LOCUS       NM_001310655            1474 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus chondromodulin (Cnmd), transcript variant 1, mRNA.
ACCESSION   NM_001310655 XM_006518662
VERSION     NM_001310655.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Yukata K, Shukunami C, Matsui Y, Takimoto A, Goto T, Takahashi M,
            Mihara A, Seto T, Sakai T, Hiraki Y and Yasui N.
  TITLE     Chondromodulin is necessary for cartilage callus distraction in
            mice
  JOURNAL   PLoS One 18 (2), e0280634 (2023)
   PUBMED   36795722
  REMARK    GeneRIF: Chondromodulin is necessary for cartilage callus
            distraction in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Szeto IYY, Chu DKH, Chen P, Chu KC, Au TYK, Leung KKH, Huang YH,
            Wynn SL, Mak ACY, Chan YS, Chan WY, Jauch R, Fritzsch B, Sham MH,
            Lovell-Badge R and Cheah KSE.
  TITLE     SOX9 and SOX10 control fluid homeostasis in the inner ear for
            hearing through independent and cooperative mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2122121119 (2022)
   PUBMED   36343245
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H,
            Yang X, Su P and Xu C.
  TITLE     Hnrnpk maintains chondrocytes survival and function during growth
            plate development via regulating Hif1alpha-glycolysis axis
  JOURNAL   Cell Death Dis 13 (9), 803 (2022)
   PUBMED   36127325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Lin D, Alberton P, Delgado Caceres M, Prein C, Clausen-Schaumann H,
            Dong J, Aszodi A, Shukunami C, Iatridis JC and Docheva D.
  TITLE     Loss of tenomodulin expression is a risk factor for age-related
            intervertebral disc degeneration
  JOURNAL   Aging Cell 19 (3), e13091 (2020)
   PUBMED   32083813
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Yan J, Li J, Hu J, Zhang L, Wei C, Sultana N, Cai X, Zhang W and
            Cai CL.
  TITLE     Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2
            transcription factor in mouse skeletal development
  JOURNAL   J Biol Chem 293 (24), 9162-9175 (2018)
   PUBMED   29735531
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Takeda S, Bonnamy JP, Owen MJ, Ducy P and Karsenty G.
  TITLE     Continuous expression of Cbfa1 in nonhypertrophic chondrocytes
            uncovers its ability to induce hypertrophic chondrocyte
            differentiation and partially rescues Cbfa1-deficient mice
  JOURNAL   Genes Dev 15 (4), 467-481 (2001)
   PUBMED   11230154
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M,
            Yamagiwa H, Kimura T, Yasui N, Ochi T, Endo N, Kitamura Y,
            Kishimoto T and Komori T.
  TITLE     Maturational disturbance of chondrocytes in Cbfa1-deficient mice
  JOURNAL   Dev Dyn 214 (4), 279-290 (1999)
   PUBMED   10213384
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Shukunami C, Iyama K, Inoue H and Hiraki Y.
  TITLE     Spatiotemporal pattern of the mouse chondromodulin-I gene
            expression and its regulatory role in vascular invasion into
            cartilage during endochondral bone formation
  JOURNAL   Int J Dev Biol 43 (1), 39-49 (1999)
   PUBMED   10213081
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Spencer JA and Misra RP.
  TITLE     Expression of the serum response factor gene is regulated by serum
            response factor binding sites
  JOURNAL   J Biol Chem 271 (28), 16535-16543 (1996)
   PUBMED   8663310
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Hiraki Y, Tanaka H, Inoue H, Kondo J, Kamizono A and Suzuki F.
  TITLE     Molecular cloning of a new class of cartilage-specific matrix,
            chondromodulin-I, which stimulates growth of cultured chondrocytes
  JOURNAL   Biochem Biophys Res Commun 175 (3), 971-977 (1991)
   PUBMED   1709014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB849846.1, BY776014.1, BY785008.1, AK013975.1, BB849764.1 and
            BU705377.1.
            
            [WARNING] On Sep 26, 2023 this sequence was replaced by
            NM_001310655.2.
