LOCUS       NM_007725               1800 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calponin 2 (Cnn2), mRNA.
ACCESSION   NM_007725
VERSION     NM_007725.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Hsieh,T.B. and Jin,J.P.
  TITLE     Loss of Calponin 2 causes premature ovarian insufficiency in mice
  JOURNAL   J Ovarian Res 17 (1), 37 (2024)
   PUBMED   38336796
  REMARK    GeneRIF: Loss of Calponin 2 causes premature ovarian insufficiency
            in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Gui,Y., Palanza,Z., Gupta,P., Li,H., Pan,Y., Wang,Y., Hargis,G.,
            Kreutzer,D.L., Wang,Y., Bastacky,S.I., Liu,Y., Liu,S. and Zhou,D.
  TITLE     Calponin 2 regulates ketogenesis to mitigate acute kidney injury
  JOURNAL   JCI Insight 8 (21), e170521 (2023)
   PUBMED   37751293
  REMARK    GeneRIF: Calponin 2 regulates ketogenesis to mitigate acute kidney
            injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Gui,Y., Wang,Y., Palanza,Z., Wang,J.L., Gupta,P., Tao,J., Qiao,Y.,
            Hargis,G., Kreutzer,D.L., Bastacky,S.I., Yu,Y., Wang,Y., Liu,S.,
            Fu,H. and Zhou,D.
  TITLE     Calponin 2 harnesses metabolic reprogramming to determine kidney
            fibrosis
  JOURNAL   Mol Metab 71, 101712 (2023)
   PUBMED   36963615
  REMARK    GeneRIF: Calponin 2 harnesses metabolic reprogramming to determine
            kidney fibrosis.
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Hsieh,T.B. and Jin,J.P.
  TITLE     Loss of Calponin 2 causes age-progressive proteinuria in mice
  JOURNAL   Physiol Rep 10 (18), e15370 (2022)
   PUBMED   36117313
  REMARK    GeneRIF: Loss of Calponin 2 causes age-progressive proteinuria in
            mice.
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1800)
  AUTHORS   Hossain,M.M., Crish,J.F., Eckert,R.L., Lin,J.J. and Jin,J.P.
  TITLE     h2-Calponin is regulated by mechanical tension and modifies the
            function of actin cytoskeleton
  JOURNAL   J Biol Chem 280 (51), 42442-42453 (2005)
   PUBMED   16236705
REFERENCE   7  (bases 1 to 1800)
  AUTHORS   Hossain,M.M., Hwang,D.Y., Huang,Q.Q., Sasaki,Y. and Jin,J.P.
  TITLE     Developmentally regulated expression of calponin isoforms and the
            effect of h2-calponin on cell proliferation
  JOURNAL   Am J Physiol Cell Physiol 284 (1), C156-C167 (2003)
   PUBMED   12388067
  REMARK    GeneRIF: Expressed h2-calponin is associated with actin-tropomyosin
            microfilaments and may regulate cytokinesis by inhibiting the
            activity of the actin cytoskeleton.
REFERENCE   8  (bases 1 to 1800)
  AUTHORS   Tollet,J., Everett,A.W. and Sparrow,M.P.
  TITLE     Spatial and temporal distribution of nerves, ganglia, and smooth
            muscle during the early pseudoglandular stage of fetal mouse lung
            development
  JOURNAL   Dev Dyn 221 (1), 48-60 (2001)
   PUBMED   11357193
REFERENCE   9  (bases 1 to 1800)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   10 (bases 1 to 1800)
  AUTHORS   Strasser,P., Gimona,M., Moessler,H., Herzog,M. and Small,J.V.
  TITLE     Mammalian calponin. Identification and expression of genetic
            variants
  JOURNAL   FEBS Lett 330 (1), 13-18 (1993)
   PUBMED   8370452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051845.1, BE656517.1 and CB590846.1.
