LOCUS       NM_177751               5521 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus connector enhancer of kinase suppressor of Ras 2
            (Cnksr2), transcript variant 1, mRNA.
ACCESSION   NM_177751
VERSION     NM_177751.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5521)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5521)
  AUTHORS   Maruo,T., Mizutani,K., Miyata,M., Kuriu,T., Sakakibara,S.,
            Takahashi,H., Kida,D., Maesaka,K., Sugaya,T., Sakane,A., Sasaki,T.,
            Takai,Y. and Mandai,K.
  TITLE     s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of
            the AMPA receptor and glutamatergic synaptic response in
            hippocampal neurons
  JOURNAL   J Biol Chem 299 (4), 103040 (2023)
   PUBMED   36803960
  REMARK    GeneRIF: s-Afadin binds to MAGUIN/Cnksr2 and regulates the
            localization of the AMPA receptor and glutamatergic synaptic
            response in hippocampal neurons.
REFERENCE   3  (bases 1 to 5521)
  AUTHORS   Ito,H., Morishita,R., Noda,M., Ishiguro,T., Nishikawa,M. and
            Nagata,K.I.
  TITLE     The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to
            mediate hippocampal granule cell development
  JOURNAL   J Biol Chem 297 (6), 101427 (2021)
   PUBMED   34800437
  REMARK    GeneRIF: The synaptic scaffolding protein CNKSR2 interacts with
            CYTH2 to mediate hippocampal granule cell development.
REFERENCE   4  (bases 1 to 5521)
  AUTHORS   Erata,E., Gao,Y., Purkey,A.M., Soderblom,E.J., McNamara,J.O. and
            Soderling,S.H.
  TITLE     Cnksr2 Loss in Mice Leads to Increased Neural Activity and
            Behavioral Phenotypes of Epilepsy-Aphasia Syndrome
  JOURNAL   J Neurosci 41 (46), 9633-9649 (2021)
   PUBMED   34580165
  REMARK    GeneRIF: Cnksr2 Loss in Mice Leads to Increased Neural Activity and
            Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.
REFERENCE   5  (bases 1 to 5521)
  AUTHORS   Li,J., Zhang,W., Yang,H., Howrigan,D.P., Wilkinson,B., Souaiaia,T.,
            Evgrafov,O.V., Genovese,G., Clementel,V.A., Tudor,J.C., Abel,T.,
            Knowles,J.A., Neale,B.M., Wang,K., Sun,F. and Coba,M.P.
  TITLE     Spatiotemporal profile of postsynaptic interactomes integrates
            components of complex brain disorders
  JOURNAL   Nat Neurosci 20 (8), 1150-1161 (2017)
   PUBMED   28671696
REFERENCE   6  (bases 1 to 5521)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 5521)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 5521)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 5521)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN173382.1 and BC043093.1.
            
            On Jul 18, 2015 this sequence version replaced NM_177751.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060716.1, SRR6116558.58996.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DN173382.1         1-34
            35-87               DN173382.1         36-88
            88-5521             BC043093.1         1-5434
FEATURES             Location/Qualifiers
     source          1..5521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.76 cM"
     gene            1..5521
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /note="connector enhancer of kinase suppressor of Ras 2"
                     /db_xref="GeneID:245684"
                     /db_xref="MGI:MGI:2661175"
     exon            1..421
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..3456
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     connector enhancer of KSR2; CNK homolog protein 2;
                     connector enhancer of KSR 2"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras 2
                     isoform 1"
                     /protein_id="NP_808419.1"
                     /db_xref="CCDS:CCDS30501.1"
                     /db_xref="GeneID:245684"
                     /db_xref="MGI:MGI:2661175"
                     /translation="MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQL
                     LRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNF
                     ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNV
                     IQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQL
                     ANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLK
                     NLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPS
                     STISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPN
                     SFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVG
                     DYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPAH
