LOCUS       NM_001081047            2467 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus connector enhancer of kinase suppressor of Ras 1
            (Cnksr1), mRNA.
ACCESSION   NM_001081047 XM_110525
VERSION     NM_001081047.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2467)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL627314.6.
            
            On Feb 6, 2007 this sequence version replaced XM_110525.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145910.1, BC113805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL627314.6         110119-110261       c
            144-301             AL627314.6         108022-108179       c
            302-483             AL627314.6         107733-107914       c
            484-568             AL627314.6         106971-107055       c
            569-610             AL627314.6         106532-106573       c
            611-715             AL627314.6         106351-106455       c
            716-775             AL627314.6         105730-105789       c
            776-838             AL627314.6         105564-105626       c
            839-940             AL627314.6         105148-105249       c
            941-1002            AL627314.6         105002-105063       c
            1003-1061           AL627314.6         104856-104914       c
            1062-1168           AL627314.6         104609-104715       c
            1169-1199           AL627314.6         104500-104530       c
            1200-1372           AL627314.6         103903-104075       c
            1373-1446           AL627314.6         102274-102347       c
            1447-1518           AL627314.6         102042-102113       c
            1519-1595           AL627314.6         101448-101524       c
            1596-1657           AL627314.6         101244-101305       c
            1658-1742           AL627314.6         101068-101152       c
            1743-1924           AL627314.6         100801-100982       c
            1925-2467           AL627314.6         99904-100446        c
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.5 cM"
     gene            1..2467
                     /gene="Cnksr1"
                     /note="connector enhancer of kinase suppressor of Ras 1"
                     /db_xref="GeneID:194231"
                     /db_xref="MGI:MGI:2670958"
     exon            1..143
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2194
                     /gene="Cnksr1"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras
                     1"
                     /protein_id="NP_001074516.1"
                     /db_xref="CCDS:CCDS38912.1"
                     /db_xref="GeneID:194231"
                     /db_xref="MGI:MGI:2670958"
                     /translation="MEPVEAWTPGKVAAWLRGLDDALQDYPFEDWQLPGKYLLQLCPQ
                     SLEALTVWPLGHQELILDGVEQLRALGSNLQTENLQSLAQGLLERTQAFQSLVQGSLG
                     NCAETPADVLKAAVELVREAHALLSWLNGYLFSHLNDFSACQEIGVLCGELGQVLQED
                     CPEAEKERNILRICSHVAGICHNILSCSPEELLEQKAVLESVQVDDPSGLEIHTTSNC
                     LHFVSRVGVQAATSSQILPGDEIVQVNEQVVVGWSHKNMLRELLREPAKVSLVLKKIP
                     VPETPSQTSLDSPHLLSQSLPLNPPSPRVPSEGLLADGTPGPSPAWTDSTSFDAQSPP
                     TPPGPPGVLPEETAEPLESSGHPDKSPILGRKKSKGIATRLSRRRVSCRELGLPDCDG
                     WLLLRKVPGGFMGPRWRRCWFVLKGHTLYWYRQPQDEKAEGLINLSNYSLESGHDQKK
                     KYVFQLTHDVYKPFIFAAETLSDLSKWVRHLITCISKYQAQGRAPSSAREEDCYSETE
                     AEDPDEEAGSRSASPGPAQAWSDTSPVASPLQSPRTSFNSSPDSSDRALEGMVQGLRQ
                     GGVSLLGQPQPLTHEQWRSSFMRRNRDPHLNERAHRIRALQSTLKAKLQELQALEEVL
                     GDPELTSAKFRQWKEQNQELYSEGLRTWGGTWAQTSSSDPNSDSRAHSPQPLPFDPEE
                     PSQLFPLTPENSRQPPDL"
     exon            144..301
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..483
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..568
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..610
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..715
