LOCUS       NM_028044               2003 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus calponin 3, acidic (Cnn3), mRNA.
ACCESSION   NM_028044 XM_978997 XM_988702
VERSION     NM_028044.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Maddala,R., Mongan,M., Xia,Y. and Rao,P.V.
  TITLE     Calponin-3 deficiency augments contractile activity, plasticity,
            fibrogenic response and Yap/Taz transcriptional activation in lens
            epithelial cells and explants
  JOURNAL   Sci Rep 10 (1), 1295 (2020)
   PUBMED   31992794
  REMARK    GeneRIF: These results reveal that CNN3 plays a crucial role in
            regulating lens epithelial contractile activity and provide
            supporting evidence that CNN-3 deficiency is associated with the
            induction of epithelial plasticity, fibrogenic activity and
            mechanosensitive Yap/Taz (Wwtr1) transcriptional activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Junghans,D. and Herzog,S.
  TITLE     Cnn3 regulates neural tube morphogenesis and neuronal stem cell
            properties
  JOURNAL   FEBS J 285 (2), 325-338 (2018)
   PUBMED   29151265
  REMARK    GeneRIF: provides evidence for an important role of Cnn3 during
            development of the embryonic brain and in regulating NSC function
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   Flemming,A., Huang,Q.Q., Jin,J.P., Jumaa,H. and Herzog,S.
  TITLE     A Conditional Knockout Mouse Model Reveals That Calponin-3 Is
            Dispensable for Early B Cell Development
  JOURNAL   PLoS One 10 (6), e0128385 (2015)
   PUBMED   26046660
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 2003)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 2003)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2003)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 2003)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK005460.1.
            
            On Apr 5, 2007 this sequence version replaced NM_028044.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005460.1, AK167613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2003              AK005460.1         3-2005
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 52.94 cM"
     gene            1..2003
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /note="calponin 3, acidic"
                     /db_xref="GeneID:71994"
                     /db_xref="MGI:MGI:1919244"
     exon            1..288
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1224
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /codon_start=1
                     /product="calponin-3"
                     /protein_id="NP_082320.1"
                     /db_xref="CCDS:CCDS17802.1"
                     /db_xref="GeneID:71994"
                     /db_xref="MGI:MGI:1919244"
                     /translation="MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGLGI
                     GTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHD
                     IFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAG
                     QSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAG
                     MLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAP
                     TEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDDYPREYQYGDDQGIDY"
     exon            289..410
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..477
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..615
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..732
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            733..879
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..2003
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /note="hexamer: AATAAA"
     polyA_site      1748
                     /gene="Cnn3"
                     /gene_synonym="1600014M03Rik; Calpo3"
                     /note="major polyA site"
ORIGIN      
        1 gggcagcgag cagggcagcc ggtcccagtc cagagcgacc cggagcctcc gcgggactcg
       61 agtcctagcg aacctcgaag catcatccgc gtccgtctgc ggcgttcggg cttctccggc
      121 gccgcgcagg ggagcgagct cgtgcatcac ccgcgcggcc gccgctgggg ctaagagcag
      181 ggacaccgag ggtgactgac cgctagaact cttccagtcg tccaaacagc catgacccac
      241 ttcaacaagg gcccttccta cgggctctcc gccgaagtta agaacaagat tgcatccaag
      301 tatgaccagc aggccgagga agatctgcgc aactggatag aagaggtgac aggcctaggc
      361 attggcacca acttccagct ggggctgaag gacggcatca tattgtgcga actcataaac
      421 aagctacagc caggctctgt gaagaaagtc aacgaatcct cactaaattg gccccagttg
      481 gagaatatcg gcaacttcat taaagctatc caggcttacg gtatgaagcc ccatgatata
      541 tttgaagcaa acgacctctt tgagaatggc aacatgaccc aggttcagac gacgctggtg
      601 gctctagcag gtctggcgaa aacaaaagga ttccatacaa ccattgacat tggcgttaag
      661 tatgcagaaa aacaaacaag acgttttgat gaaggcaaat taaaggctgg ccagagtgta
      721 attggtttac agatgggtac caacaaatgt gccagccagg cgggcatgac agcctatggg
      781 actcggaggc atctttatga tcccaagatg cagacggaca aaccctttga ccagaccacg
      841 attagcctgc agatgggcac caacaaaggg gccagccagg ctgggatgtt agcaccgggc
      901 accagaagag acatctatga ccagaagctg acattacagc cagtggacaa ctcgaccatt
      961 tctctacaga tgggcaccaa caaagttgct tcccagaaag gaatgagcgt gtatgggctt
     1021 gggcggcaag tatatgaccc caagtactgt gccgcaccca cagaacctgt cattcacaac
     1081 ggaagccagg gcacgggcac caatgggtcg gaaatcagtg atagcgatta tcaggcagaa
     1141 taccccgatg aatatcatgg cgagtaccca gacgactacc ctcgggagta ccagtatggc
     1201 gacgaccagg gcattgatta ttagagtcac acacaggagc gcagtattta gtccattgtt
     1261 ttatccagtg agacccaagc tagccttgaa taattcttct ctcgtcttcc tgaaacacta
     1321 ttatgcttgt tgtaccttta aagtatgcct tatgtacatt cctttctcct tttcctgcct
     1381 cctccctaaa tagctgcctt ctagtgctgt agcaagggag ccctactgca tagccagtaa
     1441 ctcgcgtctg taccatggaa agggcggaac gattctccag gacagccagc tctttcgttg
     1501 aagatctatc tatgcatttt tttacactta cacataaact ggtattttcg aacaatagga
     1561 aactattttt tctccttttt ttacagtttt agtacgtatc tggcttgtat gtggaagact
     1621 aaaaagttga tttgctaaat gtggtctttg ccaactaaaa tctgagatgc agctttagac
     1681 cctgacacgt ggatgttctt ctgcagtctt gtctgctaag ttttaaataa agtcatgatc
     1741 agtgtgcatt tgtgattaca tgtgtactca ttcttttccc aagctgacga ggtctctccc
     1801 gagtggcgct tcgaaaggcg tgcatgcaga aatggccgag gacatgcagg tttgggtggt
     1861 gtgcctgcag acttcatttg tgccaatgta ttactgtaga gtcgctctgt ttccttcaac
     1921 tgtatttatt gctgcgtttc tcagcataaa cttatcccat tgtatttttt ataaataaat
     1981 attttttttt gaacattcat atg
//