            
            On Oct 19, 2006 this sequence version replaced NM_007725.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009144.1, AK051845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1002              AK051845.1         2-1003
            1003-1003           BE656517.1         120-120
            1004-1706           AK051845.1         1005-1707
            1707-1800           CB590846.1         590-683
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1800
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /note="calponin 2"
                     /db_xref="GeneID:12798"
                     /db_xref="MGI:MGI:105093"
     exon            1..141
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..996
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /note="neutral calponin; calponin H2, smooth muscle;
                     h2-calponin"
                     /codon_start=1
                     /product="calponin-2"
                     /protein_id="NP_031751.1"
                     /db_xref="CCDS:CCDS24003.1"
                     /db_xref="GeneID:12798"
                     /db_xref="MGI:MGI:105093"
                     /translation="MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRSWIEGLTGL
                     SIGPDFQKGLKDGVILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNP
                     VDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMK
                     AGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHCTISLQMGTNKCASQ
                     VGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQ
                     GSAADGAPAGDGQGEAPEYLAYCQEEAGY"
     exon            142..263
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            264..330
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..468
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..585
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..732
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1782
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1750..1755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /note="hexamer: AATAAA"
     polyA_site      1772
                     /gene="Cnn2"
                     /gene_synonym="Calpo2"
                     /note="major polyA site"
ORIGIN      
        1 cgtcccgggc cgtccgcccg cagcccgacc ctctgccggt cccgctggtc ctcctgtccc
       61 gctccggggt cccgcgccat gagctccacg cagttcaaca agggcccgtc ctacgggctc
      121 tcggccgagg tcaagaaccg gctcctgtcc aaatatgacc cccaaaagga agcagaactc
      181 cgaagctgga tagagggact cacgggcctc tccattggcc ctgacttcca gaagggtctg
      241 aaagatgggg ttatcctatg cacactcatg aacaagctgc agccaggctc cgtccctaaa
      301 atcaaccgct ctatgcagaa ctggcaccag ctagaaaatc tctccaactt catcaaggcc
      361 atggtcagct acggcatgaa ccctgtggac ctgtttgagg ccaatgacct gttcgagagc
      421 gggaacatga cacaggtgca agtgtctctg cttgcactgg ctggaaaggc caagaccaag
      481 gggctgcaga gtggtgtgga cattggagtt aagtattcgg agaaacagga gaggaacttt
      541 gacgacgcca ccatgaaggc cggccagtgc gtcatcgggc tgcagatggg caccaacaag
      601 tgtgccagcc agtctggcat gacagcctat ggtaccagga gacatctcta tgaccccaag
      661 aaccatatcc tgcctcccat ggaccactgc accatcagcc tccagatggg caccaacaag
      721 tgtgccagcc aggtgggcat gacagctcca gggacccgga ggcacatcta tgacaccaag
      781 ctgggcaccg acaagtgcga caactcttcc atgtccctgc agatgggcta cacgcagggc
      841 gccaaccaga gcggtcaggt cttcggactg gggcggcaga tctacgatcc caagtattgc
      901 ccacagggct ctgcagctga cggggctcct gcgggtgacg gccaaggcga ggccccagag
      961 tacctggcct actgccagga ggaagctggc tactgagcac ccagcatgcc agctccccca
     1021 ctgcatcagc agccctgtgt gggctttggg gttttcattg tgttttgtgt ttggaaactg
     1081 gtcatctctt tgtatctctc tctggcctgg aactcactgc aatcctcctg cctcagcttc
     1141 ctaagggctg ggatgacaga tctgtgctat ctatgctcct tcctcaccca ccatgcctcg
     1201 cttccttccc aggattgacc caccagacag gggacatggg tgtccttggt gggacagtga
     1261 ggctgtgcgt ttcccagtgg gctgtgggag aggctggccc caatgggctt cctgtttctt
     1321 catctctttc acatcagttt gtggtttgtg aacccgggga aattacaggc agtttcaatg
     1381 aaagaaaaca aggggttttg tgggggtttt gcctcaaaag tattggagta cactaggctt
     1441 taaaatactg caggcattct gagggactaa gtttgctttc ccacgactct cagacttcac
     1501 cctcctgtgc cccgtgggga aactgaggca agccagatgt gaccccaacg cctgcagccc
     1561 tccctcactc ctctggtgtt tgaaggcttc cctgcccctg tgcaggccct gattaggtgt
     1621 gctagagtct gggcctcgga aggggccaca catgacccac acgggcccct gcactgccag
     1681 aaaatgtgaa attccctgtg tggaccaaaa aaacaaaaaa aaaaacaaaa acaaaacaaa
     1741 aacaaaaaca ataaaaacct ctgtttctaa gagtaaagta caaaaaaaaa aaaaaaaaaa
//
