LOCUS       NM_033569               3330 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus cyclin M2 (Cnnm2), transcript variant 1, mRNA.
ACCESSION   NM_033569
VERSION     NM_033569.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3330)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3330)
  AUTHORS   Shahsavan,A., Lee,E.L., Illes,K., Kozlov,G. and Gehring,K.
  TITLE     Dimerization of the CNNM extracellular domain
  JOURNAL   Protein Sci 33 (2), e4860 (2024)
   PUBMED   38149326
  REMARK    GeneRIF: Dimerization of the CNNM extracellular domain.
REFERENCE   3  (bases 1 to 3330)
  AUTHORS   Funato,Y., Yamazaki,D., Okuzaki,D., Yamamoto,N. and Miki,H.
  TITLE     Importance of the renal ion channel TRPM6 in the circadian
            secretion of renin to raise blood pressure
  JOURNAL   Nat Commun 12 (1), 3683 (2021)
   PUBMED   34140503
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3330)
  AUTHORS   Franken,G.A.C., Seker,M., Bos,C., Siemons,L.A.H., van der
            Eerden,B.C.J., Christ,A., Hoenderop,J.G.J., Bindels,R.J.M.,
            Muller,D., Breiderhoff,T. and de Baaij,J.H.F.
  TITLE     Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and
            developmental defects
  JOURNAL   Sci Rep 11 (1), 8217 (2021)
   PUBMED   33859252
  REMARK    GeneRIF: Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia
            and developmental defects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3330)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   6  (bases 1 to 3330)
  AUTHORS   de Baaij,J.H., Stuiver,M., Meij,I.C., Lainez,S., Kopplin,K.,
            Venselaar,H., Muller,D., Bindels,R.J. and Hoenderop,J.G.
  TITLE     Membrane topology and intracellular processing of cyclin M2 (CNNM2)
  JOURNAL   J Biol Chem 287 (17), 13644-13655 (2012)
   PUBMED   22399287
  REMARK    GeneRIF: analysis of structure of CNNM2 and its post-translational
            modifications
REFERENCE   7  (bases 1 to 3330)
  AUTHORS   Stuiver,M., Lainez,S., Will,C., Terryn,S., Gunzel,D., Debaix,H.,
            Sommer,K., Kopplin,K., Thumfart,J., Kampik,N.B., Querfeld,U.,
            Willnow,T.E., Nemec,V., Wagner,C.A., Hoenderop,J.G., Devuyst,O.,
            Knoers,N.V., Bindels,R.J., Meij,I.C. and Muller,D.
  TITLE     CNNM2, encoding a basolateral protein required for renal Mg2+
            handling, is mutated in dominant hypomagnesemia
  JOURNAL   Am J Hum Genet 88 (3), 333-343 (2011)
   PUBMED   21397062
REFERENCE   8  (bases 1 to 3330)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Functional characterization of ACDP2 (ancient conserved domain
            protein), a divalent metal transporter
  JOURNAL   Physiol Genomics 22 (3), 382-389 (2005)
   PUBMED   15899945
  REMARK    GeneRIF: ACDP2 may provide a regulated transporter for Mg2+ and
            other divalent cations in epithelial ce
REFERENCE   9  (bases 1 to 3330)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3330)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159616.1, AF216961.1 and BC052513.1.