                     YSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGAISGKSKRRISCK
                     DLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFK
                     IDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQD
                     YWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQS
                     SHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSA
                     AISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHC
                     CLNTPVSACDPQDDIQPPEVEEEEEEEEEEAAGENVGEKNENREEKLGDSLQDLYRAL
                     EEASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDK
                     VLDNPDLTSKEFQQWKQMYLDLFLDICQSTTSNDPLSISSEVDVLTSSLTHTHSYIET
                     HV"
     exon            422..585
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..788
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..876
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..918
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1038
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1098
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1167
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1314
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1448
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1660
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1750
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1965
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2014
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2187
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2261
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2333
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2401
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2502
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..3043
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3240
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..5504
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5486..5491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /note="hexamer: ATTAAA"
     polyA_site      5491
                     /gene="Cnksr2"
                     /gene_synonym="Cnk2; Ksr2"
                     /note="major polyA site"
ORIGIN      
        1 tgcgccggcg cctcttcctt tccccgccgc gacctcggcg gctcgagcca tgcactgaag
       61 cccctcggga cgctcacccc gggctgagcc gcggacgccg cagctgcggc tgccgcctgg
      121 gctgggacct agccgacccc ggcgtcttac cccggccagc tggccggccg tcgccgctcc
      181 caccgcagcc acctccgacg ctccagcctt gggaccgaaa cacaaaagcc accctctccg
      241 cgccgcccac cgcgggaggc tgcggccggc caccgacccc acctgagggc gcagcgggct
      301 gcggacttgg ctttctgtcc gagctccgcg tcccacgcgg caccgacccc gccgcccatg
      361 gctctgataa tggaaccggt gagcaaatgg tctccgagtc aagtagtgga ctggatgaaa
      421 ggtcttgatg actgtttgca gcagtacatt aagaactttg agagagagaa gatcagtgga
      481 gaccagctgc tacgcattac acatcaggag ctagaagatc tgggagtcag ccgtattggc
      541 catcaggagc tgatcttgga agcagttgac cttttgtgtg cactgaatta tggcttagaa
      601 acagaaaatc taaaaacact ttctcacaag ttgaatgcat ctgccaaaaa tctacaaaac
      661 ttcataacag gaaggagaag gagcggccat tatgatggga ggaccagccg aaaattacca
      721 aatgactttt tgacctcagt tgtggatctg attggagcag ccaagagtct tcttgcttgg
      781 ttggacaggt caccatttgc tgctgtgaca gactattcag tcacaagaaa taacgtcata
      841 cagctctgct tggaattaac aacaattgtg caacaggatt gcactgtata tgaaactgaa
      901 aataaaattc ttcatgtgtg taaaactctc tctggagtct gtgaccacat catatccctg
      961 tcatcagatc ctctggtttc acagtctgct cacctggaag tgattcagct ggcaaatatc
     1021 aaaccaagtg aagggctggg tatgtatatt aaatccacat atgatggcct ccatgtaatt
     1081 accgggacca cagaaaattc acctgcagat cgctgtaaga aaatccatgc tggtgatgaa
     1141 gtaatccaag tgaaccatca gactgtggtg gggtggcagt tgaaaaattt ggtgaatgca
     1201 ctacgagagg acccgagtgg tgttatctta actttgaaaa agcgacctca gagcatgctt
     1261 acctcagcac cagctttact gaaaaatatg agatggaagc cccttgctct gcagcctctt
     1321 atacctagaa gtcccacaag cagcgttgcc acgccctcca gcaccatcag tacacccacc
     1381 aaaagagaca gttctgctct ccaggatctc tacatccccc ctcctcctgc agaaccatat
     1441 attcccaggg atgaaaaagg aaaccttcct tgtgaagacc tcagaggaca tatggtgggc
     1501 aagccagttc ataaggggtc tgaatcccca aattcatttc tggaccaaga atatcgaaag
     1561 aggtttaaca ttgttgaaga agatactgtc ttatattgct atgaatatga aaagggacga
     1621 tcaagtagtc aaggaagacg ggaaagcaca ccaacctatg gcaagctacg acctatatct
     1681 atgccagtgg aatataattg ggtgggggac tatgaagatc caaataagat gaagagagat
     1741 agtagaagag aaaactctct acttcgatac atgagcaatg aaaaaattgc tcaagaagaa
     1801 tacatgtttc agagaaacag caaaaaagac acagggaaga agtcaaaaaa gaagggtgat
