LOCUS       NM_172546               3448 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Cnksr family member 3 (Cnksr3), mRNA.
ACCESSION   NM_172546
VERSION     NM_172546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Soundararajan,R., Ziera,T., Koo,E., Ling,K., Wang,J., Borden,S.A.
            and Pearce,D.
  TITLE     Scaffold protein connector enhancer of kinase suppressor of Ras
            isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial
            sodium channel (ENaC)-regulatory complex
  JOURNAL   J Biol Chem 287 (39), 33014-33025 (2012)
   PUBMED   22851176
  REMARK    GeneRIF: CNK3 is a molecular scaffold, which coordinates the
            assembly of a multiprotein ENaC-regulatory complex and hence plays
            a central role in Na(+) homeostasis.
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Ziera,T., Irlbacher,H., Fromm,A., Latouche,C., Krug,S.M., Fromm,M.,
            Jaisser,F. and Borden,S.A.
  TITLE     Cnksr3 is a direct mineralocorticoid receptor target gene and plays
            a key role in the regulation of the epithelial sodium channel
  JOURNAL   FASEB J 23 (11), 3936-3946 (2009)
   PUBMED   19567370
  REMARK    GeneRIF: CNKSR3, a homologue of scaffold proteins involved in MAPK
            pathway regulation, is a direct target of MR and is required for
            the maintenance of transepithelial sodium transport in the kidney.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK033015.1.
            
            On Apr 5, 2007 this sequence version replaced NM_172546.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033015.1, AY151137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3448              AK033015.1         2-3449
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 1.85 cM"
     gene            1..3448
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /note="Cnksr family member 3"
                     /db_xref="GeneID:215748"
                     /db_xref="MGI:MGI:2674130"
     exon            1..606
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             555..2222
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /note="membrane associated guanylate kinase interacting
                     protein-like 1; maguin-like protein; CNK3; CNK homolog
                     protein 3; connector enhancer of KSR 3"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras
                     3"
                     /protein_id="NP_766134.1"
                     /db_xref="CCDS:CCDS56690.1"
                     /db_xref="GeneID:215748"
                     /db_xref="MGI:MGI:2674130"
                     /translation="MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKIS
                     HQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDTMKNLVLKLRASSHNLQNYISSR
                     RKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLC
                     LDLTTAVQKDCLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLPNVR
                     PGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVR
                     KLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASL
                     KKEKPAILDLYIPPPPAVPYSPRDENVSFGYRGHSKSKQPLPVRKGSESPNSFLDQES
                     QRRRFTIADSDQLPGYSVETNVLPTKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKP
                     RGNGRKGEDALCRYFSNERITPITEESASPMYRFSRPLTERHLVRGADYIRGSRCYIN
                     SDLHSSATIPFQEEGSKKKSASSSAKASSGEPSLLVSWLTRLKLLTH"
     exon            607..770
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..973
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1061
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1103
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1223
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1283
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1352
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1499
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1624
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1833
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1923
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..3448
                     /gene="Cnksr3"
                     /gene_synonym="6820402C05; Magi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattccggca gcgccgagcg gagcagaaac tttgcaaccc gagcgcgcac gctccgcttt
