LOCUS       NM_001373992            5123 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus cyclin M1 (Cnnm1), transcript variant 1, mRNA.
ACCESSION   NM_001373992 XM_006527481
VERSION     NM_001373992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5123)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5123)
  AUTHORS   Chandran,U., Indu,S., Kumar,A.T., Devi,A.N., Khan,I., Srivastava,D.
            and Kumar,P.G.
  TITLE     Expression of Cnnm1 and Its Association with Stemness, Cell Cycle,
            and Differentiation in Spermatogenic Cells in Mouse Testis
  JOURNAL   Biol Reprod 95 (1), 7 (2016)
   PUBMED   27251091
  REMARK    GeneRIF: CNNM1 expression was restricted to c-KIT- and
            OCT3/4-positive cells in the testis, indicating that they are early
            spermatogonial cells. Spermatogonial stem cells in primary culture
            expressed Cnnm1, and their differentiation into embryoid body-like
            clusters in vitro resulted in the loss of Cnnm1 expression.
            Silencing of Cnnm1 in GC1-spg cells reduced number of cells in G1
            phase with increased cells in S and G2/M phases.
REFERENCE   3  (bases 1 to 5123)
  AUTHORS   Alderton,A., Davies,P., Illman,K. and Brown,D.R.
  TITLE     Ancient conserved domain protein-1 binds copper and modifies its
            retention in cells
  JOURNAL   J Neurochem 103 (1), 312-321 (2007)
   PUBMED   17608643
  REMARK    GeneRIF: We determined that ACDP-1 is a high affinity copper
            binding protein able to bind copper at nanomolar concentrations. In
            addition the promoter of ACDP-1 contains metal response elements
            and cellular expression of ACDP-1 alters cellular retention of
            copper.
REFERENCE   4  (bases 1 to 5123)
  AUTHORS   Guo,D., Ling,J., Wang,M.H., She,J.X., Gu,J. and Wang,C.Y.
  TITLE     Physical interaction and functional coupling between ACDP4 and the
            intracellular ion chaperone COX11, an implication of the role of
            ACDP4 in essential metal ion transport and homeostasis
  JOURNAL   Mol Pain 1, 15 (2005)
   PUBMED   15840172
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5123)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140375.2.
            
            On Oct 16, 2019 this sequence version replaced XM_006527481.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF041508.1, SRR7974084.12665.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1605              AC140375.2         131371-132975
            1606-1749           AC140375.2         156079-156222
            1750-1890           AC140375.2         159199-159339
            1891-2060           AC140375.2         160567-160736
            2061-2160           AC140375.2         162807-162906
            2161-2208           AC140375.2         163335-163382
            2209-2271           AC140375.2         167138-167200
            2272-2435           AC140375.2         175803-175966
            2436-2619           AC140375.2         182379-182562
            2620-2769           AC140375.2         182722-182871
            2770-2871           AC140375.2         184668-184769
            2872-5123           AC140375.2         185917-188168
FEATURES             Location/Qualifiers