            
            On Aug 25, 2007 this sequence version replaced NM_033569.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF216961.1, AK053711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1657              AK159616.1         7-1663
            1658-3324           AF216961.1         970-2636
            3325-3330           BC052513.1         1340-1345
FEATURES             Location/Qualifiers
     source          1..3330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.97 cM"
     gene            1..3330
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /note="cyclin M2"
                     /db_xref="GeneID:94219"
                     /db_xref="MGI:MGI:2151054"
     exon            1..1785
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2792
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /note="isoform a is encoded by transcript variant 1; metal
                     transporter CNNM2; cyclin-like protein 2; mACDP2; ancient
                     conserved domain-containing protein 2; ancient conserved
                     domain protein 2"
                     /codon_start=1
                     /product="metal transporter CNNM2 isoform a"
                     /protein_id="NP_291047.2"
                     /db_xref="CCDS:CCDS50459.1"
                     /db_xref="GeneID:94219"
                     /db_xref="MGI:MGI:2151054"
                     /translation="MIGCGACEPEVKMAGGQAAAALPTWKMAARRSLSARGRGVLQAA
                     AGRLLPLLLLSCCWGAGGCTAAGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVK
                     LRVYGQNINNETWSRIAFTEHERRRHTPSERGLGGPAPPEPDSGPQRCGIRTSDIIIL
                     PHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSASGTVGGKGGA
                     GVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLN
                     LGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILL
                     DDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYP
                     VSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVM
                     TPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDC
                     TPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGI
                     VTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQL
                     LLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPECYLYQRNKP
                     VDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTEVLA
                     AGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLSSSFLQVYIPDYSVRA
                     LSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNE
                     QNCVSHNKANHSLHSEGAI"
     exon            1786..1929
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2067
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2237
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2331
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2397
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2582
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..3330
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /note="hexamer: AATAGA"
     polyA_site      3044
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /note="major polyA site"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /note="hexamer: AAGAAA"
     polyA_site      3330
                     /gene="Cnnm2"
                     /gene_synonym="Acdp2; Clp2"
                     /note="major polyA site"
ORIGIN      
        1 gcccgggggt tcctcagctg gctcagtccg aatcagtgtc attcagagag aaggacagct
       61 aagggctggg cgcgaacgcg cggttgcagt cctgctcggg cgccggtgcc tgcgctcgcg
      121 ccgccgggtg ggaaggatga agcctcagct ggagcagcca ccctatgatt ggctgtggcg
      181 cttgtgaacc cgaagtaaag atggcgggcg ggcaggcagc cgccgcactg cccacttgga
      241 agatggcggc gcgccgcagc ctcagtgccc gcggccgggg ggtcctgcaa gcagctgcgg
