LOCUS       NM_033570               4582 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cyclin M4 (Cnnm4), mRNA.
ACCESSION   NM_033570
VERSION     NM_033570.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4582)
  AUTHORS   Gonzalez-Recio,I., Simon,J., Goikoetxea-Usandizaga,N.,
            Serrano-Macia,M., Mercado-Gomez,M., Rodriguez-Agudo,R.,
            Lachiondo-Ortega,S., Gil-Pitarch,C., Fernandez-Rodriguez,C.,
            Castellana,D., Latasa,M.U., Abecia,L., Anguita,J., Delgado,T.C.,
            Iruzubieta,P., Crespo,J., Hardy,S., Petrov,P.D., Jover,R.,
            Avila,M.A., Martin,C., Schaeper,U., Tremblay,M.L., Dear,J.W.,
            Masson,S., McCain,M.V., Reeves,H.L., Andrade,R.J., Lucena,M.I.,
            Buccella,D., Martinez-Cruz,L.A. and Martinez-Chantar,M.L.
  TITLE     Restoring cellular magnesium balance through Cyclin M4 protects
            against acetaminophen-induced liver damage
  JOURNAL   Nat Commun 13 (1), 6816 (2022)
   PUBMED   36433951
  REMARK    GeneRIF: Restoring cellular magnesium balance through Cyclin M4
            protects against acetaminophen-induced liver damage.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4582)
  AUTHORS   Funato,Y., Yamazaki,D., Okuzaki,D., Yamamoto,N. and Miki,H.
  TITLE     Importance of the renal ion channel TRPM6 in the circadian
            secretion of renin to raise blood pressure
  JOURNAL   Nat Commun 12 (1), 3683 (2021)
   PUBMED   34140503
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4582)
  AUTHORS   Franken,G.A.C., Seker,M., Bos,C., Siemons,L.A.H., van der
            Eerden,B.C.J., Christ,A., Hoenderop,J.G.J., Bindels,R.J.M.,
            Muller,D., Breiderhoff,T. and de Baaij,J.H.F.
  TITLE     Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and
            developmental defects
  JOURNAL   Sci Rep 11 (1), 8217 (2021)
   PUBMED   33859252
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4582)
  AUTHORS   Yamazaki,D., Hasegawa,A., Funato,Y., Tran,H.N., Mori,M.X., Mori,Y.,
            Sato,T. and Miki,H.
  TITLE     Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell
            proliferation in the colon epithelia
  JOURNAL   Oncogene 38 (20), 3962-3969 (2019)
   PUBMED   30670776
  REMARK    GeneRIF: The importance of CNNM4 in maintaining the normal balance
            between cell proliferation and differentiation in the colon
            epithelia.
REFERENCE   5  (bases 1 to 4582)
  AUTHORS   Funato,Y., Yamazaki,D. and Miki,H.
  TITLE     Renal function of cyclin M2 Mg2+ transporter maintains blood
            pressure
  JOURNAL   J Hypertens 35 (3), 585-592 (2017)
   PUBMED   28033128
REFERENCE   6  (bases 1 to 4582)
  AUTHORS   Yu,C., Ji,S.Y., Dang,Y.J., Sha,Q.Q., Yuan,Y.F., Zhou,J.J.,
            Yan,L.Y., Qiao,J., Tang,F. and Fan,H.Y.
  TITLE     Oocyte-expressed yes-associated protein is a key activator of the
            early zygotic genome in mouse
  JOURNAL   Cell Res 26 (3), 275-287 (2016)
   PUBMED   26902285
REFERENCE   7  (bases 1 to 4582)
  AUTHORS   Funato,Y., Yamazaki,D., Mizukami,S., Du,L., Kikuchi,K. and Miki,H.
  TITLE     Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor
            progression
  JOURNAL   J Clin Invest 124 (12), 5398-5410 (2014)
   PUBMED   25347473
  REMARK    GeneRIF: these results indicate that CNNM4-dependent Mg(2+) efflux
            suppresses tumor progression by regulating energy metabolism.
