LOCUS       NM_009922               1987 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus calponin 1 (Cnn1), mRNA.
ACCESSION   NM_009922
VERSION     NM_009922.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Wang,L., He,X., Hu,G., Liu,J., Kang,X., Yu,L., Dong,K., Zhao,J.,
            Zhang,A., Zhang,W., Brands,M.W., Su,H., Zheng,Z. and Zhou,J.
  TITLE     A novel mouse model carrying a gene trap insertion into the Hmgxb4
            gene locus to examine Hmgxb4 expression in vivo
  JOURNAL   Physiol Rep 12 (8), e16014 (2024)
   PUBMED   38644513
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Li,C., Qin,T., Zhao,J., Jin,Y., Qin,Y., He,R., Wu,T., Duan,C.,
            Jiang,L., Yuan,F., Lu,H., Cao,Y. and Hu,J.
  TITLE     Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced
            spinal cord microvascular endothelial cell senescence to balance
            neuroinflammation for improved neurological repair
  JOURNAL   Bone Res 12 (1), 19 (2024)
   PUBMED   38528029
  REMARK    GeneRIF: Kdm6a-CNN1 axis orchestrates epigenetic control of
            trauma-induced spinal cord microvascular endothelial cell
            senescence to balance neuroinflammation for improved neurological
            repair.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1987)
  AUTHORS   Kajuluri,L.P., Lyu,Q.R., Doja,J., Kumar,A., Wilson,M.P.,
            Sgrizzi,S.R., Rezaeimanesh,E., Miano,J.M. and Morgan,K.G.
  TITLE     Calponin 1 inhibits agonist-induced ERK activation and decreases
            calcium sensitization in vascular smooth muscle
  JOURNAL   J Cell Mol Med 28 (1), e18025 (2024)
   PUBMED   38147352
REFERENCE   5  (bases 1 to 1987)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1987)
  AUTHORS   Shah,N.M., Groves,A.K. and Anderson,D.J.
  TITLE     Alternative neural crest cell fates are instructively promoted by
            TGFbeta superfamily members
  JOURNAL   Cell 85 (3), 331-343 (1996)
   PUBMED   8616889
REFERENCE   7  (bases 1 to 1987)
  AUTHORS   el-Mezgueldi,M., Strasser,P., Fattoum,A. and Gimona,M.
  TITLE     Expressing functional domains of mouse calponin: involvement of the
            region around alanine 145 in the actomyosin ATPase inhibitory
            activity of calponin
  JOURNAL   Biochemistry 35 (12), 3654-3661 (1996)
   PUBMED   8619984
REFERENCE   8  (bases 1 to 1987)
  AUTHORS   Gao,J., Hwang,J.M. and Jin,J.P.
  TITLE     Complete nucleotide sequence, structural organization, and an
            alternatively spliced exon of mouse h1-calponin gene
  JOURNAL   Biochem Biophys Res Commun 218 (1), 292-297 (1996)
   PUBMED   8573148
REFERENCE   9  (bases 1 to 1987)
  AUTHORS   Samaha,F.F., Ip,H.S., Morrisey,E.E., Seltzer,J., Tang,Z., Solway,J.
            and Parmacek,M.S.
  TITLE     Developmental pattern of expression and genomic organization of the
            calponin-h1 gene. A contractile smooth muscle cell marker
  JOURNAL   J Biol Chem 271 (1), 395-403 (1996)
   PUBMED   8550594
REFERENCE   10 (bases 1 to 1987)
  AUTHORS   Strasser,P., Gimona,M., Moessler,H., Herzog,M. and Small,J.V.
  TITLE     Mammalian calponin. Identification and expression of genetic
            variants
  JOURNAL   FEBS Lett 330 (1), 13-18 (1993)
   PUBMED   8370452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY326336.1 and AK035548.1.