     source          1..5123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..5123
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /note="cyclin M1"
                     /db_xref="GeneID:83674"
                     /db_xref="MGI:MGI:1891366"
     exon            1..1605
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2951
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ancient conserved domain protein 1; cyclin-like protein 1;
                     metal transporter CNNM1; ancient conserved
                     domain-containing protein 1"
                     /codon_start=1
                     /product="metal transporter CNNM1 isoform 1"
                     /protein_id="NP_001360921.1"
                     /db_xref="CCDS:CCDS89394.1"
                     /db_xref="GeneID:83674"
                     /db_xref="MGI:MGI:1891366"
                     /translation="MAAAAAAAAALGVRLRDCCSRGAVLLLFFSLSPRPPAAAAWLLG
                     LRPEDTAGGRVSLEGGTLRAAEGTSFLLRVYFQPGPPVPAAPVPAPSLAPGENGTGDW
                     APRLVFIEEPPGAGGAAPSAVPTRPPGPQRCREQSDWASDVEVLGPLRPGGVAGSALV
                     QVRVRELRKGEAERGGAGGGGKLFSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDL
                     LPPAWLRALGALLLLALSALFSGLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVR
                     GRGTHLLCTLLLGQAGANAALAGWLYASLPPGVGDPGEDSGEAGVHFPWLPALVCTGA
                     VFLGAEICPYSVCSRHGLAIASHSVCLTRLLMAAAFPVCYPLGRLLDWALRQEISTFY
                     TREKLLETLRAADPYSDLVKEELNIIQGALELRTKVVEEVLTPLGDCFMLRSDAVLDF
                     ATVSEILRSGYTRIPVYEGDQRHNIVDILFVKDLAFVDPDDCTPLLTVTRFYNRPLHC
                     VFNDTRLDTVLEEFKKGKSHLAIVQRVNNEGEGDPFYEVMGIVTLEDIIEEIIKSEIL
                     DETDLYTDNRKKQRVPHRERRRHDFSLFKLSDSEIRVKISPQLLLATHRFMATEVEPF
                     KSLYLSEKILLRLLKHPNVIQELKFDERNKKAPEHYLYQRNRPVDYFVLLLQGKVEVE
                     VGKEGLRFENGAFTYYGVPAIMTSACSDNDVRKVGSLAGSSVFLPVSVSRTFAFSRGD
                     SLAGSPVNRSPSRCSGLNRSESPNRERSDFGGSNTQLYSSSNNLYTPDYSVHILSDVQ
                     FVKITRQQYQNALTACHMDSSPQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPVLTLLS
                     NRTSLPCSRSDGLRSPGEVVYLRMEEMAFPQEEMPNFEEHRSQQVSLSPVAVPTTAAS
                     DPECCNIHLDPEASPCSSDSEENMGKKLLRTLSGRKRKKSADGERASEENSNLTPLIT
                     "
     exon            1606..1749
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1890
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2060
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2160
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2208
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2271
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2435
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2619
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2769
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2871
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..5123
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5053..5058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /note="hexamer: AATAAA"
     polyA_site      5076
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /note="major polyA site"
     regulatory      5102..5107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /note="hexamer: AATAAA"
     polyA_site      5123
                     /gene="Cnnm1"