            
            On Jul 17, 2015 this sequence version replaced XM_006518662.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013975.1, SRR7345562.1696791.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BB849846.1         1-39
            40-93               BY776014.1         15-68
            94-401              BY785008.1         40-347
            402-493             AK013975.1         303-394
            494-495             BB849764.1         410-411
            496-1457            AK013975.1         397-1358
            1458-1474           BU705377.1         377-393
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.74 cM"
     gene            1..1474
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /note="chondromodulin"
                     /db_xref="GeneID:16840"
                     /db_xref="MGI:MGI:1341171"
     exon            1..244
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1189
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chondromodulin-1; chondromodulin-I; Chondromodulin 1;
                     leukocyte cell derived chemotaxin 1"
                     /codon_start=1
                     /product="leukocyte cell-derived chemotaxin 1 isoform 1"
                     /protein_id="NP_001297584.1"
                     /db_xref="CCDS:CCDS79348.1"
                     /db_xref="GeneID:16840"
                     /db_xref="MGI:MGI:1341171"
                     /translation="MTENSDKVPITMVGPEDVEFCSPPAYTTVTVKPSGSPTRLLKVG
                     AVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYSMSINGKLQDGSMEIDAVNNLETF
                     KMGSGAEEAIEVNDFKNGITGIRFAGGEKCYIKAQVKARIPEVGTVTKQSISELEGKI
                     MPANYEENSLIWVAVDQPVKDSSFLSSKILELCGDLPIFWLKPMYPKANFAEIQRERR
                     EVVRNSAPSTTRRPHSEPRGNAGPGRLSNGTRPNVQDDAEPFNPDNPYHQQEGESMTF
                     DPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARI
                     LGMV"
     exon            245..388
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..529
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..640
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..794
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..973
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1458
                     /gene="Cnmd"
                     /gene_synonym="Bricd3; ChM-I; Chmd; Lect1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggggtgg ggacagaagg gctggccaga gcaggacgct gctgttgctg ctgctgctgc
       61 tcctgctgct gctgttgtac agggggcatt cgttgtaggg acaagaggac agttggaaca
      121 gttaggacag tgggataggg tcttcgcgta tcttacttct ccatcttcag ccatgacaga
      181 gaactcagac aaagttccta tcaccatggt agggcctgag gacgttgagt tttgcagtcc
      241 cccggcgtac accaccgtca ccgtgaagcc ctccgggagc ccaacacggc tgctcaaggt
      301 aggagctgtg gtcctcattt ctggcgcggt actgctgctc ttcggggcca tcggggcctt
      361 ctacttctgg aaggggaatg acaatcacat ttacaatgtt cattacagta tgagtatcaa
      421 tgggaaacta caagatgggt caatggaaat agatgctgtg aacaacttgg agacctttaa
      481 aatgggaagc ggagcggaag aagcaattga agtcaacgat tttaaaaatg gcatcactgg
      541 gatccgtttt gctggaggag agaagtgcta catcaaagca caggtgaagg ctcgcatccc
      601 tgaggtgggc acagtgacca agcagagcat ctctgaactg gaaggcaaga tcatgccagc
      661 taactacgaa gagaactcgc tgatttgggt ggccgtggac cagcctgtga aggacagcag
      721 cttcttgagc tctaaaatcc ttgaactctg tggcgacctg ccgattttct ggcttaagcc
      781 catgtatcca aaagcaaatt tcgcagaaat ccagagagag agaagagaag tcgtgagaaa
      841 cagtgctccc tctaccacaa gaagaccaca cagcgaacct cgaggtaacg caggccctgg
      901 aagactgagt aacggaacca gacccaatgt tcaggacgac gcagaacctt tcaaccctga
      961 caatccttac caccagcagg aaggagaaag catgacattt gaccctagac tggaccatga
     1021 agggatctgc tgtatagaat gcaggcggag ctacacccac tgccagaaga tctgtgaacc
     1081 actgggaggc tactatccat ggccttacaa ttaccaagga tgccgctcgg cctgcagagt
     1141 cgtcatgcca tgcagctggt gggtggcccg catcttgggc atggtgtaaa tccagttcat
     1201 ctatcaggac tgccaagcaa gaatcgatat gagagttgag aaccaaagaa gcatagagca
     1261 tgtccatgcc aagagaccac aaagtatttt atattcaacc tgaataatgt tatcctaaac
     1321 gctgttgtgc accactgtgt gcaaatgtgc tgaaagggta gtttaactct acaattatta
     1381 tcattttacg acttgcttta ccaataaagc ctactgcaag tctttaaaag ctacttttga
     1441 aataaatatg aaaacttaaa aaaaaaaaaa aaaa
//
