LOCUS       NM_028408               2580 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus cornichon family AMPA receptor auxiliary protein 3
            (Cnih3), transcript variant 1, mRNA.
ACCESSION   NM_028408
VERSION     NM_028408.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Mulvey,B., Frye,H.E., Lintz,T., Fass,S., Tycksen,E., Nelson,E.C.,
            Moron,J.A. and Dougherty,J.D.
  TITLE     Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across
            the Estrous Cycle
  JOURNAL   eNeuro 10 (3) (2023)
   PUBMED   36849260
  REMARK    GeneRIF: Cnih3 Deletion Dysregulates Dorsal Hippocampal
            Transcription across the Estrous Cycle.
            Erratum:[eNeuro. 2023 Jun 7;10(6):ENEURO.0155-23.2023. doi:
            10.1523/ENEURO.0155-23.2023.. PMID: 37286355]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Frye,H.E., Izumi,Y., Harris,A.N., Williams,S.B., Trousdale,C.R.,
            Sun,M.Y., Sauerbeck,A.D., Kummer,T.T., Mennerick,S., Zorumski,C.F.,
            Nelson,E.C., Dougherty,J.D. and Moron,J.A.
  TITLE     Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic
            Plasticity
  JOURNAL   Biol Psychiatry 90 (11), 766-780 (2021)
   PUBMED   34548146
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Nelson,E.C., Agrawal,A., Heath,A.C., Bogdan,R., Sherva,R.,
            Zhang,B., Al-Hasani,R., Bruchas,M.R., Chou,Y.L., Demers,C.H.,
            Carey,C.E., Conley,E.D., Fakira,A.K., Farrer,L.A., Goate,A.,
            Gordon,S., Henders,A.K., Hesselbrock,V., Kapoor,M., Lynskey,M.T.,
            Madden,P.A., Moron,J.A., Rice,J.P., Saccone,N.L., Schwab,S.G.,
            Shand,F.L., Todorov,A.A., Wallace,L., Wang,T., Wray,N.R., Zhou,X.,
            Degenhardt,L., Martin,N.G., Hariri,A.R., Kranzler,H.R.,
            Gelernter,J., Bierut,L.J., Clark,D.J. and Montgomery,G.W.
  TITLE     Evidence of CNIH3 involvement in opioid dependence
  JOURNAL   Mol Psychiatry 21 (5), 608-614 (2016)
   PUBMED   26239289
  REMARK    GeneRIF: Study's convergent findings in humans and mice support
            CNIH3 involvement in the pathophysiology of opioid dependence,
            complementing prior studies implicating the
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            glutamate system
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Herring,B.E., Shi,Y., Suh,Y.H., Zheng,C.Y., Blankenship,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Cornichon proteins determine the subunit composition of synaptic
            AMPA receptors
  JOURNAL   Neuron 77 (6), 1083-1096 (2013)
   PUBMED   23522044
  REMARK    GeneRIF: In cornichon-3 and cornichon-2 knockout mice there is a
            profound reduction of AMPA receptor synaptic transmission in the
            hippocampus.
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113084.12 and AC119235.13.
            
            On Oct 20, 2022 this sequence version replaced NM_028408.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013789.1, SRR7652917.651320.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-879               AC113084.12        223455-224333
            880-948             AC119235.13        80452-80520         c
            949-1053            AC119235.13        77254-77358         c
            1054-1166           AC119235.13        36905-37017         c
            1167-1310           AC119235.13        32249-32392         c
            1311-2580           AC119235.13        26493-27762         c
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.53 cM"
     gene            1..2580
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /note="cornichon family AMPA receptor auxiliary protein 3"
                     /db_xref="GeneID:72978"
                     /db_xref="MGI:MGI:1920228"
     exon            1..879
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             799..1338
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein cornichon homolog 3"
                     /codon_start=1
                     /product="protein cornichon homolog 3 isoform 1"
                     /protein_id="NP_082684.1"
                     /db_xref="CCDS:CCDS35810.1"
