LOCUS       NM_001037846            2816 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus CCR4-NOT transcription complex, subunit 2 (Cnot2),
            transcript variant 1, mRNA.
ACCESSION   NM_001037846
VERSION     NM_001037846.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Kamon,M., Katano,M., Hiraki-Kamon,K., Hishida,T., Nakachi,Y.,
            Mizuno,Y., Okazaki,Y., Suzuki,A., Hirasaki,M., Ueda,A.,
            Nishimoto,M., Kato,H. and Okuda,A.
  TITLE     Identification of Ccr4-not complex components as regulators of
            transition from partial to genuine induced pluripotent stem cells
  JOURNAL   Stem Cells Dev 23 (18), 2170-2179 (2014)
   PUBMED   24200330
  REMARK    GeneRIF: These data have uncovered a novel role of core components
            of the Ccr4-Not complex as regulators of transition from partial to
            genuine induced pluripotent stem cells.
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065171.1, AK078121.1, BM245866.2 and BB353467.1.
            
            On Nov 1, 2008 this sequence version replaced NM_001037846.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078121.1, AK167834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BC065171.1         1-11
            12-595              AK078121.1         2-585
            596-708             BC065171.1         526-638
            709-2308            AK078121.1         699-2298
            2309-2783           BM245866.2         34-508              c
            2784-2816           BB353467.1         243-275
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 64.76 cM"
     gene            1..2816
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /note="CCR4-NOT transcription complex, subunit 2"
                     /db_xref="GeneID:72068"
                     /db_xref="MGI:MGI:1919318"
     exon            1..59
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            60..202
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1777
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     CCR4-associated factor 2"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 2 isoform
                     a"
                     /protein_id="NP_001032935.2"
                     /db_xref="CCDS:CCDS36064.1"
                     /db_xref="GeneID:72068"
                     /db_xref="MGI:MGI:1919318"
                     /translation="MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYY
                     SQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQ
                     GTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSS
                     SGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDG
                     SENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIH
                     NEDFPALPGSSYKDPTSSNDDSKSNLSTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKG
                     IQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSP
                     ENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYM
                     NGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWR
                     KVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF"
     exon            203..325
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            326..392
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            393..540
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..723
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            724..803
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            804..929
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1054
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1175
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1332
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1394
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1444
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1545
