsilvdai rkikddveyy vdssqdpdfe eneflyddld ledipqalva
      241 tsppshshme deifnqssst ptsttssspi ppspanctte nseddkkrgr stdsevsqsp
      301 akngskpvhs nqhpqspavp ptypsgpppt tsalsstpgn ngastpaapt salgpkaspa
      361 pshnsgtpap yaqavappna sgpsnaqprp psaqpsggsg ggsggsssns nsgtgggagk
      421 qngatsyssv vadspaevtl sssggssass qalgptsgph npapstskes staapsgagn
      481 vasgsgnnsg gpsllvplpv nppssptpsf seakaagtll ngppqfsttp eikapeplss
      541 lksmaeraai ssgiedpvpt lhltdrdiil sstsapptss qpplqlsevn iplslgvcpl
      601 gpvsltkeql yqqameeaaw hhmphpsdse rirqylprnp cptppyhhqm ppphsdtvef
      661 yqrlstetlf fifyylegtk aqylaakalk kqswrfhtky mmwfqrheep ktitdefeqg
      721 tyiyfdyekw gqrkkegftf eyryledrdl q
//