REFERENCE   8  (bases 1 to 4582)
  AUTHORS   Yamazaki,D., Funato,Y., Miura,J., Sato,S., Toyosawa,S.,
            Furutani,K., Kurachi,Y., Omori,Y., Furukawa,T., Tsuda,T.,
            Kuwabata,S., Mizukami,S., Kikuchi,K. and Miki,H.
  TITLE     Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+
            transport across epithelia: a mouse model
  JOURNAL   PLoS Genet 9 (12), e1003983 (2013)
   PUBMED   24339795
REFERENCE   9  (bases 1 to 4582)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4582)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ168962.1, AK173209.1 and AK164200.1.
            
            On Dec 11, 2007 this sequence version replaced NM_033570.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173209.1, AF216963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CJ168962.1         2-24
            24-2665             AK173209.1         1-2642
            2666-4564           AK173209.1         2645-4543
            4565-4582           AK164200.1         1900-1917
FEATURES             Location/Qualifiers
     source          1..4582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.28 cM"
     gene            1..4582
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /note="cyclin M4"
                     /db_xref="GeneID:94220"
                     /db_xref="MGI:MGI:2151060"
     exon            1..1489
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2412
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /note="metal transporter CNNM4; mACDP4; ancient conserved
                     domain-containing protein 4; ancient conserved domain
                     protein 4"
                     /codon_start=1
                     /product="metal transporter CNNM4 precursor"
                     /protein_id="NP_291048.2"
                     /db_xref="CCDS:CCDS14879.2"
                     /db_xref="GeneID:94220"
                     /db_xref="MGI:MGI:2151060"
                     /translation="MAPGGGGGRRDGWPARGRLLLAALLLLWTRAASGQSSPQQSVIL
                     GMRLASCNKSCGMNPDGIIFVSEGSTVNLRLYGHSLGDISSNLISFTEVDDAEAVHNS
                     TNCLELTKDLVVQRLVNVSRGNTSGMLVVITKFLRRSENMKLYALCTRPRADGPWTRW
                     TDKDSLLFMVEEHGRFLPLWLHILLVMVLLVLSGIFSGLNLGLMALDPMELRIVQNCG
                     TEKERKYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGIMAVASSTIGI
                     VIFGEILPQALCSRHGLAVGANTIVLTKVFMLLTFPLSFPISKLLDFVLGQEIRTVYN
                     REKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLHDCFMIRSDAILDFN
                     TMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVF
                     HDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDE
                     SDMYTDNRTRKRVSVKNKRDFSAFKDTDNELKVKISPQLLLAAHRFLATEVPQFSPSL
                     MSEKILLRLLKYPDVIQELRFNEHNRYCVRHYLYTRNKPADCFVLILQGKVEVEAGKE
                     NMKFETGAFSYYGTMALSVAPPDRSPALPTPLSRSASLSYPDRNTDLTSTSLAGSNQF
                     GSCILGQYVSDFSVRALTDLQYIKITRQQYQNGLMASRMDNSPQPTFDGCATCSENFM
                     ERPELPPVDETTTLLNERNSLLHRASEEETI"
     exon            1490..1633
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1768