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1690
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..2816
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2789..2794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2812
                     /gene="Cnot2"
                     /gene_synonym="2600016M12Rik; 2810470K03Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagcctccg cggtggatac gtcgccatct tggatccgcg ggacaagaaa attcatgcga
       61 gggagaactg gtgggcggtc cttcctgtga cacgaccctt gagtgacagt tctatttgat
      121 tgcctccagt actgtgagga aaggacacga ctctatggtg aggactgatg gacatacatt
      181 atctgagaaa agaaactacc aggtgacaaa cagcatgttt ggtgcttcaa gaaagaagtt
      241 tgtagagggg gtggacagcg actaccatga tgagaacatg tactacagcc agtcttctat
      301 gttcccacat cggtcagaga aagatatgct ggcatcgcca tctacgtcag gtcagctgtc
      361 tcaatttggg gcaagtttat acgggcaaca aagtgcacta ggccttccaa tgagggggat
      421 gagcaacaat acccctcagt taaatcgcag cttatcacaa ggcactcagt taccgagcca
      481 cgtcacgcca acaacagggg taccaacaat gtcacttcac acgcctccat ctccaagcag
      541 gggtattttg cctatgaatc ctaggaatat gatgaaccac tcccaggttg gtcagggcat
      601 tggaattcct agcaggacaa atagcatgag cagttcaggg ttaggtagcc ccaacagaag
      661 ctcgccaagc ataatatgta tgccaaagca acagccttct cgacagcctt ttactgtgaa
      721 cagtatgtct ggatttggaa tgaacaggaa tcaggcattt ggaatgaata actccttatc
      781 aagtaacatt tttaatggaa cagatggcag tgaaaatgtg acaggattgg acctttcaga
      841 tttcccagcg ttagctgacc ggaatagaag ggaagggagc ggcaacccaa ctccattaat
      901 aaaccccttg gctggaagag ctccttacgt tggaatggta acaaaacctg caaatgagca
      961 atcccaagac ttctcaatac acaacgaaga ttttccagca ttacctggtt ccagctataa
     1021 agatccaacg tcaagtaatg acgacagcaa atctaatttg agtacatcgg ggaagacgac
     1081 ttcaagtaca gatggaccca aattccctgg agataaaagt tcaacaacac aaaacaataa
     1141 tcaacagaaa aaggggatcc aggtgttacc tgatggtcga gttactaaca ttcctcaagg
     1201 gatggtgacg gaccaatttg gaatgattgg cctgttaaca tttatcaggg cagcagagac
     1261 agacccagga atggtacatc ttgctttagg aagtgactta acaacattag gcctcaatct
     1321 gaactcacct gaaaatctct atcccaaatt tgcatcaccc tgggcttctt caccttgtcg
     1381 gcctcaagac atagacttcc atgttccatc agaatattta acaaacattc acattaggga
     1441 taagctggct gcaatcaaac ttggccgata tggagaagac ctcctcttct atctgtatta
     1501 catgaacggc ggggatgtat tacaactctt agctgcggta gaacttttta accgtgattg
     1561 gagataccac aaggaggagc gggtatggat taccagggca ccaggcatgg agccaacaat
     1621 gaaaaccaac acgtatgagc gggggaccta ctatttcttt gactgtctca actggaggaa
     1681 agtagctaag gagttccatc tggaatatga caaattagaa gagcggcctc acctgccatc
     1741 caccttcaac tacaaccctg ctcagcaagc cttctaaaaa gacttccctt ttcttggggt
     1801 atggctgtct cagcacaata ctcgacataa ctgcagagct gatgtggctc aggcaccctg
     1861 gttttaatcc cttgaggatc tggcaattgg cttacgtaaa gaaagggtca ccatttgagg
     1921 tcctgcctta ccaattatgt gctgcccaac aactaaattt gtaatttgtt ttctctactt
     1981 tgagcagggt ctgaattttt tcatttattt tctttttgcc agcagacaga cttgggtcta
     2041 taaagacaag caagtacact gacagaaatt accatttagt ttcttaaatg taaaaaaaga
     2101 aaacccacaa aagactcaac aaaattagac cacaaaattt gcattgttca ttgtagcact
     2161 attggtaata aaagaacaga tgtttgtgca tttttatgtg aagatccttc tcgtatttca
     2221 tttggaagga tgagcgaggt ctgcttcttt ctttttactt cccctgtgtt tctgaaaggc
     2281 ggtttggcca ggcttactgc aggcatccga ctgtagagat cgccacagtc tctggggctc
     2341 cagggctgcg ctgtaactga gcttcatcca gaatgagcaa aacactgtcc agtctttgtt
     2401 acgattttgt aataaatgtg tacatttttt ttaaattttg gacatcacat gaataaaggt
     2461 atgtatgtac gaatgtgtat atattatata tatgacatct attttggaaa atgtttgccc
     2521 tgctgtacct catttttagg aggtgtgcat ggatgcaata tatgaaaatg ggacattctg
     2581 gaactgctgg tcaggggact ttgtcgccct gtgcactaaa gggccagatt ttcagcagcc
     2641 aaggacatcc atacccaagt gaatgtgatg gggcttcaag acgtgaactg agacaattca
     2701 ctctggctgt ttgaacagca gcgtttcata ggaagagaaa aagatcaatc ttgtattttc
     2761 tgaccacata aaggcttctt ctctttgtaa taaagtagaa aagctctcct cactgc
//