                     /gene_synonym="Acdp1; CLP-1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtatcac gtgcaaccgc gccgggtgca ggatggcggc ggcggccgcg gcggcagcag
       61 cgctgggtgt caggctccgg gactgctgca gccggggcgc cgtactcctg ctcttcttct
      121 ccctgtcccc tcggcccccg gccgccgctg cctggttact gggtctgcga cccgaagaca
      181 ctgccggagg ccgcgtgtct ctggaggggg gcaccctgcg ggcggccgaa ggcaccagct
      241 tcctcctgcg ggtctacttc cagcctggcc cgccggtccc cgccgcgccc gtgcccgcac
      301 cctccctggc cccgggggaa aacggcacgg gcgattgggc cccgcggctc gtgttcatcg
      361 aggagccccc gggcgcgggc ggcgcggcgc ccagcgcggt ccccacgcgt cccccgggac
      421 ctcagcgctg ccgcgagcag agcgactggg cgtcggacgt ggaggtcctg gggcccctgc
      481 gccccggggg cgtggcgggc tcggccctgg tccaggtgcg ggtgcgggag ctgcggaagg
      541 gcgaggcgga gcgcggcggc gcgggcggcg gcgggaagct cttttcgctg tgcgcctggg
      601 acgggcgcgc ttggcaccac cacggcgccg ccggcggctt cctgctgcgc gtccgcccgc
      661 gcctctacgg cccgggtggg gacctgctgc cgcccgcgtg gctgcgagcg ctcggggcgc
      721 tcctgctgct ggccctgtcc gccctgttca gcggcctgcg cctgagcctg ctctcgctgg
      781 acccggtgga gttacgggtg ctgcggaaca gtggctcggc cgccgagcag gagcaggcgc
      841 gccgcgtgca ggccgtgcgc ggcaggggga cccatctgct ctgcaccctg ctcctgggcc
      901 aagccggcgc caatgccgcg ctggccggct ggctgtacgc ctcgctgccg ccgggcgtcg
      961 gggaccccgg ggaggactcc ggcgaggcgg gggttcactt cccgtggctg ccggcgctgg
     1021 tgtgcaccgg cgccgtgttc ctgggagccg agatctgtcc gtactcggtg tgctcgcgcc
     1081 acgggttggc catcgcctcg cacagtgtgt gcctgacccg gctcctcatg gcggctgcct
     1141 tcccggtgtg ctaccctctg ggccgcctcc tggactgggc tctgcgccag gagatcagca
     1201 ccttctacac gagggaaaag ctgctggaga cgctgcgggc cgccgaccct tacagcgacc
     1261 tggtgaagga agagctcaac atcattcagg gagccctgga gctgcgcacc aaggtggtag
     1321 aggaggtgct gacccctcta ggggactgct tcatgttgcg ctctgacgcc gtgcttgact
     1381 tcgccactgt atccgagatc ctccgtagtg gctacactcg catcccggtg tatgagggcg
     1441 accagaggca caacattgtg gacattctgt tcgtcaaaga cttggccttt gtggacccgg
     1501 acgactgtac cccgctgctc acagtcaccc gcttctacaa caggcccctg cattgtgtct
     1561 tcaatgatac ccggctggac actgtactgg aggagtttaa gaagggaaaa tctcacttgg
     1621 ccattgtcca gagagtgaac aacgagggtg aaggagaccc tttctatgag gtgatgggca
     1681 ttgtgactct ggaggacatc atagaagaga tcatcaagtc ggagatcctc gacgaaactg
     1741 acctctacac tgacaatcgg aaaaagcaga gggtcccaca ccgggagaga aggcggcatg
     1801 atttctctct gttcaagctt tcagactccg agatcagagt caagatctcg ccacagctgc
     1861 tgcttgccac acaccgcttc atggccacag aagtggagcc ctttaagtcc ctgtaccttt
     1921 cggagaagat cctgctccgg cttctgaaac atcccaacgt gatccaggag cttaagtttg
     1981 atgagaggaa caagaaagcc ccagaacact acctctacca gcgcaaccgc ccggtggact
     2041 attttgtgct gctcttacag gggaaagtgg aagtggaggt tggtaaggaa ggccttcgct
     2101 ttgagaacgg agcctttacc tactatggtg ttccagccat catgaccagc gcttgctcag
     2161 ataatgacgt gcggaaggtt ggaagtctgg ctggatcctc tgtcttcctg cccgtctctg
     2221 tgtctcgtac cttcgccttc agcagagggg actctctggc aggctcccca gtaaaccggt
     2281 ccccttctcg ctgcagcggg ttgaatcgct ccgagtctcc aaaccgagag cgcagtgact
     2341 tcggcggaag caacacgcaa ctgtacagca gcagcaacaa cctctacaca cctgactact
     2401 cggtgcacat tctcagtgat gtgcagttcg tgaagatcac acgacaacag taccagaacg
     2461 cactcacggc ctgccacatg gacagctcac cccagtcccc ggatatggaa gccttcactg