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..775
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..838
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..940
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1002
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1061
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1168
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1199
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1372
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1446
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1518
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1595
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1657
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1742
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1924
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2467
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctctggcc cagccccgcg gcctccgggc tcgggctcgg actgggagcg gaaattcctg
       61 caggggctgg acgctacggg cagagctcag gatggagccc gtggaggcct ggacccccgg
      121 gaaggtggca gcttggctga gaggccttga tgatgcccta caggactatc ccttcgagga
      181 ctggcagctg cctgggaagt acctgctgca gctctgtccc caaagcctcg aggctctgac
      241 tgtgtggcct ttgggccacc aggaactcat tctagatggg gtggaacagc tccgggccct
      301 gggctctaat ctacagacag agaacctgca gagcctggct caggggctgc tggaaaggac
      361 ccaggccttc caaagcttgg tccaaggctc tctgggcaac tgtgctgaga caccggctga
      421 cgtcctcaag gctgcggtgg agctggtgcg ggaagcccat gccctcctct cttggctcaa
      481 cgggtacctc ttctctcact taaatgactt ctctgcctgc caggagattg gcgtgctgtg
      541 cggggagctg ggccaagtcc tgcaggagga ctgcccagag gctgagaagg aacgaaacat
      601 cctaaggatt tgcagccacg tggctgggat ctgtcacaac atcctgagct gcagcccaga
      661 ggagctgctg gaacagaagg ccgtgctgga gtcggtgcag gtggacgacc cttccggtct
      721 agaaattcac accaccagca actgcctgca ctttgtgtcc cgagtagggg ttcaggctgc
      781 caccagctcc cagatcctgc caggagacga gattgtccag gtcaatgagc aggtggtggt
      841 gggctggtcc cataagaaca tgctgaggga gctgctgagg gaaccagcaa aggtcagcct
      901 ggtactgaag aagattcccg tgccagagac cccctcacag acgtccctgg actctcctca
      961 cctgctaagc caatcgctgc ccctgaaccc accgtctccc agggttccgt ctgaaggtct
     1021 tttagcagat ggaactcctg gacccagccc tgcttggaca gactctacct cctttgacgc
     1081 tcagtccccg cccactcccc ctggaccacc aggcgtactt ccagaagaaa cagcagaacc
     1141 tctggagtct tcgggacacc ctgacaagag tcccatcctt ggtcggaaga aatctaaagg
     1201 tatagccacg aggctgagcc gccgccgggt gtcctgccga gagttgggtc tgccggattg
     1261 tgatggatgg cttctactgc ggaaggtacc cggtggcttt atgggcccac gctggcgccg
     1321 ctgctggttt gtgctcaagg gacacaccct atactggtac cgccaacccc aggatgaaaa
     1381 ggccgaaggg cttatcaatc tctccaacta cagcctagag agtggacatg accagaagaa
     1441 aaaatatgtg ttccagctga cccatgatgt gtacaagccc ttcatctttg ctgccgagac
     1501 cctgtctgat ctgagcaagt gggtgcgaca tctcattacc tgcatttcca agtaccaggc
     1561 tcaaggccgg gccccctcct ctgccagaga ggaagactgc tacagtgaga cagaagcaga
     1621 agaccccgat gaggaggctg ggtcccgctc cgcttctcct ggcccagctc aagcgtggag
     1681 tgacacatca cccgtggctt cacccctgca gagtccgaga acttccttta actcttcacc
     1741 agacagcagt gacagagccc tggaaggaat ggtacagggg ctgaggcagg gaggggtgtc
     1801 cctcctgggc cagccccagc ccctgaccca tgaacaatgg cggagttctt tcatgaggcg
     1861 caaccgtgac cctcatctca atgagcgtgc acaccgtatc cgggcactcc agagcaccct
     1921 caaggcaaag ctgcaggaac tgcaggccct ggaggaagtg ctgggtgatc ctgaactcac
     1981 aagtgcaaag ttccgacagt ggaaggaaca gaaccaggag ctatactcag agggcctgag
     2041 aacctgggga gggacgtggg cccagaccag ctcctcagac ccaaactctg actccagggc
     2101 tcattcccca cagcccctcc cctttgaccc tgaagagccc tcccagcttt ttcccttaac
     2161 cccagagaac agccgccaac ctcctgacct ctgaccctgg ctgaggacta cttcattccc
     2221 agtctctgac gtgtttaaga catctccaag aacagacctt ccacacactc tgctcacgtg
     2281 tcccctagag tggaaggaaa tctcccgccc tctctgtgag gcagaaatcc ctcaacccat
     2341 cctcagatct gggatgtccc tgccttcctg gggcattcaa aaaggtttcc cagaccagat
     2401 ctggataggt gtttatttta cacgagagcc gcttttccac caaataaagt tgatttctct
     2461 gacgtga
//