                     /db_xref="GeneID:72978"
                     /db_xref="MGI:MGI:1920228"
                     /translation="MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQ
                     CNPVHARERLRNIERICFLLRKVRGVPPGGRRKGRRERGQQLVLPEYSIHSLFCIMFL
                     CAQEWLTLGLNVPLLFYHFWRYFHCPADSSELAYDPPVVMNADTLSYCQKEAWCKLAF
                     YLLSFFYYLYCMIYTLVSS"
     exon            880..948
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1053
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1166
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1310
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..2580
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2580
                     /gene="Cnih3"
                     /gene_synonym="2900075G08Rik; CNIH-3"
                     /note="major polyA site"
ORIGIN      
        1 gcattcctcg cggcgcccgc ggcagcagca gaagcagcag cagcagcagg tggagcccca
       61 ttcagctgcg agccgctctt ggccggaaac ccgcgccgca gccgcctggc cgggagctgg
      121 ccctccaggc tggagcccac gccgccccgg cccgacccag tttcccaggc accgggttac
      181 cgaagccggc ggccggggga cgcggttggg tccggggccg gatgcatctc agtgcgcata
      241 gctgcgctgg gagaccccag cccggggcgc agggctaacg ggacctggcc cacctcaaga
      301 cttgtgctct ggggacagag cggctttggg attcggagtc caggcacctg gccggaggct
      361 gttgaagtct gggtgtcgtg ctcaccccac ctctttgctt gggcaccaac agagagagct
      421 ctttccagag gaccggacct cctcgcctgg tccagagtgg agtcctcgca cccggtgcct
      481 gttagtttcg agaacctttc tagttgacac tggtctgcag gtgttctctg ctggttaggt
      541 ttcttcttcg gctaggggga ctgttgctac cagaggcatt ctgtgcctgt gggcgctcca
      601 agtcccgggt ctccagtcct gccagaatcg tccgggcttc gctgaccctc aactctgtct
      661 ctgcttgtcg tgggtgcttc tagtcgtttg ggtttttacc cggagtgtgt agactagaca
      721 tctttctgac tgctaattgg gaaggcactg gtctccaggg agcggctttg tgtgtggtgg
      781 gatccggggt cctcagccat ggccttcact ttcgctgctt tctgctacat gctgtccctg
      841 gtgctctgcg ctgcgctcat ctttttcgct atctggcaca taatcgcctt tgacgagcta
      901 agaacggatt tcaagagtcc catagaccag tgcaacccgg ttcatgcgag agaacggctg
      961 aggaacatcg aacgcatctg cttccttctg agaaaggtca gaggggtccc cccaggtgga
     1021 cggaggaagg gtcgcagaga aaggggtcag cagctggtgc tgcccgagta ctctatccac
     1081 agcctcttct gcatcatgtt cctgtgcgct caggagtggc tcaccctggg actcaatgtt
     1141 cctctgcttt tctatcactt ctggaggtat ttccactgtc cagcagatag ctcagagcta
     1201 gcctacgacc caccagttgt catgaatgcg gacaccttga gctactgcca gaaggaggcc
     1261 tggtgtaagc tggccttcta cctcctctcc ttcttctact acctgtactg catgatttac
     1321 accttagtga gctcctaact cagaccctgc tgatggagag gccgaagctg ggaaccactg
     1381 cggctgtggc tagaggagca ccagatgggg atgacggaga gacccagatg gcagagaccg
     1441 aatgaaagga acgggagtca tacagcagtc agagccatgt tacccacgtg tgtctgtttc
     1501 tgccttcgca tttcacatcc cacatgggtt gcagggcccc tctgagcatg ggcgtgccag
     1561 cttgtagctg atgaaacact caacctctgg agatgccatt attacttcct tcatccactt
     1621 cactgagcag cagaactgtg cgagtttcac atggagagct cgtctggatg gtagaaatga
     1681 ggccagatgc tggcaggtgt cgaacaaggg acagaatggc tcagggccaa ggccagatct
     1741 tcagggatgg ctgagaccca cagggacacc atgggctgcc caagactctt gtcatttttt
     1801 ttccagagct gtggtcacat gctttgctca gtgcaaggca gaaagctgtg gggactgccc
     1861 tgagccacct ctcacgtcac ttttacgctc tgtgtccagg agcctgggct gtggcttcct
     1921 gagctgggtg tggcagcaag ccctgtccag tgtgaactgg ggagggggag aaaatggatt
     1981 tctaaaaatg tctgcaacat gtcccaggtg tgagttcttc accctcccaa gatgtattct
     2041 gccactgtgc caaaaattca tcagagtcat tacatgccaa tcagctggct ggcatgagcc
     2101 aaagcaaaaa acaaaacaaa acaccaaacc aaaccaaacc cctcaaaata gtgcgaagcc
     2161 cagaaacaga gagctgctct gtgtgtgggt atggacagcc aggaagtgag acaacacaat
     2221 tatcacatcc attgatgctt cacggccttt gtgctcctca gttcaatgtg gggacatcgc
     2281 ttatttagaa atttccactt gacttttgct ccttttttgg gtgggagttg caggacaggt
     2341 gtaaatactg acaaggctga gtttttatga tgcttaaact gggcacaatg attttaacct
     2401 gattccccaa actgccttgc tttctaccat tacacacaca tacacacaca cacacacaca
     2461 cacacacaca cacactattt atatatgtac tggttcccat ctgaattctg tgactcagtt
     2521 ttttgaatgg tgtttgtgta acacattgtg tgctatgttt aagatgcagc aacaacttga
//