      301 gccggctgct gccgctgcta ctgctgagct gctgctgggg agcgggcggc tgcacagcgg
      361 ccggcgagaa cgaggagacc gtgatcatcg ggctgcggct ggaggatacg aacgacgtgt
      421 cgttcatgga agggggtgct ctgcgggtga gcgagcggac ccgggtcaag ctgcgggtgt
      481 acgggcagaa catcaacaac gagacgtggt cccgcatcgc cttcactgag cacgagcggc
      541 gccggcacac acccagcgag cgtgggctgg ggggccccgc gcctccggag ccggacagcg
      601 gcccccagcg ctgcggcatc cgcacctcag acatcatcat cttgccccac atcattctca
      661 atcgccgcac atcgggcatc atcgagatcg agattaaacc gctgcgcaag atggagaaga
      721 gcaagtctta ttacctgtgc acgtctctct ccacgcccgc actaggcgcc ggcggctccg
      781 ggtctgcgag tggcaccgtc gggggcaagg gtggcgcggg ggtggccgga ctcccgcctc
      841 ctccgtgggc cgagaccacc tggatttacc acgacggtga ggacaccaag atgatagtgg
      901 gcgaggagaa gaagttcttg ctgcccttct ggctgcaagt gatcttcatc tcgctgctgc
      961 tgtgcctgtc gggcatgttc agcggcctca acctggggct catggctctg gacccgatgg
     1021 agctgcgcat cgtgcaaaac tgcggcacgg agaaagagaa gaattatgcc aagcgcatcg
     1081 agccggtgcg caggcagggc aactacctgc tgtgctcgct gctgctgggc aacgtactgg
     1141 tcaacaccac gctcaccatc ctgctggacg acattgcggg ctcaggcctt gtggcggtgg
     1201 tggtctccac cattggcatc gtcatcttcg gagaaatcgt gccccaagcc atctgctccc
     1261 gacacggcct ggcggtaggg gccaacacca tcttcctcac caagtttttc atgatgatga
     1321 cattccccgc ttcttatccg gttagcaaac tgctggactg cgtcctgggc caggagatag
     1381 gcacggtcta taaccgggaa aaactgctgg agatgctccg ggttactgac ccctataacg
     1441 acctcgttaa ggaagagctg aacatcatcc aaggggcgct ggagctccgc accaagacgg
     1501 tggaggacgt gatgactccc ctcagggact gcttcatgat aaccggcgag gctatcctgg
     1561 acttcaacac catgtcggag atcatggaga gtggctacac tcgaatcccg gtgttcgagg
     1621 gagaacgttc caacatcgtg gacctgctct ttgtcaaaga cttggccttc gtggatccgg
     1681 atgactgtac tcccttgaaa accatcacca agttttacaa tcaccctttg cacttcgttt
     1741 tcaacgacac caagttggac gctatgctgg aagaatttaa gaaagggaaa tcccacctgg
     1801 ccattgtgca gcgagtgaac aatgagggtg aaggggaccc attttatgaa gttctgggaa
     1861 ttgtcacctt ggaagatgtg attgaagaaa tcatcaaatc tgaaatcttg gatgagacag
     1921 acctgtacac cgataacaga acaaaaaaga aagtggccca ccgtgaaaga aagcaagatt
     1981 tctctgcctt taagcagacg gacagcgaga tgaaggttaa aatatcaccg cagcttctcc
     2041 tggccatgca ccgtttccta gcaacagaag tagaagcgtt tagcccatcc cagatgtcag
     2101 agaagatcct cctaaggctg ctaaagcacc ccaatgtcat ccaggagctg aagtacgacg
     2161 agaagaacaa gaaagcccct gagtgctacc tctaccagcg gaacaagccc gtagactact
     2221 tcgtcctcat tcttcagggg aaggtggagg tggaagctgg gaaagaaggc atgaagtttg
     2281 aagccagcgc tttctcctac tatggtgtga tggccctcac agcctctcca gttcctttgt
     2341 ccctgtctcg cacctttgtt gtcagcagga cagaggtgtt agctgcgggc tctccagggg
     2401 aaaataagtc acctcctcgc ccctgtggcc tgaatcactc agattctctc agtcggagcg
     2461 accggattga cgccatgacg ccaaccttgg ggagcagcaa caaccagctc agctcttcct
     2521 tccttcaagt ctacatccct gactactcag tacgagccct ctctgaccta cagttcgtca
     2581 agatctccag acagcaatac caaaatgcct tgatggcgtc tcggatggac aaaacgcctc
     2641 agtcttcaga cagtgaaaat actaaaattg aattgactct tacggagctg catgacggct
     2701 tgccagatga gacggccaac ttgctcaatg aacagaactg tgtgtcacac aacaaggcca
     2761 accacagcct gcacagtgaa ggcgccatct agggcccctc gggccccctt gtccggccct
     2821 cctggacttg gtctgaccat gacttccgct agttgagctt gtctgccatg ctgcgtccta
     2881 cagccttgag accaaagact ttgccccttt ccctggaagc cgcggaggac ggctggggga
     2941 gggatggaaa ctggacacgt gacatccaca gctggggcat ggctttcaag aattcggaga
     3001 caaacttctt ccacccaaat agaatcatgt ttattttttc agaacctttt atcgtttctt
     3061 tcatccctca atttgcatga aatttaaaaa ttgtttcatt atgttttttt ccaagagatc
     3121 atgtttttgt ttctaagtgt cttttgcaga gtttgaagtt ggtctttcca agctaactct
     3181 gctgtagccc caccgtgtga ccccgacagg atggacttgc ccctttaacg gccttccctg
     3241 gccgtcccca ggagggatac ctttcctctg tgcccggtgg gtgtcgctgt cgaacttgat
     3301 ggatgaatga agaaaaatca tgtcactgca
//