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1938
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2035
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2214
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..4582
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4548..4553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /note="hexamer: AATAAA"
     polyA_site      4570
                     /gene="Cnnm4"
                     /gene_synonym="5430430O18Rik; Acdp4"
                     /note="major polyA site"
ORIGIN      
        1 agttggcgcg gcggcagcgg agcggcagga gggcaggagc ggaggcgccg agtgaggcgc
       61 gcggcggggc gcgggcagcg gcggggccgg agcaacatgg cgccgggggg cgggggcggg
      121 cggcgggacg gctggccggc ccgagggcgc ctcctcctgg ctgcgctgct gctgctatgg
      181 acgcgggcgg ccagcggcca gagcagcccc cagcagagcg tgatcctagg catgaggcta
      241 gcgagctgca acaagtcgtg cgggatgaac ccggatggca tcatcttcgt gtccgagggc
      301 agcacggtga acttgaggct ctatggccac agcctgggcg atatctccag caacctgatc
      361 tccttcaccg aggtggacga cgccgaggcg gtccacaact ccaccaactg cctggagctc
      421 accaaggact tagtggtcca gcggctggtc aacgtgagcc gcgggaacac gtcggggatg
      481 ctagtggtga ttaccaagtt cctgcggagg agcgagaaca tgaagctgta cgcgctgtgc
      541 acccggcccc gggccgacgg gccctggacc agatggacgg acaaggactc cctgctcttc
      601 atggtggagg agcatgggag gtttctgccg ctctggctgc acatccttct cgttatggtg
      661 ctgttggtgc tgtcgggcat cttttctggc ctcaacctgg ggcttatggc cctggacccg
      721 atggagctgc gcatcgtgca gaactgtgga actgagaagg agagaaagta tgctcgcaag
      781 atagagccca tcaggcgcaa gggcaactac ctgctctgct cgctgctcct ggggaacgtg
      841 ctagtcaaca cctccctcac catccttcta gacaacctca tcgggtctgg catcatggca
      901 gtggcctcct ctaccattgg cattgtcatc tttggggaga tcttacctca agccctgtgc
      961 tcccggcacg ggctggctgt gggtgccaac actattgttc tcaccaaagt ctttatgctc
     1021 ctcacttttc ccttgagttt ccccattagc aaactcctgg acttcgtctt aggtcaggag
     1081 attcgcactg tttacaatcg ggagaagctg atggagatgt tgaaggtgac agagccctat
     1141 aatgacttgg tgaaggagga gttaaatatg atccagggtg ccctggaact aaggaccaaa
     1201 actgtggagg atatcatgac ccagctacac gactgcttca tgatccgcag tgatgccatt
     1261 ctggacttca acaccatgtc ggagattatg gagagtggct acactcgcat tcctgtgttt
     1321 gaagatgagc aatccaatat tgtagatatc ctgtatgtca aagacttggc ttttgttgac
     1381 ccggatgact gcaccccgct caagaccatc actcgcttct acaaccaccc ggtacatttt
     1441 gtttttcatg acaccaagct ggatgccatg ctagaggaat ttaagaaggg caagtcccac
     1501 ctggccatcg tgcagaaggt gaacaatgag ggcgagggcg accccttcta cgaggtgctg
     1561 ggcctggtca ctctggagga cgtcatcgag gagatcatca agtccgagat cctcgatgag
     1621 tcggacatgt acactgataa tcggacccgg aaacgggtgt ccgtgaaaaa caagcgtgac
     1681 ttctctgcct tcaaggacac tgacaatgaa ctcaaagtga aaatctcacc tcagcttctt
     1741 ctggctgctc atcgcttcct ggccacagag gtgccccagt ttagcccctc tctgatgtca
     1801 gagaagatcc tgctccggct gctcaagtac cccgacgtca ttcaggagct caggttcaat
     1861 gagcacaaca ggtactgcgt tcgccactac ctgtacaccc ggaacaagcc ggccgattgc
     1921 ttcgtcctca tcctgcaggg gaaggtggag gtagaagcag gcaaggagaa catgaagttt
     1981 gagacgggcg ccttctcgta ctatggaacc atggcactct ccgtggcacc cccagaccgg
     2041 tccccagccc tcccaactcc actcagccgc tcagcttccc tcagttaccc ggaccgcaac