     1861 aagagtaata gcccagccca ctactcattg ctgcctagtt tgcaaatgga tgcattgaga
     1921 caagacatca tgggcacacc agtgccagaa accacactgt accatacatt tcaacagtcc
     1981 tctctgcagc acaaatcaaa gaagaaaaac aaaggagcta tatcaggcaa gagcaaaaga
     2041 agaatttctt gcaaggatct tggccgtggt gactgtgaag gatggctttg gaaaaagaaa
     2101 gatgcaaaga gctatttttc acagaaatgg aagaagtact ggtttgtcct aaaggatgca
     2161 tccctatact ggtatattaa tgaagaggat gaaaaagcag aaggattcat cagtctgcct
     2221 gaatttaaaa tcgatagagc cagtgaatgc cgcaagaaat atgcattcaa agcctgccat
     2281 cctaaaatca aaagctttta ttttgctgct gaacatcttg atgacatgaa caggtggctt
     2341 aacagaatta acatgctgac tgcaggatat gcagaaagag agaggattaa acaagaacaa
     2401 gattactgga gcgagagtga caaagaagaa gcagatactc catcgacacc aaaacaagac
     2461 agccctccgc ccccctatga cacataccca cggcctccct ctatgagttg tgccagtcct
     2521 tatgtggaag caaaacacag ccggctttcc tccacagaga cctctcagtc tcagtcttca
     2581 cacgaggagt tccgccagga agtcactggg agcagtgctg tgtctcccat tcgcaagaca
     2641 gccagtcagc gccgctcctg gcaggattta atcgagacac cgctgacaag ctcaggctta
     2701 cactatcttc agactctgcc tctggaagat tctgtcttct cggattcagc agccatctcc
     2761 cctgagcaca ggcggcagtc cactcttcca actcagaagt gccacctcca ggatcattat
     2821 ggcccatacc ctttagcaga gagcgagagg atgcaagtgt taaacggcaa tgggggcaag
     2881 cctcgaagtt ttactctgcc tcgagatagc gggttcaacc attgctgtct gaacacacca
     2941 gttagtgcct gtgacccaca agatgacata cagccaccag aggtggagga agaagaggag
     3001 gaggaagaag aggaagcagc aggagaaaac gttggagaga aaaatgaaaa cagggaagaa
     3061 aaattaggag actccttgca agatttatac agggcactgg aggaagccag tctgtcacca
     3121 ctaggagaac atcgcatttc aaccaagatg gaatacaaac tatcattcat aaaacggtgt
     3181 aatgatcctg tgatgaatga gaaactgcac aggctgagaa ttcttaaaag cactttaaag
     3241 gccagagaag gggaagtagc cattattgat aaagtcctag acaatccaga cttgacttct
     3301 aaagaattcc aacaatggaa gcagatgtac ctcgaccttt tcttggatat ctgtcaaagc
     3361 accacctcaa atgacccact aagtatctct tctgaagtag atgttctcac ttcctctcta
     3421 acacacactc actcatacat tgagacacat gtgtaagtgc actcggcctc gaggtcacct
     3481 agtacctgac ggtactctga atcagtggat aaggtagttt tttttatcag tgtgttggat
     3541 acttgacaag ctctacttta atgttaccaa actatatgaa acaaagcata catggtcaca
     3601 ttgccactgt ctttaaagag catttgtatg ttttatatgc agtcagtgct cagcttatgt
     3661 taccatatgc agaatcaact atctttaatg acttaaatta acttttgcag acaattctga
     3721 aaacagatga tcttcaagta gaaaaactac aaaaaggcag ttttctatct gaggtcatct
     3781 cttctccctt taagttcatt ttatatataa tgaaacttca accgtaaatc acaatttttt
     3841 caggtgcaga catccttgtg ggtgggaaag aatttaaacc tttttatatt tattaaaatg
     3901 ttctaagaat tttcttaaac attgcacaaa gtttaatgct gtagttttat ttttatgaaa
     3961 tgtaggtgcg tataaaagag ttaagcaaac tagaagagca tgaacatacg aaaagttcag
     4021 gtctaatatc tgtcttaaga gtctattaac ttgtgccgac tggttaaggg aggcacgatt
     4081 gcaaacccat gcgagcactg cgcggcgtat cagggcaaag ctttgtgaga tgcttttgta
     4141 actgagacca aaattgaaca tagagctgct ttattttctt gctttaaatc ttcctttatt
     4201 tttgtagtga tgaaatgctg attgtgtaca gaagaattta agaatggatt ttttaaaaca
     4261 gacttaactc acccagaaag gcagctaaca gctacacaca cacacacaca cacacacaca
     4321 cacacacaca cacacacttt cagcccaaac tcgtgttttt tgaactctta aaagacaagg
     4381 tatacactga aatgagtcca ttttccaggc attttgcaat tttcccttgg tctgtaacta
     4441 aacttctgta attatacatc aggcaaggga gtaaaatgca tttagtcgtg gcagatagaa
     4501 gttgcagtag agaaaataat gttgaaaaac cttaatgggt ttctctacta aggagcagag
     4561 gatggcagtc attcagggag ttattacatt gagtggcctg agatcaaaca cttagaggtt
     4621 tttcctagaa tcctgaactg tttataggtg gagtctatga aaaagtcctc ttgacatatt
     4681 gccattttta tgtgtctagt tttggaaagt gaccacagca tgaaagtgac ttgctgcttt
     4741 ttagtgtgtg gctgcataat atacaagtca caatttgctg ttttttcagg agggatagat
     4801 cctcctttac tattctatat cctgaaatct acttctgatc agctttatcc tgttgcctgt
     4861 acagctcagt gaatgtattt acatctctaa gagttcagat atatgccagt gaatattttt
     4921 gctgtagaga agaaagtaaa aactacacag cgggatcttt ttctttgctt ttgaaatcac
     4981 attaaatcac tatcgttttg cagactttgc acaagtgtac aggagagtgg cctttctaca
     5041 gcacattttc agtaatccta tctttagtca aaatggatga gaaacatgca ttaatgtttg
     5101 tatggaattg tgggtccagt gtaatatttt tatcatttag aataccctat ttgtaaaaac
     5161 atttatttac tgcatggtta ttgacaaaca ttaaatttgt gggattttgt atatgtaaaa
     5221 gaaagagaga gaaagaacag acaaacaaaa cccctcttgt cataaaatga agtgtgcttg
     5281 ttacagttgt ttaggcatat tgatgttcac tagaccaatg tggtgtatct tcacttaaaa
     5341 ctatttgtac atgatggatg cgtcacgtat acagtggaca aacagcctgc aaacaacagg
     5401 cagttggtgg gaaggctagc tctgttacta gtatgcagct tctacttttg taaagtcagc
     5461 tgttgtttta ctggtaaaaa aaaaaattaa actaatgaat tttaaaaaaa aaaaaaaaaa
     5521 a
//