     2521 atggggactc caccaaggcc cccaccaccc ggggcacacc ccagactcca aaggacgacc
     2581 cggtcctcac cctcctgagc aacaggacca gcttgccatg cagccgctcg gatggtctga
     2641 gaagcccagg cgaggttgtg tacctgagga tggaggagat ggccttcccc caagaagaga
     2701 tgcccaactt tgaggagcac aggtcacagc aagtctcgct gtcccctgtc gcagttccta
     2761 caacagcagc ttcggatcct gaatgctgta atatccacct ggatccagag gccagcccct
     2821 gcagcagcga ctctgaggaa aacatgggca agaagctgct gagaaccttg agtggccgga
     2881 aaagaaagaa gtccgcagac ggggagcgag cctccgagga aaactccaat ttaacgcccc
     2941 tgatcacatg accaggtctt ccctcattgg ctgagtgtga gactctgagg ctttggggga
     3001 agacccaccc tcccgtcact cgccaccccc aaggcctccc atcagtgaca gaacattcgg
     3061 cccttcaccc ttcacccctc agtcagtctg gcacgtttta tcagttgcct ccagtctgac
     3121 acagaaggag acgcctgtaa tggaagacgc tagaaatggt tttgtctgta gcatagtcta
     3181 agaactggcc agggccgacg caaagctgag aatgccattc tgaggctccc aataataatc
     3241 tttgttcttt ggtgtccctg ggccacagga gacccatgtc ctggaattca ccattctttc
     3301 ttccaggaca aaataatgct ttctaccata gttcatgctt agcattcgct cagacagtga
     3361 tgcgggcaga gaggtgtact ggagtctaga ggagccggtg tgaaaatcag ctccagggat
     3421 ggacagatgg acaaggattg ttccctgtta gtgtgtggat tctccccaca gcctggggaa
     3481 gggcagttcg gctgcagtga agaaagagag aggaagccct gagtccctgt atctcccaga
     3541 gacgtcagtt tgggcttccc gagtctataa gcttgcttca gaagaggagg ttcaggggac
     3601 acagagacca agttgtgagc cagatacaga acttcaggtt ttaagtgaaa ataaaagcag
     3661 gaaaaaaaaa aaaaaacaac ttacatgaaa aattgtaagt tgttaaaatt tgtgtagcca
     3721 tgataaacca aagagtgccc aggtcggcca ggacggatgt gccgtgctgt cacgggactt
     3781 cactgtgctt gacacaggaa tgttgaacgc tcatttttct ttttcacata ccccctcctc
     3841 aggcctcttt actacatccc ttgctggtca gctaagtatt ccaaaaacct accagatcca
     3901 ggggttttag ccctggatgt tggggcagat gcaattctaa tcataaccac aagatggcag
     3961 agtgaccatg catatctact cctacgaatc atgtaggtgt tgggaaacac aaccagccca
     4021 agggaaaatt tcaaagtcaa gtttgagttt ctgattcgtt tcccacccca tccttgcaca
     4081 cctccagtca gtgcccagag atccagtgct gcctgctgaa tctccaacta ttccctagct
     4141 gcctccccca acctccactc ccaccccacc cccattcagt cacggggaaa tacttgccca
     4201 caggaacttt taactcaggg gttgttgacc tggggccatt accccatggg ggtccatagt
     4261 ttgactccag tgggctaaag agcccttaaa attgtcggaa gtgtttttgt gtgtttttca
     4321 gaagcttgaa gctttcttaa tattctcaaa gttcccagat ccaggaaggc tttttaactg
     4381 ttttgaataa tggaactttc agcccgatgt ttctgcaatg cagagtgaat tctgggatgc
     4441 ttgagaagag tgtttgatta taaagtggtg aagcattctt gtcaatgggg gaaggttggg
     4501 acccaccaag acagggtcct tagaaatccc tggcacacca cgcagtaggg tcacaaccta
     4561 catcccatat aacttttgcc cactgtctac caaacccaca gtaggtattg ccaagagggc
     4621 cgtagcccat gggagggaag tttggagcca gagatgcctc ttctgtgtat gtcatggact
     4681 tcacatgccc cttgtttagc ctggctgccc tgaggctcag ccatgcatgt gttctagcta
     4741 agtccacagc cacctctccc aacctgctcc tgcctgctca gaatacagtg ccagccctta
     4801 gtgctggtgt cgcagaccta ggccagtaag tgatgatgag tttggaacaa gatctcacaa
     4861 gggagccctg ctaggtaaag ttccctctca ttagtccttt ggccaccagg ctcaggccac
     4921 tactgttgta ttaactccac cctctgcaga ccctctaagg gacctgtcac cattcctttc
     4981 cctagctccc aagccccacc ccccccctcc gattttcttc aggttaaaat acattttaaa
     5041 aaaagatttt aaaataaagt atttatgaaa actcaataaa ttgtaaataa tttttaaata
     5101 aaataaaaat gtgttttcct gga
//