            
            On Apr 7, 2009 this sequence version replaced NM_009922.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035548.1, Z19542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               BY326336.1         39-295
            258-1987            AK035548.1         231-1960
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 8.3 cM"
     gene            1..1987
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /note="calponin 1"
                     /db_xref="GeneID:12797"
                     /db_xref="MGI:MGI:104979"
     exon            1..166
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..997
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /note="basic calponin; calponin H1, smooth muscle"
                     /codon_start=1
                     /product="calponin-1"
                     /protein_id="NP_034052.3"
                     /db_xref="CCDS:CCDS22921.1"
                     /db_xref="GeneID:12797"
                     /db_xref="MGI:MGI:104979"
                     /translation="MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGR
                     RIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKP
                     HDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREG
                     RNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAG
                     MTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLNP
                     EYPELSEPTHNHHPHNYYNSA"
     exon            167..288
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     exon            289..355
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     exon            356..493
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     exon            494..604
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     exon            605..751
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1987
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /note="hexamer: AATAAA"
     polyA_site      1493
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /note="major polyA site"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="Cnn1"
                     /gene_synonym="CN; CnnI"
ORIGIN      
        1 aaaaacgtgt gaggagggaa gagggtgcag acggaggctc ggctgcctgt tgcgcttgtc
       61 tgtgtcatct gcacctctgc tttgccagag ccccctggcc agcatgtctt ctgcacattt
      121 taaccgaggt cctgcctacg gcttgtctgc tgaagtaaag aacaagctgg cccagaaata
      181 cgaccatcag cgggagcagg agctgagaga gtggattgag ggggtgacag gccggcgcat
      241 cgggaacaac ttcatggatg gcctcaaaga cgggatcatt ctttgcgaat ttatcaacaa
      301 gctgcagccg ggttctgtga agaaggtcaa tgagtcaact cagaactggc accagctgga
      361 gaacataggt aatttcatca aagccattac caagtatggg gtgaaacccc acgacatctt
      421 tgaggccaac gacctgtttg aaaacaccaa ccatacacaa gttcagtcca ctctcctggc
      481 tctggccagc atggccaaga caaaaggaaa caaagtcaat gtgggagtca agtatgcaga
      541 gaaacaagag cggagatttg agccggagaa gttgagagaa ggcaggaaca tcattggact
      601 gcagatgggc accaacaagt ttgccagtca gcagggcatg acggcctacg gtacacggcg
      661 tcacctctat gatcccaaac tgggtacaga tcagcctctg gaccaggcga ccatcagcct
      721 gcagatgggc accaacaagg gtgccagcca ggctggcatg actgcaccag gcaccaagcg
      781 gcagatcttt gagccaggtc tgggcatgga acactgcgac acactcaacg tcagcttgca
      841 gatgggcagc aacaaggggg cctcccagag gggcatgaca gtgtatgggc ttcctcgcca
      901 ggtgtacgat cccaagtact gcctgaaccc ggagtaccca gagctgagtg agcccaccca
      961 caatcaccac ccgcacaact actacaactc tgcctagggg cccccaaggg gctggctgct
     1021 gctcttggct ggacccagct ggcccagcca accccatctc ctgcatggcg tcctcccagc
     1081 cccctggcac ctgcctatag ggttacggtt tggggagatg aggccgaggg gggcaatggg
     1141 aagaaggggg cccctcatcc ctggagcttt cgcagggccc aacatagaac tgggtgtccc
     1201 caacagtgcc cgaaggaagc actgagttga gctgtttcag ctgcccccct ttattccctc
     1261 acaagtaagt acctcccaga accagaaacc cttccagcga agcccccaga acccaggctt
     1321 ggcctgaccc ctgccccatt cctgcgacgg gagcagatgc atgcctggaa acgcagtgga
     1381 cacacgcatt ttggttttgc agtgactggt gtttgtggat gtgacagcag cgtttgtaac
     1441 tcgaacacat tcttttctat ttcactggag cacaataaat ggctgtgaca tcattggagt
     1501 cttggggcca gttgtttagg agcatggctt agataatctc catcctccca tatatgtagg
     1561 aggtatacat accctcctat acacactagg atcagtgaga tggctcagag ctagtaaatg
     1621 cacttgacac caatcaagtg cctttactta tgacttgagt tcaatccttg agacccacat
     1681 ggccagaaag aataggtttc tgcagtaccc actgacctcc acacacaggc catgtgatac
     1741 atacccttcc ttaaatatgt atttaaaaaa attaaataaa cctagacctt acaccactac
     1801 acaaggtgag cacatagcaa atgccacata tattttaaca aaatgatcag gagtgtcttg
     1861 gggtgggagg ggaggggcgg catcccagat tgtgtgcatg cggtgtgcac tggttctact
     1921 gggccaggta atgtacctaa tattggcaga gcagttgagt agctaacttt gggacatggc
     1981 tttctct
//