     2101 acagacttga catccacctc cctggcaggc agcaaccagt ttggcagctg cattctgggc
     2161 cagtatgtct ctgacttcag tgtgcgggcg ctcacggacc tgcagtacat taagatcaca
     2221 aggcagcagt accagaatgg gctgatggcc tcccgcatgg acaacagccc ccagcctacc
     2281 ttcgatggct gtgccacctg ctcagagaac tttatggaga ggcctgagct gcccccggtg
     2341 gacgagacca cgactcttct caatgaacgc aactcgttgc tgcacagagc ctccgaagag
     2401 gaaaccatct gacaggaggg cccggggact cccgcccacc ctgcgggggt ctccccagtg
     2461 ggcccacatg aagtcaggag cctgttaggc tagaaggggt gcaggtagat atcctgcatg
     2521 actgagcaac cagacatccc tgtccagggg ctctggctgc agatagggac ctctgaacag
     2581 ctctgacatg atgcctgccc tgcccagcta gtgagcaaag gctgttgggt tgttgttggt
     2641 tttttttttt tttttttttt tttttaaaca ctgagagaag ttttaagcta ggctcattgc
     2701 tcctctttta aaatatcatt tggggaaggg aagacagggt taaggaactt tatgtaaaaa
     2761 aaaaaaaatt ttttttttca agaagcccca cagactttaa aaggggagga gggttcttcg
     2821 ccccgggaag caatggccat agcctgtttc cagctgagac cttgcagcct gtgtctgtca
     2881 ctctaggagg cactcttctg cagcagtggg ggcctggagc ccacaggagg ggcttcctgg
     2941 gaggaaaatg acatcaactg cgggacacac gggctgaggt catagagaag tgccgagcaa
     3001 cgcatcaggg atgcgatgac cccggcctcg gagaggaata catctgcctt taactgccag
     3061 atccagtgat gatctagacg cctgctcagg ggctctccta gagagctctg gctctcagcc
     3121 acccctttgg ccacttttct cctggaaggg tccggctcca agagttgggc gtggtctttg
     3181 gctctgcagt tgcctatctg cttcctggct tcactcttac caaaggtttt ctttcagagg
     3241 ggagagcatc accattagca gtgacctgtt gggcattccc tgtggtttca ggctgagtct
     3301 gatgacagga agatctgtgt cagcagttac tcctacccac tcacctgcac aaagagtcag
     3361 gactcagcag tccacccagg aagcttcctt tcctgacttc tctctctcct ggtccctcgg
     3421 aggactgaaa gccaccaaag ctgggtcgtt gcgccctgcc tgcatggctg gctgaggatc
     3481 cctgagctca ttcccactta aggacctgct atgcgagggc agtgctaagc ttgggctcag
     3541 gctgttggca ctgcagcgca gtcctacccc agtgccacct gggaaacctg agtagactca
     3601 ggccatgggg gcagagctgc acatgtctct tgtagggagg ctggaggacc aagggccgca
     3661 tctattgttg ggatggatgg agctggaata tcagagccag gcgagcggga gcacgggcca
     3721 tctgtgttta ttcattcact cctttcctca gccagtggag tcctgtcacc ccatgtactc
     3781 tgctgtctgt gtgcccagag aatcctaact cataggatgc accagggtgt cctatacccc
     3841 tggccaacct gaggtctctt ccactcacag aatttactcc gagaagcctg gtgatggcgg
     3901 ctctcagtga taagggaaaa aggcatcaga cttctagttc cttaggaaac tcttagttct
     3961 ctgtaggtgc agcatgctcc caggtctcta gacgaggtgc ctagctgtgt tcctgagaga
     4021 cctaagtgcc aggtagagca aaaccatgtg gtgggtgtga ggcaaccgta gcaggtgcgc
     4081 acacttccac agctacctct ctatatccag tcaccaccta cagacaggct ccacccatcc
     4141 ccacccctcc cctcctcatt tagaatcact tcttgcagag ggccataatt gtttccaaat
     4201 attactggtc tgatgacttc ctcctcccgg tgcaattttt cacttcctct tccagcctct
     4261 ggttcctggg cagagccata ccctggaact ggcccagtct gcatgtcttc ccagcagagg
     4321 aggactctgc agacggcatc caagtgggtg gccaagtcac agccgccata gcagatgact
     4381 cctatttatt ttgcattaag attttaattt gtatattttt gtgatttatt ttggcattgt
     4441 tatgagtttg actctcgggg agttttgttg ttatgactct tgtgtctttt gtcacaaaac
     4501 aatgataata tttgctaaac aatatatgga ctttattttt gattggtaat aaaaaatgaa
     4561 atgtatataa gttttggtga gc
//