       61 tttcctccgc ccgggcggcc cgcgacggtg gcgcaggagg tgggacccac tggcgggaag
      121 gctcgaggcg ggggcgcacg cggagtgggg acctcgggga cggacaccgc tcgcaggagc
      181 cgcggagggc cagccgacct agaagttccc ggccagaaga gtcccacgcc agggcagccc
      241 cggcctgggg tttgaggttg caacctgctc ccgctgctgc ggtggttgcg gagaagcagc
      301 tgtagcagag agcggcgtcg ggggaactgc atctggacag cggtagctgc ggggagcagc
      361 cgtacgggac atagctgtcc cgtgcgcaga gacccagggc cgcgcttccc tcgcagaaac
      421 cgcagcgcga tggcccgctg actgcggcca tgcaggcttg agcggactcc cggcacacgc
      481 aggggacaac cacgggcgca ggctgcagga ctcctgtcga ttgcctagcc cagcggacag
      541 cgaagctgct taccatggag cccgtgacca agtggagccc caaacaagtg gtggactgga
      601 ctagagggtt ggatgactgc ctgcagccat atgtgcacaa gtttgagcgg gagaagatag
      661 acggggagca gttgctgaaa atctcccacc aggatctcga ggaactgggg gtcacacgga
      721 tcggccacca agagctggtg ttggaggctg tggatcttct ctgtgcactg aattatggcc
      781 ttgaaactga tactatgaag aacttggttc tgaaactgcg ggcatcttcc cacaacttgc
      841 agaattacat cagtagccgc cggaagagtc cagcctacga tgggaatacg tcccgtaagc
      901 cccccaacga gttcctgact tctgtggtgg aactcattgg tgctgccaag gccctgctgg
      961 cttggctgga ccgggctcca ttcacaggga tcacagatct ctctgtgaca aagaacaaaa
     1021 tcatccaact gtgcctggac ctgaccacag cagtccagaa ggattgcctc atagcagaaa
     1081 tggaggataa agttttaaat gtggtcaagg ttttaaatgg catctgtgac aaaacaatgc
     1141 gctctactac agaccctgtt atgagccagt gtgcctgcct ggaggaagtt cacttaccaa
     1201 atgttagacc cggggaaggc ctgggcatgt acatcaagtc aacctacgac ggactgcatg
     1261 tgattactgg aaccacagaa aattctcctg cagacagatc tcaaaagatt cacgctggcg
     1321 atgaggtcat tcaagtcaat cggcagacag tggttgggtg gcagttgaaa aatctggtga
     1381 gaaagttgag agagaacccc acgggcgtgg tgctgctgct gaagaagagg cccacgggct
     1441 ccttcagctt cactccggcc ccactgaaga acctgcggtg gaagccaccg ctcgtgcaga
     1501 cctcaccccc gcccaccacc acccagtccc cagagagtac catggatgcc tccctgaaga
     1561 aggagaagcc agccatcctg gatctataca tccctccccc acctgctgtc ccctactctc
     1621 cccgggatga gaatgtgagt ttcggctaca gaggacacag taagagtaag cagccgttgc
     1681 ctgtgcgcaa gggttccgag tcccctaact ccttcctgga ccaggagagc caaagacgca
     1741 gatttaccat tgcagattcc gatcagctgc ccgggtattc ggtggaaacc aatgttctgc
     1801 ccacaaaaat gagagggaag acaccatcct acggcaaacc ccggcctctg tccatgcctg
     1861 ccgatgggaa ctggatgggg atcgtggacc cttttgctaa acctcgagga aatgggagga
     1921 aaggggaaga tgccctctgc cggtacttca gcaatgagcg gatcacaccc atcactgaag
     1981 aaagtgcctc tcctatgtac cggttctcta gacccctgac tgagcggcac ctggtccgag
     2041 gtgcggacta catccgaggg agcaggtgct acatcaactc cgacctacac agcagtgcca
     2101 ccattccatt ccaggaggaa ggttccaaga agaaatcagc ctcctcatcg gccaaggcgt
     2161 cctctgggga gccgtcgctg ctggtcagct ggctgactcg cctcaagctg ttgactcact
     2221 gaggtggctg ctccaccagc ttcctgcctg tctcctgcta gcaagtgcct tcttcctcag
     2281 tggacagctt ctttagactc cttccacagt gctccgtggc aactttactt cattccattt
     2341 tttttaaggt tgtatactgt tgttcctgga gtgttcaagt caaccagagg gcatcaaatc
     2401 cagtggatct taggtgccat ctgtggaggc agaaggaagg acagacatgg cacagcctgc
     2461 ctagttctgc cgtcccactg tgggaacatg gagacatgct ctttaaagtg tggtgttggt
     2521 cagacaactt aatgtcagga attggcaaaa ttgttcactt ttgttttctt ggacagcggg
     2581 gactgaaatt gatgggtttt gtcgcataga taaaacccat agtcagtttg tggtccaact
     2641 tctgcatctg aaaaagccaa aggagaaaag cctttgcttt gatttttaaa gctatagaac
     2701 atatttataa gtatggcagc gtccgccaca gaatgatgtg tgtgaggctc tttgtagcag
     2761 ggctttcttt acctacagat cagctgttac ccgcgcccag ccaccccccc accccccttt
     2821 cagtaacagc ctccatgtag gtgagccaat acacaaattc acgagcacgc tttgatggaa
     2881 cttagcatat gcaaagaagt gtgtgctttt tgtgaatggt gttgcagttg tatatgggaa
     2941 aggagctata agatttgctg acagccaaag tgtattgttc aggaagcaga agcaaccaga
     3001 gttagagtta tgaggcattg gtcagtttgc agtgttgatc tgtttgatgt ctgtgttcga
     3061 gggggggggg gggaaaccta cagtccttcc caggtgtaca catttttgct aattagaaat
     3121 atcttggaaa gcctcatcgt cactgatttt caactaggat caggtatttt gaaaatgtgt
     3181 gtctgcatat taactcttgt ttaaaactga atgtacaata ttttgctaga gtggaaaaag
     3241 ccctatcttg ttaatttaag tgttttaaat agagttgtat atttttctta ctcttagtca
     3301 cacataattg aaatgtttct gttttgtgtc atatgtgaaa cccaaggaaa aagagtattc
     3361 aacgtggttt cagatttaca agtgacccac tcctggccgt tggcagtgtg ggcacttata
     3421 ttaaagacgg aaataaattc ttccaagc
//
